Strain Name:
C57BL/6J-MtgxR0743Btlr/Mmmh
Stock Number:
038924-MU
Citation ID:
RRID:MMRRC_038924-MU
Other Names:
R0743 (G1), C57BL/6J-MtgxR0743Btlr
Major Collection:

Gene Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: OREBP, TonEBP, nfatz, B130038B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Dnm2
Name: dynamin 2
Synonyms: b2b2159Clo, Dyn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: RPTPz, PTPzeta, Ptprz, Ptpz, DSD-1-PG, Rptpbeta, phosphacan, PTPbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Glrb
Name: glycine receptor, beta subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14658
HGNC: HGNC:4329
Homologene: 20224
Denn2b
Name: DENN domain containing 2B
Synonyms: St5, 2010004M01Rik, 2610305K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76954
Homologene: 3951
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: 2810017C20Rik, E130319N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215351
Homologene: 9196
Kif5b
Name: kinesin family member 5B
Synonyms: kinesin heavy chain, Khc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227648
Homologene: 10533
Abcc4
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Synonyms: MOAT-B, D630049P08Rik, MRP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239273
VEGA: 14
HGNC: HGNC:55
Homologene: 74563
Tmem39a
Name: transmembrane protein 39a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67846
Homologene: 9985
Taf2
Name: TATA-box binding protein associated factor 2
Synonyms: CIF150, TAF2B, 150kDa, TAFII150, 4732460C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 319944
VEGA: 15
Homologene: 31137
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, 6530403D07Rik, D2Ertd145e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 51869
Homologene: 41231
Slc38a10
Name: solute carrier family 38, member 10
Synonyms: 1810073N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72055
Homologene: 41556
Syt9
Name: synaptotagmin IX
Synonyms: Sytv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60510
Homologene: 11062
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Otof
Name: otoferlin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, crf11, eyes2, heb, QBRICK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329872
Homologene: 27049
Pamr1
Name: peptidase domain containing associated with muscle regeneration 1
Synonyms: RAMP, E430002G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 210622
Homologene: 9134
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Gosr1
Name: golgi SNAP receptor complex member 1
Synonyms: GS28, GOS-28, Cis-Golgi SNARE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53334
HGNC: HGNC:4430
Homologene: 37977
Kmt5a
Name: lysine methyltransferase 5A
Synonyms: 2410195B05Rik, PR-SET7, Setd8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67956
Homologene: 41372
Wdtc1
Name: WD and tetratricopeptide repeats 1
Synonyms: adipose, LOC230796, adp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230796
Homologene: 8997
Gpr155
Name: G protein-coupled receptor 155
Synonyms: PGR22, 1110017O10Rik, F730029F15Rik, DEPDC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68526
Homologene: 16584
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: pcy, 3632410F03Rik, D330020E01Rik, nephrocystin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Anapc4
Name: anaphase promoting complex subunit 4
Synonyms: D5Ertd249e, APC4, 2610306D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52206
Homologene: 40873
Gabarapl2
Name: gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2
Synonyms: 0610012F20Rik, Gef2, 2900019O08Rik, GATE-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 93739
Homologene: 68550
Sirt4
Name: sirtuin 4
Synonyms: 4930596O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75387
Homologene: 8164
Ttn
Name: titin
Synonyms: D830007G01Rik, L56, 1100001C23Rik, mdm, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, shru, connectin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mep1b
Name: meprin 1 beta
Synonyms: Mep-1b, meprin beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17288
VEGA: 18
HGNC: HGNC:7020
Homologene: 48382
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
Slc35b2
Name: solute carrier family 35, member B2
Synonyms: PAPST1, 1110003M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73836
VEGA: 17
Homologene: 24504
Dnase1l2
Name: deoxyribonuclease 1-like 2
Synonyms: 4733401H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66705
HGNC: HGNC:2958
Homologene: 74391
Nebl
Name: nebulette
Synonyms: A630080F05Rik, D830029A09Rik, 1200007O21Rik, Lnebl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74103
Homologene: 128431
4932425I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Synpo2
Name: synaptopodin 2
Synonyms: 9530006G20Rik, Myo, myopodin, 1110069I04Rik, 2310068J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 118449
Homologene: 15400
C330019G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Olfr376
Name: olfactory receptor 376
Synonyms: MOR135-12, GA_x6K02T2P1NL-3535075-3536028
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258924
Homologene: 133579
Ksr1
Name: kinase suppressor of ras 1
Synonyms: D11Bhm184e, B-KSR1, D11Bhm183e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16706
HGNC: HGNC:6465
Homologene: 8410
Olfr1100
Name: olfactory receptor 1100
Synonyms: MOR206-4, GA_x6K02T2Q125-48465387-48464422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258587
Homologene: 34954
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20419
Homologene: 32123
Zfp454
Name: zinc finger protein 454
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237758
Homologene: 72226
Pramel23
Name: PRAME like 23
Synonyms: Gm13089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277667
Papolg
Name: poly(A) polymerase gamma
Synonyms: 9630006B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216578
Homologene: 56959
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319734
Homologene: 26544
Adam7
Name: a disintegrin and metallopeptidase domain 7
Synonyms: EAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11500
HGNC: HGNC:214
Homologene: 2830
Prtn3
Name: proteinase 3
Synonyms: PR3, mPR3, myeloblastin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19152
HGNC: HGNC:9495
Homologene: 120934
Ovgp1
Name: oviductal glycoprotein 1
Synonyms: muc9, Chit5, MOGP, oviductin, mucin 9, OGP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12659
HGNC: HGNC:8524
Homologene: 74442
Nmt2
Name: N-myristoyltransferase 2
Synonyms: A930001K02Rik, hNMT-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18108
HGNC: HGNC:7858
Homologene: 101539
Epsti1
Name: epithelial stromal interaction 1 (breast)
Synonyms: 2310046K10Rik, 5033415K03Rik, BRESI1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108670
VEGA: 14
Homologene: 12630
Uqcrc1
Name: ubiquinol-cytochrome c reductase core protein 1
Synonyms: 1110032G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22273
Homologene: 2525
Pate8
Name: prostate and testis expressed 8
Synonyms: Gm17689
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100312948
Nfatc4
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
Synonyms: 3110041H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 73181
VEGA: 14
HGNC: HGNC:7778
Homologene: 3349
Padi3
Name: peptidyl arginine deiminase, type III
Synonyms: PAD type III, Pad3, Pdi3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18601
Homologene: 7882
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Slc10a2
Name: solute carrier family 10, member 2
Synonyms: 9130221J18Rik, ASBT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20494
Homologene: 390
Cyp2a12
Name: cytochrome P450, family 2, subfamily a, polypeptide 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13085
Homologene: 69128
Tnnt2
Name: troponin T2, cardiac
Synonyms: cTnT, cardiac TnT, Tnt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21956
Homologene: 68050
Bend7
Name: BEN domain containing 7
Synonyms: E130319B15Rik, 1110017O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209645
Homologene: 17660
Plrg1
Name: pleiotropic regulator 1
Synonyms: Tango4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53317
HGNC: HGNC:9089
Homologene: 2004
Olfr610
Name: olfactory receptor 610
Synonyms: GA_x6K02T2PBJ9-6221839-6220892, MOR9-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259085
Homologene: 17495
Olfr798
Name: olfactory receptor 798
Synonyms: MOR108-1, GA_x6K02T2PULF-11304679-11303744
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258549
Homologene: 133881
Nol7
Name: nucleolar protein 7
Synonyms: 5730556I21Rik, 2210008F15Rik, RARG-1, NOP27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70078
VEGA: 13
Homologene: 49451
Gm7152
Name: predicted gene 7152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 635209
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 135,842,042 bp
  • A to T, chromosome 2 at 3,314,785 bp
  • A to T, chromosome 2 at 4,744,244 bp
  • A to C, chromosome 2 at 17,411,118 bp
  • G to A, chromosome 2 at 26,419,722 bp
  • GCCACCA to GCCA, chromosome 2 at 52,110,324 bp
  • G to A, chromosome 2 at 73,349,700 bp
  • G to A, chromosome 2 at 76,749,269 bp
  • G to A, chromosome 2 at 86,978,499 bp
  • A to G, chromosome 2 at 102,609,907 bp
  • T to A, chromosome 3 at 80,879,680 bp
  • T to C, chromosome 3 at 83,059,917 bp
  • T to C, chromosome 3 at 103,902,171 bp
  • T to A, chromosome 3 at 105,974,932 bp
  • A to G, chromosome 3 at 123,112,706 bp
  • A to T, chromosome 4 at 83,005,892 bp
  • A to G, chromosome 4 at 133,300,661 bp
  • G to T, chromosome 4 at 140,786,429 bp
  • A to T, chromosome 4 at 143,698,564 bp
  • C to T, chromosome 5 at 30,378,741 bp
  • C to A, chromosome 5 at 32,831,194 bp
  • T to A, chromosome 5 at 52,857,163 bp
  • T to C, chromosome 5 at 115,482,955 bp
  • C to A, chromosome 5 at 124,447,219 bp
  • C to T, chromosome 6 at 23,044,367 bp
  • C to T, chromosome 6 at 119,307,286 bp
  • T to C, chromosome 7 at 27,032,542 bp
  • C to T, chromosome 7 at 103,506,862 bp
  • A to G, chromosome 7 at 107,436,561 bp
  • A to G, chromosome 7 at 109,557,345 bp
  • T to A, chromosome 8 at 4,764,906 bp
  • A to G, chromosome 8 at 5,089,132 bp
  • G to A, chromosome 8 at 107,368,066 bp
  • A to T, chromosome 8 at 111,942,505 bp
  • T to A, chromosome 9 at 21,500,265 bp
  • T to C, chromosome 9 at 36,581,301 bp
  • C to T, chromosome 9 at 80,093,589 bp
  • GCATCATCATCATCATC to GCATCATCATCATC, chromosome 9 at 104,022,768 bp
  • C to T, chromosome 9 at 108,944,705 bp
  • C to T, chromosome 10 at 77,995,243 bp
  • T to A, chromosome 10 at 79,879,677 bp
  • T to A, chromosome 10 at 86,887,895 bp
  • T to A, chromosome 10 at 129,625,843 bp
  • A to T, chromosome 11 at 23,870,818 bp
  • A to G, chromosome 11 at 50,873,937 bp
  • A to T, chromosome 11 at 73,374,889 bp
  • A to G, chromosome 11 at 76,730,146 bp
  • A to T, chromosome 11 at 79,021,503 bp
  • C to T, chromosome 11 at 120,140,643 bp
  • T to C, chromosome 13 at 11,554,529 bp
  • G to A, chromosome 13 at 43,400,615 bp
  • A to G, chromosome 14 at 42,826,356 bp
  • A to C, chromosome 14 at 55,826,644 bp
  • A to C, chromosome 14 at 68,498,475 bp
  • A to T, chromosome 14 at 77,931,275 bp
  • A to T, chromosome 14 at 118,553,288 bp
  • GCTTCTTCTTCTTCTTCTT to GCTTCTTCTTCTTCTT, chromosome 15 at 55,016,461 bp
  • A to G, chromosome 16 at 38,335,634 bp
  • A to T, chromosome 16 at 38,585,402 bp
  • A to G, chromosome 17 at 24,441,880 bp
  • T to A, chromosome 17 at 45,566,825 bp
  • G to T, chromosome 18 at 6,209,192 bp
  • A to G, chromosome 18 at 21,080,458 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0743 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038924-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.