Strain Name:
C57BL/6J-MtgxR0762Btlr/Mmmh
Stock Number:
038942-MU
Citation ID:
RRID:MMRRC_038942-MU
Other Names:
R0762 (G1), C57BL/6J-MtgxR0762Btlr
Major Collection:

Gene Information

Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk2, Tsk-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Prss12
Name: protease, serine 12 neurotrypsin (motopsin)
Synonyms: motopsin, Bssp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19142
HGNC: HGNC:9477
Homologene: 7490
Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Ephx2
Name: epoxide hydrolase 2, cytoplasmic
Synonyms: sEH, Eph2, sEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13850
VEGA: 14
HGNC: HGNC:3402
Homologene: 37558
Pcm1
Name: pericentriolar material 1
Synonyms: 9430077F19Rik, 2600002H09Rik, C030044G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Bbx
Name: bobby sox HMG box containing
Synonyms: 5530401J07Rik, 5730403O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70508
Homologene: 10634
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: 220kDa, Rpo2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Gars
Name: glycyl-tRNA synthetase
Synonyms: Gena201, GENA202, Sgrp23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353172
HGNC: HGNC:4162
Homologene: 1547
Atg2b
Name: autophagy related 2B
Synonyms: C630028L02Rik, 2410024A21Rik, C030004M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Git1
Name: GIT ArfGAP 1
Synonyms: Cat-1, p95Cat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216963
HGNC: HGNC:4272
Homologene: 32204
Klf13
Name: Kruppel-like factor 13
Synonyms: RFLAT-1, NSLP1, Bteb3, RFLAT1, FKLF-2, 9430029L20Rik, Klf13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 50794
Homologene: 32288
Dcc
Name: deleted in colorectal carcinoma
Synonyms: C030036D22Rik, Igdcc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Rbm10
Name: RNA binding motif protein 10
Synonyms: E430039K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236732
HGNC: HGNC:9896
Homologene: 31330
Hjurp
Name: Holliday junction recognition protein
Synonyms: C330011F01Rik, 6430706D22Rik, A730008H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381280
Homologene: 10184
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Amtn
Name: amelotin
Synonyms: 5430427O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71421
Homologene: 52640
Tom1
Name: target of myb1 trafficking protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21968
Homologene: 88453
Arhgef3
Name: Rho guanine nucleotide exchange factor (GEF) 3
Synonyms: C76747, 9830169H03Rik, 1200004I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71704
VEGA: 14
HGNC: HGNC:683
Homologene: 41329
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: 2700048G21Rik, 5730470G24Rik, CCCAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76816
Homologene: 4839
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: C330012F17Rik, C130096N06Rik, GIV, HkRP1, Girdin, A430106J12Rik, D130005J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108686
Homologene: 41180
Rspo3
Name: R-spondin 3
Synonyms: Thsd2, Cristin1, 2810459H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72780
VEGA: 10
Homologene: 12484
Adar
Name: adenosine deaminase, RNA-specific
Synonyms: Adar1p150, mZaADAR, ADAR1, Adar1p110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56417
HGNC: HGNC:225
Homologene: 9281
Slc5a2
Name: solute carrier family 5 (sodium/glucose cotransporter), member 2
Synonyms: Sglt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246787
Homologene: 2289
Fbxo33
Name: F-box protein 33
Synonyms: 5730501N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70611
Homologene: 16501
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh4, C130041O22Rik, Zfh-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Spats2l
Name: spermatogenesis associated, serine-rich 2-like
Synonyms: 2810022L02Rik, A230104H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67198
Homologene: 56711
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Jbts17, b2b012Clo, 2410089E03Rik, Hug
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73692
Homologene: 11315
Rab44
Name: RAB44, member RAS oncogene family
Synonyms: 9830134C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 442827
Homologene: 53300
Cdhr3
Name: cadherin-related family member 3
Synonyms: 1110049B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68764
VEGA: 12
Homologene: 45146
Myo7b
Name: myosin VIIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17922
HGNC: HGNC:7607
Homologene: 81947
Bcl11b
Name: B cell leukemia/lymphoma 11B
Synonyms: COUP-TF interacting protein 2, B630002E05Rik, 9130430L19Rik, Rit1, CTIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58208
Homologene: 10974
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230622
Homologene: 135888
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: 3110047P20Rik, B830017A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319807
Homologene: 14974
Gp1ba
Name: glycoprotein 1b, alpha polypeptide
Synonyms: GP Ib-alpha, GPIb-alpha, GPIba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14723
HGNC: HGNC:4439
Homologene: 143
Ptpre
Name: protein tyrosine phosphatase, receptor type, E
Synonyms: PTPepsilon, RPTPepsilon, PTPe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19267
HGNC: HGNC:9669
Homologene: 31387
Zfp777
Name: zinc finger protein 777
Synonyms: 2500002G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72306
Homologene: 56721
Zfp267
Name: zinc finger protein 267
Synonyms: D3Ertd254e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241944
Homologene: 117700
Krt77
Name: keratin 77
Synonyms: 4732484G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 406220
Homologene: 45490
Tfb2m
Name: transcription factor B2, mitochondrial
Synonyms: Hkp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15278
Homologene: 7362
Ap1g2
Name: adaptor protein complex AP-1, gamma 2 subunit
Synonyms: gamma 2-adaptin, Adtg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11766
HGNC: HGNC:556
Homologene: 49141
Slc22a20
Name: solute carrier family 22 (organic anion transporter), member 20
Synonyms: mOAT6, LOC381203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381203
Homologene: 87203
Zcwpw2
Name: zinc finger, CW type with PWWP domain 2
Synonyms: 4930430K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Homologene: 87409
Catsperg1
Name: cation channel sperm associated auxiliary subunit gamma 1
Synonyms: A230107C01Rik, Catsperg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320225
Homologene: 10915
Plbd1
Name: phospholipase B domain containing 1
Synonyms: 1100001H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66857
Homologene: 11745
Vps52
Name: VPS52 GARP complex subunit
Synonyms: Sacm2l, tcl-w5, D430041K17Rik, ARE1, tclw5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224705
Homologene: 5756
Aldh3b3
Name: aldehyde dehydrogenase 3 family, member B3
Synonyms: 1700055N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73458
HGNC: HGNC:411
Homologene: 133295
Dnajb8
Name: DnaJ heat shock protein family (Hsp40) member B8
Synonyms: 1700016F14Rik, mDj6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56691
Homologene: 23184
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70909
Homologene: 87049
Ces2e
Name: carboxylesterase 2E
Synonyms: 9030624L02Rik, Ces5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234673
HGNC: HGNC:1864
Homologene: 86210
Pkd2l1
Name: polycystic kidney disease 2-like 1
Synonyms: Pkdl, PKD2L, TRPP3, PCL, polycystin-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329064
HGNC: HGNC:9011
Homologene: 22946
Ifnlr1
Name: interferon lambda receptor 1
Synonyms: IFNLR1, CRF2-12, Il28ra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242700
Homologene: 52086
Ldc1
Name: leucine decarboxylase 1
Synonyms: LOC332942, Gm853
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 332942
Homologene: 128653
Rhd
Name: Rh blood group, D antigen
Synonyms: Rh, Rhl1, Rhced
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19746
Homologene: 7918
Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Synonyms: Coh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13087
Homologene: 85917
Taar8a
Name: trace amine-associated receptor 8A
Synonyms: LOC215859
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215859
Homologene: 77586
Cdk3
Name: cyclin-dependent kinase 3
Synonyms: Cdk3-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69681
HGNC: HGNC:1772
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 45,321,526 bp
  • T to C, chromosome 1 at 57,885,884 bp
  • G to C, chromosome 1 at 88,277,215 bp
  • T to A, chromosome 1 at 176,946,144 bp
  • T to C, chromosome 1 at 179,545,833 bp
  • T to A, chromosome 2 at 19,477,856 bp
  • G to A, chromosome 3 at 5,403,820 bp
  • G to A, chromosome 3 at 36,165,867 bp
  • T to C, chromosome 3 at 89,739,983 bp
  • T to C, chromosome 3 at 123,485,504 bp
  • T to A, chromosome 4 at 112,865,651 bp
  • A to G, chromosome 4 at 130,221,624 bp
  • C to T, chromosome 4 at 134,876,301 bp
  • A to G, chromosome 4 at 135,701,329 bp
  • T to C, chromosome 4 at 148,055,443 bp
  • T to G, chromosome 5 at 63,800,414 bp
  • C to T, chromosome 5 at 88,385,000 bp
  • C to T, chromosome 6 at 48,029,360 bp
  • T to G, chromosome 6 at 55,077,580 bp
  • A to G, chromosome 6 at 88,223,054 bp
  • A to G, chromosome 6 at 113,574,658 bp
  • C to T, chromosome 6 at 136,641,147 bp
  • T to A, chromosome 7 at 26,838,873 bp
  • T to C, chromosome 7 at 29,189,952 bp
  • T to C, chromosome 7 at 63,891,623 bp
  • A to G, chromosome 7 at 128,267,482 bp
  • A to G, chromosome 7 at 135,679,235 bp
  • A to T, chromosome 8 at 41,261,020 bp
  • C to T, chromosome 8 at 75,052,306 bp
  • T to A, chromosome 8 at 104,929,864 bp
  • A to G, chromosome 9 at 79,681,374 bp
  • T to G, chromosome 9 at 110,643,808 bp
  • A to T, chromosome 9 at 118,014,114 bp
  • T to A, chromosome 10 at 24,077,077 bp
  • T to A, chromosome 10 at 29,499,921 bp
  • C to T, chromosome 11 at 29,463,112 bp
  • G to A, chromosome 11 at 69,735,117 bp
  • C to T, chromosome 11 at 70,641,427 bp
  • A to C, chromosome 11 at 77,499,834 bp
  • C to T, chromosome 11 at 116,216,684 bp
  • C to A, chromosome 12 at 33,060,301 bp
  • A to G, chromosome 12 at 59,204,499 bp
  • A to C, chromosome 12 at 105,674,970 bp
  • C to T, chromosome 12 at 107,965,663 bp
  • A to G, chromosome 14 at 27,397,627 bp
  • A to G, chromosome 14 at 55,100,411 bp
  • A to T, chromosome 14 at 66,102,179 bp
  • A to G, chromosome 15 at 8,218,416 bp
  • T to C, chromosome 15 at 101,861,126 bp
  • G to A, chromosome 16 at 50,225,166 bp
  • T to C, chromosome 17 at 29,145,270 bp
  • G to T, chromosome 17 at 33,960,011 bp
  • T to A, chromosome 18 at 31,983,944 bp
  • T to A, chromosome 18 at 71,342,705 bp
  • A to T, chromosome 19 at 3,965,747 bp
  • G to A, chromosome 19 at 5,986,008 bp
  • T to C, chromosome 19 at 44,150,470 bp
  • C to T, chromosome X at 20,637,664 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0762 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038942-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.