Strain Name:
C57BL/6J-MtgxR0786Btlr/Mmmh
Stock Number:
038966-MU
Citation ID:
RRID:MMRRC_038966-MU
Other Names:
R0786 (G1), C57BL/6J-MtgxR0786Btlr
Major Collection:

Gene Information

Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: alpha6 nAChR, Acra6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11440
Homologene: 20888
Nsmf
Name: NMDA receptor synaptonuclear signaling and neuronal migration factor
Synonyms: Nelf, Jacob
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56876
Homologene: 10648
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhcb, MYH-beta/slow, beta-MHC, Myhc-b, B-MHC, betaMHC, MyHC-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Efr3a
Name: EFR3 homolog A
Synonyms: A130089M23Rik, D030063F01Rik, C920006C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76740
Homologene: 44222
Cep57
Name: centrosomal protein 57
Synonyms: Tsp57, 3110002L15Rik, 4921510P06Rik, 4931428M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74360
Homologene: 8790
Tle1
Name: transducin-like enhancer of split 1
Synonyms: Grg1, Estm14, C230057C06Rik, Tle4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21885
Homologene: 21058
Atg2b
Name: autophagy related 2B
Synonyms: C630028L02Rik, 2410024A21Rik, C030004M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Rasgrp1
Name: RAS guanyl releasing protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19419
HGNC: HGNC:9878
Homologene: 4195
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17279
Homologene: 32111
Dsg4
Name: desmoglein 4
Synonyms: CDHF13, lah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Gpr12
Name: G-protein coupled receptor 12
Synonyms: Gpcr20, Gpcr12, Gpcr01
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14738
HGNC: HGNC:4466
Homologene: 3868
Clec12b
Name: C-type lectin domain family 12, member B
Synonyms: 4933425B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71183
Homologene: 19247
Recql5
Name: RecQ protein-like 5
Synonyms: Recql5b, Recq5b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Kirrel3
Name: kirre like nephrin family adhesion molecule 3
Synonyms: Neph2, 2900036G11Rik, 1500010O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67703
Homologene: 57050
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Nte, MSws, Swiss-cheese
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50767
Homologene: 21333
Bpifb1
Name: BPI fold containing family B, member 1
Synonyms: LPlunc1, von Ebner minor salivary protein, U46068
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228801
Homologene: 50047
Col27a1
Name: collagen, type XXVII, alpha 1
Synonyms: 5730512J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 373864
Homologene: 69400
Casc1
Name: cancer susceptibility candidate 1
Synonyms: Las1, A230084G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320662
Homologene: 41242
Gm872
Name: predicted gene 872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: Myak, 1110062K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15257
Homologene: 56483
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545030
Homologene: 83473
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: PTP-BK, PTPROt, PTP-oc, Ptpn15, GLEPP1, PTP-U2, D28, PTP-phi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217143
Homologene: 34917
Mrps21
Name: mitochondrial ribosomal protein S21
Synonyms: 1810031B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66292
Homologene: 45365
Ccdc148
Name: coiled-coil domain containing 148
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227933
Homologene: 16353
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74424
Homologene: 11713
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22313
Homologene: 129751
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75729
Homologene: 123434
Fes
Name: feline sarcoma oncogene
Synonyms: c-fes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14159
HGNC: HGNC:3657
Homologene: 37563
Cwh43
Name: cell wall biogenesis 43 C-terminal homolog
Synonyms: C130090K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231293
Homologene: 5474
Mak
Name: male germ cell-associated kinase
Synonyms: A930010O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17152
VEGA: 13
HGNC: HGNC:6816
Homologene: 31344
Gbp3
Name: guanylate binding protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 55932
Homologene: 137329
Rnf130
Name: ring finger protein 130
Synonyms: 2510042A13Rik, G1RP, G1RZFP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 59044
Homologene: 41267
Adora3
Name: adenosine A3 receptor
Synonyms: A3AR, 1700001D09Rik, 4930578J19Rik, A3R, Gpcr 2, ARA3, AA3R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11542
HGNC: HGNC:268
Homologene: 550
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: collaborator of Stat6, 1600029O10Rik, CoaSt6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 547253
Homologene: 19697
Smg9
Name: smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms: N28092, 1500002O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71997
Homologene: 10426
Prss8
Name: protease, serine 8 (prostasin)
Synonyms: CAP1, 2410039E18Rik, fr, mCAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76560
HGNC: HGNC:9491
Homologene: 20613
Trdn
Name: triadin
Synonyms: triadin-3, triadin 2, 2310045H21Rik, EG432451, triadin 1, triadin-2, triadin-1, triadin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Rhbg
Name: Rhesus blood group-associated B glycoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 58176
Homologene: 9469
Zfp964
Name: zinc finger protein 964
Synonyms: Gm7187
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 636741
Homologene: 130114
Tgm2
Name: transglutaminase 2, C polypeptide
Synonyms: G[a]h, tissue transglutaminase, TG2, TGase2, tTGas, TG C, protein-glutamine gamma-glutamyltransferase, tTG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21817
Homologene: 3391
Adrb3
Name: adrenergic receptor, beta 3
Synonyms: beta 3-AR, Beta-3 AR, Adrb-3, beta3-adrenergic receptor, Beta-3 adrenoceptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11556
HGNC: HGNC:288
Homologene: 37250
Ppl
Name: periplakin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Efna3
Name: ephrin A3
Synonyms: Epl3, LERK-3, Ehk1-L, EFL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13638
HGNC: HGNC:3223
Homologene: 3635
Hspb1
Name: heat shock protein 1
Synonyms: Hsp25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15507
HGNC: HGNC:5246
Homologene: 1180
Vgll3
Name: vestigial like family member 3
Synonyms: Vito-2, 1700110N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 73569
VEGA: 16
Homologene: 53442
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 25,060,510 bp
  • C to A, chromosome 2 at 58,829,747 bp
  • G to T, chromosome 2 at 117,300,499 bp
  • C to T, chromosome 2 at 154,202,661 bp
  • T to C, chromosome 2 at 158,124,381 bp
  • C to T, chromosome 3 at 88,244,568 bp
  • T to C, chromosome 3 at 89,316,573 bp
  • C to A, chromosome 3 at 95,870,481 bp
  • T to C, chromosome 3 at 103,744,304 bp
  • T to A, chromosome 3 at 105,917,002 bp
  • T to A, chromosome 3 at 142,570,971 bp
  • A to G, chromosome 4 at 44,303,649 bp
  • T to C, chromosome 4 at 63,291,578 bp
  • T to A, chromosome 4 at 72,199,361 bp
  • T to A, chromosome 5 at 73,408,183 bp
  • T to C, chromosome 5 at 135,889,243 bp
  • A to T, chromosome 5 at 146,583,504 bp
  • T to C, chromosome 6 at 129,380,688 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 6 at 145,181,757 bp
  • T to C, chromosome 7 at 24,420,864 bp
  • T to A, chromosome 7 at 80,386,920 bp
  • T to C, chromosome 7 at 118,627,210 bp
  • C to T, chromosome 7 at 127,926,474 bp
  • A to T, chromosome 8 at 3,523,317 bp
  • T to C, chromosome 8 at 27,226,852 bp
  • A to T, chromosome 8 at 27,408,380 bp
  • A to G, chromosome 8 at 69,664,081 bp
  • T to A, chromosome 9 at 13,809,870 bp
  • A to G, chromosome 9 at 35,034,865 bp
  • A to T, chromosome 10 at 33,305,081 bp
  • A to T, chromosome 10 at 92,967,535 bp
  • A to G, chromosome 11 at 50,087,437 bp
  • T to C, chromosome 11 at 97,343,274 bp
  • T to C, chromosome 11 at 115,895,802 bp
  • T to C, chromosome 12 at 105,636,508 bp
  • G to T, chromosome 13 at 41,046,069 bp
  • A to G, chromosome 14 at 32,973,699 bp
  • T to C, chromosome 14 at 54,992,873 bp
  • A to G, chromosome 15 at 65,853,551 bp
  • A to T, chromosome 15 at 79,626,268 bp
  • T to C, chromosome 16 at 5,089,054 bp
  • A to G, chromosome 16 at 35,840,802 bp
  • A to T, chromosome 16 at 65,860,682 bp
  • A to T, chromosome 17 at 20,042,725 bp
  • T to C, chromosome 18 at 20,449,372 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0786 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038966-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.