Strain Name:
C57BL/6J-MtgxR0790Btlr/Mmmh
Stock Number:
038970-MU
Citation ID:
RRID:MMRRC_038970-MU
Other Names:
R0790 (G1), C57BL/6J-MtgxR0790Btlr
Major Collection:

Strain Information

Kif5a
Name: kinesin family member 5A
Synonyms: Khc, D10Bwg0738e, Kns, Kif5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Hsp90ab1
Name: heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms: Hspcb, Hsp90, C81438, Hsp84, Hsp84-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15516
Homologene: 74306
Smad7
Name: SMAD family member 7
Synonyms: Madh7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17131
HGNC: HGNC:6773
Homologene: 4314
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68145
Homologene: 10369
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 108912
Homologene: 18444
Psmd1
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Synonyms: P112, S1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70247
HGNC: HGNC:9554
Homologene: 2100
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320365
Homologene: 113770
Vrk1
Name: vaccinia related kinase 1
Synonyms: 51PK
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22367
VEGA: 12
Homologene: 2541
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 360013
Homologene: 7977
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 1600013L13Rik, 4930541M15Rik, Camsap1l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Fam83h
Name: family with sequence similarity 83, member H
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105732
VEGA: 15
Homologene: 15890
Chd8
Name: chromodomain helicase DNA binding protein 8
Synonyms: 5830451P18Rik, Duplin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67772
Homologene: 72405
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Pirb
Name: paired Ig-like receptor B
Synonyms: Lilrb3, Gp91
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18733
Homologene: 134028
Lifr
Name: LIF receptor alpha
Synonyms: soluble differentiation-stimulating factor receptor, A230075M04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Zfp748
Name: zinc finger protein 748
Synonyms: Zfp208, KRAB-O, mszf54, 2610014M12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212276
Homologene: 134552
Retnlb
Name: resistin like beta
Synonyms: 9030012B21Rik, Relmb, RELMbeta, Xcp3, Fizz2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57263
VEGA: 16
Homologene: 10735
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Arhgef28
Name: Rho guanine nucleotide exchange factor 28
Synonyms: D13Bwg1089e, p190RhoGEF, RIP2, Rho specific exchange factor, RhoGEF, 9230110L08Rik, Rgnef
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Stk10
Name: serine/threonine kinase 10
Synonyms: Gek1, Lok
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20868
Homologene: 38122
Sh3rf1
Name: SH3 domain containing ring finger 1
Synonyms: Posh, 2200003J05Rik, Sh3md2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 59009
Homologene: 10988
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76295
Homologene: 32919
Ccdc150
Name: coiled-coil domain containing 150
Synonyms: 4930511H11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78016
Homologene: 15814
Myrfl
Name: myelin regulatory factor-like
Synonyms: LOC237558, Gm239
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237558
VEGA: 10
Homologene: 88588
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Raet1d
Name: retinoic acid early transcript delta
Synonyms: RAE-1delta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56554
Homologene: 134115
Or51s1
Name: olfactory receptor family 51 subfamily S member 1
Synonyms: Olfr571, MOR21-1, GA_x6K02T2PBJ9-5620890-5619922
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259089
Homologene: 17498
Synpo
Name: synaptopodin
Synonyms: 9030217H17Rik, 9330140I15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104027
Homologene: 5274
Chit1
Name: chitinase 1
Synonyms: 2300002L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71884
HGNC: HGNC:1936
Homologene: 68318
Or12j4
Name: olfactory receptor family 12 subfamily J member 4
Synonyms: MOR252-3P, GA_x6K02T2PBJ9-42615403-42616365, Olfr533
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258056
Homologene: 128384
Mrap2
Name: melanocortin 2 receptor accessory protein 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244958
Homologene: 16307
Cpsf4l
Name: cleavage and polyadenylation specific factor 4-like
Synonyms: 0610010C04Rik, 1500000C01Rik, D11Ertd636e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52670
Homologene: 32669
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 54,277,776 bp
  • G to A, chromosome 1 at 82,524,996 bp
  • T to C, chromosome 1 at 86,077,450 bp
  • T to G, chromosome 1 at 134,138,752 bp
  • C to T, chromosome 1 at 136,273,737 bp
  • G to A, chromosome 2 at 118,712,483 bp
  • T to A, chromosome 3 at 35,832,923 bp
  • A to G, chromosome 5 at 150,466,437 bp
  • A to T, chromosome 7 at 3,717,638 bp
  • A to G, chromosome 7 at 102,909,636 bp
  • T to C, chromosome 7 at 140,467,049 bp
  • T to C, chromosome 8 at 61,329,258 bp
  • T to C, chromosome 9 at 87,182,782 bp
  • T to C, chromosome 10 at 22,370,896 bp
  • A to G, chromosome 10 at 74,631,053 bp
  • T to C, chromosome 10 at 116,817,788 bp
  • T to C, chromosome 10 at 127,246,009 bp
  • G to T, chromosome 11 at 17,946,051 bp
  • T to C, chromosome 11 at 32,598,653 bp
  • G to A, chromosome 11 at 77,840,709 bp
  • A to G, chromosome 11 at 113,706,408 bp
  • A to G, chromosome 12 at 8,010,245 bp
  • C to T, chromosome 12 at 106,070,624 bp
  • A to C, chromosome 13 at 67,545,362 bp
  • A to G, chromosome 13 at 97,981,406 bp
  • T to C, chromosome 14 at 52,204,025 bp
  • C to T, chromosome 14 at 67,680,291 bp
  • A to G, chromosome 15 at 7,185,715 bp
  • C to T, chromosome 15 at 76,003,392 bp
  • T to A, chromosome 16 at 48,817,226 bp
  • ACTTCTT to ACTT, chromosome 17 at 45,569,499 bp
  • A to G, chromosome 18 at 34,651,613 bp
  • A to G, chromosome 18 at 60,603,503 bp
  • C to T, chromosome 18 at 75,393,862 bp
  • T to A, chromosome 19 at 41,103,850 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0790 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038970-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.