Strain Name:
C57BL/6J-MtgxR0863Btlr/Mmmh
Stock Number:
039037-MU
Citation ID:
RRID:MMRRC_039037-MU
Other Names:
R0863 (G1), C57BL/6J-MtgxR0863Btlr
Major Collection:

Gene Information

Tnf
Name: tumor necrosis factor
Synonyms: TNF-alpha, tumor necrosis factor-alpha, TNF alpha, TNFalpha, DIF, Tnfsf1a, Tnfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21926
Homologene: 496
Uri1
Name: URI1, prefoldin-like chaperone
Synonyms: NNX3, Rmp, C80913
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19777
Homologene: 2813
Ctnnbl1
Name: catenin, beta like 1
Synonyms: NYD-SP19, FLJ21108, P14L, 5730471K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66642
Homologene: 12003
Actr2
Name: ARP2 actin-related protein 2
Synonyms: 4921510D23Rik, D6Ertd746e, Arp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66713
HGNC: HGNC:169
Homologene: 4181
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74081
Homologene: 8879
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730455C01Rik, 9130215G10Rik, 5730555F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Oga
Name: O-GlcNAcase
Synonyms: Hy5, 4833427O07Rik, 5830447M11Rik, 2810009A20Rik, Mgea5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76055
VEGA: 19
HGNC: HGNC:7056
Homologene: 8154
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Nlrp3
Name: NLR family, pyrin domain containing 3
Synonyms: NALP3, Pypaf1, Cias1, Mmig1, cryopyrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216799
Homologene: 3600
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, ELKS2alpha, CAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 238988
Homologene: 69188
Ppp1r12c
Name: protein phosphatase 1, regulatory subunit 12C
Synonyms: 2410197A17Rik, Mbs85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232807
Homologene: 75071
Pask
Name: PAS domain containing serine/threonine kinase
Synonyms: Paskin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269224
Homologene: 9038
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: mSSH-1L, LOC384311
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231637
Homologene: 41299
Sema4a
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Synonyms: SemB, SemB, Semab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20351
Homologene: 8425
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, D830007G01Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Ms4a10
Name: membrane-spanning 4-domains, subfamily A, member 10
Synonyms: 2010001N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69826
Homologene: 11355
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 637515
Homologene: 19080
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Lonp1
Name: lon peptidase 1, mitochondrial
Synonyms: LON, 1200017E13Rik, Prss15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74142
VEGA: 17
HGNC: HGNC:9479
Homologene: 3521
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
2310016G11Rik
Name: RIKEN cDNA 2310016G11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69578
Arnt2
Name: aryl hydrocarbon receptor nuclear translocator 2
Synonyms: bHLHe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11864
Homologene: 7230
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: 0710001E20Rik, LGL3, 4930565N16Rik, tomosyn 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 78808
Homologene: 16402
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: 2410066K11Rik, line 158, Thm1, aln
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 73668
Homologene: 57006
Gm5155
Name: predicted gene 5155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381852
Homologene: 115938
Abca14
Name: ATP-binding cassette, sub-family A (ABC1), member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67928
Homologene: 86128
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Fes
Name: feline sarcoma oncogene
Synonyms: c-fes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14159
HGNC: HGNC:3657
Homologene: 37563
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665227
Homologene: 129751
Acap1
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms: Centb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216859
Homologene: 22835
Fsd2
Name: fibronectin type III and SPRY domain containing 2
Synonyms: Spryd1, 9830160G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244091
Homologene: 18252
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Tbc1d7
Name: TBC1 domain family, member 7
Synonyms: 2610009C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67046
VEGA: 13
Homologene: 9538
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
Ube4a
Name: ubiquitination factor E4A
Synonyms: UFD2b, 9930123J21Rik, 4732444G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 140630
Homologene: 3517
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: F830032C23Rik, Card15, Nlrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Scel
Name: sciellin
Synonyms: 9230114I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 64929
VEGA: 14
Homologene: 2850
St3gal4
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Synonyms: ST3Gal IV, Siat4c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20443
VEGA: 9
Homologene: 4572
Or5p50
Name: olfactory receptor family 5 subfamily P member 50
Synonyms: GA_x6K02T2PBJ9-10152980-10152036, MOR204-21, Olfr469
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258418
Homologene: 44979
Thnsl2
Name: threonine synthase-like 2 (bacterial)
Synonyms: TSH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232078
Homologene: 5489
Iqca
Name: IQ motif containing with AAA domain
Synonyms: 4930585L22Rik, 4930465P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74918
Homologene: 49784
Gfm1
Name: G elongation factor, mitochondrial 1
Synonyms: D3Wsu133e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 28030
Homologene: 6449
H2-Ab1
Name: histocompatibility 2, class II antigen A, beta 1
Synonyms: A beta, Abeta, H-2Ab, Ia-2, Ia2, H2-Ab, IAb, I-Ab, I-Abeta, Rmcs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14961
HGNC: HGNC:4945
Homologene: 1603
4930433I11Rik
Name: RIKEN cDNA 4930433I11 gene
Synonyms: LOC243944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243944
Homologene: 77912
Phf1
Name: PHD finger protein 1
Synonyms: Tctex-3, D17Ertd455e, PHF2, Tctex3, mPcl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21652
VEGA: 17
HGNC: HGNC:8919
Homologene: 7567
Fank1
Name: fibronectin type 3 and ankyrin repeat domains 1
Synonyms: 1700007B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66930
Homologene: 12055
Or10ab5
Name: olfactory receptor family 10 subfamily AB member 5
Synonyms: GA_x6K02T2PBJ9-10976304-10975339, MOR267-14, Olfr509
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258369
Homologene: 131128
1700057G04Rik
Name: RIKEN cDNA 1700057G04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78459
Homologene: 134508
Tinf2
Name: Terf1 (TRF1)-interacting nuclear factor 2
Synonyms: TIN2, D14Wsu146e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 28113
VEGA: 14
Homologene: 8264
H2-M10.3
Name: histocompatibility 2, M region locus 10.3
Synonyms: 5.3H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 110696
Homologene: 117973
Or7e173
Name: olfactory receptor family 7 subfamily E member 173
Synonyms: GA_x6K02T2PVTD-13768406-13767468, MOR145-5, Olfr866
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258551
HGNC: HGNC:8396
Homologene: 133687
Spag1
Name: sperm associated antigen 1
Synonyms: TPR-containing protein involved in spermatogenesis, tpis
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26942
VEGA: 15
Homologene: 8081
Gm9493
Name: predicted gene 9493
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 102638448
VEGA: 19
Homologene: 137145
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 90,142,731 bp
  • A to T, chromosome 1 at 93,314,339 bp
  • T to A, chromosome 1 at 155,862,235 bp
  • T to C, chromosome 2 at 66,242,773 bp
  • T to C, chromosome 2 at 76,707,047 bp
  • C to T, chromosome 2 at 157,799,417 bp
  • T to A, chromosome 3 at 5,245,315 bp
  • T to C, chromosome 3 at 67,474,595 bp
  • C to T, chromosome 3 at 88,448,149 bp
  • G to A, chromosome 3 at 114,138,765 bp
  • C to T, chromosome 5 at 113,966,731 bp
  • T to A, chromosome 5 at 137,458,639 bp
  • A to T, chromosome 6 at 71,134,224 bp
  • G to T, chromosome 7 at 4,486,366 bp
  • A to T, chromosome 7 at 17,902,742 bp
  • A to T, chromosome 7 at 37,969,675 bp
  • A to T, chromosome 7 at 40,993,056 bp
  • A to G, chromosome 7 at 44,677,808 bp
  • A to T, chromosome 7 at 80,380,886 bp
  • A to G, chromosome 7 at 81,542,165 bp
  • T to A, chromosome 7 at 84,265,584 bp
  • T to C, chromosome 7 at 107,823,374 bp
  • A to G, chromosome 7 at 108,645,658 bp
  • A to T, chromosome 7 at 120,216,230 bp
  • A to G, chromosome 7 at 133,880,623 bp
  • A to G, chromosome 7 at 141,867,717 bp
  • G to A, chromosome 8 at 88,672,662 bp
  • A to T, chromosome 9 at 20,027,213 bp
  • C to A, chromosome 9 at 35,053,448 bp
  • A to G, chromosome 9 at 44,949,816 bp
  • A to G, chromosome 9 at 70,561,908 bp
  • A to T, chromosome 9 at 92,351,087 bp
  • C to T, chromosome 10 at 9,809,040 bp
  • C to T, chromosome 11 at 20,080,760 bp
  • T to C, chromosome 11 at 58,995,415 bp
  • A to G, chromosome 11 at 59,565,850 bp
  • C to A, chromosome 11 at 69,887,056 bp
  • T to A, chromosome 11 at 71,181,347 bp
  • T to C, chromosome 11 at 101,524,770 bp
  • A to T, chromosome 12 at 55,762,681 bp
  • C to A, chromosome 12 at 55,782,777 bp
  • G to T, chromosome 13 at 43,154,685 bp
  • A to C, chromosome 14 at 28,025,148 bp
  • T to A, chromosome 14 at 31,369,757 bp
  • G to A, chromosome 14 at 55,680,109 bp
  • T to C, chromosome 14 at 55,783,599 bp
  • T to C, chromosome 14 at 62,419,062 bp
  • T to A, chromosome 14 at 103,586,480 bp
  • G to T, chromosome 15 at 36,192,047 bp
  • G to A, chromosome 15 at 76,174,080 bp
  • T to G, chromosome 17 at 18,257,711 bp
  • T to C, chromosome 17 at 26,937,140 bp
  • T to C, chromosome 17 at 34,267,354 bp
  • T to C, chromosome 17 at 35,201,144 bp
  • T to A, chromosome 17 at 36,366,690 bp
  • T to C, chromosome 17 at 46,537,822 bp
  • T to C, chromosome 17 at 56,618,331 bp
  • A to G, chromosome 17 at 75,252,386 bp
  • G to A, chromosome 18 at 37,295,657 bp
  • C to T, chromosome 19 at 10,968,593 bp
  • A to T, chromosome 19 at 23,619,809 bp
  • C to T, chromosome 19 at 45,782,986 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0863 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039037-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.