Strain Name:
C57BL/6J-MtgxR0866Btlr/Mmmh
Stock Number:
039040-MU
Citation ID:
RRID:MMRRC_039040-MU
Other Names:
R0866 (G1), C57BL/6J-MtgxR0866Btlr
Major Collection:

Strain Information

Mtmr3
Name: myotubularin related protein 3
Synonyms: FYVE-DSP1, 1700092A20Rik, ZFYVE10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74302
HGNC: HGNC:7451
Homologene: 23662
Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 269473
Homologene: 8882
Hmox1
Name: heme oxygenase 1
Synonyms: Hsp32, HO-1, heme oxygenase 1, D8Wsu38e, Hmox, HO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15368
HGNC: HGNC:5013
Homologene: 31075
Tlx3
Name: T cell leukemia, homeobox 3
Synonyms: Tlx1l2, Rnx, Hox11l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27140
Homologene: 23181
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, MYH-beta/slow, beta-MHC, B-MHC, MyHC-I, betaMHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluR-B, GluR2, Glur-2, Glur2, GluA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: AS3, Aprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100710
Homologene: 41001
Mtmr14
Name: myotubularin related protein 14
Synonyms: 1110061O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 97287
Homologene: 11203
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Fbxo21
Name: F-box protein 21
Synonyms: 2810425J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231670
Homologene: 14145
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 2010005B09Rik, 4432404J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66691
Homologene: 32637
Isy1
Name: ISY1 splicing factor homolog
Synonyms: 5830446M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 57905
Homologene: 6283
Rtn1
Name: reticulon 1
Synonyms: Nsp, Rtn1-b, Rtn1-c, 0710005K15Rik, Rtn1-a, 4930441F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104001
Homologene: 49654
Rgs2
Name: regulator of G-protein signaling 2
Synonyms: GOS8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19735
HGNC: HGNC:9998
Homologene: 2192
Tor1b
Name: torsin family 1, member B
Synonyms: DQ1, 2610016F05Rik, torsinB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 30934
Homologene: 56677
Zbtb14
Name: zinc finger and BTB domain containing 14
Synonyms: ZF5, Zfp161, b2b1982Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22666
Homologene: 2560
Crb3
Name: crumbs family member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224912
Homologene: 134352
Pcca
Name: propionyl-Coenzyme A carboxylase, alpha polypeptide
Synonyms: C79630
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110821
HGNC: HGNC:8653
Homologene: 236
Zfp386
Name: zinc finger protein 386 (Kruppel-like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56220
Homologene: 51668
Zfp574
Name: zinc finger protein 574
Synonyms: A630056B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232976
Homologene: 11238
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216345
Homologene: 17017
Ckap4
Name: cytoskeleton-associated protein 4
Synonyms: CLIMP-63, P63, 5630400A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216197
VEGA: 10
Homologene: 4970
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80892
Homologene: 23477
Lrp1
Name: low density lipoprotein receptor-related protein 1
Synonyms: CD91, A2mr, b2b1554Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16971
HGNC: HGNC:6692
Homologene: 1744
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: A230067G21Rik, RGC2, AS250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241694
Homologene: 28131
Slc22a1
Name: solute carrier family 22 (organic cation transporter), member 1
Synonyms: Lx1, Oct1, Orct, Oct1, Orct1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20517
VEGA: 17
Homologene: 20665
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242274
Homologene: 10817
Tspyl3
Name: TSPY-like 3
Synonyms: LOC241732
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241732
Homologene: 19093
Or5h18
Name: olfactory receptor family 5 subfamily H member 18
Synonyms: GA_x54KRFPKG5P-55257214-55256285, MOR183-9, Olfr186
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258318
Homologene: 133671
Mtrf1l
Name: mitochondrial translational release factor 1-like
Synonyms: 9130004K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 108853
Homologene: 5905
Speg
Name: SPEG complex locus
Synonyms: BPEG, SPEGbeta, SPEGalpha, D1Bwg1450e, SPEG, Apeg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11790
Homologene: 55619
Abcd4
Name: ATP-binding cassette, sub-family D (ALD), member 4
Synonyms: P69r, Pxmp1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19300
VEGA: 12
HGNC: HGNC:68
Homologene: 3703
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: MDC2, 2900022I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Rbbp9
Name: retinoblastoma binding protein 9, serine hydrolase
Synonyms: Bog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26450
HGNC: HGNC:9892
Homologene: 4816
Kiz
Name: kizuna centrosomal protein
Synonyms: LOC228730, Ncrna00153, Gm114, Plk1s1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228730
Homologene: 10219
H2-M11
Name: histocompatibility 2, M region locus 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224754
Homologene: 52241
Acsm5
Name: acyl-CoA synthetase medium-chain family member 5
Synonyms: C730027J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 272428
Homologene: 69242
Hspa8
Name: heat shock protein 8
Synonyms: Hsp73, Hsc71, Hsc70, 2410008N15Rik, Hsc73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 15481
HGNC: HGNC:5241
Homologene: 68524
5430401F13Rik
Name: RIKEN cDNA 5430401F13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71392
Homologene: 136510
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 75,417,083 bp
  • A to G, chromosome 1 at 144,002,250 bp
  • A to G, chromosome 2 at 30,956,916 bp
  • A to T, chromosome 2 at 34,709,217 bp
  • T to C, chromosome 2 at 144,550,708 bp
  • A to T, chromosome 2 at 146,436,003 bp
  • C to A, chromosome 2 at 146,856,053 bp
  • A to T, chromosome 2 at 153,224,934 bp
  • A to T, chromosome 3 at 5,412,212 bp
  • A to T, chromosome 3 at 80,722,024 bp
  • T to C, chromosome 3 at 104,464,275 bp
  • C to A, chromosome 3 at 158,164,266 bp
  • T to C, chromosome 4 at 148,486,056 bp
  • T to C, chromosome 5 at 8,082,156 bp
  • G to T, chromosome 5 at 117,977,033 bp
  • T to A, chromosome 5 at 150,739,191 bp
  • C to A, chromosome 6 at 87,819,112 bp
  • T to C, chromosome 6 at 113,239,582 bp
  • G to T, chromosome 6 at 131,552,779 bp
  • A to T, chromosome 7 at 25,079,898 bp
  • T to A, chromosome 7 at 119,540,900 bp
  • A to G, chromosome 8 at 75,097,303 bp
  • G to A, chromosome 9 at 40,802,624 bp
  • T to C, chromosome 10 at 5,813,376 bp
  • C to T, chromosome 10 at 84,527,520 bp
  • G to A, chromosome 10 at 115,427,716 bp
  • A to T, chromosome 10 at 127,539,278 bp
  • A to T, chromosome 11 at 4,488,474 bp
  • C to A, chromosome 11 at 33,203,315 bp
  • G to T, chromosome 12 at 72,308,382 bp
  • G to T, chromosome 12 at 84,611,733 bp
  • A to G, chromosome 12 at 100,913,192 bp
  • G to T, chromosome 12 at 116,054,709 bp
  • C to T, chromosome 13 at 40,208,829 bp
  • T to C, chromosome 14 at 54,973,139 bp
  • A to G, chromosome 14 at 122,889,545 bp
  • C to T, chromosome 16 at 59,027,428 bp
  • T to C, chromosome 17 at 12,657,046 bp
  • T to C, chromosome 17 at 36,548,937 bp
  • T to A, chromosome 17 at 57,062,743 bp
  • C to A, chromosome 17 at 69,388,502 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0866 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039040-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.