Strain Name:
C57BL/6J-MtgxR0988Btlr/Mmmh
Stock Number:
039108-MU
Citation ID:
RRID:MMRRC_039108-MU
Other Names:
R0988 (G1), C57BL/6J-MtgxR0988Btlr
Major Collection:

Gene Information

Macroh2a1
Name: macroH2A.1 histone
Synonyms: MACROH2A1.2, mH2a1, H2AF12M, H2afy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26914
HGNC: HGNC:4740
Homologene: 3598
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101772
Homologene: 75079
Micu1
Name: mitochondrial calcium uptake 1
Synonyms: C730016L05Rik, Cbara1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216001
HGNC: HGNC:1530
Homologene: 4431
Cop1
Name: COP1, E3 ubiquitin ligase
Synonyms: Rfwd2, Cop1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26374
Homologene: 115565
Ptpn23
Name: protein tyrosine phosphatase, non-receptor type 23
Synonyms: PTP-TD14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 104831
Homologene: 135706
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: HTRX1, Mll1, Cxxc7, All1, ALL-1, trithorax Drosophila, Mll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Mfsd14b
Name: major facilitator superfamily domain containing 14B
Synonyms: 5730414C17Rik, Hiatl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66631
Homologene: 64464
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Ephb2
Name: Eph receptor B2
Synonyms: Erk, eteck, Nuk, Cek5, Qek5, Prkm5, Sek3, Hek5, Tyro5, Drt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13844
HGNC: HGNC:3393
Homologene: 37925
Nav3
Name: neuron navigator 3
Synonyms: 9630020C08Rik, 4732483H20Rik, steerin 3, unc53H3, POMFIL1, Pomfil1p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 260315
Homologene: 56688
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: p150, Vps15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Cst11
Name: cystatin 11
Synonyms: CRES2, mCST E1, 9230101F08Rik, cystatin E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78240
Homologene: 15634
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, 2300002I04Rik, MUC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Serac1
Name: serine active site containing 1
Synonyms: D17Ertd141e, 4930511N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 321007
Homologene: 41900
Abcb5
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Proc
Name: protein C
Synonyms: inactivator of coagulation factors Va, VIII, PC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 19123
VEGA: 18
HGNC: HGNC:9451
Homologene: 37288
Extl1
Name: exostosin-like glycosyltransferase 1
Synonyms: D430033M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56219
HGNC: HGNC:3515
Homologene: 3277
Lgmn
Name: legumain
Synonyms: preprolegumain, Prsc1, AEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19141
HGNC: HGNC:9472
Homologene: 38075
Hpn
Name: hepsin
Synonyms: Hlb320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15451
HGNC: HGNC:5155
Homologene: 20498
Napg
Name: N-ethylmaleimide sensitive fusion protein attachment protein gamma
Synonyms: 2400003O04Rik, SNARE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108123
HGNC: HGNC:7642
Homologene: 2838
Olfr1451
Name: olfactory receptor 1451
Synonyms: GA_x6K02T2RE5P-3328502-3329434, MOR202-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258700
Homologene: 128082
1110020G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Thrb
Name: thyroid hormone receptor beta
Synonyms: Nr1a2, c-erbAbeta, T3R[b], T3Rbeta, Thrb2, TR beta, Thrb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21834
Homologene: 36025
Ntpcr
Name: nucleoside-triphosphatase, cancer-related
Synonyms: 2310079N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66566
Homologene: 11989
Pdia2
Name: protein disulfide isomerase associated 2
Synonyms: 1810041F13Rik, Pdipl, Pdip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69191
Homologene: 55994
Olfr807
Name: olfactory receptor 807
Synonyms: GA_x6K02T2PULF-11434134-11433199, MOR117-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258931
Homologene: 27300
4921506M07Rik
Name: RIKEN cDNA 4921506M07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Rragc
Name: Ras-related GTP binding C
Synonyms: YGR163W, TIB929, Gtr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 54170
Homologene: 39141
Olfr609
Name: olfactory receptor 609
Synonyms: MOR9-1, GA_x6K02T2PBJ9-6207735-6206776
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259086
Homologene: 64952
Olfr341
Name: olfactory receptor 341
Synonyms: MOR136-2, GA_x6K02T2NLDC-33174915-33173974
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258952
Homologene: 74160
Platr26
Name: pluripotency associated transcript 26
Synonyms: Gm1631, LOC381371
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381371
Zfp607b
Name: zinc finger protein 607B
Synonyms: C030039L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 112415
Homologene: 134321
Snrpd3
Name: small nuclear ribonucleoprotein D3
Synonyms: 2310009E13Rik, 1700043E15Rik, SMD3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67332
Homologene: 3078
Krtap4-9
Name: keratin associated protein 4-9
Synonyms: OTTMUSG00000002198
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 665998
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 159,232,847 bp
  • A to G, chromosome 1 at 159,244,672 bp
  • T to C, chromosome 2 at 31,335,451 bp
  • T to C, chromosome 2 at 36,479,767 bp
  • A to T, chromosome 2 at 71,723,287 bp
  • G to A, chromosome 2 at 148,770,426 bp
  • T to A, chromosome 4 at 123,924,782 bp
  • TGCGTTGCACCGATACCGGG to TG, chromosome 4 at 134,357,677 bp
  • T to A, chromosome 4 at 136,659,708 bp
  • T to A, chromosome 7 at 27,702,976 bp
  • T to C, chromosome 7 at 31,099,898 bp
  • T to A, chromosome 7 at 103,492,747 bp
  • A to G, chromosome 7 at 141,871,795 bp
  • T to G, chromosome 7 at 144,633,653 bp
  • T to C, chromosome 8 at 125,737,431 bp
  • A to G, chromosome 9 at 44,848,549 bp
  • A to G, chromosome 9 at 105,687,205 bp
  • C to T, chromosome 9 at 110,388,777 bp
  • C to A, chromosome 10 at 59,756,727 bp
  • A to G, chromosome 10 at 75,532,205 bp
  • G to A, chromosome 10 at 109,716,528 bp
  • A to G, chromosome 10 at 129,754,997 bp
  • T to A, chromosome 11 at 99,785,536 bp
  • T to C, chromosome 12 at 57,688,649 bp
  • T to C, chromosome 12 at 102,398,277 bp
  • T to C, chromosome 12 at 118,932,575 bp
  • T to C, chromosome 13 at 56,083,296 bp
  • T to C, chromosome 13 at 65,112,493 bp
  • G to T, chromosome 14 at 17,981,837 bp
  • T to A, chromosome 15 at 9,102,992 bp
  • A to T, chromosome 17 at 6,061,580 bp
  • A to G, chromosome 17 at 26,198,829 bp
  • T to C, chromosome 18 at 32,133,483 bp
  • T to C, chromosome 18 at 62,983,360 bp
  • A to G, chromosome 19 at 12,999,787 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0988 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039108-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.