Strain Name:
C57BL/6J-MtgxR1080Btlr/Mmmh
Stock Number:
039166-MU
Citation ID:
RRID:MMRRC_039166-MU
Other Names:
R1080 (G1), C57BL/6J-MtgxR1080Btlr
Major Collection:

Strain Information

Gad2
Name: glutamic acid decarboxylase 2
Synonyms: GAD65, Gad-2, 6330404F12Rik, GAD(65)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223
Zfp809
Name: zinc finger protein 809
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235047
VEGA: 9
Slc2a3
Name: solute carrier family 2 (facilitated glucose transporter), member 3
Synonyms: Glut-3, Glut3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20527
Homologene: 74302
Tut4
Name: terminal uridylyl transferase 4
Synonyms: 6030404K05Rik, 9230115F04Rik, Tent3a, Zcchc11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230594
Homologene: 35279
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Tdrd3
Name: tudor domain containing 3
Synonyms: 4732418C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219249
Homologene: 12771
Mnat1
Name: menage a trois 1
Synonyms: MAT1, E130115E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17420
HGNC: HGNC:7181
Homologene: 1821
Lrrc28
Name: leucine rich repeat containing 28
Synonyms: 2310058O11Rik, 2210012C09Rik, 1300004K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67867
Homologene: 16944
Rtf2
Name: replication termination factor 2
Synonyms: 1700067C04Rik, 5730427M17Rik, 2410001C21Rik, Rtfdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66404
Homologene: 9501
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66725
Homologene: 18982
Zswim6
Name: zinc finger SWIM-type containing 6
Synonyms: 2900036G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67263
VEGA: 13
Homologene: 83517
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Galr1
Name: galanin receptor 1
Synonyms: Galnr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14427
VEGA: 18
HGNC: HGNC:4132
Homologene: 74396
Khsrp
Name: KH-type splicing regulatory protein
Synonyms: 6330409F21Rik, KSRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16549
VEGA: 17
HGNC: HGNC:6316
Homologene: 2734
Plod2
Name: procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms: lysyl hydroxylase 2, LH2, Plod-2, D530025C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26432
HGNC: HGNC:9082
Homologene: 22681
2310022A10Rik
Name: RIKEN cDNA 2310022A10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 66367
Homologene: 35272
Zfp386
Name: zinc finger protein 386 (Kruppel-like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56220
Homologene: 51668
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225115
Homologene: 25090
Tmprss2
Name: transmembrane protease, serine 2
Synonyms: epitheliasin, D16Ertd61e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50528
VEGA: 16
Homologene: 4136
Pcdh7
Name: protocadherin 7
Synonyms: BH-protocadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 54216
HGNC: HGNC:8659
Homologene: 36101
Cd180
Name: CD180 antigen
Synonyms: RP105, Ly78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Kcnn3
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Synonyms: small conductance calcium-activated potassium channel 3, SK3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 140493
HGNC: HGNC:6292
Homologene: 20516
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 2900053G10Rik, 6530406M24Rik, 4930431N21Rik, Ccp3, Ccp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76223
Homologene: 35330
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: Slo, mSlo1, Slo1, MaxiK, BK channel alpha subunit, 5730414M22Rik, BKCa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: SMC1beta, Smc1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70381
Homologene: 9120
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 628185
Homologene: 86604
Smtn
Name: smoothelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 29856
Homologene: 8482
Prss40
Name: protease, serine 40
Synonyms: Tesp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21756
Homologene: 69043
Calu
Name: calumenin
Synonyms: 9530075H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12321
HGNC: HGNC:1458
Homologene: 936
Nkd1
Name: naked cuticle 1
Synonyms: 2810434J10Rik, 9030215G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 93960
Homologene: 12343
Fbln5
Name: fibulin 5
Synonyms: EVEC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 23876
VEGA: 12
HGNC: HGNC:3602
Homologene: 38170
Nck2
Name: non-catalytic region of tyrosine kinase adaptor protein 2
Synonyms: NCKbeta, Grb4, 4833426I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17974
HGNC: HGNC:7665
Homologene: 20794
Zfy2
Name: zinc finger protein 2, Y-linked
Synonyms: Zfy-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22768
Homologene: 56456
Akp3
Name: alkaline phosphatase 3, intestine, not Mn requiring
Synonyms: IAP, Akp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11648
HGNC: HGNC:437
Homologene: 134333
Dus4l
Name: dihydrouridine synthase 4-like (S. cerevisiae)
Synonyms: 2700089B10Rik, 2310069P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71916
VEGA: 12
Homologene: 6535
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74419
Homologene: 69456
Klhdc8b
Name: kelch domain containing 8B
Synonyms: 4931406O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78267
Homologene: 45463
Or4e5
Name: olfactory receptor family 4 subfamily E member 5
Synonyms: GA_x6K02T2RJGY-491851-492792, MOR244-1, MOR28, Olfr1507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57269
HGNC: HGNC:8296
Homologene: 10736
Cnbd2
Name: cyclic nucleotide binding domain containing 2
Synonyms: 5430421B09Rik, 4921517L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70873
Homologene: 15440
Fam136b-ps
Name: family with sequence similarity 136, member B, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 625796
VEGA: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 34,557,846 bp
  • T to C, chromosome 1 at 43,533,581 bp
  • T to A, chromosome 1 at 87,127,001 bp
  • A to T, chromosome 2 at 22,635,056 bp
  • A to G, chromosome 2 at 156,339,273 bp
  • G to T, chromosome 2 at 172,468,746 bp
  • A to G, chromosome 3 at 36,988,255 bp
  • G to T, chromosome 3 at 89,661,258 bp
  • A to G, chromosome 4 at 108,479,499 bp
  • T to C, chromosome 5 at 57,719,426 bp
  • A to G, chromosome 5 at 144,216,929 bp
  • A to G, chromosome 6 at 29,366,920 bp
  • A to T, chromosome 6 at 34,828,235 bp
  • A to T, chromosome 6 at 122,779,904 bp
  • A to G, chromosome 7 at 27,565,684 bp
  • A to T, chromosome 7 at 67,560,069 bp
  • G to A, chromosome 8 at 66,512,347 bp
  • T to A, chromosome 8 at 88,592,019 bp
  • T to G, chromosome 9 at 22,235,109 bp
  • T to A, chromosome 9 at 92,606,756 bp
  • T to C, chromosome 9 at 108,449,638 bp
  • C to A, chromosome 11 at 3,517,693 bp
  • T to A, chromosome 12 at 31,641,735 bp
  • T to C, chromosome 12 at 73,272,518 bp
  • A to T, chromosome 12 at 101,750,872 bp
  • T to A, chromosome 12 at 116,059,806 bp
  • G to T, chromosome 13 at 48,885,743 bp
  • G to A, chromosome 13 at 102,706,220 bp
  • A to G, chromosome 13 at 107,787,651 bp
  • G to C, chromosome 14 at 23,494,607 bp
  • A to T, chromosome 14 at 52,490,585 bp
  • T to C, chromosome 14 at 87,506,398 bp
  • T to C, chromosome 15 at 31,276,593 bp
  • A to T, chromosome 15 at 85,121,860 bp
  • T to C, chromosome 15 at 91,673,689 bp
  • G to A, chromosome 16 at 97,591,498 bp
  • T to C, chromosome 17 at 22,618,999 bp
  • GTCATT to GT, chromosome 17 at 57,024,410 bp
  • C to T, chromosome 18 at 5,058,147 bp
  • A to C, chromosome 18 at 82,405,507 bp
  • T to A, chromosome Y at 2,121,645 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1080 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039166-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.