Strain Name:
C57BL/6J-MtgxR1110Btlr/Mmmh
Stock Number:
039183-MU
Citation ID:
RRID:MMRRC_039183-MU
Other Names:
R1110 (G1), C57BL/6J-MtgxR1110Btlr
Major Collection:

Strain Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: Mll3, HALR, E330008K23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Eomes
Name: eomesodermin
Synonyms: Tbr2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13813
HGNC: HGNC:3372
Homologene: 3971
Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: trp2, Trrp2, mTrp2, TRPC2b, 3010009O07Rik, TRPC2a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22064
Homologene: 135989
Pkp4
Name: plakophilin 4
Synonyms: 9430019K17Rik, Armrp, 5031422I09Rik, p0071
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227937
HGNC: HGNC:9026
Homologene: 2689
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: Mll5, 9530077A04Rik, D230038D11Rik, 1810033J14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 1700017E21Rik, 4933438D16Rik, D14Ertd581e, 4933439E17Rik, 4930513H15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: Myosin IIB, Myhn2, nonmuscle myosin heavy chain II-B, Myhn-2, NMHC-B, 5730504C04Rik, nonmuscle myosin heavy chain IIB, SMemb, 9330167F11Rik, NMHC II-B, myosin IIB, Fltn, Fltn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Akap13
Name: A kinase anchor protein 13
Synonyms: AKAP-Lbc, Ht31, 1700026G02Rik, 5830460E08Rik, PROTO-LBC, 5730522G15Rik, PROTO-LB
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Pcgf2
Name: polycomb group ring finger 2
Synonyms: Rnf110, mel-18, Zfp144, Mel18
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22658
Homologene: 5174
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: crf11, QBRICK, eyes2, eyem02Jus, heb
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Prune2
Name: prune homolog 2
Synonyms: A330102H22Rik, Olfaxin, A230083H22Rik, 6330414G02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Cdan1
Name: codanin 1
Synonyms: 1500015A01Rik, codanin-1, CDA-I, CDA1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Oit3
Name: oncoprotein induced transcript 3
Synonyms: EF-9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18302
Homologene: 7870
Cntrl
Name: centriolin
Synonyms: Cep1, Cep110, 6720467O09Rik, b2b1468Clo, Ma2a8, IB3/5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: Hnrpul2, 1110031M08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: LOC380767, 9330197E15Rik, A630028O16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Nup160
Name: nucleoporin 160
Synonyms: 2810011M03Rik, Gtl1-13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59015
Homologene: 32509
Slc9a1
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
Synonyms: antiporter, Nhe1, Apnh, Nhe-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20544
Homologene: 20660
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, Hch, CED-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Cntn3
Name: contactin 3
Synonyms: Pang
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18488
HGNC: HGNC:2173
Homologene: 7461
Kdm5d
Name: lysine demethylase 5D
Synonyms: HY, Jarid1d, Smcy
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 20592
Homologene: 55838
Vnn1
Name: vanin 1
Synonyms: pantetheinase, V-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22361
Homologene: 32130
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: ASC2, PRIP, AIB3, RAP250, ASC-2, NRC
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56406
Homologene: 137337
Kif1a
Name: kinesin family member 1A
Synonyms: LOC381283, Kns1, ATSV, N-3 kinesin, C630002N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Plcb3
Name: phospholipase C, beta 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18797
VEGA: 19
HGNC: HGNC:9056
Homologene: 47960
Or11g27
Name: olfactory receptor family 11 subfamily G member 27
Synonyms: Olfr743-ps1, Olfr265, Olfr743, GA_x6K02T2N6FY-3870-3385, GA_x6K02T2N6FY-2320-2039, MOR106-14, GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, Olfr264
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219019
Homologene: 74163
Sorbs2
Name: sorbin and SH3 domain containing 2
Synonyms: 2010203O03Rik, 9430041O17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234214
Homologene: 83295
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Pitrm1
Name: pitrilysin metallepetidase 1
Synonyms: Ntup1, PreP, MP-1, 2310012C15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69617
VEGA: 13
Homologene: 5742
Lpin3
Name: lipin 3
Synonyms: 9130206L11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64899
Homologene: 84844
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Dstyk
Name: dual serine/threonine and tyrosine protein kinase
Synonyms: A930019K20Rik, C430014H23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213452
Homologene: 19711
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Alk
Name: anaplastic lymphoma kinase
Synonyms: CD246, Tcrz
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11682
VEGA: 17
HGNC: HGNC:427
Homologene: 68387
Parp6
Name: poly (ADP-ribose) polymerase family, member 6
Synonyms: 1700119G14Rik, C030013N01Rik, 2310028P13Rik, 3110038K10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67287
VEGA: 9
Homologene: 10627
Gabbr2
Name: gamma-aminobutyric acid type B receptor subunit 2
Synonyms: LOC242425, Gababr2, Gpr51, GB2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Acap3
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Synonyms: Centb5, Kiaa1716-hp
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 140500
Homologene: 23708
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192166
Homologene: 5149
Urgcp
Name: upregulator of cell proliferation
Synonyms: 2010005J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72046
Homologene: 69243
Cdh18
Name: cadherin 18
Synonyms: B230220E17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320865
HGNC: HGNC:1757
Homologene: 55858
Dzip1
Name: DAZ interacting protein 1
Synonyms: 2510025K24Rik, 2810422M04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66573
VEGA: 14
Homologene: 45708
Arhgef39
Name: Rho guanine nucleotide exchange factor 39
Synonyms: E130306D19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230098
Homologene: 19225
Cyp2u1
Name: cytochrome P450, family 2, subfamily u, polypeptide 1
Synonyms: 8430436A10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71519
Homologene: 77704
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Zp3r
Name: zona pellucida 3 receptor
Synonyms: SP56
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22789
HGNC: HGNC:1325
Homologene: 7609
Spata31e3
Name: spermatogenesis associated 31 subfamily E member 3
Synonyms: LOC380882, Gm906
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380882
VEGA: 13
Homologene: 134512
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: Aatyk3, AATYK3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381983
Homologene: 79449
Olfml2a
Name: olfactomedin-like 2A
Synonyms: 4932431K08Rik, photomedin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241327
Homologene: 35248
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: WI-18508, WI-16786, 9330155G14Rik, Nope
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Zfp84
Name: zinc finger protein 84
Synonyms: Zfp69, 2210410P13Rik, KRAB18, 4633401C23Rik, C86188
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74352
Homologene: 51858
Ift70a1
Name: intraflagellar transport 70A1
Synonyms: 4930506L13Rik, Ttc30a1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78802
Homologene: 136638
Acp2
Name: acid phosphatase 2, lysosomal
Synonyms: LAP, Acp-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11432
HGNC: HGNC:123
Homologene: 1217
Svs5
Name: seminal vesicle secretory protein 5
Synonyms: Svp1, Svp-1, SVS V, seminal vesicle protein F, Svp5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20944
Homologene: 49199
Calhm5
Name: calcium homeostasis modulator family member 5
Synonyms: Fam26e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103511
VEGA: 10
Homologene: 17807
Or9r7
Name: olfactory receptor family 9 subfamily R member 7
Synonyms: GA_x6K02T2PULF-11797746-11796799, Olfr824, MOR210-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258669
Homologene: 45026
Tcl1b1
Name: T cell leukemia/lymphoma 1B, 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27379
VEGA: 12
Homologene: 83274
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Gm9755
Name: predicted pseudogene 9755
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 100041265
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 93,023,453 bp
  • A to G, chromosome 1 at 130,577,884 bp
  • A to G, chromosome 1 at 132,453,325 bp
  • G to A, chromosome 2 at 27,191,919 bp
  • T to A, chromosome 2 at 35,160,627 bp
  • A to T, chromosome 2 at 38,959,753 bp
  • T to C, chromosome 2 at 59,338,765 bp
  • A to T, chromosome 2 at 75,979,976 bp
  • A to G, chromosome 2 at 90,733,219 bp
  • A to G, chromosome 2 at 91,208,422 bp
  • T to C, chromosome 2 at 118,790,439 bp
  • G to A, chromosome 2 at 120,720,602 bp
  • A to T, chromosome 2 at 155,411,520 bp
  • A to G, chromosome 2 at 160,894,079 bp
  • A to T, chromosome 2 at 164,333,587 bp
  • A to G, chromosome 3 at 131,293,609 bp
  • T to C, chromosome 4 at 43,496,834 bp
  • C to T, chromosome 4 at 46,718,838 bp
  • T to C, chromosome 4 at 82,950,320 bp
  • T to A, chromosome 4 at 133,370,548 bp
  • T to A, chromosome 4 at 155,905,399 bp
  • T to C, chromosome 5 at 21,484,036 bp
  • A to T, chromosome 5 at 22,034,775 bp
  • C to T, chromosome 5 at 23,502,655 bp
  • T to C, chromosome 5 at 25,314,362 bp
  • T to A, chromosome 6 at 3,374,267 bp
  • T to A, chromosome 6 at 102,245,158 bp
  • T to C, chromosome 6 at 141,459,316 bp
  • T to A, chromosome 7 at 29,771,372 bp
  • T to A, chromosome 7 at 45,795,003 bp
  • T to G, chromosome 7 at 75,611,377 bp
  • A to G, chromosome 7 at 102,082,974 bp
  • G to A, chromosome 8 at 15,122,413 bp
  • A to G, chromosome 8 at 45,795,730 bp
  • A to T, chromosome 8 at 67,515,058 bp
  • T to C, chromosome 9 at 35,456,437 bp
  • G to T, chromosome 9 at 59,649,564 bp
  • A to G, chromosome 9 at 65,126,926 bp
  • A to G, chromosome 9 at 118,484,599 bp
  • A to T, chromosome 10 at 23,899,601 bp
  • T to G, chromosome 10 at 34,096,017 bp
  • A to G, chromosome 10 at 43,999,093 bp
  • G to A, chromosome 10 at 59,428,194 bp
  • T to C, chromosome 10 at 76,607,740 bp
  • T to A, chromosome 10 at 93,239,033 bp
  • A to G, chromosome 10 at 130,126,653 bp
  • T to C, chromosome 11 at 5,716,004 bp
  • A to T, chromosome 11 at 34,256,535 bp
  • T to C, chromosome 11 at 68,791,850 bp
  • A to G, chromosome 11 at 97,691,850 bp
  • G to A, chromosome 12 at 79,280,067 bp
  • G to T, chromosome 12 at 105,159,815 bp
  • A to G, chromosome 13 at 6,558,244 bp
  • A to T, chromosome 13 at 50,248,260 bp
  • T to C, chromosome 14 at 50,533,702 bp
  • C to T, chromosome 14 at 99,112,973 bp
  • T to C, chromosome 14 at 118,889,305 bp
  • A to G, chromosome 15 at 23,474,317 bp
  • G to A, chromosome 17 at 71,984,745 bp
  • G to A, chromosome 18 at 78,857,860 bp
  • C to A, chromosome 19 at 6,961,913 bp
  • A to G, chromosome 19 at 8,826,746 bp
  • T to C, chromosome 19 at 17,125,222 bp
  • T to A, chromosome Y at 910,539 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1110 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039183-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.