Strain Name:
C57BL/6J-MtgxR1187Btlr/Mmmh
Stock Number:
039259-MU
Citation ID:
RRID:MMRRC_039259-MU
Other Names:
R1187 (G1), C57BL/6J-MtgxR1187Btlr
Major Collection:

Gene Information

Sema3e
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms: Semah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20349
Homologene: 8247
Etv1
Name: ets variant 1
Synonyms: Etsrp81, ER81
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Ppp4c
Name: protein phosphatase 4, catalytic subunit
Synonyms: 1110002D08Rik, PPX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56420
HGNC: HGNC:9319
Homologene: 2038
Phf14
Name: PHD finger protein 14
Synonyms: 5730446A07Rik, 1110001C23Rik, 4932409F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75725
Homologene: 8775
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, DNA-PK, DNAPDcs, DOXNPH, XRCC7, dxnph, slip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Plcb4
Name: phospholipase C, beta 4
Synonyms: C230058B11Rik, A930039J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18798
HGNC: HGNC:9059
Homologene: 8471
Nsrp1
Name: nuclear speckle regulatory protein 1
Synonyms: Ccdc55, NSpr70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237859
Homologene: 134095
Dvl2
Name: dishevelled segment polarity protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13543
HGNC: HGNC:3086
Homologene: 20927
Ctdp1
Name: CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
Synonyms: 4930563P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67655
HGNC: HGNC:2498
Homologene: 31254
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: C330027C09Rik, Cip2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224171
Homologene: 10842
Soat1
Name: sterol O-acyltransferase 1
Synonyms: 8430426K15Rik, hid, Acact, ACAT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20652
Homologene: 2333
Zbtb14
Name: zinc finger and BTB domain containing 14
Synonyms: Zfp161, b2b1982Clo, ZF5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22666
Homologene: 2560
Dnajc1
Name: DnaJ heat shock protein family (Hsp40) member C1
Synonyms: MTJ1, D230036H06Rik, ERdj1, Dnajl1, 4733401K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13418
Homologene: 7293
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, A530083I02Rik, ALS2CR17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, fibrocystin L, PKHDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 5330435L01Rik, 4632412F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237979
Homologene: 10406
Plb1
Name: phospholipase B1
Synonyms: 4632413E21Rik, 4930433E17Rik, 4930539A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665270
Homologene: 82108
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20849
Homologene: 20679
Zfp629
Name: zinc finger protein 629
Synonyms: 9330199A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320683
Homologene: 65318
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242274
Homologene: 10817
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Trpm5
Name: transient receptor potential cation channel, subfamily M, member 5
Synonyms: Mtr1, Ltrpc5, 9430099A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56843
Homologene: 22818
Ush1c
Name: USH1 protein network component harmonin
Synonyms: 2010016F01Rik, harmonin, Usher syndrome 1C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72088
Homologene: 77476
Smgc
Name: submandibular gland protein C
Synonyms: DXImx49e, Sfc21, 2310010P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223809
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Aox4
Name: aldehyde oxidase 4
Synonyms: AOH2, 2310003G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71872
Homologene: 70273
Myrfl
Name: myelin regulatory factor-like
Synonyms: LOC237558, Gm239
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237558
VEGA: 10
Homologene: 88588
Olfr1390
Name: olfactory receptor 1390
Synonyms: GA_x6K02T2QP88-6094111-6093176, MOR256-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259068
Dgkq
Name: diacylglycerol kinase, theta
Synonyms: 110kDa, Dagk4, Dgk theta, DAGK7, Dgkd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 110524
HGNC: HGNC:2856
Homologene: 20352
Zfp85
Name: zinc finger protein 85
Synonyms: KRAB19, Zfp71, Zfp85-rs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 22746
Homologene: 133709
Scgb1b27
Name: secretoglobin, family 1B, member 27
Synonyms: Abpa, Tcp, Abpa27, Sal-1, Abp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11354
Homologene: 114479
Rgl1
Name: ral guanine nucleotide dissociation stimulator,-like 1
Synonyms: Rgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19731
Homologene: 9039
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Acvrl1
Name: activin A receptor, type II-like 1
Synonyms: Alk-1, Alk1, activin receptor-like kinase-1, Acvrlk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11482
HGNC: HGNC:175
Homologene: 20058
Slfn8
Name: schlafen 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276950
Homologene: 45432
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 627479
Homologene: 129606
Olfr167
Name: olfactory receptor 167
Synonyms: MOR272-1, GA_x54KRFPKG5P-15963726-15962788
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258937
Homologene: 78689
Zbed6
Name: zinc finger, BED type containing 6
Synonyms: Gm8466, MGR, similar to Zinc finger BED domain containing protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 667118
Homologene: 130066
Cma2
Name: chymase 2, mast cell
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545055
VEGA: 14
Homologene: 115745
Col26a1
Name: collagen, type XXVI, alpha 1
Synonyms: Emid2, Collagen XXVI, 9430032K24Rik, Emu2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140709
Homologene: 136636
Clca1
Name: chloride channel accessory 1
Synonyms: gob-5, gob5, Clca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Sh2d7
Name: SH2 domain containing 7
Synonyms: 4933412E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244885
Homologene: 18355
Capsl
Name: calcyphosine-like
Synonyms: 1700028N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75568
VEGA: 15
Homologene: 16959
Apol7b
Name: apolipoprotein L 7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 278679
Homologene: 40940
Lrr1
Name: leucine rich repeat protein 1
Synonyms: Ppil5, 2410005L11Rik, LRR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69706
VEGA: 12
Homologene: 32677
Olfml2a
Name: olfactomedin-like 2A
Synonyms: photomedin-1, 4932431K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241327
Homologene: 35248
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10a-1, Col10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Rnf19b
Name: ring finger protein 19B
Synonyms: 4930555L03Rik, Ibrdc3, 4930534K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75234
Homologene: 34999
Sgsh
Name: N-sulfoglucosamine sulfohydrolase (sulfamidase)
Synonyms: 4632406A19Rik, sulphamidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27029
Homologene: 167
Sri
Name: sorcin
Synonyms: Sor, 2210417O06Rik, 2900070H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109552
Homologene: 37736
Zfp758
Name: zinc finger protein 758
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224598
Homologene: 138293
Mepe
Name: matrix extracellular phosphoglycoprotein with ASARM motif (bone)
Synonyms: OF45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 94111
Homologene: 10623
D730045B01Rik
Name: RIKEN cDNA D730045B01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Krcc1
Name: lysine-rich coiled-coil 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 57896
Homologene: 9595
Olfr680-ps1
Name: olfactory receptor 680, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-7720330-7719479, MOR40-10P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257981
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 52,076,677 bp
  • A to G, chromosome 1 at 58,257,314 bp
  • T to C, chromosome 1 at 60,194,528 bp
  • G to A, chromosome 1 at 133,659,203 bp
  • T to C, chromosome 1 at 152,544,433 bp
  • T to A, chromosome 1 at 156,434,175 bp
  • A to G, chromosome 2 at 18,284,709 bp
  • A to G, chromosome 2 at 38,959,813 bp
  • C to T, chromosome 2 at 112,958,176 bp
  • A to G, chromosome 2 at 135,968,394 bp
  • T to C, chromosome 3 at 145,009,743 bp
  • T to A, chromosome 3 at 158,160,402 bp
  • T to G, chromosome 4 at 129,075,567 bp
  • T to C, chromosome 5 at 8,059,416 bp
  • G to A, chromosome 5 at 14,232,084 bp
  • C to A, chromosome 5 at 32,354,902 bp
  • G to A, chromosome 5 at 104,338,248 bp
  • G to A, chromosome 5 at 108,652,519 bp
  • G to T, chromosome 5 at 108,803,219 bp
  • G to A, chromosome 5 at 136,744,166 bp
  • T to C, chromosome 5 at 151,369,153 bp
  • T to G, chromosome 6 at 11,941,496 bp
  • A to T, chromosome 6 at 71,284,628 bp
  • T to C, chromosome 7 at 34,021,744 bp
  • T to A, chromosome 7 at 46,208,914 bp
  • T to A, chromosome 7 at 105,091,137 bp
  • T to A, chromosome 7 at 126,786,200 bp
  • A to G, chromosome 7 at 127,610,229 bp
  • T to C, chromosome 7 at 127,611,887 bp
  • A to G, chromosome 7 at 143,074,469 bp
  • T to A, chromosome 9 at 54,541,187 bp
  • A to T, chromosome 10 at 34,394,838 bp
  • G to A, chromosome 10 at 116,831,542 bp
  • G to T, chromosome 11 at 9,528,981 bp
  • T to G, chromosome 11 at 49,340,590 bp
  • A to T, chromosome 11 at 70,006,136 bp
  • G to A, chromosome 11 at 77,046,027 bp
  • A to T, chromosome 11 at 83,003,488 bp
  • C to T, chromosome 11 at 113,838,646 bp
  • A to T, chromosome 11 at 119,346,578 bp
  • A to G, chromosome 12 at 38,865,564 bp
  • A to T, chromosome 12 at 69,175,022 bp
  • T to C, chromosome 12 at 101,625,732 bp
  • C to T, chromosome 13 at 40,208,829 bp
  • T to A, chromosome 13 at 67,749,716 bp
  • T to C, chromosome 14 at 55,972,823 bp
  • C to T, chromosome 15 at 9,457,721 bp
  • T to C, chromosome 15 at 44,498,051 bp
  • A to T, chromosome 15 at 77,423,403 bp
  • G to A, chromosome 15 at 91,860,600 bp
  • C to A, chromosome 15 at 101,143,332 bp
  • T to C, chromosome 16 at 15,759,746 bp
  • T to C, chromosome 16 at 19,515,046 bp
  • T to A, chromosome 16 at 49,000,293 bp
  • T to A, chromosome 17 at 22,375,190 bp
  • C to A, chromosome 17 at 69,388,502 bp
  • C to T, chromosome 18 at 37,265,544 bp
  • A to G, chromosome 18 at 80,449,487 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1187 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039259-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.