Strain Name:
C57BL/6J-MtgxR1263Btlr/Mmmh
Stock Number:
039330-MU
Citation ID:
RRID:MMRRC_039330-MU
Other Names:
R1263 (G1), C57BL/6J-MtgxR1263Btlr
Major Collection:

Gene Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: D230017O13Rik, 2610103K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 268281
Homologene: 6489
Dop1b
Name: DOP1 leucine zipper like protein B
Synonyms: 2610510B01Rik, Dopey2, 0610038M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 70028
VEGA: 16
HGNC: HGNC:1291
Homologene: 21068
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20975
Homologene: 117703
L3mbtl2
Name: L3MBTL2 polycomb repressive complex 1 subunit
Synonyms: m4mbt, 4732493N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 214669
Homologene: 12882
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107182
Homologene: 31978
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: C130040D16Rik, MICAL-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 194401
Homologene: 85288
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 84505
Homologene: 32157
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21745
VEGA: 14
Homologene: 5157
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: Adprtl1, VPARP, C030027K23Rik, E230037B21Rik, VAULT3, PH5P, p193
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Sft2d1
Name: SFT2 domain containing 1
Synonyms: 5630401J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 106489
Homologene: 34525
Polg
Name: polymerase (DNA directed), gamma
Synonyms: polymerase gamma, Pol gamma, Polga, mitochondrial DNA polymerase gamma, mitochondrial DNA polymerase-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18975
HGNC: HGNC:9179
Homologene: 2016
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20264
VEGA: 9
Homologene: 21300
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230895
Homologene: 15583
Zfp277
Name: zinc finger protein 277
Synonyms: NIRF4, 2410017E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 246196
VEGA: 12
Homologene: 11087
Arhgef1
Name: Rho guanine nucleotide exchange factor (GEF) 1
Synonyms: Lsc, Lbcl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Txnl4a
Name: thioredoxin-like 4A
Synonyms: Txnl4, D18Wsu98e, ENSMUSG00000057130, U5-15kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 27366
Homologene: 7150
Brd3
Name: bromodomain containing 3
Synonyms: Fsrg2, 2410084F24Rik, RINGL3, ORFX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67382
HGNC: HGNC:1104
Homologene: 81801
Pold3
Name: polymerase (DNA-directed), delta 3, accessory subunit
Synonyms: P66, 2410142G14Rik, C85233, GC12, P68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67967
Homologene: 38202
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 72333
Homologene: 75052
Gpr107
Name: G protein-coupled receptor 107
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 277463
Homologene: 81077
Rfx7
Name: regulatory factor X, 7
Synonyms: D130086K05Rik, 2510005N23Rik, Rfxdc2, 9930116O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319758
Homologene: 11275
Gkap1
Name: G kinase anchoring protein 1
Synonyms: D13Ertd340e, 4933400B15Rik, 42kDa, Gkap42
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56278
VEGA: 13
Homologene: 10515
C87499
Name: expressed sequence C87499
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381590
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 8430415N23Rik, 9830132G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226470
Homologene: 27795
Slc9b2
Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Synonyms: NHA2, Nhedc2, C80638, NHE10, nha-oc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 97086
Homologene: 45381
Tgfbi
Name: transforming growth factor, beta induced
Synonyms: Beta-ig, bIG-h3, 68kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 21810
VEGA: 13
Homologene: 37294
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 195046
Homologene: 133820
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 56552
Homologene: 135915
Krt71
Name: keratin 71
Synonyms: Cu, Krt2-6g, mK6irs1, Cal4, Ca, mK6irs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 56735
Homologene: 88864
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245026
Homologene: 18260
Nrp1
Name: neuropilin 1
Synonyms: Npn1, NPN-1, NP-1, Neuropilin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: LOC381522, E230008N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381522
Homologene: 117988
Abca8b
Name: ATP-binding cassette, sub-family A (ABC1), member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74424
Homologene: 11713
Chil1
Name: chitinase-like 1
Synonyms: Gp39, Chi3l1, Brp39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12654
HGNC: HGNC:1932
Homologene: 55569
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 68915
Homologene: 57502
Acbd4
Name: acyl-Coenzyme A binding domain containing 4
Synonyms: 2010009P05Rik, 2010015A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67131
Homologene: 32596
Atp13a4
Name: ATPase type 13A4
Synonyms: 9330174J19Rik, 4631413J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224079
Homologene: 75330
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627743
Homologene: 129680
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 637908
Homologene: 104040
Rnf122
Name: ring finger protein 122
Synonyms: 1110063C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68867
Homologene: 11717
0610010F05Rik
Name: RIKEN cDNA 0610010F05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71675
Homologene: 19038
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100041449
Homologene: 135775
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Hs3st6
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 328779
VEGA: 17
Homologene: 84633
Cyp4a31
Name: cytochrome P450, family 4, subfamily a, polypeptide 31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 666168
HGNC: HGNC:2642
Homologene: 128044
Olfr1385
Name: olfactory receptor 1385
Synonyms: MOR256-42P, MOR256-42P, GA_x6K02T2QP88-5941817-5940888, Olfr1549-ps1, MOR256-41P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258027
Homologene: 86692
Olfr338
Name: olfactory receptor 338
Synonyms: MOR136-5, GA_x6K02T2NLDC-33070879-33071799
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258949
Homologene: 133647
Ccdc185
Name: coiled-coil domain containing 185
Synonyms: 4922505E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 433386
Homologene: 17631
Trim38
Name: tripartite motif-containing 38
Synonyms: LOC214158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 214158
Homologene: 48427
Klhdc3
Name: kelch domain containing 3
Synonyms: 1300011D16Rik, Peas
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 71765
VEGA: 17
Homologene: 14290
Serpinb13
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms: HUR7, headpin, PI13, HURPIN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241196
HGNC: HGNC:8944
Homologene: 22718
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: 9230107O05Rik, D1Mgi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Vps28
Name: vacuolar protein sorting 28
Synonyms: D730005C08Rik, 1110014J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66914
VEGA: 15
Homologene: 69205
Pih1d3
Name: PIH1 domain containing 3
Synonyms: 4930521A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74708
Homologene: 16553
Npas2
Name: neuronal PAS domain protein 2
Synonyms: MOP4, bHLHe9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18143
HGNC: HGNC:7895
Homologene: 1887
Styxl1
Name: serine/threonine/tyrosine interacting-like 1
Synonyms: Dusp24, 1700011C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 76571
Homologene: 9378
Erich4
Name: glutamate rich 4
Synonyms: Gm7092
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 632778
Homologene: 86877
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 21,479,378 bp
  • A to T, chromosome 1 at 31,223,215 bp
  • C to A, chromosome 1 at 39,334,768 bp
  • T to A, chromosome 1 at 107,000,736 bp
  • G to A, chromosome 1 at 134,189,242 bp
  • A to G, chromosome 1 at 139,441,875 bp
  • A to T, chromosome 1 at 182,747,353 bp
  • A to C, chromosome 2 at 27,462,522 bp
  • T to G, chromosome 2 at 31,178,255 bp
  • T to A, chromosome 2 at 36,376,994 bp
  • T to C, chromosome 3 at 95,327,611 bp
  • C to A, chromosome 3 at 135,336,395 bp
  • A to G, chromosome 4 at 45,903,887 bp
  • G to T, chromosome 4 at 88,634,105 bp
  • A to G, chromosome 4 at 115,574,711 bp
  • A to G, chromosome 4 at 131,819,707 bp
  • T to A, chromosome 4 at 145,170,348 bp
  • G to T, chromosome 5 at 135,753,883 bp
  • A to C, chromosome 5 at 146,104,711 bp
  • A to T, chromosome 6 at 73,144,965 bp
  • T to C, chromosome 6 at 120,952,469 bp
  • T to A, chromosome 6 at 124,050,708 bp
  • T to C, chromosome 7 at 12,581,606 bp
  • T to A, chromosome 7 at 24,913,133 bp
  • T to A, chromosome 7 at 25,615,134 bp
  • T to C, chromosome 7 at 79,459,786 bp
  • T to A, chromosome 7 at 100,119,683 bp
  • G to A, chromosome 7 at 118,666,870 bp
  • T to G, chromosome 8 at 31,112,149 bp
  • TGCGTAGCG to TGCG, chromosome 8 at 61,513,457 bp
  • T to A, chromosome 8 at 128,468,389 bp
  • T to A, chromosome 9 at 72,577,047 bp
  • T to A, chromosome 9 at 105,709,489 bp
  • T to A, chromosome 9 at 119,617,733 bp
  • A to G, chromosome 10 at 11,159,530 bp
  • A to T, chromosome 11 at 23,620,278 bp
  • A to T, chromosome 11 at 49,495,021 bp
  • A to G, chromosome 11 at 71,097,122 bp
  • T to A, chromosome 11 at 103,103,851 bp
  • A to C, chromosome 11 at 109,941,607 bp
  • A to T, chromosome 12 at 40,364,165 bp
  • A to G, chromosome 13 at 23,791,134 bp
  • T to A, chromosome 13 at 56,630,655 bp
  • A to T, chromosome 13 at 58,255,773 bp
  • C to A, chromosome 14 at 50,845,513 bp
  • T to C, chromosome 14 at 56,641,252 bp
  • T to A, chromosome 15 at 76,622,562 bp
  • A to G, chromosome 15 at 81,682,968 bp
  • C to T, chromosome 15 at 101,735,466 bp
  • T to A, chromosome 16 at 29,471,953 bp
  • C to A, chromosome 16 at 93,777,386 bp
  • T to C, chromosome 17 at 6,019,359 bp
  • A to G, chromosome 17 at 8,320,638 bp
  • A to G, chromosome 17 at 20,208,322 bp
  • A to G, chromosome 17 at 24,758,530 bp
  • A to G, chromosome 17 at 35,661,609 bp
  • A to T, chromosome 17 at 46,676,966 bp
  • T to A, chromosome 18 at 80,207,321 bp
  • A to T, chromosome 19 at 36,956,524 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1263 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039330-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.