Strain Name:
C57BL/6J-MtgxR1331Btlr/Mmmh
Stock Number:
039396-MU
Citation ID:
RRID:MMRRC_039396-MU
Other Names:
R1331 (G1), C57BL/6J-MtgxR1331Btlr
Major Collection:

Gene Information

Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: Nedd4, E430025J12Rik, Nedd4a, Nedd4-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Penk
Name: preproenkephalin
Synonyms: Penk1, PPA, Penk, ENK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18619
HGNC: HGNC:8831
Homologene: 4528
Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 21752
VEGA: 13
Homologene: 31141
Eri3
Name: exoribonuclease 3
Synonyms: PINT1, Prnpip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 140546
Homologene: 15403
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230793
Homologene: 17144
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: Hsp90, Hsp89, Hsp86-1, hsp4, Hspca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: 1110005P14Rik, D1Ertd101e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Alkbh8
Name: alkB homolog 8, tRNA methyltransferase
Synonyms: 9430088N01Rik, Abh8, 4930562C03Rik, 8030431D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67667
Homologene: 44488
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 12808
Homologene: 9058
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228850
Homologene: 10666
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 360013
Homologene: 7977
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki67, D630048A14Rik, Ki-67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: dynein heavy chain, retrograde transport, Dnchc1, Loa, MAP1C, Swl, Dnec1, 9930018I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Slc45a4
Name: solute carrier family 45, member 4
Synonyms: 9330175B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 106068
Homologene: 69908
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, mitosin, Lek1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Orc3
Name: origin recognition complex, subunit 3
Synonyms: Orc3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 50793
HGNC: HGNC:8489
Homologene: 8225
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 627872
Homologene: 41287
Lpl
Name: lipoprotein lipase
Synonyms: O 1-4-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16956
HGNC: HGNC:6677
Homologene: 200
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: Fam65b, E430013J17Rik, 1700108N18Rik, 6330500D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 193385
Homologene: 9284
Trim33
Name: tripartite motif-containing 33
Synonyms: Tif1g, ectodermin, Ecto, 8030451N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 94093
Homologene: 9296
D430042O09Rik
Name: RIKEN cDNA D430042O09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233865
Homologene: 45841
Sh3bgrl2
Name: SH3 domain binding glutamic acid-rich protein like 2
Synonyms: A930014C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 212531
Homologene: 12876
Myo7a
Name: myosin VIIA
Synonyms: Hdb, nmf371, Myo7, USH1B, polka
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Cd202b, Hyk, Tie2, tie-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 21687
Homologene: 397
Loxhd1
Name: lipoxygenase homology domains 1
Synonyms: sba, 1700096C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240411
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, PKHDL1, D86 mRNA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 192190
Homologene: 16332
Fbxo24
Name: F-box protein 24
Synonyms: 4933422D21Rik, Fbx24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71176
Homologene: 14131
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20849
Homologene: 20679
Phf7
Name: PHD finger protein 7
Synonyms: 1700006H01Rik, 1700010P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 71838
VEGA: 14
Homologene: 69217
Slc35b1
Name: solute carrier family 35, member B1
Synonyms: Ugalt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 110172
Homologene: 4252
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: D030051B22Rik, mr-gef
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217944
VEGA: 12
Homologene: 56563
Stard9
Name: START domain containing 9
Synonyms: 4831403C07Rik, E230025N21Rik, Kif16a, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 668880
Homologene: 130712
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: D3Ertd789e, 4921507O14Rik, b2b1735Clo, b2b2025.1Clo, prh, b2b1304Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 51938
Homologene: 12149
Col14a1
Name: collagen, type XIV, alpha 1
Synonyms: 5730412L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 12818
HGNC: HGNC:2191
Homologene: 18741
Ccdc180
Name: coiled-coil domain containing 180
Synonyms: LOC381522, E230008N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381522
Homologene: 117988
Impdh1
Name: inosine monophosphate dehydrogenase 1
Synonyms: B930086D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 23917
HGNC: HGNC:6052
Homologene: 68096
Map1a
Name: microtubule-associated protein 1 A
Synonyms: 6330416M19Rik, Mtap1a, Mtap1, Mtap-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Acap1
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms: Centb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216859
Homologene: 22835
Arhgef26
Name: Rho guanine nucleotide exchange factor (GEF) 26
Synonyms: 8430436L14Rik, 4631416L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 622434
Homologene: 9204
Mogat2
Name: monoacylglycerol O-acyltransferase 2
Synonyms: Mgat2, DGAT2L5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233549
Homologene: 57020
Olfr853
Name: olfactory receptor 853
Synonyms: GA_x6K02T2PVTD-13277703-13276786, MOR154-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258908
HGNC: HGNC:8466
Homologene: 133623
Mark1
Name: MAP/microtubule affinity regulating kinase 1
Synonyms: B930025N23Rik, Emk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226778
HGNC: HGNC:6896
Homologene: 49552
Gm7589
Name: predicted gene 7589
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 665330
Ptprb
Name: protein tyrosine phosphatase, receptor type, B
Synonyms: 3230402H02Rik, VE-PTP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: Gpd-1, G6pd1, Gpd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Ephb4
Name: Eph receptor B4
Synonyms: Myk1, Tyro11, Htk, b2b2412Clo, MDK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13846
HGNC: HGNC:3395
Homologene: 20939
Acat1
Name: acetyl-Coenzyme A acetyltransferase 1
Synonyms: 6330585C21Rik, Acat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110446
HGNC: HGNC:93
Homologene: 6
Vmn1r212
Name: vomeronasal 1 receptor 212
Synonyms: V1rh18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 171275
Homologene: 110880
Bid
Name: BH3 interacting domain death agonist
Synonyms: 2700049M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12122
HGNC: HGNC:1050
Homologene: 923
Glra1
Name: glycine receptor, alpha 1 subunit
Synonyms: nmf11, oscillator, B230397M16Rik, ot
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14654
HGNC: HGNC:4326
Homologene: 20083
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 52,013,927 bp
  • A to G, chromosome 1 at 53,468,669 bp
  • T to A, chromosome 1 at 93,421,131 bp
  • T to C, chromosome 1 at 184,928,048 bp
  • A to G, chromosome 1 at 189,642,801 bp
  • T to C, chromosome 2 at 29,179,686 bp
  • C to A, chromosome 2 at 120,673,636 bp
  • G to T, chromosome 2 at 121,306,220 bp
  • T to C, chromosome 2 at 158,430,533 bp
  • T to C, chromosome 3 at 33,815,485 bp
  • A to G, chromosome 3 at 62,340,028 bp
  • T to A, chromosome 3 at 103,310,354 bp
  • A to G, chromosome 4 at 4,134,287 bp
  • T to G, chromosome 4 at 34,599,748 bp
  • T to C, chromosome 4 at 45,909,359 bp
  • T to A, chromosome 4 at 94,739,706 bp
  • T to C, chromosome 4 at 117,564,907 bp
  • T to C, chromosome 4 at 133,063,691 bp
  • T to C, chromosome 4 at 149,982,415 bp
  • A to G, chromosome 5 at 137,366,534 bp
  • A to G, chromosome 5 at 137,619,629 bp
  • A to T, chromosome 6 at 29,206,478 bp
  • C to T, chromosome 6 at 120,897,255 bp
  • A to G, chromosome 7 at 98,107,008 bp
  • T to C, chromosome 7 at 99,223,515 bp
  • A to G, chromosome 7 at 125,866,455 bp
  • A to T, chromosome 7 at 135,698,276 bp
  • A to G, chromosome 8 at 68,896,629 bp
  • T to A, chromosome 9 at 3,347,916 bp
  • T to C, chromosome 9 at 19,537,546 bp
  • T to C, chromosome 9 at 53,584,883 bp
  • C to A, chromosome 9 at 59,146,042 bp
  • T to A, chromosome 9 at 72,677,386 bp
  • C to T, chromosome 9 at 83,577,631 bp
  • A to T, chromosome 10 at 116,367,532 bp
  • A to T, chromosome 11 at 12,375,853 bp
  • A to C, chromosome 11 at 55,515,070 bp
  • A to G, chromosome 11 at 59,086,928 bp
  • A to T, chromosome 11 at 69,882,376 bp
  • C to G, chromosome 11 at 77,841,579 bp
  • T to A, chromosome 11 at 95,385,863 bp
  • T to C, chromosome 12 at 110,649,264 bp
  • C to A, chromosome 12 at 110,692,820 bp
  • G to T, chromosome 12 at 117,721,349 bp
  • A to T, chromosome 13 at 22,883,392 bp
  • G to T, chromosome 13 at 24,677,841 bp
  • T to A, chromosome 13 at 73,648,354 bp
  • G to A, chromosome 14 at 31,240,405 bp
  • G to A, chromosome 15 at 44,505,547 bp
  • C to T, chromosome 15 at 44,589,597 bp
  • T to A, chromosome 15 at 55,410,188 bp
  • C to T, chromosome 15 at 73,586,747 bp
  • C to T, chromosome 16 at 37,041,747 bp
  • C to T, chromosome 18 at 77,402,936 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1331 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039396-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.