Strain Name:
C57BL/6J-MtgxR1337Btlr/Mmmh
Stock Number:
039402-MU
Citation ID:
RRID:MMRRC_039402-MU
Other Names:
R1337 (G1), C57BL/6J-MtgxR1337Btlr
Major Collection:

Gene Information

Abca12
Name: ATP-binding cassette, sub-family A (ABC1), member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 74591
Homologene: 45441
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11426
Homologene: 136191
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12695
Homologene: 72199
Srrm1
Name: serine/arginine repetitive matrix 1
Synonyms: SRm160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 51796
Homologene: null
Hdc
Name: histidine decarboxylase
Synonyms: Hdc-c, Hdc-e, Hdc-s, L-histidine decarboxylase, Hdc-a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 15186
HGNC: HGNC:4855
Homologene: 20490
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A230083H22Rik, A330102H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 353211
VEGA: 19
Homologene: 18939
Hapln3
Name: hyaluronan and proteoglycan link protein 3
Synonyms: 4930554N11Rik, Lpr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67666
Homologene: 18654
Amph
Name: amphiphysin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Nup88
Name: nucleoporin 88
Synonyms: Prei2, Nup84
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 19069
HGNC: HGNC:8067
Homologene: 1901
Cdk12
Name: cyclin-dependent kinase 12
Synonyms: D11Ertd752e, 1810022J16Rik, Crk7, Crkrs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69131
Homologene: 128632
Zfp644
Name: zinc finger protein 644
Synonyms: BM-005, D5Ertd689e, 1110068L01Rik, Zep-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 52397
Homologene: 12971
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: FLASH, D4Ertd659e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Ppil1
Name: peptidylprolyl isomerase (cyclophilin)-like 1
Synonyms: 1110060O10Rik, Cypl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 68816
HGNC: HGNC:9260
Homologene: 9367
Cenpk
Name: centromere protein K
Synonyms: B130045K24Rik, Solt, C530004N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 60411
VEGA: 13
Homologene: 11035
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, L-type Cav1.2, Cav1.2, Cchl1a1, D930026N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Stk32a
Name: serine/threonine kinase 32A
Synonyms: A930015B13Rik, YANK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 269019
VEGA: 18
Homologene: 65357
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237979
Homologene: 10406
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20192
Homologene: 68151
Ces2g
Name: carboxylesterase 2G
Synonyms: 2210023G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 72361
HGNC: HGNC:1864
Homologene: 77154
Xkr9
Name: X-linked Kx blood group related 9
Synonyms: LOC381246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381246
Homologene: 20056
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, MUC9, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Capn8
Name: calpain 8
Synonyms: nCL-2, nCL-2'
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 170725
HGNC: HGNC:1485
Homologene: 15643
Gm839
Name: predicted gene 839
Synonyms: LOC330379
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330379
HGNC: null
Homologene: null
Engase
Name: endo-beta-N-acetylglucosaminidase
Synonyms: D230014K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217364
Homologene: 13666
Gsdma
Name: gasdermin A
Synonyms: Gsdma1, H312E, Gsdm1, Gsdm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 57911
Homologene: 10962
Ttc7
Name: tetratricopeptide repeat domain 7
Synonyms: 1700007L07Rik, 1110035E02Rik, fsn, hea
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 225049
Homologene: 12515
Sema5a
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Synonyms: semF, M-Sema D, 9130201M22Rik, Semaf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 20356
VEGA: 15
Homologene: 2949
Mog
Name: myelin oligodendrocyte glycoprotein
Synonyms: B230317G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17441
HGNC: HGNC:7197
Homologene: 111009
Ehbp1l1
Name: EH domain binding protein 1-like 1
Synonyms: G430002G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 114601
VEGA: 19
Homologene: 136059
5730522E02Rik
Name: RIKEN cDNA 5730522E02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70626
HGNC: null
Homologene: null
Larp1b
Name: La ribonucleoprotein domain family, member 1B
Synonyms: Larp2, 4933421B21Rik, 1700108L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 214048
Homologene: 103869
Slco5a1
Name: solute carrier organic anion transporter family, member 5A1
Synonyms: A630033C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240726
Homologene: 57135
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: EAAT5, A930031E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242607
Homologene: 21327
Sertad3
Name: SERTA domain containing 3
Synonyms: Rbt1, Sei3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 170742
Homologene: 8361
Olfr566
Name: olfactory receptor 566
Synonyms: GA_x6K02T2PBJ9-5560696-5559746, MOR14-7P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258168
Homologene: 133721
Olfr836
Name: olfactory receptor 836
Synonyms: MOR152-3, GA_x6K02T2PVTD-12857805-12858749
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258557
HGNC: null
Homologene: 115507
Ager
Name: advanced glycosylation end product-specific receptor
Synonyms: RAGE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 11596
HGNC: HGNC:320
Homologene: 883
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 12,939,142 bp
  • C to A, chromosome 1 at 13,701,124 bp
  • T to C, chromosome 1 at 71,294,819 bp
  • T to G, chromosome 1 at 182,632,074 bp
  • C to A, chromosome 2 at 112,779,963 bp
  • T to C, chromosome 2 at 126,616,276 bp
  • C to T, chromosome 3 at 41,033,402 bp
  • T to C, chromosome 4 at 32,645,721 bp
  • A to G, chromosome 4 at 98,429,037 bp
  • T to C, chromosome 4 at 108,012,226 bp
  • T to G, chromosome 4 at 123,476,275 bp
  • A to G, chromosome 4 at 135,346,733 bp
  • A to G, chromosome 5 at 106,637,554 bp
  • A to G, chromosome 6 at 89,212,483 bp
  • A to G, chromosome 6 at 118,627,455 bp
  • T to C, chromosome 7 at 27,476,441 bp
  • T to C, chromosome 7 at 79,118,076 bp
  • T to C, chromosome 7 at 102,856,871 bp
  • A to G, chromosome 7 at 141,858,624 bp
  • A to T, chromosome 8 at 104,963,965 bp
  • A to G, chromosome 9 at 19,121,803 bp
  • A to G, chromosome 11 at 25,769,033 bp
  • T to A, chromosome 11 at 70,944,890 bp
  • T to C, chromosome 11 at 98,245,671 bp
  • C to T, chromosome 11 at 98,669,707 bp
  • A to C, chromosome 11 at 113,832,331 bp
  • A to G, chromosome 11 at 118,482,574 bp
  • G to A, chromosome 13 at 19,142,028 bp
  • A to T, chromosome 13 at 104,242,741 bp
  • T to A, chromosome 15 at 32,609,214 bp
  • G to A, chromosome 17 at 29,262,181 bp
  • G to T, chromosome 17 at 34,600,622 bp
  • A to T, chromosome 17 at 37,012,098 bp
  • A to T, chromosome 17 at 87,290,296 bp
  • A to G, chromosome 18 at 43,261,349 bp
  • A to T, chromosome 19 at 5,718,230 bp
  • C to T, chromosome 19 at 17,119,607 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1337 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039402-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.