Strain Name:
C57BL/6J-MtgxR1340Btlr/Mmmh
Stock Number:
039405-MU
Citation ID:
RRID:MMRRC_039405-MU
Other Names:
R1340 (G1), C57BL/6J-MtgxR1340Btlr
Major Collection:

Gene Information

Nefh
Name: neurofilament, heavy polypeptide
Synonyms: NF-H, NF200, NEFH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380684
HGNC: HGNC:7737
Homologene: 40755
Mtarc2
Name: mitochondrial amidoxime reducing component 2
Synonyms: 2810484M10Rik, Mosc2, Marc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67247
Homologene: 9904
Csrnp3
Name: cysteine-serine-rich nuclear protein 3
Synonyms: mbu1, A330102K23Rik, CSRNP-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77771
Homologene: 11803
Gfpt2
Name: glutamine fructose-6-phosphate transaminase 2
Synonyms: GFAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14584
HGNC: HGNC:4242
Homologene: 68439
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: E130319N12Rik, 2810017C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215351
Homologene: 9196
Epb41l5
Name: erythrocyte membrane protein band 4.1 like 5
Synonyms: NBL5, 1700030C16Rik, E230025E14Rik, Lulu1, Epb4.1l5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226352
Homologene: 32492
Ccdc9
Name: coiled-coil domain containing 9
Synonyms: 2600011L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243846
Homologene: 9209
Uhrf1bp1
Name: UHRF1 (ICBP90) binding protein 1
Synonyms: 1110020K19Rik, F830021D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224648
Homologene: 9816
Actn1
Name: actinin, alpha 1
Synonyms: 3110023F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 109711
VEGA: 12
HGNC: HGNC:163
Homologene: 55553
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Polr3f
Name: polymerase (RNA) III (DNA directed) polypeptide F
Synonyms: 3110032A07Rik, 2810411G20Rik, RPC39, RPC6, 3010019O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70408
Homologene: 4722
Adam8
Name: a disintegrin and metallopeptidase domain 8
Synonyms: CD156, MS2, E430039A18Rik, CD156a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11501
HGNC: HGNC:215
Homologene: 74384
Nt5c3
Name: 5'-nucleotidase, cytosolic III
Synonyms: p36, lupin, Umph-1, PN-1, cN-III, PSN1, PN-I, Umph1, 1600024P05Rik, 2610206B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107569
Homologene: 9534
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Cep120
Name: centrosomal protein 120
Synonyms: Ccdc100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225523
VEGA: 18
Homologene: 27415
Gm2381
Name: predicted gene 2381
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039706
Rps17
Name: ribosomal protein S17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20068
Homologene: 110867
Cndp1
Name: carnosine dipeptidase 1 (metallopeptidase M20 family)
Synonyms: Cn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 338403
Homologene: 57178
Wscd1
Name: WSC domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216881
Homologene: 18590
Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Synonyms: Cox-2, cyclooxygenase 2, Pghs2, COX2, prostaglandin G/H synthase, PHS-2, cyclooxygenase-2, PGHS-2, Tis10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19225
HGNC: HGNC:9605
Homologene: 31000
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: F630004O05Rik, B930091H02Rik, D030022P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Slc38a4
Name: solute carrier family 38, member 4
Synonyms: Ata3, 1700012A18Rik, 1110012E16Rik, SNAT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69354
VEGA: 15
Homologene: 75077
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: D-LTCC, Cchl1a, Cchl1a2, Cacnl1a2, 8430418G19Rik, Cav1.3alpha1, C79217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Aldh9a1
Name: aldehyde dehydrogenase 9, subfamily A1
Synonyms: TMABA-DH, ESTM40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56752
HGNC: HGNC:412
Homologene: 55483
Nrp1
Name: neuropilin 1
Synonyms: Neuropilin-1, NP-1, NPN-1, Npn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Vmn2r75
Name: vomeronasal 2, receptor 75
Synonyms: EG546981
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546981
Homologene: 115466
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212392
Homologene: 17668
Abcc9
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms: SUR2B, SUR2A, Sur2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50720
Txlnb
Name: taxilin beta
Synonyms: Mdp77, 2310001N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 378431
Homologene: 44534
Vmn1r178
Name: vomeronasal 1 receptor 178
Synonyms: LOC232959, V1rd13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232959
Homologene: 104166
Gsdma2
Name: gasdermin A2
Synonyms: 2210411P14Rik, 2210009F20Rik, 2200001G21Rik, Gsdml2, 2210006M16Rik, Gsdm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76758
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, Snep, D430044C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 328505
Homologene: 106613
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: Abh2, mABH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231642
Homologene: 18393
Lrriq4
Name: leucine-rich repeats and IQ motif containing 4
Synonyms: 4930558O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68307
Homologene: 12260
Olfr364-ps1
Name: olfactory receptor 364, pseudogene 1
Synonyms: GA_x6K02T2NLDC-33831282-33832243, MOR138-4P, MOR138-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227794
HGNC: HGNC:8216
Ces3a
Name: carboxylesterase 3A
Synonyms: Es-male carboxylesterase, Es31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382053
HGNC: HGNC:1865
Homologene: 84407
Nt5c1b
Name: 5'-nucleotidase, cytosolic IB
Synonyms: 4921514H13Rik, CN-IB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70881
Homologene: 12370
Slc35f1
Name: solute carrier family 35, member F1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215085
Homologene: 33552
Sox15
Name: SRY (sex determining region Y)-box 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20670
Homologene: 74586
Cgref1
Name: cell growth regulator with EF hand domain 1
Synonyms: 1110004G24Rik, CGR11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68567
Homologene: 4790
Olfr449
Name: olfactory receptor 449
Synonyms: GA_x6K02T2P3E9-4722003-4721068, MOR103-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 259067
HGNC: HGNC:8354
Homologene: 17485
Olfr527
Name: olfactory receptor 527
Synonyms: GA_x6K02T2PBJ9-42486061-42486978, MOR251-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257939
Homologene: 73958
Acat3
Name: acetyl-Coenzyme A acetyltransferase 3
Synonyms: ACTL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224530
HGNC: HGNC:94
Homologene: 55855
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 93,281,654 bp
  • A to T, chromosome 1 at 119,549,131 bp
  • T to G, chromosome 1 at 150,105,477 bp
  • A to G, chromosome 1 at 154,472,657 bp
  • T to G, chromosome 1 at 167,357,344 bp
  • T to C, chromosome 1 at 169,998,084 bp
  • T to C, chromosome 1 at 184,822,547 bp
  • T to G, chromosome 2 at 37,146,757 bp
  • T to C, chromosome 2 at 40,702,794 bp
  • T to A, chromosome 2 at 66,002,396 bp
  • A to G, chromosome 2 at 144,538,628 bp
  • A to C, chromosome 3 at 30,650,323 bp
  • T to C, chromosome 4 at 111,980,219 bp
  • A to G, chromosome 5 at 30,945,346 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • G to A, chromosome 6 at 42,838,009 bp
  • A to G, chromosome 6 at 56,883,033 bp
  • G to A, chromosome 6 at 85,667,957 bp
  • C to T, chromosome 6 at 137,441,081 bp
  • A to T, chromosome 6 at 142,682,855 bp
  • G to A, chromosome 7 at 16,275,390 bp
  • A to G, chromosome 7 at 23,893,856 bp
  • A to G, chromosome 7 at 29,116,012 bp
  • A to G, chromosome 7 at 42,820,404 bp
  • A to G, chromosome 7 at 81,343,733 bp
  • T to C, chromosome 7 at 86,148,590 bp
  • T to A, chromosome 7 at 127,560,738 bp
  • G to A, chromosome 7 at 139,991,377 bp
  • A to G, chromosome 7 at 140,336,125 bp
  • A to G, chromosome 8 at 45,942,181 bp
  • C to T, chromosome 8 at 105,057,913 bp
  • T to C, chromosome 8 at 128,434,355 bp
  • T to C, chromosome 9 at 80,122,023 bp
  • A to T, chromosome 10 at 17,842,740 bp
  • T to C, chromosome 10 at 53,089,454 bp
  • G to GNNNNNNNNNNNNNNNNNN, chromosome 11 at 4,941,002 bp
  • A to G, chromosome 11 at 49,832,861 bp
  • T to A, chromosome 11 at 69,655,547 bp
  • T to C, chromosome 11 at 71,768,760 bp
  • T to C, chromosome 11 at 98,657,649 bp
  • T to C, chromosome 12 at 10,377,276 bp
  • T to C, chromosome 12 at 80,173,144 bp
  • G to A, chromosome 12 at 110,636,509 bp
  • G to A, chromosome 13 at 100,189,122 bp
  • A to G, chromosome 14 at 30,072,067 bp
  • T to C, chromosome 14 at 61,204,509 bp
  • C to A, chromosome 15 at 97,010,272 bp
  • C to T, chromosome 17 at 12,929,677 bp
  • A to G, chromosome 17 at 27,894,721 bp
  • A to T, chromosome 18 at 53,724,391 bp
  • G to A, chromosome 18 at 84,634,652 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1340 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039405-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.