Strain Name:
C57BL/6J-MtgxR1347Btlr/Mmmh
Stock Number:
039412-MU
Citation ID:
RRID:MMRRC_039412-MU
Other Names:
R1347 (G1), C57BL/6J-MtgxR1347Btlr
Major Collection:

Strain Information

Gpd2
Name: glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms: Gdm1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14571
HGNC: HGNC:4456
Homologene: 352
Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
Synonyms: Rock2m, B230113H15Rik, Rock-II, Rho-kinase, ROKalpha
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19878
VEGA: 12
Homologene: 21010
Zfhx3
Name: zinc finger homeobox 3
Synonyms: A230102L03Rik, Atbf1, Sci, WBP9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Fry
Name: FRY microtubule binding protein
Synonyms: 9330186A19Rik, cg003
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320365
Homologene: 113770
Kpna1
Name: karyopherin subunit alpha 1
Synonyms: m-importin-alpha-S1, NPI1, Rch2, mSRP1, importin alpha 5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16646
HGNC: HGNC:6394
Homologene: 55642
Glyr1
Name: glyoxylate reductase 1 homolog (Arabidopsis)
Synonyms: 2810419J22Rik, NDF, Npac, 3930401K13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74022
VEGA: 16
Homologene: 12525
Kif23
Name: kinesin family member 23
Synonyms: 3110001D19Rik, Knsl5, C87313, CHO1, MKLP-1, MKLP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71819
VEGA: 9
HGNC: HGNC:6392
Homologene: 11491
Furin
Name: furin, paired basic amino acid cleaving enzyme
Synonyms: PACE, Fur, 9130404I01Rik, Pcsk3, SPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18550
HGNC: HGNC:8568
Homologene: 1930
Rbm15
Name: RNA binding motif protein 15
Synonyms: C230088J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229700
Homologene: 23383
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana2, Mana-2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Arpc1a
Name: actin related protein 2/3 complex, subunit 1A
Synonyms: Sid32, 0610010H08Rik, 1110030K07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56443
HGNC: HGNC:703
Homologene: 4675
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Ip3r3, Itpr-3, tf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Zim1
Name: zinc finger, imprinted 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22776
Homologene: 129793
Tbx15
Name: T-box 15
Synonyms: Tbx14, de, Tbx8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21384
Homologene: 7967
Serpinb6e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6e
Synonyms: Gm11396, SPI3B, ovalbumin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435350
HGNC: HGNC:8950
Homologene: 50933
Or5b105
Name: olfactory receptor family 5 subfamily B member 105
Synonyms: MOR202-24, GA_x6K02T2RE5P-3430689-3429787, EG667271, Olfr1458
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667271
HGNC: HGNC:8324
Mrpl44
Name: mitochondrial ribosomal protein L44
Synonyms: 1810030E18Rik, 5730593H20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69163
Homologene: 11293
4932441B19Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Or2a56
Name: olfactory receptor family 2 subfamily A member 56
Synonyms: Olfr444, MOR261-2, GA_x6K02T2P3E9-4602571-4601639
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258650
Homologene: 88438
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MyHC-IIb, Myhsf, MHC2B, Minmus, MYH-2B, Minimsc, MM
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Vmn2r114
Name: vomeronasal 2, receptor 114
Synonyms: EG666002
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 666002
Homologene: 86604
Rims3
Name: regulating synaptic membrane exocytosis 3
Synonyms: Rim3, Nim3, A730060M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242662
Homologene: 8837
Fpr-rs6
Name: formyl peptide receptor, related sequence 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 321020
HGNC: HGNC:3827
Homologene: 104303
Ak5
Name: adenylate kinase 5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229949
HGNC: HGNC:365
Homologene: 76103
Vmn1r11
Name: vomeronasal 1 receptor 11
Synonyms: V1rc3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113860
Homologene: 128345
Filip1l
Name: filamin A interacting protein 1-like
Synonyms: 4631422O05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78749
Homologene: 37121
Foxa1
Name: forkhead box A1
Synonyms: Hnf3a, Tcf3a, Hnf-3a, Tcf-3a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15375
VEGA: 12
HGNC: HGNC:5021
Homologene: 3307
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 79,777,952 bp
  • A to T, chromosome 2 at 57,357,671 bp
  • C to A, chromosome 3 at 99,352,111 bp
  • G to T, chromosome 3 at 107,332,630 bp
  • G to T, chromosome 3 at 152,533,434 bp
  • G to A, chromosome 4 at 120,883,125 bp
  • G to T, chromosome 5 at 145,097,272 bp
  • A to T, chromosome 5 at 150,495,818 bp
  • A to C, chromosome 6 at 42,955,705 bp
  • G to A, chromosome 6 at 57,137,978 bp
  • C to A, chromosome 7 at 6,677,431 bp
  • C to T, chromosome 7 at 80,392,184 bp
  • T to C, chromosome 8 at 108,800,698 bp
  • A to G, chromosome 9 at 61,927,156 bp
  • A to G, chromosome 11 at 67,244,741 bp
  • G to A, chromosome 12 at 16,977,624 bp
  • A to T, chromosome 12 at 57,542,284 bp
  • C to T, chromosome 13 at 33,841,197 bp
  • C to T, chromosome 13 at 65,035,388 bp
  • T to C, chromosome 16 at 5,021,339 bp
  • T to A, chromosome 16 at 36,009,326 bp
  • A to G, chromosome 16 at 57,570,987 bp
  • T to C, chromosome 17 at 20,182,749 bp
  • ATTT to ATT, chromosome 17 at 23,290,932 bp
  • T to C, chromosome 17 at 27,111,561 bp
  • T to C, chromosome 17 at 64,712,450 bp
  • T to C, chromosome 19 at 13,102,690 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1347 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039412-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.