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Strain Name:
C57BL/6J-MtgxR1350Btlr/Mmmh
Stock Number:
039415-MU
Citation ID:
RRID:MMRRC_039415-MU
Other Names:
R1350 (G1), C57BL/6J-MtgxR1350Btlr
Major Collection:

Strain Information

Dntt
Name: deoxynucleotidyltransferase, terminal
Synonyms: Tdt
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21673
VEGA: 19
HGNC: HGNC:2983
Homologene: 3014
Pcif1
Name: phosphorylated CTD interacting factor 1
Synonyms: 2310022K11Rik, F730014I05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228866
Homologene: 11134
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Ggtb3, 2610509D04Rik, D5Ertd66e, Bwf1, Bchs, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Tasp1
Name: taspase, threonine aspartase 1
Synonyms: 4930485D02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75812
Homologene: 9795
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Kcnk1
Name: potassium channel, subfamily K, member 1
Synonyms: TWIK-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16525
HGNC: HGNC:6272
Homologene: 1691
Dnaja2
Name: DnaJ heat shock protein family (Hsp40) member A2
Synonyms: mDj3, DNJ3, PRO3015, HIRIP4, 2010206B19Rik, 1500017M13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56445
Homologene: 21193
Lipc
Name: lipase, hepatic
Synonyms: HL, Hpl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15450
VEGA: 9
HGNC: HGNC:6619
Homologene: 199
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Ube3b
Name: ubiquitin protein ligase E3B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117146
Homologene: 13775
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: 9030221A05Rik, A930018H20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Car9
Name: carbonic anhydrase 9
Synonyms: CAIX, MN/CA9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Hepacam2
Name: HEPACAM family member 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101202
Homologene: 18724
Khdrbs1
Name: KH domain containing, RNA binding, signal transduction associated 1
Synonyms: p62, Sam68
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20218
Homologene: 4781
Garnl3
Name: GTPase activating RANGAP domain-like 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99326
Homologene: 13003
Col13a1
Name: collagen, type XIII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12817
HGNC: HGNC:2190
Homologene: 22421
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239393
Homologene: 8385
Or8b37
Name: olfactory receptor family 8 subfamily B member 37
Synonyms: GA_x6K02T2PVTD-31726544-31727473, MOR162-11P, MOR162-9P, MOR162-13, MOR162-11P, Olfr1550-ps1, Olfr884
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257996
Homologene: 79400
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: PBP, Moca
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Nox3
Name: NADPH oxidase 3
Synonyms: het, nmf250
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224480
HGNC: HGNC:7890
Homologene: 49435
Ssu2
Name: ssu-2 homolog
Synonyms: D630042P16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243612
Homologene: 136556
Gsdme
Name: gasdermin E
Synonyms: 4932441K13Rik, 2310037D07Rik, Fin15, Dfna5h, Dfna5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54722
HGNC: HGNC:2810
Homologene: 3242
AI661453
Name: expressed sequence AI661453
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224833
Homologene: 138294
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: 5730550L01Rik, argonaute 4, Eif2c4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76850
Homologene: 41184
Tfb1m
Name: transcription factor B1, mitochondrial
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224481
VEGA: 17
Homologene: 9343
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Axdnd1
Name: axonemal dynein light chain domain containing 1
Synonyms: LOC381304, 9430070O13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77352
Homologene: 52328
Or51b17
Name: olfactory receptor family 51 subfamily B member 17
Synonyms: 5'[b]2, MOR1-2, GA_x6K02T2PBJ9-6648196-6649143, Olfr64
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18366
Homologene: 56593
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 328505
Homologene: 106613
Or4b12
Name: olfactory receptor family 4 subfamily B member 12
Synonyms: GA_x6K02T2Q125-51620802-51619885, MOR227-5, Olfr1271
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258789
HGNC: HGNC:8290
Bivm
Name: basic, immunoglobulin-like variable motif containing
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 246229
Homologene: 9783
Vwa2
Name: von Willebrand factor A domain containing 2
Synonyms: Amaco
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240675
Homologene: 18238
Or12e9
Name: olfactory receptor family 12 subfamily E member 9
Synonyms: GA_x6K02T2Q125-48863863-48864807, MOR264-18, Olfr1121
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258345
Homologene: 74084
Or13a18
Name: olfactory receptor family 13 subfamily A member 18
Synonyms: IF5, ID12, IB7, MOR253-8, GA_x6K02T2PBJ9-42759973-42760905, Olfr46
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18345
Homologene: 110491
Fibp
Name: fibroblast growth factor (acidic) intracellular binding protein
Synonyms: 2010004G08Rik, 3010027N18Rik, 2010005N21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58249
VEGA: 19
HGNC: HGNC:3705
Homologene: 3106
Or3a1b
Name: olfactory receptor family 3 subfamily A member 1B
Synonyms: GA_x6K02T2P1NL-4278037-4278984, MOR255-6, Olfr401
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258701
HGNC: HGNC:8282
Homologene: 73922
Klhdc2
Name: kelch domain containing 2
Synonyms: HCLP-1, 2310022K15Rik, D12Ertd522e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69554
Homologene: 8631
Vmn1r202
Name: vomeronasal 1 receptor 202
Synonyms: V1ri7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171258
Homologene: 110880
Zbtb9
Name: zinc finger and BTB domain containing 9
Synonyms: 3930402F13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 474156
Homologene: 45145
Ccn6
Name: cellular communication network factor 6
Synonyms: LOC327743, CCN6, Wisp3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327743
VEGA: 10
Homologene: 77038
Usp18
Name: ubiquitin specific peptidase 18
Synonyms: UBP43, 1110058H21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 24110
Homologene: 8047
Crb2
Name: crumbs family member 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241324
Homologene: 45474
Prxl2b
Name: peroxiredoxin like 2B
Synonyms: PM/PGFS, 2810405K02Rik, Fam213b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66469
Homologene: 11976
Atp10d
Name: ATPase, class V, type 10D
Synonyms: IMAGE:1069176, D5Buc24e, 9830145H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231287
Or7g29
Name: olfactory receptor family 7 subfamily G member 29
Synonyms: GA_x6K02T2PVTD-13113073-13112135, MOR149-2, Olfr847
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258518
Homologene: 17281
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 44,126,703 bp
  • A to G, chromosome 1 at 156,378,380 bp
  • A to G, chromosome 2 at 33,052,214 bp
  • A to G, chromosome 2 at 37,792,069 bp
  • T to A, chromosome 2 at 87,372,357 bp
  • A to T, chromosome 2 at 90,266,346 bp
  • T to C, chromosome 2 at 140,057,421 bp
  • T to C, chromosome 2 at 164,886,767 bp
  • T to A, chromosome 3 at 96,657,477 bp
  • A to G, chromosome 3 at 146,624,575 bp
  • G to T, chromosome 4 at 43,512,439 bp
  • G to T, chromosome 4 at 111,980,324 bp
  • A to G, chromosome 4 at 126,507,132 bp
  • G to A, chromosome 4 at 129,720,752 bp
  • C to A, chromosome 4 at 154,898,128 bp
  • T to A, chromosome 5 at 36,613,737 bp
  • A to G, chromosome 5 at 72,261,126 bp
  • C to A, chromosome 5 at 101,898,552 bp
  • A to G, chromosome 5 at 114,406,137 bp
  • G to A, chromosome 6 at 3,467,530 bp
  • A to T, chromosome 6 at 50,246,128 bp
  • A to T, chromosome 6 at 112,374,846 bp
  • A to G, chromosome 6 at 121,262,692 bp
  • A to T, chromosome 6 at 136,743,914 bp
  • A to G, chromosome 7 at 103,893,730 bp
  • T to C, chromosome 7 at 140,610,709 bp
  • A to T, chromosome 8 at 85,540,088 bp
  • C to T, chromosome 8 at 126,025,228 bp
  • T to G, chromosome 9 at 19,375,414 bp
  • G to A, chromosome 9 at 38,047,815 bp
  • T to C, chromosome 9 at 70,798,367 bp
  • C to T, chromosome 9 at 106,914,632 bp
  • C to T, chromosome 10 at 39,158,306 bp
  • G to A, chromosome 10 at 61,894,069 bp
  • T to C, chromosome 11 at 74,122,213 bp
  • T to A, chromosome 11 at 79,412,687 bp
  • A to G, chromosome 12 at 51,762,434 bp
  • T to A, chromosome 12 at 69,305,710 bp
  • A to T, chromosome 12 at 85,014,082 bp
  • T to C, chromosome 13 at 22,501,716 bp
  • A to T, chromosome 15 at 39,878,250 bp
  • A to T, chromosome 17 at 3,545,680 bp
  • A to G, chromosome 17 at 3,650,121 bp
  • A to G, chromosome 17 at 25,964,692 bp
  • G to A, chromosome 17 at 26,974,406 bp
  • C to T, chromosome 17 at 47,467,928 bp
  • T to C, chromosome 19 at 5,461,391 bp
  • C to T, chromosome 19 at 41,037,139 bp
  • T to A, chromosome 19 at 56,909,126 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1350 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039415-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.