Strain Name:
C57BL/6J-MtgxR1366Btlr/Mmmh
Stock Number:
039431-MU
Citation ID:
RRID:MMRRC_039431-MU
Other Names:
R1366 (G1), C57BL/6J-MtgxR1366Btlr
Major Collection:

Gene Information

Mkrn1
Name: makorin, ring finger protein, 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54484
HGNC: HGNC:7112
Homologene: 32175
Msi2
Name: musashi RNA-binding protein 2
Synonyms: msi2h, Musashi2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76626
Homologene: 62199
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231326
Homologene: 71711
Mid1
Name: midline 1
Synonyms: DXHXS1141, Fxy, Trim18, 61B3-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 17318
HGNC: HGNC:7095
Homologene: 7837
Ube4b
Name: ubiquitination factor E4B
Synonyms: UFD2, Ufd2p, 4930551I19Rik, 4933406G05Rik, D4Bwg0973e, UFD2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 63958
Homologene: 107623
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, 4632407J06Rik, B130055D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: Cegf1, 4932442O19Rik, ICRFP703N2430Q5.1, ICRFP703B1614Q5.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56788
Homologene: 36383
Cir1
Name: corepressor interacting with RBPJ, 1
Synonyms: 1700023B02Rik, 2810021A19Rik, CIR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66935
Homologene: 3589
Tpd52
Name: tumor protein D52
Synonyms: mD52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 21985
Homologene: 38007
Cyhr1
Name: cysteine and histidine rich 1
Synonyms: Chrp, 1110031M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54151
Homologene: 32791
Ilkap
Name: integrin-linked kinase-associated serine/threonine phosphatase 2C
Synonyms: 0710007A14Rik, PP2C-DELTA, 1600009O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67444
Homologene: 31525
Chd1l
Name: chromodomain helicase DNA binding protein 1-like
Synonyms: 4432404A22Rik, Snf2p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68058
HGNC: HGNC:1916
Homologene: 11590
Frmd6
Name: FERM domain containing 6
Synonyms: 4930488L10Rik, 2610019M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319710
VEGA: 12
Homologene: 12449
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171395
Homologene: 51376
Tnfaip2
Name: tumor necrosis factor, alpha-induced protein 2
Synonyms: Tnfip2, Exoc3l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 21928
Homologene: 4583
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Mmp9
Name: matrix metallopeptidase 9
Synonyms: MMP-9, Clg4b, Gelatinase B, B/MMP9, Gel B, gelatinase B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Acsm1
Name: acyl-CoA synthetase medium-chain family member 1
Synonyms: Bucs1, Macs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 117147
Homologene: 24930
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319695
Homologene: 85163
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75146
Homologene: 12592
Plcxd1
Name: phosphatidylinositol-specific phospholipase C, X domain containing 1
Synonyms: LOC231597, A330045H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 403178
Homologene: 138628
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74441
Homologene: 65259
Gmpr2
Name: guanosine monophosphate reductase 2
Synonyms: 5730544D12Rik, 1810008P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105446
VEGA: 14
HGNC: HGNC:4377
Homologene: 22983
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Olfr114
Name: olfactory receptor 114
Synonyms: GA_x6K02T2PSCP-2049802-2048870, MOR218-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258284
Homologene: 133642
Hck
Name: hemopoietic cell kinase
Synonyms: Hck-1, Bmk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15162
HGNC: HGNC:4840
Homologene: 20489
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72277
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: nmf192, 4930564O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 260305
Homologene: 9024
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 383258
Homologene: 129687
Cpxm1
Name: carboxypeptidase X 1 (M14 family)
Synonyms: Cpx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56264
Homologene: 10485
Ifnab
Name: interferon alpha B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15974
HGNC: HGNC:5425
Homologene: 68536
Rasl10b
Name: RAS-like, family 10, member B
Synonyms: VTS58635, B230331P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276952
Homologene: 14108
Fam98a
Name: family with sequence similarity 98, member A
Synonyms: 2810405J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72722
Homologene: 41042
4930548H24Rik
Name: RIKEN cDNA 4930548H24 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67656
Prl3b1
Name: prolactin family 3, subfamily b, member 1
Synonyms: Csh2, PL, prolactin-like, mplII, Pl2, mPL-II, Pl-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18776
Homologene: 7476
Olfr1014
Name: olfactory receptor 1014
Synonyms: GA_x6K02T2Q125-47255337-47256254, MOR213-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258562
Homologene: 83447
Nkain1
Name: Na+/K+ transporting ATPase interacting 1
Synonyms: 2810426C15Rik, 2610200G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67149
Homologene: 11566
Olfr57
Name: olfactory receptor 57
Synonyms: GA_x6K02T2QGN0-2777431-2776472, MOR139-3, IF12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18357
HGNC: HGNC:8368
Homologene: 133620
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 72,698,649 bp
  • A to G, chromosome 1 at 91,387,215 bp
  • T to A, chromosome 1 at 97,128,203 bp
  • T to C, chromosome 2 at 31,928,847 bp
  • A to T, chromosome 2 at 73,306,413 bp
  • G to A, chromosome 2 at 85,777,004 bp
  • G to A, chromosome 2 at 130,396,122 bp
  • G to A, chromosome 2 at 153,138,295 bp
  • T to A, chromosome 2 at 164,953,342 bp
  • T to C, chromosome 3 at 8,963,933 bp
  • T to C, chromosome 3 at 97,581,149 bp
  • T to A, chromosome 4 at 88,691,100 bp
  • A to G, chromosome 4 at 130,537,316 bp
  • T to C, chromosome 4 at 149,335,149 bp
  • T to A, chromosome 4 at 152,502,926 bp
  • T to A, chromosome 5 at 31,487,517 bp
  • A to T, chromosome 5 at 76,888,804 bp
  • A to C, chromosome 5 at 110,102,230 bp
  • A to T, chromosome 5 at 124,753,326 bp
  • T to C, chromosome 6 at 39,405,917 bp
  • A to G, chromosome 7 at 109,804,614 bp
  • T to C, chromosome 7 at 119,658,288 bp
  • G to A, chromosome 8 at 123,304,281 bp
  • T to A, chromosome 9 at 27,057,940 bp
  • T to G, chromosome 10 at 79,035,042 bp
  • T to C, chromosome 11 at 8,941,038 bp
  • G to A, chromosome 11 at 83,417,839 bp
  • A to T, chromosome 11 at 88,716,580 bp
  • T to C, chromosome 12 at 70,887,889 bp
  • T to G, chromosome 12 at 111,449,322 bp
  • G to A, chromosome 13 at 27,243,865 bp
  • T to C, chromosome 14 at 55,676,743 bp
  • T to C, chromosome 15 at 76,648,969 bp
  • T to A, chromosome 15 at 99,943,389 bp
  • T to C, chromosome 17 at 37,589,764 bp
  • G to A, chromosome 17 at 55,593,237 bp
  • A to G, chromosome 17 at 75,539,386 bp
  • C to T, chromosome 19 at 46,366,504 bp
  • A to C, chromosome X at 169,986,094 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1366 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039431-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.