Strain Name:
C57BL/6J-MtgxR1396Btlr/Mmmh
Stock Number:
039458-MU
Citation ID:
RRID:MMRRC_039458-MU
Other Names:
R1396 (G1), C57BL/6J-MtgxR1396Btlr
Major Collection:

Strain Information

Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22427
Homologene: 6659
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: Sema6D-1, 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195
Lemd2
Name: LEM domain containing 2
Synonyms: Lem2, NET25
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224640
VEGA: 17
Homologene: 17136
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Etf1
Name: eukaryotic translation termination factor 1
Synonyms: TB3-1, ERF1, SUP45L1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225363
HGNC: HGNC:3477
Homologene: 3475
Polk
Name: polymerase (DNA directed), kappa
Synonyms: Dinb1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27015
VEGA: 13
HGNC: HGNC:9183
Homologene: 32140
Nln
Name: neurolysin (metallopeptidase M3 family)
Synonyms: 4930472G13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75805
VEGA: 13
Homologene: 69315
Fxr1
Name: FMR1 autosomal homolog 1
Synonyms: 9530073J07Rik, Fxr1h, 1110050J02Rik, Fxr1p
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14359
HGNC: HGNC:4023
Homologene: 3573
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Loa, MAP1C, Dnec1, Swl, dynein heavy chain, retrograde transport, 9930018I23Rik, Dnchc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Senp1
Name: SUMO1/sentrin specific peptidase 1
Synonyms: 2310046A20Rik, E330036L07Rik, D15Ertd528e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223870
Homologene: 8731
Nova1
Name: NOVA alternative splicing regulator 1
Synonyms: 9430099M15Rik, Nova-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 664883
VEGA: 12
HGNC: HGNC:7886
Homologene: 21296
Lrpprc
Name: leucine-rich PPR-motif containing
Synonyms: Lrp130, 3110001K13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72416
Homologene: 32695
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Clock
Name: clock circadian regulator
Synonyms: bHLHe8, KAT13D, 5330400M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Slit2
Name: slit guidance ligand 2
Synonyms: E130320P19Rik, Slil3, Drad-1, b2b1200.1Clo, E030015M03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20563
Homologene: 3516
Fndc3b
Name: fibronectin type III domain containing 3B
Synonyms: fad104, 1600019O04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72007
Homologene: 11244
Adamts12
Name: ADAM metallopeptidase with thrombospondin type 1 motif 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239337
VEGA: 15
Homologene: 12808
Inpp5b
Name: inositol polyphosphate-5-phosphatase B
Synonyms: 75kDa
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16330
HGNC: HGNC:6077
Homologene: 69021
Mcm6
Name: minichromosome maintenance complex component 6
Synonyms: D1Wsu22e, Mcmd6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17219
HGNC: HGNC:6949
Homologene: 4322
Rnf41
Name: ring finger protein 41
Synonyms: D10Ertd722e, FLRF, Nrdp1, 4933415P08Rik, 2210404G21Rik, 4930511A05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67588
VEGA: 10
Homologene: 4226
Sfr1
Name: SWI5 dependent recombination repair 1
Synonyms: 6330577E15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67788
VEGA: 19
Homologene: 12189
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70422
Homologene: 10801
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71389
Homologene: 32772
Tbk1
Name: TANK-binding kinase 1
Synonyms: 1200008B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56480
VEGA: 10
Homologene: 22742
Usp6nl
Name: USP6 N-terminal like
Synonyms: TRE2NL
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98910
Homologene: 6879
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: Jbo, Mds1, Evi-1, Evi1, ZNFPR1B1, Prdm3, MDS1-EVI1, D630039M04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
Synonyms: Tmem76, D8Ertd354e, 9430010M12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52120
Homologene: 15586
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Slc9c1
Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
Synonyms: LOC208169, Slc9a10, spermNHE
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208169
Homologene: 19505
Sbk3
Name: SH3 domain binding kinase family, member 3
Synonyms: Gm1078, LOC381835
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381835
Homologene: 82595
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50791
Homologene: 8189
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG620718, EG667069
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Vmn2r116
Name: vomeronasal 2, receptor 116
Synonyms: V2Rp5, EG619697
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619697
Homologene: 86604
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: GLEPP1, Ptpn15, PTP-BK, PTP-oc, D28, PTPROt, PTP-phi, PTP-U2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Krt72
Name: keratin 72
Synonyms: Krt72-ps, K6irs2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105866
Homologene: 25876
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
4930486L24Rik
Name: RIKEN cDNA 4930486L24 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214639
VEGA: 13
Homologene: 138410
AC139206.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Mpeg1
Name: macrophage expressed gene 1
Synonyms: MPS1, Perforin-2, Mpg-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17476
VEGA: 19
Homologene: 11216
Ccdc40
Name: coiled-coil domain containing 40
Synonyms: B930008I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207607
Homologene: 27890
Vmn2r62
Name: vomeronasal 2, receptor 62
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546964
Homologene: 104832
Akr1c20
Name: aldo-keto reductase family 1, member C20
Synonyms: 2610528B18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 116852
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
Adamdec1
Name: ADAM-like, decysin 1
Synonyms: 2210414L24Rik, Dcsn
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58860
VEGA: 14
Homologene: 8711
Tnk1
Name: tyrosine kinase, non-receptor, 1
Synonyms: Tnk1a, Kos1, Tnk1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83813
Homologene: 2966
Mgat4e
Name: MGAT4 family, member E
Synonyms: 4931440L10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71001
Homologene: 129994
Gss
Name: glutathione synthetase
Synonyms: GS-A/GS-B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14854
HGNC: HGNC:4624
Homologene: 148
Ugt2b35
Name: UDP glucuronosyltransferase 2 family, polypeptide B35
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243085
Homologene: 128251
Ccdc202
Name: coiled-coil domain containing 202
Synonyms: 4921530L21Rik, Spertl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66732
VEGA: 14
Homologene: 41645
Ppig
Name: peptidyl-prolyl isomerase G (cyclophilin G)
Synonyms: SRCyp, B230312B02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228005
Homologene: 3520
Tspoap1
Name: TSPO associated protein 1
Synonyms: Bzrap1, peripheral
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207777
Homologene: 37961
Stard4
Name: StAR related lipid transfer domain containing 4
Synonyms: 4632419C16Rik, 9030213J02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170459
Homologene: 15874
Zhx3
Name: zinc fingers and homeoboxes 3
Synonyms: 4932418O04Rik, 9530010N21Rik, 1810059C13Rik, Tix1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320799
Homologene: 9000
Kng1
Name: kininogen 1
Synonyms: H-kininigen, L-kininogen
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16644
HGNC: HGNC:6383
Homologene: 88343
Vmn1r203
Name: vomeronasal 1 receptor 203
Synonyms: V1rh11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171270
Homologene: 110880
Clstn2
Name: calsyntenin 2
Synonyms: CSTN2, 2900042C18Rik, Cst-2, CS2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64085
Homologene: 49698
Vmn1r89
Name: vomeronasal 1 receptor 89
Synonyms: V1rj2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171260
Homologene: 74345
Tedc2
Name: tubulin epsilon and delta complex 2
Synonyms: 1600002H07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72016
Homologene: 45943
Gm17661
Name: predicted gene, 17661
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Tmem102
Name: transmembrane protein 102
Synonyms: Cbap, Tmem102-ps
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380705
Homologene: 86820
Cln6
Name: ceroid-lipofuscinosis, neuronal 6
Synonyms: 1810065L06Rik, D9Bwg1455e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76524
HGNC: HGNC:2077
Homologene: 9898
Gm5431
Name: predicted gene 5431
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432555
Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Synonyms: Cyp2e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13106
HGNC: HGNC:2631
Homologene: 68089
Slc25a4
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
Synonyms: adenine nucleotide translocase-1, Ant1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11739
Homologene: 36058
Cdk20
Name: cyclin dependent kinase 20
Synonyms: 4932702G04Rik, Ccrk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105278
VEGA: 13
Homologene: 8109
Ccdc22
Name: coiled-coil domain containing 22
Synonyms: DXImx40e, Sfc22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 54638
Homologene: 8515
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 128,351,476 bp
  • T to C, chromosome 1 at 134,541,533 bp
  • A to T, chromosome 1 at 157,164,666 bp
  • A to T, chromosome 1 at 195,169,253 bp
  • A to G, chromosome 2 at 6,426,998 bp
  • C to T, chromosome 2 at 69,749,018 bp
  • GA to GAA, chromosome 2 at 90,917,709 bp
  • T to C, chromosome 2 at 124,664,011 bp
  • G to A, chromosome 2 at 155,567,721 bp
  • T to A, chromosome 2 at 160,781,020 bp
  • A to G, chromosome 2 at 160,983,103 bp
  • C to T, chromosome 3 at 27,456,977 bp
  • T to C, chromosome 3 at 29,979,800 bp
  • T to A, chromosome 3 at 34,046,434 bp
  • T to A, chromosome 3 at 64,556,005 bp
  • G to A, chromosome 4 at 124,789,080 bp
  • T to A, chromosome 5 at 20,389,195 bp
  • C to T, chromosome 5 at 48,250,307 bp
  • G to C, chromosome 5 at 76,266,802 bp
  • A to G, chromosome 5 at 87,011,530 bp
  • A to G, chromosome 6 at 124,531,051 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 7 at 4,967,453 bp
  • T to A, chromosome 7 at 13,220,011 bp
  • A to T, chromosome 7 at 42,764,837 bp
  • A to G, chromosome 7 at 140,773,079 bp
  • C to A, chromosome 8 at 25,957,335 bp
  • C to T, chromosome 8 at 33,268,819 bp
  • C to A, chromosome 8 at 46,209,288 bp
  • A to T, chromosome 9 at 60,680,527 bp
  • T to C, chromosome 9 at 62,847,581 bp
  • A to G, chromosome 9 at 67,955,022 bp
  • A to G, chromosome 9 at 97,461,393 bp
  • G to A, chromosome 10 at 121,571,916 bp
  • G to A, chromosome 10 at 128,435,571 bp
  • T to C, chromosome 11 at 48,895,434 bp
  • A to T, chromosome 11 at 69,804,370 bp
  • A to T, chromosome 11 at 69,853,136 bp
  • G to T, chromosome 11 at 86,249,248 bp
  • A to C, chromosome 11 at 87,766,120 bp
  • A to G, chromosome 11 at 119,231,803 bp
  • A to C, chromosome 12 at 46,816,893 bp
  • G to A, chromosome 12 at 110,636,509 bp
  • A to T, chromosome 13 at 4,507,727 bp
  • C to T, chromosome 13 at 12,406,046 bp
  • C to T, chromosome 13 at 22,524,508 bp
  • G to A, chromosome 13 at 60,853,243 bp
  • T to C, chromosome 13 at 64,437,403 bp
  • T to C, chromosome 13 at 96,484,208 bp
  • C to T, chromosome 13 at 104,061,753 bp
  • A to G, chromosome 14 at 68,580,528 bp
  • A to G, chromosome 14 at 95,882,551 bp
  • A to T, chromosome 14 at 96,381,958 bp
  • G to T, chromosome 15 at 11,311,472 bp
  • A to G, chromosome 15 at 98,076,554 bp
  • C to T, chromosome 15 at 101,786,005 bp
  • A to G, chromosome 16 at 23,078,980 bp
  • A to T, chromosome 16 at 45,573,347 bp
  • A to T, chromosome 17 at 19,792,968 bp
  • A to C, chromosome 17 at 23,386,141 bp
  • T to A, chromosome 17 at 24,216,317 bp
  • C to A, chromosome 17 at 24,216,318 bp
  • G to C, chromosome 17 at 27,190,732 bp
  • C to T, chromosome 17 at 84,726,303 bp
  • A to T, chromosome 18 at 33,206,210 bp
  • G to A, chromosome 18 at 34,908,167 bp
  • A to G, chromosome 19 at 12,462,804 bp
  • A to G, chromosome 19 at 47,733,690 bp
  • G to T, chromosome X at 7,595,408 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1396 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039458-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.