Strain Name:
C57BL/6J-MtgxR1577Btlr/Mmmh
Stock Number:
039615-MU
Citation ID:
RRID:MMRRC_039615-MU
Other Names:
R1577 (G1), C57BL/6J-MtgxR1577Btlr
Major Collection:

Gene Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Col2, Col2a-1, Col2a, Rgsc856, M100856, Rgsc413, Lpk, M100413, Del1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Dntt
Name: deoxynucleotidyltransferase, terminal
Synonyms: Tdt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21673
VEGA: 19
HGNC: HGNC:2983
Homologene: 3014
Xrcc1
Name: X-ray repair complementing defective repair in Chinese hamster cells 1
Synonyms: Xrcc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22594
Homologene: 31368
Tfpi
Name: tissue factor pathway inhibitor
Synonyms: A630013F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21788
Homologene: 4579
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: Edd1, Edd, 4432411E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Rprd2
Name: regulation of nuclear pre-mRNA domain containing 2
Synonyms: 2810036A19Rik, 6720469I21Rik, 4930535B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75137
Homologene: 19997
Med13l
Name: mediator complex subunit 13-like
Synonyms: 9030618F05Rik, Thrap2, 2210413I17Rik, 6330591G05Rik, Trap240L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76199
Homologene: 25256
Eif4b
Name: eukaryotic translation initiation factor 4B
Synonyms: 2310046H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75705
VEGA: 15
HGNC: HGNC:3285
Homologene: 83162
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 4432404J10Rik, 2010005B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66691
Homologene: 32637
Cep85
Name: centrosomal protein 85
Synonyms: Ccdc21, 2410030J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 70012
Homologene: 11254
Zfp180
Name: zinc finger protein 180
Synonyms: 2310040I01Rik, HHZ168, D130011P11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210135
Homologene: 8306
Syn3
Name: synapsin III
Synonyms: Synapsin IIIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27204
Homologene: 68320
Egfr
Name: epidermal growth factor receptor
Synonyms: Wa5, Erbb, Errb1, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, 9030024J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Lypd6
Name: LY6/PLAUR domain containing 6
Synonyms: E130115E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320343
Homologene: 18555
Map2
Name: microtubule-associated protein 2
Synonyms: G1-397-34, Mtap2, MAP-2, repro4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Fat1
Name: FAT atypical cadherin 1
Synonyms: 2310038E12Rik, mFat1, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Ercc8
Name: excision repaiross-complementing rodent repair deficiency, complementation group 8
Synonyms: 2810431L23Rik, Ckn1, Csa, 2410022P04Rik, B130065P18Rik, 4631412O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71991
HGNC: HGNC:3439
Homologene: 62
Spats2
Name: spermatogenesis associated, serine-rich 2
Synonyms: 59kDa, 2700012F11Rik, Scr59, p59scr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72572
VEGA: 15
Homologene: 11314
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 252972
Homologene: 9905
Tmtc1
Name: transmembrane and tetratricopeptide repeat containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387314
Homologene: 65299
Fgd3
Name: FYVE, RhoGEF and PH domain containing 3
Synonyms: 5830461L01Rik, ZFYVE5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 30938
Homologene: 22925
Chst4
Name: carbohydrate sulfotransferase 4
Synonyms: HEC-GlcNAc6ST, high endothelial cell GlcNAC-6-sulphotransferase, GST-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26887
HGNC: HGNC:1972
Homologene: 4216
Ncoa1
Name: nuclear receptor coactivator 1
Synonyms: bHLHe74, steroid receptor coactivator-1, SRC1, KAT13A, SRC-a/NCoA-1, SRC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 17977
VEGA: 12
HGNC: HGNC:7668
Homologene: 7859
Grm6
Name: glutamate receptor, metabotropic 6
Synonyms: nob3, mGluR6, nerg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108072
HGNC: HGNC:4598
Homologene: 20232
Zbtb5
Name: zinc finger and BTB domain containing 5
Synonyms: 9430083K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230119
Homologene: 8913
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233651
Homologene: 2771
Il12rb1
Name: interleukin 12 receptor, beta 1
Synonyms: IL-12R[b], CD212
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16161
HGNC: HGNC:5971
Homologene: 4042
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: A930038D23Rik, Ae3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20536
Homologene: 129474
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: A830096D10Rik, Bai3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Cldnd1
Name: claudin domain containing 1
Synonyms: 1110019C08Rik, Cldn25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224250
HGNC: HGNC:1322
Homologene: 10534
Olfr520
Name: olfactory receptor 520
Synonyms: GA_x6K02T2PBJ9-2411789-2412739, MOR101-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259066
Homologene: 17484
Zfand4
Name: zinc finger, AN1-type domain 4
Synonyms: Anubl1, 2810002D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67492
VEGA: 6
Homologene: 18373
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76376
Homologene: 10669
Rapgef5
Name: Rap guanine nucleotide exchange factor (GEF) 5
Synonyms: D030051B22Rik, mr-gef
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217944
VEGA: 12
Homologene: 56563
Olfr1395
Name: olfactory receptor 1395
Synonyms: GA_x6K02T2QP88-6286247-6285294, MOR277-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258877
Homologene: 105890
Gm5800
Name: predicted gene 5800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545047
Homologene: 128452
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230622
Homologene: 135888
Gdap1l1
Name: ganglioside-induced differentiation-associated protein 1-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228858
HGNC: HGNC:4213
Homologene: 11426
Acad9
Name: acyl-Coenzyme A dehydrogenase family, member 9
Synonyms: NPD002, 2600017P15Rik, C630012L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229211
Homologene: 8539
Rnf139
Name: ring finger protein 139
Synonyms: 4930555P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75841
VEGA: 15
Homologene: 5222
Gal3st2c
Name: galactose-3-O-sulfotransferase 2C
Synonyms: Gm6086
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 619597
Homologene: 41471
Lgals4
Name: lectin, galactose binding, soluble 4
Synonyms: galectin-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16855
HGNC: HGNC:6565
Homologene: 21239
Them4
Name: thioesterase superfamily member 4
Synonyms: 4921507I02Rik, 2700077M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75778
Homologene: 14208
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244668
Homologene: 18956
Gabbr2
Name: gamma-aminobutyric acid (GABA) B receptor, 2
Synonyms: Gpr51, LOC242425, Gababr2, GB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Clca3b
Name: chloride channel accessory 3B
Synonyms: Clca4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229927
Homologene: 135610
Ppm1l
Name: protein phosphatase 1 (formerly 2C)-like
Synonyms: 5930404J21Rik, PP2C-epsilon, Pp2ce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242083
Homologene: 33158
Olfr1419
Name: olfactory receptor 1419
Synonyms: GA_x6K02T2RE5P-2222521-2221490, MOR266-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 257938
Homologene: 79473
Cntnap3
Name: contactin associated protein-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238680
VEGA: 13
Homologene: 129602
Olfr706
Name: olfactory receptor 706
Synonyms: MOR283-11, GA_x6K02T2PBJ9-9271198-9270248
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258350
Homologene: 133646
Ldhb
Name: lactate dehydrogenase B
Synonyms: Ldh-2, H-Ldh, lactate dehydrogenase-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16832
HGNC: HGNC:6541
Homologene: 55647
Slc22a16
Name: solute carrier family 22 (organic cation transporter), member 16
Synonyms: FLIPT2, OKB1, OCT6, CT2, 4921504E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70840
Homologene: 41957
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101100
Homologene: 134361
Stard4
Name: StAR-related lipid transfer (START) domain containing 4
Synonyms: 4632419C16Rik, 9030213J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 170459
Homologene: 15874
Fmo4
Name: flavin containing monooxygenase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226564
HGNC: HGNC:3772
Homologene: 68219
Olfr1107
Name: olfactory receptor 1107
Synonyms: GA_x6K02T2Q125-48565383-48564445, MOR172-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258841
Homologene: 131138
Hs3st1
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Synonyms: 3-OST, D5Wsu110e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15476
HGNC: HGNC:5194
Homologene: 3751
Slc25a23
Name: solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
Synonyms: 2310067G05Rik, SCaMC-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66972
Homologene: 11467
Mtres1
Name: mitochondrial transcription rescue factor 1
Synonyms: 1700021F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67851
Homologene: 41137
CAAA01066805.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 25,094,183 bp
  • A to G, chromosome 1 at 66,416,560 bp
  • T to C, chromosome 1 at 75,550,891 bp
  • G to A, chromosome 1 at 94,006,928 bp
  • T to C, chromosome 1 at 162,803,700 bp
  • C to T, chromosome 2 at 34,709,228 bp
  • C to T, chromosome 2 at 50,190,698 bp
  • A to G, chromosome 2 at 84,433,103 bp
  • T to C, chromosome 2 at 87,071,397 bp
  • T to G, chromosome 2 at 163,438,604 bp
  • G to A, chromosome 3 at 36,081,896 bp
  • G to A, chromosome 3 at 69,553,070 bp
  • T to C, chromosome 3 at 94,317,387 bp
  • C to T, chromosome 3 at 95,764,735 bp
  • A to T, chromosome 3 at 144,823,519 bp
  • T to C, chromosome 4 at 44,995,129 bp
  • T to A, chromosome 4 at 46,684,319 bp
  • T to C, chromosome 4 at 86,991,411 bp
  • T to C, chromosome 4 at 113,148,523 bp
  • T to C, chromosome 4 at 134,152,288 bp
  • C to T, chromosome 4 at 156,240,622 bp
  • A to T, chromosome 5 at 39,615,050 bp
  • G to A, chromosome 5 at 118,721,392 bp
  • A to C, chromosome 5 at 120,544,420 bp
  • C to A, chromosome 6 at 113,409,628 bp
  • C to A, chromosome 6 at 116,329,412 bp
  • C to A, chromosome 6 at 142,492,598 bp
  • T to A, chromosome 6 at 148,412,820 bp
  • G to T, chromosome 7 at 24,105,908 bp
  • T to A, chromosome 7 at 24,565,627 bp
  • T to A, chromosome 7 at 28,840,404 bp
  • T to C, chromosome 7 at 99,735,356 bp
  • T to C, chromosome 7 at 105,765,955 bp
  • T to C, chromosome 7 at 106,886,010 bp
  • C to T, chromosome 8 at 45,023,383 bp
  • A to G, chromosome 8 at 70,810,606 bp
  • A to T, chromosome 8 at 110,029,844 bp
  • G to A, chromosome 8 at 125,492,262 bp
  • G to T, chromosome 10 at 40,603,815 bp
  • A to G, chromosome 10 at 43,525,415 bp
  • A to G, chromosome 10 at 86,448,864 bp
  • A to G, chromosome 11 at 16,869,241 bp
  • T to A, chromosome 11 at 49,149,189 bp
  • T to A, chromosome 11 at 50,863,145 bp
  • T to C, chromosome 12 at 4,295,196 bp
  • C to T, chromosome 12 at 117,595,291 bp
  • T to C, chromosome 13 at 49,281,937 bp
  • T to C, chromosome 13 at 64,758,290 bp
  • T to A, chromosome 13 at 108,169,365 bp
  • A to T, chromosome 14 at 51,714,559 bp
  • A to T, chromosome 15 at 38,030,730 bp
  • T to C, chromosome 15 at 58,899,518 bp
  • C to T, chromosome 15 at 97,979,202 bp
  • T to A, chromosome 15 at 99,178,452 bp
  • C to T, chromosome 15 at 102,089,901 bp
  • T to G, chromosome 16 at 58,732,653 bp
  • T to C, chromosome 17 at 57,047,306 bp
  • A to T, chromosome 18 at 33,205,098 bp
  • T to C, chromosome 19 at 11,870,377 bp
  • A to G, chromosome 19 at 41,055,785 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1577 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039615-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.