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Strain Name:
C57BL/6J-MtgxR1624Btlr/Mmmh
Stock Number:
039661-MU
Citation ID:
RRID:MMRRC_039661-MU
Other Names:
R1624 (G1), C57BL/6J-MtgxR1624Btlr
Major Collection:

Strain Information

Lamb1
Name: laminin B1
Synonyms: Lamb-1, C81607, C80098, D130003D08Rik, Lamb1-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Epha4
Name: Eph receptor A4
Synonyms: Sek, Sek1, Tyro1, Hek8, Cek8, 2900005C20Rik, rb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, OB-cadherin, Cad11
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21873
VEGA: 19
Homologene: 3541
Arid4b
Name: AT-rich interaction domain 4B
Synonyms: RBBP1L1, SAP180, BRCAA1, Rbp1l1, 6720480E17Rik, 6330417L24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Mybl1
Name: myeloblastosis oncogene-like 1
Synonyms: A-myb, repro9, G1-419-6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17864
HGNC: HGNC:7547
Homologene: 32045
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 9,673,735 bp
  • A to G, chromosome 1 at 63,303,859 bp
  • T to C, chromosome 1 at 77,399,692 bp
  • T to C, chromosome 2 at 4,925,683 bp
  • T to C, chromosome 2 at 26,281,075 bp
  • A to G, chromosome 2 at 32,691,188 bp
  • A to G, chromosome 2 at 91,068,526 bp
  • G to A, chromosome 2 at 102,451,164 bp
  • A to G, chromosome 2 at 104,832,682 bp
  • T to A, chromosome 2 at 112,008,532 bp
  • T to A, chromosome 2 at 144,567,129 bp
  • A to T, chromosome 2 at 152,434,111 bp
  • G to A, chromosome 2 at 162,997,859 bp
  • A to G, chromosome 2 at 180,206,758 bp
  • A to T, chromosome 3 at 64,509,695 bp
  • T to C, chromosome 3 at 83,067,994 bp
  • G to A, chromosome 3 at 83,069,744 bp
  • T to A, chromosome 3 at 101,455,227 bp
  • A to G, chromosome 3 at 114,158,155 bp
  • T to C, chromosome 3 at 116,787,246 bp
  • A to G, chromosome 4 at 43,024,661 bp
  • G to A, chromosome 4 at 43,566,375 bp
  • A to T, chromosome 4 at 116,034,200 bp
  • A to G, chromosome 4 at 120,529,228 bp
  • A to G, chromosome 4 at 126,463,741 bp
  • G to A, chromosome 4 at 131,772,550 bp
  • A to T, chromosome 4 at 143,949,830 bp
  • C to T, chromosome 4 at 148,547,676 bp
  • G to T, chromosome 4 at 154,177,121 bp
  • A to T, chromosome 5 at 18,003,843 bp
  • G to A, chromosome 5 at 29,646,619 bp
  • A to G, chromosome 5 at 30,264,262 bp
  • A to C, chromosome 5 at 73,669,545 bp
  • C to A, chromosome 5 at 121,682,859 bp
  • G to A, chromosome 5 at 123,758,477 bp
  • A to C, chromosome 5 at 145,390,415 bp
  • A to G, chromosome 6 at 65,052,647 bp
  • A to T, chromosome 6 at 73,095,234 bp
  • A to T, chromosome 6 at 121,220,426 bp
  • A to T, chromosome 7 at 87,004,039 bp
  • A to G, chromosome 7 at 90,455,409 bp
  • T to A, chromosome 7 at 119,652,573 bp
  • A to T, chromosome 7 at 120,019,695 bp
  • A to G, chromosome 7 at 127,992,798 bp
  • A to C, chromosome 7 at 139,089,553 bp
  • T to C, chromosome 7 at 140,201,951 bp
  • A to G, chromosome 8 at 76,909,944 bp
  • A to T, chromosome 8 at 90,998,535 bp
  • T to C, chromosome 8 at 102,664,601 bp
  • T to C, chromosome 9 at 56,888,470 bp
  • A to T, chromosome 9 at 61,925,700 bp
  • T to A, chromosome 9 at 69,479,708 bp
  • T to C, chromosome 9 at 69,759,316 bp
  • T to A, chromosome 9 at 104,320,001 bp
  • T to A, chromosome 10 at 24,185,005 bp
  • T to A, chromosome 10 at 30,704,659 bp
  • G to A, chromosome 10 at 39,153,243 bp
  • A to G, chromosome 10 at 77,711,772 bp
  • T to C, chromosome 10 at 84,679,805 bp
  • A to T, chromosome 10 at 89,640,736 bp
  • A to T, chromosome 10 at 94,137,436 bp
  • T to G, chromosome 10 at 121,855,373 bp
  • A to T, chromosome 11 at 29,569,287 bp
  • T to C, chromosome 11 at 51,027,125 bp
  • A to T, chromosome 11 at 100,014,246 bp
  • T to C, chromosome 11 at 101,076,525 bp
  • T to C, chromosome 11 at 101,667,016 bp
  • A to G, chromosome 11 at 103,103,959 bp
  • A to G, chromosome 11 at 120,813,111 bp
  • T to C, chromosome 12 at 31,278,652 bp
  • T to A, chromosome 12 at 40,127,930 bp
  • A to C, chromosome 12 at 104,268,638 bp
  • T to A, chromosome 13 at 4,446,364 bp
  • T to C, chromosome 13 at 14,184,394 bp
  • T to A, chromosome 13 at 22,003,313 bp
  • C to A, chromosome 13 at 38,037,511 bp
  • G to T, chromosome 14 at 49,318,699 bp
  • A to G, chromosome 14 at 50,533,643 bp
  • T to C, chromosome 14 at 55,781,927 bp
  • A to G, chromosome 14 at 64,738,619 bp
  • A to T, chromosome 15 at 58,100,019 bp
  • T to A, chromosome 16 at 19,407,704 bp
  • T to C, chromosome 16 at 21,653,746 bp
  • A to G, chromosome 16 at 90,779,039 bp
  • A to T, chromosome 16 at 96,008,144 bp
  • T to A, chromosome 17 at 26,196,521 bp
  • T to A, chromosome 17 at 53,426,278 bp
  • G to A, chromosome 17 at 74,445,189 bp
  • T to A, chromosome 19 at 24,131,412 bp
  • A to G, chromosome 19 at 38,724,775 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1624 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039661-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.