Strain Name:
C57BL/6J-MtgxR1632Btlr/Mmmh
Stock Number:
039669-MU
Citation ID:
RRID:MMRRC_039669-MU
Other Names:
R1632 (G1), C57BL/6J-MtgxR1632Btlr
Major Collection:

Gene Information

Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: KHS, 4432415E19Rik, MAPKKKK5, GCKR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Slc32a1
Name: solute carrier family 32 (GABA vesicular transporter), member 1
Synonyms: R75019, VGAT, Viaat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22348
Homologene: 56451
Cd86
Name: CD86 antigen
Synonyms: B7-2, B70, Ly58, B7.2, Cd28l2, Ly-58, MB7-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12524
HGNC: HGNC:1705
Homologene: 10443
Dhrs3
Name: dehydrogenase/reductase (SDR family) member 3
Synonyms: retSDR1, Rsdr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20148
Homologene: 20994
Mthfd1
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
Synonyms: E430024A07Rik, Mthfd, DCS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 108156
VEGA: 12
HGNC: HGNC:7432
Homologene: 55940
Cops4
Name: COP9 signalosome subunit 4
Synonyms: D5Ertd774e, COP9 complex S4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26891
Homologene: 8067
Dhcr24
Name: 24-dehydrocholesterol reductase
Synonyms: seladin-1, 3-beta-hydroxysterol delta-24 reductase, 5830417J06Rik, 2310076D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74754
HGNC: HGNC:2859
Homologene: 8850
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 9030205D12Rik, A330063D19Rik, AD013, 1810014J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109151
Homologene: 11844
Nploc4
Name: NPL4 homolog, ubiquitin recognition factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217365
Homologene: 5403
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
C77080
Name: expressed sequence C77080
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 97130
Homologene: 45837
Kri1
Name: KRI1 homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215194
Homologene: 133742
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: AF529169, DD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209743
Homologene: 17782
Crip2
Name: cysteine rich protein 2
Synonyms: ESP1, Hlp, 0610010I23Rik, Crp, CRP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68337
HGNC: HGNC:2361
Homologene: 133917
Il6st
Name: interleukin 6 signal transducer
Synonyms: D13Ertd699e, CD130, gp130, 5133400A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16195
HGNC: HGNC:6021
Homologene: 1645
Map2
Name: microtubule-associated protein 2
Synonyms: MAP-2, G1-397-34, repro4, Mtap2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Dync1li2
Name: dynein, cytoplasmic 1 light intermediate chain 2
Synonyms: Dncli2, Dnclic2, LIC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234663
HGNC: HGNC:2966
Homologene: 4474
Limk2
Name: LIM motif-containing protein kinase 2
Synonyms: Limk2a, LIM kinase 2, A930024P04Rik, whe, Limk2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16886
HGNC: HGNC:6614
Homologene: 55911
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: D12Ertd364e, C730036B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
D430042O09Rik
Name: RIKEN cDNA D430042O09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233865
Homologene: 45841
Cachd1
Name: cache domain containing 1
Synonyms: Vwcd1, 1190007F10Rik, B430218L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320508
Homologene: 10854
Gemin4
Name: gem nuclear organelle associated protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276919
Homologene: 69193
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: B230373P09Rik, Dnahc1, E030034C22Rik, MDHC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, skrr, Ryr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Hoxa13
Name: homeobox A13
Synonyms: Hox-1.10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15398
HGNC: HGNC:5102
Homologene: 73882
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Enpp4
Name: ectonucleotide pyrophosphatase/phosphodiesterase 4
Synonyms: 4933413N07Rik, LOC224794
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224794
HGNC: HGNC:3359
Homologene: 28264
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668940
Homologene: 66117
Ephb3
Name: Eph receptor B3
Synonyms: HEK2, Etk2, MDK5, Sek4, Cek10, Tyro6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13845
HGNC: HGNC:3394
Homologene: 20938
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: ENSMUSG00000073143, Kdm7a, A630082K20Rik, Jhdm1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 338523
Homologene: 25281
Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
Synonyms: 4732414G15Rik, 2310047A08Rik, eIF-2 alpha, Prkr, Tik, Pkr, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, dsRNA-activated kinase, eIF-2 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19106
HGNC: HGNC:9437
Homologene: 48134
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Mll2, Wbp7, 2610014H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75410
Homologene: 22838
Zfp329
Name: zinc finger protein 329
Synonyms: 2810439M05Rik, 4632409L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67230
Homologene: 23459
Phf19
Name: PHD finger protein 19
Synonyms: 3321402G02Rik, 3110009G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74016
Homologene: 12524
Vmn2r72
Name: vomeronasal 2, receptor 72
Synonyms: EG244114, Vmn2r72-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244114
Homologene: 115466
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: A830007B11Rik, Glur-5, D16Ium24e, GluK5, Glur5, Glurbeta1, D16Ium24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: 4632401C08Rik, B0AT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74338
Homologene: 52819
Tpte
Name: transmembrane phosphatase with tensin homology
Synonyms: Pten2, Vsp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234129
Homologene: 50411
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4930432K16Rik, 4921529O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 78257
Homologene: 12692
Pdzd7
Name: PDZ domain containing 7
Synonyms: EG435601, Pdzk7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 100503041
Homologene: 129509
Tas2r118
Name: taste receptor, type 2, member 118
Synonyms: Tas2r18, mGR18, mt2r40, T2R18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387347
Homologene: 9660
Socs4
Name: suppressor of cytokine signaling 4
Synonyms: A730004F22Rik, 3110032M18Rik, Socs7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67296
Homologene: 15442
Nostrin
Name: nitric oxide synthase trafficker
Synonyms: mDaIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329416
Homologene: 43142
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: Abh2, mABH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231642
Homologene: 18393
Psg18
Name: pregnancy specific glycoprotein 18
Synonyms: mmCGM6, Cea3, Cea-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26438
Homologene: 110989
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68655
Olfr988
Name: olfactory receptor 988
Synonyms: GA_x6K02T2Q125-46830591-46829662, MOR203-5P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258166
Homologene: 103791
Usp17la
Name: ubiquitin specific peptidase 17-like A
Synonyms: Dub1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13531
Homologene: 131315
Card10
Name: caspase recruitment domain family, member 10
Synonyms: Bimp1, CARMA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105844
Homologene: 8728
Cyp2j8
Name: cytochrome P450, family 2, subfamily j, polypeptide 8
Synonyms: Cyp2j8-ps, OTTMUSG00000007938
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 665095
Homologene: 133819
Gtpbp2
Name: GTP binding protein 2
Synonyms: nmf205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56055
HGNC: HGNC:4670
Homologene: 10420
Speer4f2
Name: spermatogenesis associated glutamate (E)-rich protein 4f2
Synonyms: Gm3535, Gm3495
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100041749
Nphp1
Name: nephronophthisis 1 (juvenile) homolog (human)
Synonyms: nephrocystin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53885
HGNC: HGNC:7905
Homologene: 229
Nme5
Name: NME/NM23 family member 5
Synonyms: non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase), Nm23-M5, 1700019D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75533
HGNC: HGNC:7853
Homologene: 2628
H2-M3
Name: histocompatibility 2, M region locus 3
Synonyms: H-2M3, Hmt, R4B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14991
HGNC: HGNC:4964
Homologene: 133255
Capn15
Name: calpain 15
Synonyms: Solh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50817
Homologene: 45782
1810046K07Rik
Name: RIKEN cDNA 1810046K07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69809
Homologene: 18881
Mpp5
Name: membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Synonyms: Pals1, 3830420B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56217
VEGA: 12
Homologene: 9512
Hspb3
Name: heat shock protein 3
Synonyms: spb3, 2310035K17Rik, 27kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56534
VEGA: 13
HGNC: HGNC:5248
Homologene: 31369
Slc25a2
Name: solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2
Synonyms: Ornt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 83885
Homologene: 129775
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 66,415,086 bp
  • G to A, chromosome 2 at 34,911,619 bp
  • A to G, chromosome 2 at 69,175,734 bp
  • A to T, chromosome 2 at 85,353,242 bp
  • G to T, chromosome 2 at 127,770,392 bp
  • A to G, chromosome 2 at 155,620,525 bp
  • C to T, chromosome 2 at 158,613,890 bp
  • T to A, chromosome 4 at 96,447,324 bp
  • A to G, chromosome 4 at 100,966,972 bp
  • G to T, chromosome 4 at 106,585,951 bp
  • A to G, chromosome 4 at 129,222,666 bp
  • T to C, chromosome 4 at 144,893,546 bp
  • A to C, chromosome 5 at 14,680,003 bp
  • A to G, chromosome 5 at 17,373,302 bp
  • T to C, chromosome 5 at 100,543,833 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • A to G, chromosome 6 at 23,969,261 bp
  • A to G, chromosome 6 at 39,152,898 bp
  • G to T, chromosome 6 at 52,259,937 bp
  • T to C, chromosome 7 at 12,810,949 bp
  • G to A, chromosome 7 at 18,350,899 bp
  • T to C, chromosome 7 at 29,094,261 bp
  • T to C, chromosome 7 at 30,583,962 bp
  • T to A, chromosome 7 at 85,751,792 bp
  • A to T, chromosome 7 at 104,860,911 bp
  • A to T, chromosome 7 at 125,842,574 bp
  • G to A, chromosome 8 at 22,349,347 bp
  • A to T, chromosome 8 at 90,956,707 bp
  • A to T, chromosome 8 at 104,437,491 bp
  • T to C, chromosome 9 at 21,282,211 bp
  • T to C, chromosome 9 at 51,290,402 bp
  • T to A, chromosome 9 at 89,602,360 bp
  • A to G, chromosome 11 at 3,346,250 bp
  • A to T, chromosome 11 at 76,210,989 bp
  • G to A, chromosome 11 at 120,383,285 bp
  • T to G, chromosome 12 at 65,130,331 bp
  • T to C, chromosome 12 at 69,828,047 bp
  • T to A, chromosome 12 at 72,460,020 bp
  • T to C, chromosome 12 at 76,307,212 bp
  • T to A, chromosome 12 at 78,797,038 bp
  • A to G, chromosome 12 at 113,144,305 bp
  • A to T, chromosome 13 at 73,689,908 bp
  • G to T, chromosome 13 at 112,504,332 bp
  • A to G, chromosome 13 at 113,663,053 bp
  • A to T, chromosome 14 at 31,273,873 bp
  • A to G, chromosome 14 at 47,289,577 bp
  • G to A, chromosome 15 at 78,791,220 bp
  • T to C, chromosome 16 at 21,212,937 bp
  • A to G, chromosome 16 at 36,665,939 bp
  • T to C, chromosome 16 at 87,896,900 bp
  • T to C, chromosome 17 at 7,773,200 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • A to T, chromosome 17 at 25,960,665 bp
  • G to A, chromosome 17 at 37,271,163 bp
  • G to T, chromosome 17 at 44,099,653 bp
  • A to G, chromosome 17 at 46,168,592 bp
  • A to T, chromosome 17 at 67,849,074 bp
  • C to A, chromosome 17 at 78,864,034 bp
  • A to T, chromosome 18 at 34,571,673 bp
  • T to C, chromosome 18 at 37,637,687 bp
  • C to T, chromosome 18 at 89,009,336 bp
  • A to G, chromosome 19 at 45,028,489 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1632 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039669-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.