Strain Name:
C57BL/6J-MtgxR1645Btlr/Mmmh
Stock Number:
039681-MU
Citation ID:
RRID:MMRRC_039681-MU
Other Names:
R1645 (G1), C57BL/6J-MtgxR1645Btlr
Major Collection:

Gene Information

Nrp2
Name: neuropilin 2
Synonyms: NP2, Npn-2, Npn2, NP-2, 1110048P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Prkd3
Name: protein kinase D3
Synonyms: 4930557O20Rik, 5730497N19Rik, PKD3, Prkcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: NBL2, 4.1G, D10Ertd398e, Epb4.1l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Rbm47
Name: RNA binding motif protein 47
Synonyms: 9530077J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 245945
Homologene: 36932
Rngtt
Name: RNA guanylyltransferase and 5'-phosphatase
Synonyms: mouse capping enzyme
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 24018
Homologene: 37851
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328977
Homologene: 138627
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphh1, Lec1, Lphn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99633
Homologene: 22712
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Asr2, Ars2, 2810019G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83701
Homologene: 9298
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, Apc1, 2610021O03Rik, Mcpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17222
Homologene: 7414
Myo9b
Name: myosin IXb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Brca1
Name: breast cancer 1, early onset
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12189
HGNC: HGNC:1100
Homologene: 5276
Rab5b
Name: RAB5B, member RAS oncogene family
Synonyms: C030027M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19344
VEGA: 10
HGNC: HGNC:9784
Homologene: 104027
Rbm26
Name: RNA binding motif protein 26
Synonyms: Pro1777, C230097K14Rik, 1700009P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74213
Homologene: 41468
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Fam114a2
Name: family with sequence similarity 114, member A2
Synonyms: 9030624B09Rik, 1810073G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67726
HGNC: HGNC:1333
Homologene: 10270
C2cd5
Name: C2 calcium-dependent domain containing 5
Synonyms: C030008B15Rik, CDP138, 5730419I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74741
Homologene: 8873
Acvr1
Name: activin A receptor, type 1
Synonyms: ActR-I, ALK2, Acvr, Acvrlk2, ActRIA, SKR1, Tsk7L, D330013D15Rik, Alk8, Alk-2, Acvr1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11477
HGNC: HGNC:171
Homologene: 7
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKK-beta, IKK-2, IKK2, IKK[b], IKKbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Psrc1
Name: proline/serine-rich coiled-coil 1
Synonyms: DDA3, 5430413I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56742
Homologene: 49603
Pcdhb16
Name: protocadherin beta 16
Synonyms: PcdhbP, Pcdhb8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93887
HGNC: HGNC:8693
Homologene: 99843
Slc44a4
Name: solute carrier family 44, member 4
Synonyms: NG22, 2210409B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70129
Homologene: 11359
Clec4f
Name: C-type lectin domain family 4, member f
Synonyms: kupffer cell receptor, D18063, Clecsf13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 51811
Homologene: 9630
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Mroh7
Name: maestro heat-like repeat family member 7
Synonyms: LOC381538, Gm1027, Heatr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381538
Homologene: 19633
Abca4
Name: ATP-binding cassette, sub-family A (ABC1), member 4
Synonyms: Rim protein, RmP, Abc10, D430003I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Wdr11
Name: WD repeat domain 11
Synonyms: 2900055P10Rik, Wdr11, Brwd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207425
Homologene: 41229
Srp72
Name: signal recognition particle 72
Synonyms: 72kDa, 5730576P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66661
Homologene: 38254
Sntg1
Name: syntrophin, gamma 1
Synonyms: G1SYN, SYN4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71096
Homologene: 56834
Ccny
Name: cyclin Y
Synonyms: 4631402G10Rik, 3110050L10Rik, 1700025H17Rik, 5730405I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67974
VEGA: 18
Homologene: 12219
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: EG638102, V2Rp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 638102
Homologene: 86604
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Chl1
Name: cell adhesion molecule L1-like
Synonyms: CALL, A530023M13Rik, close homolog of L1, LICAM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
C4b
Name: complement component 4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12268
Homologene: 36030
Cby2
Name: chibby family member 2
Synonyms: 1700086N05Rik, Nurit, Spert
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67926
VEGA: 14
Homologene: 12213
Klra2
Name: killer cell lectin-like receptor, subfamily A, member 2
Synonyms: Ly49b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16633
Homologene: 133782
Ephb1
Name: Eph receptor B1
Synonyms: Elk, Hek6, Net, Cek6, Elkh, C130099E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270190
HGNC: HGNC:3392
Homologene: 20936
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20419
Homologene: 32123
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384752
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 57764
Homologene: 10934
Impa1
Name: inositol (myo)-1(or 4)-monophosphatase 1
Synonyms: lithium-sensitive myo-inositol monophosphatase A1, 2610002K09Rik, 2900059K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 55980
HGNC: HGNC:6050
Homologene: 4043
Olfr827
Name: olfactory receptor 827
Synonyms: GA_x6K02T2PULF-11878777-11877809, MOR210-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258297
Homologene: 27117
Gabbr2
Name: gamma-aminobutyric acid (GABA) B receptor, 2
Synonyms: Gababr2, LOC242425, Gpr51, GB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Pdlim3
Name: PDZ and LIM domain 3
Synonyms: ALP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 53318
Homologene: 75063
P3h2
Name: prolyl 3-hydroxylase 2
Synonyms: Leprel1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 210530
Homologene: 10062
Bcas1
Name: brain enriched myelin associated protein 1
Synonyms: NABC1, 2210416M21Rik, 9030223A09Rik, breast carcinoma amplified sequence 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76960
HGNC: HGNC:974
Homologene: 2714
Olfr640
Name: olfactory receptor 640
Synonyms: GA_x6K02T2PBJ9-6756759-6755815, MOR13-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258819
Homologene: 17404
Vmn1r174
Name: vomeronasal 1 receptor 174
Synonyms: V1rd22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404291
Homologene: 79577
Fastkd1
Name: FAST kinase domains 1
Synonyms: 5330408N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320720
Homologene: 36420
Dyrk4
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
Synonyms: Dyrk4b, Dyrk4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101320
HGNC: HGNC:3095
Homologene: 37858
Fam189b
Name: family with sequence similarity 189, member B
Synonyms: 1110013L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68521
HGNC: HGNC:1233
Homologene: 4805
AC122012.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Pigu
Name: phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms: 5430426F17Rik, Cdc91l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228812
Homologene: 6553
Nat8b-ps
Name: N-acetyltransferase 8B, pseudogene
Synonyms: Nat8b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434057
Camk2b
Name: calcium/calmodulin-dependent protein kinase II, beta
Synonyms: CaMK II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12323
HGNC: HGNC:1461
Homologene: 111050
Gm6358
Name: predicted gene 6358
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 102637070
Olfr120
Name: olfactory receptor 120
Synonyms: MOR263-3, GA_x6K02T2PSCP-2184981-2185946
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258624
Homologene: 110622
Snx24
Name: sorting nexing 24
Synonyms: 2810011K15Rik, 5730433I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69226
VEGA: 18
Homologene: 8529
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 8,803,931 bp
  • T to A, chromosome 1 at 34,225,722 bp
  • C to T, chromosome 1 at 62,785,124 bp
  • A to T, chromosome 2 at 58,462,899 bp
  • A to T, chromosome 2 at 69,694,656 bp
  • A to G, chromosome 2 at 128,658,246 bp
  • A to C, chromosome 2 at 155,328,678 bp
  • T to A, chromosome 2 at 170,387,167 bp
  • A to T, chromosome 3 at 10,328,441 bp
  • C to A, chromosome 3 at 89,186,847 bp
  • C to T, chromosome 3 at 108,385,238 bp
  • A to G, chromosome 3 at 122,155,277 bp
  • A to T, chromosome 3 at 148,865,608 bp
  • A to G, chromosome 4 at 33,362,939 bp
  • A to T, chromosome 4 at 46,664,963 bp
  • G to A, chromosome 4 at 106,720,668 bp
  • A to G, chromosome 5 at 59,053,987 bp
  • G to T, chromosome 5 at 66,027,138 bp
  • T to C, chromosome 5 at 76,998,278 bp
  • A to T, chromosome 5 at 96,700,586 bp
  • A to T, chromosome 5 at 96,707,502 bp
  • T to A, chromosome 5 at 137,302,139 bp
  • G to A, chromosome 6 at 29,451,531 bp
  • A to G, chromosome 6 at 83,646,026 bp
  • C to A, chromosome 6 at 85,932,890 bp
  • G to T, chromosome 6 at 103,683,180 bp
  • C to A, chromosome 6 at 126,894,793 bp
  • A to T, chromosome 6 at 131,243,894 bp
  • A to G, chromosome 6 at 143,050,126 bp
  • T to C, chromosome 7 at 10,382,251 bp
  • G to A, chromosome 7 at 23,754,352 bp
  • A to G, chromosome 7 at 104,022,003 bp
  • A to G, chromosome 7 at 129,613,889 bp
  • T to A, chromosome 8 at 4,749,645 bp
  • C to A, chromosome 8 at 22,691,066 bp
  • A to G, chromosome 8 at 45,896,748 bp
  • A to G, chromosome 8 at 71,322,978 bp
  • A to G, chromosome 9 at 101,927,559 bp
  • A to G, chromosome 10 at 25,495,433 bp
  • T to A, chromosome 10 at 27,368,985 bp
  • C to T, chromosome 10 at 93,707,353 bp
  • A to G, chromosome 10 at 128,686,826 bp
  • T to A, chromosome 10 at 130,210,212 bp
  • A to T, chromosome 11 at 5,972,719 bp
  • A to T, chromosome 11 at 57,499,795 bp
  • G to A, chromosome 11 at 101,510,053 bp
  • A to T, chromosome 13 at 11,718,482 bp
  • C to A, chromosome 14 at 75,583,649 bp
  • A to T, chromosome 14 at 79,182,987 bp
  • A to G, chromosome 14 at 105,150,817 bp
  • A to T, chromosome 15 at 64,089,475 bp
  • A to G, chromosome 15 at 80,882,958 bp
  • T to A, chromosome 16 at 25,997,232 bp
  • T to C, chromosome 16 at 89,141,079 bp
  • T to A, chromosome 17 at 23,346,218 bp
  • A to G, chromosome 17 at 34,740,597 bp
  • G to A, chromosome 17 at 34,929,070 bp
  • A to T, chromosome 17 at 37,726,338 bp
  • A to T, chromosome 17 at 67,737,682 bp
  • A to C, chromosome 17 at 78,956,520 bp
  • T to C, chromosome 18 at 9,345,199 bp
  • T to C, chromosome 18 at 37,479,370 bp
  • T to C, chromosome 18 at 53,389,562 bp
  • C to A, chromosome 18 at 65,687,264 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1645 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039681-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.