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Strain Name:
C57BL/6J-MtgxR1673Btlr/Mmmh
Stock Number:
039709-MU
Citation ID:
RRID:MMRRC_039709-MU
Other Names:
R1673 (G1), C57BL/6J-MtgxR1673Btlr
Major Collection:

Strain Information

Elp2
Name: elongator acetyltransferase complex subunit 2
Synonyms: Stat3-interacting protein, StIP1, Statip1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58523
VEGA: 18
Homologene: 6019
Wnt5b
Name: wingless-type MMTV integration site family, member 5B
Synonyms: Wnt-5b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22419
Homologene: 22530
Kcns2
Name: K+ voltage-gated channel, subfamily S, 2
Synonyms: Kv9.2, E130006J24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16539
VEGA: 15
HGNC: HGNC:6301
Homologene: 22465
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Rbpms2
Name: RNA binding protein with multiple splicing 2
Synonyms: 2400008B06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71973
VEGA: 9
Homologene: 49895
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 75,411,163 bp
  • T to A, chromosome 1 at 87,264,682 bp
  • A to G, chromosome 1 at 93,006,884 bp
  • A to T, chromosome 1 at 152,830,479 bp
  • A to G, chromosome 1 at 164,179,520 bp
  • A to T, chromosome 2 at 18,872,282 bp
  • A to T, chromosome 2 at 70,716,604 bp
  • T to C, chromosome 2 at 76,807,083 bp
  • G to A, chromosome 2 at 76,810,287 bp
  • G to A, chromosome 2 at 91,646,008 bp
  • A to G, chromosome 2 at 111,369,207 bp
  • G to A, chromosome 2 at 119,381,936 bp
  • G to A, chromosome 2 at 181,588,493 bp
  • T to C, chromosome 3 at 28,793,818 bp
  • T to A, chromosome 3 at 89,231,772 bp
  • T to A, chromosome 3 at 103,817,845 bp
  • T to A, chromosome 3 at 145,126,082 bp
  • A to G, chromosome 3 at 152,368,282 bp
  • C to T, chromosome 3 at 157,537,640 bp
  • T to C, chromosome 4 at 53,542,468 bp
  • T to A, chromosome 4 at 104,732,056 bp
  • T to C, chromosome 4 at 121,616,458 bp
  • A to T, chromosome 5 at 16,299,990 bp
  • G to T, chromosome 5 at 110,008,988 bp
  • T to C, chromosome 5 at 115,582,297 bp
  • G to T, chromosome 5 at 118,008,064 bp
  • T to A, chromosome 5 at 136,104,637 bp
  • A to G, chromosome 5 at 141,948,506 bp
  • A to T, chromosome 6 at 88,892,078 bp
  • A to T, chromosome 6 at 119,446,354 bp
  • A to T, chromosome 6 at 124,854,840 bp
  • A to C, chromosome 6 at 128,333,943 bp
  • T to G, chromosome 7 at 12,616,211 bp
  • T to A, chromosome 7 at 84,916,117 bp
  • C to A, chromosome 7 at 103,506,689 bp
  • T to A, chromosome 7 at 104,306,057 bp
  • G to A, chromosome 7 at 105,747,673 bp
  • C to A, chromosome 7 at 119,971,179 bp
  • A to G, chromosome 8 at 3,877,113 bp
  • T to A, chromosome 8 at 64,017,469 bp
  • A to C, chromosome 8 at 71,508,457 bp
  • A to G, chromosome 8 at 104,257,351 bp
  • C to G, chromosome 8 at 117,040,775 bp
  • G to A, chromosome 9 at 4,537,637 bp
  • A to T, chromosome 9 at 8,902,068 bp
  • T to C, chromosome 9 at 20,347,653 bp
  • T to C, chromosome 9 at 58,623,732 bp
  • T to A, chromosome 9 at 60,872,156 bp
  • T to A, chromosome 9 at 65,651,536 bp
  • T to C, chromosome 9 at 75,395,569 bp
  • T to G, chromosome 9 at 79,693,538 bp
  • G to T, chromosome 9 at 109,382,128 bp
  • T to C, chromosome 9 at 110,421,788 bp
  • T to A, chromosome 9 at 110,604,180 bp
  • T to A, chromosome 9 at 123,178,021 bp
  • T to C, chromosome 10 at 60,413,527 bp
  • T to C, chromosome 10 at 77,942,944 bp
  • C to T, chromosome 10 at 81,322,435 bp
  • A to G, chromosome 10 at 108,249,565 bp
  • A to G, chromosome 10 at 119,217,933 bp
  • A to G, chromosome 10 at 126,010,167 bp
  • T to C, chromosome 11 at 11,352,696 bp
  • A to T, chromosome 11 at 55,184,913 bp
  • A to G, chromosome 11 at 65,712,172 bp
  • T to C, chromosome 11 at 66,052,994 bp
  • T to C, chromosome 11 at 67,352,119 bp
  • A to G, chromosome 11 at 77,151,853 bp
  • C to T, chromosome 11 at 102,198,805 bp
  • T to C, chromosome 11 at 110,212,339 bp
  • A to T, chromosome 11 at 117,747,168 bp
  • G to A, chromosome 12 at 8,790,409 bp
  • A to T, chromosome 12 at 13,244,966 bp
  • A to G, chromosome 13 at 3,584,498 bp
  • A to T, chromosome 13 at 21,639,044 bp
  • A to T, chromosome 13 at 42,305,380 bp
  • G to A, chromosome 13 at 61,567,554 bp
  • A to T, chromosome 13 at 97,760,360 bp
  • A to G, chromosome 13 at 100,813,383 bp
  • T to C, chromosome 14 at 30,864,434 bp
  • C to T, chromosome 14 at 54,476,309 bp
  • A to G, chromosome 14 at 59,791,240 bp
  • C to T, chromosome 14 at 78,908,230 bp
  • T to A, chromosome 14 at 121,337,571 bp
  • A to G, chromosome 15 at 28,290,148 bp
  • A to G, chromosome 15 at 34,648,695 bp
  • A to T, chromosome 15 at 34,838,820 bp
  • A to T, chromosome 15 at 54,910,196 bp
  • A to G, chromosome 15 at 85,932,457 bp
  • T to A, chromosome 16 at 32,756,902 bp
  • A to T, chromosome 17 at 25,567,482 bp
  • CTTCAT to CTTCATTCAT, chromosome 17 at 34,896,308 bp
  • TCATC to TCATCCATC, chromosome 17 at 34,896,310 bp
  • A to T, chromosome 17 at 56,010,455 bp
  • G to A, chromosome 18 at 20,331,504 bp
  • T to A, chromosome 18 at 24,611,926 bp
  • T to A, chromosome 18 at 42,552,581 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1673 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039709-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.