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Strain Name:
C57BL/6J-MtgxR1692Btlr/Mmmh
Stock Number:
039725-MU
Citation ID:
RRID:MMRRC_039725-MU
Other Names:
R1692 (G1), C57BL/6J-MtgxR1692Btlr
Major Collection:

Strain Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Pip5k1a
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
Synonyms: Pipk5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18720
HGNC: HGNC:8994
Homologene: 93492
Kif5a
Name: kinesin family member 5A
Synonyms: Kns, Kif5, D10Bwg0738e, Khc
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Gpx1
Name: glutathione peroxidase 1
Synonyms: CGPx, cellular GPx, GSHPx-1, Gpx, GPx-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14775
HGNC: HGNC:4553
Homologene: 20155
Mtap
Name: methylthioadenosine phosphorylase
Synonyms: 1300019I21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66902
HGNC: HGNC:7413
Homologene: 1838
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 75,190,355 bp
  • T to C, chromosome 2 at 31,450,844 bp
  • A to G, chromosome 2 at 31,921,781 bp
  • A to T, chromosome 2 at 136,550,426 bp
  • T to A, chromosome 3 at 59,602,622 bp
  • G to A, chromosome 3 at 90,087,586 bp
  • A to G, chromosome 3 at 95,063,730 bp
  • C to T, chromosome 4 at 89,176,914 bp
  • G to A, chromosome 4 at 126,242,308 bp
  • T to C, chromosome 4 at 135,775,551 bp
  • A to G, chromosome 5 at 67,268,554 bp
  • A to T, chromosome 5 at 77,275,222 bp
  • A to G, chromosome 5 at 137,664,371 bp
  • A to G, chromosome 5 at 150,370,227 bp
  • T to G, chromosome 6 at 42,313,098 bp
  • C to T, chromosome 6 at 90,378,951 bp
  • T to A, chromosome 7 at 24,901,456 bp
  • C to T, chromosome 7 at 99,004,663 bp
  • A to C, chromosome 7 at 121,091,551 bp
  • G to T, chromosome 7 at 127,384,480 bp
  • A to T, chromosome 7 at 133,887,944 bp
  • A to G, chromosome 8 at 69,813,903 bp
  • C to T, chromosome 8 at 89,028,400 bp
  • T to C, chromosome 8 at 105,616,054 bp
  • T to C, chromosome 8 at 105,886,312 bp
  • A to T, chromosome 9 at 14,464,511 bp
  • T to C, chromosome 9 at 14,551,722 bp
  • T to C, chromosome 9 at 44,715,420 bp
  • C to T, chromosome 9 at 64,506,137 bp
  • T to C, chromosome 9 at 65,795,311 bp
  • A to G, chromosome 9 at 108,339,475 bp
  • G to T, chromosome 9 at 109,221,709 bp
  • T to A, chromosome 9 at 110,174,004 bp
  • C to A, chromosome 10 at 53,699,347 bp
  • A to G, chromosome 10 at 59,896,377 bp
  • C to A, chromosome 10 at 127,243,641 bp
  • C to T, chromosome 10 at 127,719,334 bp
  • A to G, chromosome 10 at 128,571,725 bp
  • T to A, chromosome 11 at 6,400,795 bp
  • T to A, chromosome 11 at 29,188,123 bp
  • T to C, chromosome 11 at 35,659,344 bp
  • C to T, chromosome 11 at 59,009,675 bp
  • T to C, chromosome 11 at 78,751,331 bp
  • A to C, chromosome 11 at 84,877,066 bp
  • C to T, chromosome 11 at 105,857,500 bp
  • C to T, chromosome 12 at 99,955,001 bp
  • T to G, chromosome 13 at 32,974,995 bp
  • A to G, chromosome 13 at 46,929,557 bp
  • A to G, chromosome 14 at 21,024,182 bp
  • G to A, chromosome 14 at 56,804,193 bp
  • T to C, chromosome 15 at 31,602,151 bp
  • G to A, chromosome 15 at 37,927,322 bp
  • T to A, chromosome 15 at 100,800,573 bp
  • C to T, chromosome 17 at 20,890,609 bp
  • T to C, chromosome 17 at 35,013,725 bp
  • T to C, chromosome 17 at 54,281,726 bp
  • T to A, chromosome 17 at 55,898,299 bp
  • A to T, chromosome 18 at 34,609,833 bp
  • T to A, chromosome 19 at 6,519,268 bp
  • C to T, chromosome 19 at 20,630,818 bp
  • C to A, chromosome 19 at 46,372,076 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1692 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039725-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.