Strain Name:
C57BL/6J-MtgxR1692Btlr/Mmmh
Stock Number:
039725-MU
Citation ID:
RRID:MMRRC_039725-MU
Other Names:
R1692 (G1), C57BL/6J-MtgxR1692Btlr
Major Collection:

Strain Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Pip5k1a
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
Synonyms: Pipk5a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18720
HGNC: HGNC:8994
Homologene: 93492
Kif5a
Name: kinesin family member 5A
Synonyms: Kns, Kif5, D10Bwg0738e, Khc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20564
Homologene: 2303
Gpx1
Name: glutathione peroxidase 1
Synonyms: CGPx, cellular GPx, GSHPx-1, Gpx, GPx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14775
HGNC: HGNC:4553
Homologene: 20155
Mtap
Name: methylthioadenosine phosphorylase
Synonyms: 1300019I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66902
HGNC: HGNC:7413
Homologene: 1838
Smarcc1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Synonyms: BAF155, SRG3, msp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20588
Homologene: 68296
Zfp609
Name: zinc finger protein 609
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214812
Homologene: 72220
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22330
VEGA: 14
Homologene: 7594
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320365
Homologene: 113770
Sall1
Name: spalt like transcription factor 1
Synonyms: Msal-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 58198
Homologene: 2230
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: 4921509N21Rik, SCAN1, 2810481F14Rik, E430034L06Rik, Gm40556
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104884
Homologene: 5424
Uvrag
Name: UV radiation resistance associated gene
Synonyms: 9530039D02Rik, Uvragl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78610
Homologene: 31150
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: LL5A, D330037A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102693
Homologene: 15903
Vars
Name: valyl-tRNA synthetase
Synonyms: G7a, D17H6S56E, Bat-6, Bat6, Vars2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22321
Homologene: 4587
Amotl1
Name: angiomotin-like 1
Synonyms: 4932416D09Rik, JEAP, 2310067L22Rik, 2310010G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75723
Homologene: 43977
Cd79a
Name: CD79A antigen (immunoglobulin-associated alpha)
Synonyms: mb-1, Iga, Ig alpha, Ly54, Cd79a, Ig-alpha, Ly-54, Igalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12518
HGNC: HGNC:1698
Homologene: 31053
Adam12
Name: a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Synonyms: Mltna, ADAM12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Tpm3
Name: tropomyosin 3, gamma
Synonyms: hTMnm, hTM30nm, gamma-TM, skalphaTM.2, Tpm-5, Trop-5, Tpm5, Tm5NM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 59069
Homologene: 81889
Erbb3
Name: erb-b2 receptor tyrosine kinase 3
Synonyms: Erbb-3, Erbb3r, HER3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13867
HGNC: HGNC:3431
Homologene: 20457
Kif13a
Name: kinesin family member 13A
Synonyms: N-3 kinesin, 4930505I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16553
VEGA: 13
Homologene: 22589
Brd8
Name: bromodomain containing 8
Synonyms: p120, SMAP, 2610007E11Rik, 4432404P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 78656
Homologene: 41790
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104570
Homologene: 68886
Rrm2b
Name: ribonucleotide reductase M2 B (TP53 inducible)
Synonyms: p53R2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 382985
Homologene: 56723
Edc4
Name: enhancer of mRNA decapping 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234699
Homologene: 40937
Aldh1a1
Name: aldehyde dehydrogenase family 1, subfamily A1
Synonyms: ALDH1, E1, Ahd-2, Ahd2, Raldh1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 11668
HGNC: HGNC:402
Homologene: 110441
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: SMCC1, Clc-1, Clc1, NMF355, nmf355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Zmiz2
Name: zinc finger, MIZ-type containing 2
Synonyms: 2410117E06Rik, D11Bwg0280e, Zimp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52915
Homologene: 18000
Lamc3
Name: laminin gamma 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23928
HGNC: HGNC:6494
Homologene: 21222
Slc4a8
Name: solute carrier family 4 (anion exchanger), member 8
Synonyms: sodium bicarbonate cotransporter isoform 3 kNBC-3, KNBC-3, NDCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 59033
Homologene: 68419
Agfg2
Name: ArfGAP with FG repeats 2
Synonyms: A630095P14Rik, Hrbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231801
HGNC: HGNC:5177
Homologene: 4430
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Atg9a
Name: autophagy related 9A
Synonyms: Apg9l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 245860
Homologene: 34495
Otoa
Name: otoancorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246190
Homologene: 71803
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75146
Homologene: 12592
Vmn1r231
Name: vomeronasal 1 receptor 231
Synonyms: V1re7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 171230
Zxdc
Name: ZXD family zinc finger C
Synonyms: B930086F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 80292
Homologene: 82340
AC138665.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Myo1a
Name: myosin IA
Synonyms: BBM-I, brush border myosin 1, Myhl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Gmip
Name: Gem-interacting protein
Synonyms: 5031419I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78816
Homologene: 9570
Map7d1
Name: MAP7 domain containing 1
Synonyms: Parcc1, Rprc1, Mtap7d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 245877
Homologene: 17009
Zfp959
Name: zinc finger protein 959
Synonyms: BC011426
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224893
Homologene: 138295
Kdm4d
Name: lysine (K)-specific demethylase 4D
Synonyms: Jmjd2d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244694
Homologene: 69244
Megf11
Name: multiple EGF-like-domains 11
Synonyms: 2410080H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214058
Homologene: 13031
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242702
Homologene: 19432
Slc5a7
Name: solute carrier family 5 (choline transporter), member 7
Synonyms: CHT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 63993
VEGA: 17
Homologene: 32516
Serpinb6b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6b
Synonyms: ovalbumin, Spi12, NK13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20708
HGNC: HGNC:8950
Homologene: 22633
Zmym5
Name: zinc finger, MYM-type 5
Synonyms: 9830124H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219105
Homologene: 16997
Atpsckmt
Name: ATP synthase C subunit lysine N-methyltransferase
Synonyms: A930016P21Rik, Fam173b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68073
Homologene: 16780
Fam184a
Name: family with sequence similarity 184, member A
Synonyms: 3110012E06Rik, 4930438C08Rik, 4930589M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75906
Homologene: 11600
Dnajb12
Name: DnaJ heat shock protein family (Hsp40) member B12
Synonyms: mDj10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56709
Homologene: 9749
Tmem33
Name: transmembrane protein 33
Synonyms: 5430406L04Rik, 2410089A21Rik, 2700052H22Rik, 1600019D15Rik, 1110006G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67878
Homologene: 10018
Ripor1
Name: RHO family interacting cell polarization regulator 1
Synonyms: 2310066E14Rik, Fam65a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75687
Homologene: 11564
Fbxw20
Name: F-box and WD-40 domain protein 20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434440
Homologene: 110776
Pigw
Name: phosphatidylinositol glycan anchor biosynthesis, class W
Synonyms: Gwt1, 2610044A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70325
Homologene: 6243
Ankef1
Name: ankyrin repeat and EF-hand domain containing 1
Synonyms: Ankrd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 319196
Homologene: 11130
9130019O22Rik
Name: RIKEN cDNA 9130019O22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78921
Homologene: 118005
Ccnq
Name: cyclin Q
Synonyms: 1810009O10Rik, cyclin M, Fam58b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69109
Homologene: 13362
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 75,190,355 bp
  • T to C, chromosome 2 at 31,450,844 bp
  • A to G, chromosome 2 at 31,921,781 bp
  • A to T, chromosome 2 at 136,550,426 bp
  • T to A, chromosome 3 at 59,602,622 bp
  • G to A, chromosome 3 at 90,087,586 bp
  • A to G, chromosome 3 at 95,063,730 bp
  • C to T, chromosome 4 at 89,176,914 bp
  • G to A, chromosome 4 at 126,242,308 bp
  • T to C, chromosome 4 at 135,775,551 bp
  • A to G, chromosome 5 at 67,268,554 bp
  • A to T, chromosome 5 at 77,275,222 bp
  • A to G, chromosome 5 at 137,664,371 bp
  • A to G, chromosome 5 at 150,370,227 bp
  • T to G, chromosome 6 at 42,313,098 bp
  • C to T, chromosome 6 at 90,378,951 bp
  • T to A, chromosome 7 at 24,901,456 bp
  • C to T, chromosome 7 at 99,004,663 bp
  • A to C, chromosome 7 at 121,091,551 bp
  • G to T, chromosome 7 at 127,384,480 bp
  • A to T, chromosome 7 at 133,887,944 bp
  • A to G, chromosome 8 at 69,813,903 bp
  • C to T, chromosome 8 at 89,028,400 bp
  • T to C, chromosome 8 at 105,616,054 bp
  • T to C, chromosome 8 at 105,886,312 bp
  • A to T, chromosome 9 at 14,464,511 bp
  • T to C, chromosome 9 at 14,551,722 bp
  • T to C, chromosome 9 at 44,715,420 bp
  • C to T, chromosome 9 at 64,506,137 bp
  • T to C, chromosome 9 at 65,795,311 bp
  • A to G, chromosome 9 at 108,339,475 bp
  • G to T, chromosome 9 at 109,221,709 bp
  • T to A, chromosome 9 at 110,174,004 bp
  • C to A, chromosome 10 at 53,699,347 bp
  • A to G, chromosome 10 at 59,896,377 bp
  • C to A, chromosome 10 at 127,243,641 bp
  • C to T, chromosome 10 at 127,719,334 bp
  • A to G, chromosome 10 at 128,571,725 bp
  • T to A, chromosome 11 at 6,400,795 bp
  • T to A, chromosome 11 at 29,188,123 bp
  • T to C, chromosome 11 at 35,659,344 bp
  • C to T, chromosome 11 at 59,009,675 bp
  • T to C, chromosome 11 at 78,751,331 bp
  • A to C, chromosome 11 at 84,877,066 bp
  • C to T, chromosome 11 at 105,857,500 bp
  • C to T, chromosome 12 at 99,955,001 bp
  • T to G, chromosome 13 at 32,974,995 bp
  • A to G, chromosome 13 at 46,929,557 bp
  • A to G, chromosome 14 at 21,024,182 bp
  • G to A, chromosome 14 at 56,804,193 bp
  • T to C, chromosome 15 at 31,602,151 bp
  • G to A, chromosome 15 at 37,927,322 bp
  • T to A, chromosome 15 at 100,800,573 bp
  • C to T, chromosome 17 at 20,890,609 bp
  • T to C, chromosome 17 at 35,013,725 bp
  • T to C, chromosome 17 at 54,281,726 bp
  • T to A, chromosome 17 at 55,898,299 bp
  • A to T, chromosome 18 at 34,609,833 bp
  • T to A, chromosome 19 at 6,519,268 bp
  • C to T, chromosome 19 at 20,630,818 bp
  • C to A, chromosome 19 at 46,372,076 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1692 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039725-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.