Strain Name:
C57BL/6J-MtgxR1723Btlr/Mmmh
Stock Number:
039755-MU
Citation ID:
RRID:MMRRC_039755-MU
Other Names:
R1723 (G1), C57BL/6J-MtgxR1723Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Exoc6b
Name: exocyst complex component 6B
Synonyms: 4930569O18Rik, G430127E12Rik, Sec15b, Sec15l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75914
Homologene: 44781
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 4930538C18Rik, 2310007L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 75826
VEGA: 16
Homologene: 11005
Sfswap
Name: splicing factor SWAP
Synonyms: 6330437E22Rik, 1190005N23Rik, Sfrs8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231769
Homologene: 134548
Anapc5
Name: anaphase-promoting complex subunit 5
Synonyms: 2510006G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 59008
Homologene: 41118
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 360013
Homologene: 7977
Mtf2
Name: metal response element binding transcription factor 2
Synonyms: M96, 9230112N11Rik, C76717, Pcl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17765
Homologene: 7207
Kif18a
Name: kinesin family member 18A
Synonyms: N-8 kinesin, B130001M12Rik, gcd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228421
Homologene: 41820
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKbeta, MLTKalpha, B230120H23Rik, Zak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65964
Homologene: 32331
Med29
Name: mediator complex subunit 29
Synonyms: 2810405O22Rik, Ixl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67224
Homologene: 12102
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 668303
Homologene: 18970
Ecel1
Name: endothelin converting enzyme-like 1
Synonyms: DINE, XCE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13599
HGNC: HGNC:3147
Homologene: 3549
Jph4
Name: junctophilin 4
Synonyms: JPHL1, JP-4, 9330157P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319984
Homologene: 13034
Rad51
Name: RAD51 recombinase
Synonyms: Reca, Rad51a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19361
HGNC: HGNC:9817
Homologene: 2155
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Hpcal4
Name: hippocalcin-like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 170638
Homologene: 9441
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268878
Homologene: 77451
Calcoco1
Name: calcium binding and coiled coil domain 1
Synonyms: 1810009B06Rik, CoCoA, Gcap11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67488
Homologene: 10845
Gask1b
Name: golgi associated kinase 1B
Synonyms: 2210419I08Rik, Ened, 1110032E23Rik, Fam198b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68659
Homologene: 9590
Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
Synonyms: CD29, beta1 integrin, 4633401G24Rik, Fnrb, Gm9863
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16412
HGNC: HGNC:6153
Homologene: 22999
Vav2
Name: vav 2 oncogene
Synonyms: 2810040F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22325
Homologene: 2530
Cbwd1
Name: COBW domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226043
VEGA: 19
Homologene: 6843
Zfp599
Name: zinc finger protein 599
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235048
Homologene: 138456
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77505
Homologene: 131117
Adamts13
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
Synonyms: LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Nlrc4
Name: NLR family, CARD domain containing 4
Synonyms: 9530011P19Rik, Card12, Ipaf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268973
VEGA: 17
Homologene: 10924
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, D830007G01Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Uckl1
Name: uridine-cytidine kinase 1-like 1
Synonyms: 1110007H10Rik, Urkl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68556
Homologene: 101414
Kdm5d
Name: lysine (K)-specific demethylase 5D
Synonyms: Smcy, Jarid1d, HY
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 20592
Homologene: 55838
Zbtb41
Name: zinc finger and BTB domain containing 41
Synonyms: 8430415N23Rik, 9830132G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226470
Homologene: 27795
Mob3b
Name: MOB kinase activator 3B
Synonyms: MOB3B, A430018A01Rik, 8430436F23Rik, Mobkl2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214944
Homologene: 69385
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Lrrc43
Name: leucine rich repeat containing 43
Synonyms: LOC381741
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381741
Homologene: 17662
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210510
Homologene: 19364
Poln
Name: DNA polymerase N
Synonyms: POL4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 272158
Homologene: 131253
Auh
Name: AU RNA binding protein/enoyl-coenzyme A hydratase
Synonyms: W91705
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 11992
HGNC: HGNC:890
Homologene: 1284
Gm7247
Name: predicted gene 7247
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 638695
Nubpl
Name: nucleotide binding protein-like
Synonyms: 2410170E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76826
Homologene: 11854
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71947
Homologene: 8831
Fam110c
Name: family with sequence similarity 110, member C
Synonyms: 9030611O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104943
VEGA: 12
Homologene: 75262
St18
Name: suppression of tumorigenicity 18
Synonyms: Nzf3, Myt3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240690
Homologene: 8792
Dglucy
Name: D-glutamate cyclase
Synonyms: 9030617O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217830
Homologene: 11798
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320277
Homologene: 23371
Or51q1c
Name: olfactory receptor family 51 subfamily Q member 1C
Synonyms: GA_x6K02T2PBJ9-6737723-6738670, MOR5-1, Olfr638
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259124
Homologene: 133592
Zfp954
Name: zinc finger protein 954
Synonyms: 5730403M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232853
Homologene: 129792
Tmem163
Name: transmembrane protein 163
Synonyms: 2610024A01Rik, SV31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72160
Homologene: 12798
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Slc40a1
Name: solute carrier family 40 (iron-regulated transporter), member 1
Synonyms: Ol5, ferroportin1, IREG1, FPN1, metal transporting protein 1, MTP1, Dusg, Slc11a3, Pcm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53945
Homologene: 40959
Cpeb1
Name: cytoplasmic polyadenylation element binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12877
Homologene: 7278
Aoc3
Name: amine oxidase, copper containing 3
Synonyms: SSAO, semicarbazide-sensitive amine oxidase, VAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11754
HGNC: HGNC:550
Homologene: 2770
Pnliprp1
Name: pancreatic lipase related protein 1
Synonyms: Plrp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18946
VEGA: 19
HGNC: HGNC:9156
Homologene: 21253
Polm
Name: polymerase (DNA directed), mu
Synonyms: Tdt-N, B230309I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 54125
HGNC: HGNC:9185
Homologene: 41170
Otud3
Name: OTU domain containing 3
Synonyms: 3110030K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73162
Homologene: 66103
Slc35a4
Name: solute carrier family 35, member A4
Synonyms: 2610030J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67843
Homologene: 12195
Zfp382
Name: zinc finger protein 382
Synonyms: 5930415A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233060
Homologene: 32798
Tff2
Name: trefoil factor 2 (spasmolytic protein 1)
Synonyms: mSP, SP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21785
Homologene: 3956
Zfp784
Name: zinc finger protein 784
Synonyms: C730049F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 654801
Homologene: 52408
Cd70
Name: CD70 antigen
Synonyms: Ki-24 antigen, CD27LG, Tnfsf7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21948
VEGA: 17
Homologene: 956
Gm15409
Name: predicted gene 15409
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Vmn2r30
Name: vomeronasal 2, receptor 30
Synonyms: V2r15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22306
Homologene: 113703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 6,810,685 bp
  • A to G, chromosome 1 at 45,924,761 bp
  • T to C, chromosome 1 at 87,154,421 bp
  • C to A, chromosome 1 at 127,551,371 bp
  • A to T, chromosome 1 at 139,423,563 bp
  • T to C, chromosome 2 at 26,986,974 bp
  • T to C, chromosome 2 at 27,318,964 bp
  • T to C, chromosome 2 at 72,389,492 bp
  • T to A, chromosome 2 at 76,750,410 bp
  • A to G, chromosome 2 at 109,302,882 bp
  • T to G, chromosome 2 at 119,123,814 bp
  • T to A, chromosome 2 at 181,570,600 bp
  • T to A, chromosome 3 at 79,936,663 bp
  • A to G, chromosome 4 at 34,954,026 bp
  • A to G, chromosome 4 at 123,190,739 bp
  • T to C, chromosome 4 at 138,898,018 bp
  • C to T, chromosome 5 at 25,315,005 bp
  • A to G, chromosome 5 at 34,122,672 bp
  • T to C, chromosome 5 at 108,088,070 bp
  • T to C, chromosome 5 at 122,799,343 bp
  • T to A, chromosome 5 at 123,492,213 bp
  • A to G, chromosome 5 at 129,539,694 bp
  • C to A, chromosome 5 at 148,959,501 bp
  • A to G, chromosome 6 at 85,069,344 bp
  • G to T, chromosome 6 at 85,628,753 bp
  • T to A, chromosome 7 at 5,035,783 bp
  • T to C, chromosome 7 at 7,115,838 bp
  • T to A, chromosome 7 at 7,334,260 bp
  • T to A, chromosome 7 at 28,392,705 bp
  • C to T, chromosome 7 at 30,130,838 bp
  • C to T, chromosome 7 at 81,436,226 bp
  • T to C, chromosome 7 at 104,003,311 bp
  • C to A, chromosome 7 at 105,714,920 bp
  • A to G, chromosome 8 at 128,726,038 bp
  • T to C, chromosome 9 at 22,258,065 bp
  • T to A, chromosome 10 at 106,915,672 bp
  • T to A, chromosome 11 at 5,834,776 bp
  • G to A, chromosome 11 at 77,853,314 bp
  • T to A, chromosome 11 at 101,336,435 bp
  • T to A, chromosome 11 at 115,794,748 bp
  • A to G, chromosome 12 at 31,074,395 bp
  • A to T, chromosome 12 at 52,181,140 bp
  • A to G, chromosome 12 at 100,842,679 bp
  • T to C, chromosome 12 at 112,173,858 bp
  • G to A, chromosome 13 at 52,835,496 bp
  • A to T, chromosome 14 at 51,521,961 bp
  • A to G, chromosome 14 at 55,110,064 bp
  • T to C, chromosome 15 at 9,614,209 bp
  • C to A, chromosome 15 at 102,719,553 bp
  • A to G, chromosome 16 at 22,028,042 bp
  • T to A, chromosome 16 at 29,232,799 bp
  • A to C, chromosome 17 at 31,144,158 bp
  • T to C, chromosome 17 at 43,628,327 bp
  • T to C, chromosome 17 at 57,146,401 bp
  • A to T, chromosome 17 at 71,750,378 bp
  • T to A, chromosome 17 at 74,441,908 bp
  • C to A, chromosome 18 at 36,682,735 bp
  • A to G, chromosome 19 at 24,948,094 bp
  • T to A, chromosome 19 at 58,732,142 bp
  • A to T, chromosome Y at 927,753 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1723 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039755-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.