Strain Name:
C57BL/6J-MtgxR1736Btlr/Mmmh
Stock Number:
039768-MU
Citation ID:
RRID:MMRRC_039768-MU
Other Names:
R1736 (G1), C57BL/6J-MtgxR1736Btlr
Major Collection:

Gene Information

Sall4
Name: spalt like transcription factor 4
Synonyms: 5730441M18Rik, C330011P20Rik, Tex20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99377
Homologene: 10716
Sema3e
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Synonyms: Semah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20349
Homologene: 8247
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, Mll3, E330008K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Slc17a6
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: 2900073D12Rik, VGLUT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 140919
Homologene: 121617
Tbce
Name: tubulin-specific chaperone E
Synonyms: C530005D02Rik, 2610206D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 70430
Homologene: 37744
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, Depdc2, 6230420N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Csnk1g1
Name: casein kinase 1, gamma 1
Synonyms: 9130020E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214897
HGNC: HGNC:2454
Homologene: 48692
Sf3b3
Name: splicing factor 3b, subunit 3
Synonyms: 5730409A01Rik, RSE1, 1810061H24Rik, D8Ertd633e, SAP130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 101943
Homologene: 6579
Sap30bp
Name: SAP30 binding protein
Synonyms: 2700016D05Rik, Hcngp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57230
Homologene: 8308
Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: KMT6, Enx1h, Enx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14056
HGNC: HGNC:3527
Homologene: 37926
Tsc22d1
Name: TSC22 domain family, member 1
Synonyms: TSC-22, Tgfb1i4, Egr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21807
Homologene: 7573
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, b2b327Clo, opm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 2610207I05Rik, C130002K18Rik, 5430435M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Map3k11
Name: mitogen-activated protein kinase kinase kinase 11
Synonyms: 2610017K16Rik, Mlk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26403
VEGA: 19
HGNC: HGNC:6850
Homologene: 37618
Cbl
Name: Casitas B-lineage lymphoma
Synonyms: 4732447J05Rik, Cbl-2, c-Cbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12402
HGNC: HGNC:1541
Homologene: 3802
Gosr2
Name: golgi SNAP receptor complex member 2
Synonyms: SNARE, 2310032N09Rik, GS27, membrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56494
HGNC: HGNC:4431
Homologene: 37907
Uchl1
Name: ubiquitin carboxy-terminal hydrolase L1
Synonyms: PGP 9.5, PGP9.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22223
Homologene: 37894
Dsp
Name: desmoplakin
Synonyms: 2300002E22Rik, rul, 5730453H04Rik, DP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Clint1
Name: clathrin interactor 1
Synonyms: C530049I24Rik, Epn4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216705
Homologene: 133740
Scyl2
Name: SCY1-like 2 (S. cerevisiae)
Synonyms: CVAK104, D10Ertd802e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 213326
Homologene: 13349
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Nxph4
Name: neurexophilin 4
Synonyms: 1110036M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 104080
HGNC: HGNC:8078
Homologene: 11020
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: D8Ertd281e, NFAT4, NFATx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Taf9
Name: TATA-box binding protein associated factor 9
Synonyms: 2310012M09Rik, Taf2g
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 108143
Homologene: 39986
Mrnip
Name: MRN complex interacting protein
Synonyms: 3010026O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68067
Homologene: 75241
Sec63
Name: SEC63-like (S. cerevisiae)
Synonyms: 5730478J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 140740
Homologene: 5220
Dse
Name: dermatan sulfate epimerase
Synonyms: Sart2, B130024B19Rik, DS-epi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 212898
VEGA: 10
Homologene: 8354
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Retsat
Name: retinol saturase (all trans retinol 13,14 reductase)
Synonyms: 0610039N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67442
Homologene: 41195
Shisa4
Name: shisa family member 4
Synonyms: Tmem58, 9330132O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77552
Homologene: 18428
Cep295
Name: centrosomal protein 295
Synonyms: 5830418K08Rik, LOC382128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319675
Homologene: 27936
Stag3
Name: stromal antigen 3
Synonyms: SA-2, stromalin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50878
Homologene: 40844
Klf7
Name: Kruppel-like factor 7 (ubiquitous)
Synonyms: 9830124P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 93691
HGNC: HGNC:6350
Homologene: 2751
Adcy3
Name: adenylate cyclase 3
Synonyms: ACIII, AC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104111
HGNC: HGNC:234
Homologene: 2978
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: Cchl1a, 8430418G19Rik, D-LTCC, Cacnl1a2, Cchl1a2, Cav1.3alpha1, C79217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Adamts16
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 271127
Homologene: 15146
Tulp4
Name: tubby like protein 4
Synonyms: 2210038L17Rik, 1110057P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68842
Homologene: 32467
Tpk1
Name: thiamine pyrophosphokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 29807
Homologene: 6960
Ly6g2
Name: lymphocyte antigen 6 complex, locus G2
Synonyms: BC025446
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223631
Ugt2b38
Name: UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms: 9430041C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100559
Homologene: 137225
Mindy2
Name: MINDY lysine 48 deubiquitinase 2
Synonyms: B230380D07Rik, Fam63b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235461
VEGA: 9
Homologene: 101023
Per3
Name: period circadian clock 3
Synonyms: mPer3, 2810049O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18628
HGNC: HGNC:8847
Homologene: 7886
Gm15217
Name: predicted gene 15217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100041724
Fam71e2
Name: family with sequence similarity 71, member E2
Synonyms: 4930401F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243822
Homologene: 89225
Npas1
Name: neuronal PAS domain protein 1
Synonyms: MOP5, bHLHe11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18142
HGNC: HGNC:7894
Homologene: 1886
Ces4a
Name: carboxylesterase 4A
Synonyms: Ces8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234677
Homologene: 71949
Fscn2
Name: fascin actin-bundling protein 2
Synonyms: ahl8, C630046B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238021
HGNC: HGNC:3960
Homologene: 22722
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: 4930544G21Rik, A930009L15Rik, SKIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77629
Homologene: 18172
Npffr2
Name: neuropeptide FF receptor 2
Synonyms: NPFF2, Gpr74
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 104443
HGNC: HGNC:4525
Homologene: 56982
Carf
Name: calcium response factor
Synonyms: Als2cr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241066
Homologene: 11689
Otud4
Name: OTU domain containing 4
Synonyms: D8Ertd69e, 4930431L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73945
Homologene: 35370
Atp8b2
Name: ATPase, class I, type 8B, member 2
Synonyms: Id
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 54667
Homologene: 23226
4932411G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Gm9696
Name: predicted gene 9696
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 676914
Smim7
Name: small integral membrane protein 7
Synonyms: 9130011J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66818
Homologene: 52095
CT010585.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,089,884 bp
  • T to C, chromosome 1 at 60,150,573 bp
  • C to A, chromosome 1 at 64,079,213 bp
  • G to A, chromosome 1 at 83,277,515 bp
  • A to G, chromosome 1 at 90,779,059 bp
  • G to A, chromosome 1 at 130,841,803 bp
  • A to T, chromosome 1 at 135,371,962 bp
  • G to A, chromosome 2 at 168,752,635 bp
  • T to C, chromosome 3 at 59,972,275 bp
  • G to A, chromosome 3 at 89,952,694 bp
  • A to G, chromosome 4 at 151,009,248 bp
  • C to T, chromosome 5 at 14,210,376 bp
  • A to T, chromosome 5 at 25,290,527 bp
  • T to C, chromosome 5 at 66,677,074 bp
  • T to A, chromosome 5 at 87,423,633 bp
  • T to A, chromosome 5 at 89,568,066 bp
  • T to A, chromosome 5 at 121,349,530 bp
  • T to C, chromosome 5 at 138,304,509 bp
  • G to A, chromosome 6 at 43,611,350 bp
  • A to T, chromosome 6 at 47,576,660 bp
  • G to T, chromosome 6 at 72,606,864 bp
  • A to G, chromosome 7 at 4,758,154 bp
  • G to T, chromosome 7 at 16,474,616 bp
  • G to A, chromosome 7 at 51,661,585 bp
  • T to G, chromosome 7 at 118,165,967 bp
  • G to A, chromosome 7 at 141,859,107 bp
  • C to T, chromosome 8 at 72,571,005 bp
  • T to A, chromosome 8 at 79,651,665 bp
  • G to A, chromosome 8 at 105,138,097 bp
  • T to G, chromosome 8 at 106,078,850 bp
  • T to C, chromosome 8 at 110,813,832 bp
  • C to T, chromosome 9 at 15,340,883 bp
  • A to T, chromosome 9 at 44,152,895 bp
  • A to G, chromosome 9 at 66,019,915 bp
  • A to G, chromosome 9 at 70,631,030 bp
  • A to T, chromosome 10 at 34,153,149 bp
  • T to A, chromosome 10 at 42,827,918 bp
  • A to G, chromosome 10 at 89,660,365 bp
  • T to A, chromosome 10 at 127,526,596 bp
  • A to G, chromosome 11 at 45,906,177 bp
  • G to A, chromosome 11 at 50,176,891 bp
  • G to A, chromosome 11 at 103,679,250 bp
  • A to G, chromosome 11 at 115,964,220 bp
  • G to A, chromosome 11 at 120,368,026 bp
  • A to G, chromosome 12 at 4,200,998 bp
  • A to G, chromosome 12 at 51,764,010 bp
  • A to G, chromosome 13 at 14,009,642 bp
  • A to G, chromosome 13 at 38,192,990 bp
  • C to T, chromosome 13 at 59,726,497 bp
  • G to A, chromosome 13 at 70,779,518 bp
  • T to A, chromosome 13 at 100,655,181 bp
  • C to T, chromosome 14 at 30,089,863 bp
  • A to G, chromosome 14 at 46,383,206 bp
  • A to G, chromosome 14 at 76,418,357 bp
  • G to A, chromosome 15 at 75,217,720 bp
  • C to T, chromosome 15 at 76,186,218 bp
  • T to G, chromosome 17 at 6,233,215 bp
  • T to C, chromosome 17 at 43,543,518 bp
  • A to G, chromosome 19 at 5,697,401 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1736 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039768-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.