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Strain Name:
C57BL/6J-MtgxR1737Btlr/Mmmh
Stock Number:
039769-MU
Citation ID:
RRID:MMRRC_039769-MU
Other Names:
R1737 (G1), C57BL/6J-MtgxR1737Btlr
Major Collection:

Strain Information

Sulf2
Name: sulfatase 2
Synonyms: 2010004N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72043
Homologene: 10313
Gabrg1
Name: gamma-aminobutyric acid type A receptor subunit gamma 1
Synonyms: GabaA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14405
HGNC: HGNC:4086
Homologene: 22570
Nfib
Name: nuclear factor I/B
Synonyms: 6720429L07Rik, E030026I10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18028
HGNC: HGNC:7785
Homologene: 4087
Smyd1
Name: SET and MYND domain containing 1
Synonyms: Bop, 4632404M21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12180
Homologene: 7645
Pip5k1b
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Synonyms: Pipk5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18719
HGNC: HGNC:8995
Homologene: 100644
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22330
VEGA: 14
Homologene: 7594
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 64,079,213 bp
  • T to C, chromosome 1 at 92,934,955 bp
  • G to A, chromosome 2 at 21,194,295 bp
  • T to C, chromosome 2 at 21,399,308 bp
  • C to A, chromosome 2 at 25,503,584 bp
  • A to T, chromosome 2 at 38,738,943 bp
  • A to T, chromosome 2 at 76,800,591 bp
  • G to T, chromosome 2 at 114,121,195 bp
  • T to C, chromosome 2 at 118,915,923 bp
  • A to T, chromosome 2 at 166,082,678 bp
  • T to A, chromosome 3 at 88,245,874 bp
  • A to T, chromosome 3 at 93,203,621 bp
  • A to T, chromosome 3 at 98,711,546 bp
  • T to A, chromosome 4 at 6,272,848 bp
  • T to C, chromosome 4 at 32,762,238 bp
  • T to C, chromosome 4 at 82,498,589 bp
  • A to T, chromosome 4 at 132,460,109 bp
  • A to T, chromosome 4 at 136,010,770 bp
  • T to C, chromosome 5 at 70,794,722 bp
  • T to A, chromosome 5 at 149,201,858 bp
  • A to T, chromosome 6 at 55,968,304 bp
  • A to G, chromosome 6 at 71,216,891 bp
  • A to G, chromosome 6 at 112,681,537 bp
  • C to T, chromosome 6 at 136,840,308 bp
  • A to T, chromosome 7 at 5,611,061 bp
  • T to C, chromosome 7 at 28,268,499 bp
  • T to C, chromosome 7 at 34,013,314 bp
  • A to T, chromosome 7 at 43,970,359 bp
  • A to T, chromosome 7 at 45,519,777 bp
  • A to G, chromosome 7 at 46,012,669 bp
  • G to A, chromosome 7 at 56,328,785 bp
  • T to C, chromosome 7 at 58,827,238 bp
  • A to T, chromosome 7 at 67,295,593 bp
  • T to C, chromosome 8 at 4,214,370 bp
  • A to G, chromosome 8 at 22,545,566 bp
  • G to A, chromosome 8 at 71,570,860 bp
  • A to C, chromosome 8 at 76,908,329 bp
  • A to G, chromosome 8 at 83,541,416 bp
  • A to G, chromosome 8 at 95,748,276 bp
  • G to T, chromosome 8 at 104,740,824 bp
  • G to A, chromosome 8 at 105,138,097 bp
  • G to A, chromosome 8 at 105,368,134 bp
  • C to T, chromosome 9 at 18,484,929 bp
  • T to C, chromosome 9 at 39,426,958 bp
  • A to T, chromosome 9 at 71,285,171 bp
  • C to A, chromosome 9 at 79,703,451 bp
  • A to T, chromosome 10 at 3,259,914 bp
  • T to C, chromosome 10 at 81,242,085 bp
  • T to A, chromosome 10 at 129,570,828 bp
  • T to A, chromosome 11 at 73,907,085 bp
  • T to C, chromosome 11 at 74,288,811 bp
  • G to A, chromosome 11 at 86,733,727 bp
  • A to G, chromosome 11 at 99,387,387 bp
  • A to G, chromosome 12 at 40,807,001 bp
  • A to T, chromosome 12 at 64,474,581 bp
  • A to T, chromosome 12 at 91,647,907 bp
  • C to A, chromosome 12 at 105,191,222 bp
  • G to A, chromosome 12 at 105,742,332 bp
  • A to G, chromosome 12 at 112,736,627 bp
  • A to C, chromosome 13 at 70,606,325 bp
  • G to A, chromosome 13 at 70,779,518 bp
  • A to G, chromosome 13 at 93,498,795 bp
  • T to C, chromosome 14 at 21,020,536 bp
  • A to G, chromosome 14 at 45,001,771 bp
  • A to T, chromosome 15 at 18,964,063 bp
  • G to A, chromosome 15 at 44,547,509 bp
  • T to A, chromosome 15 at 55,344,961 bp
  • T to C, chromosome 15 at 81,626,347 bp
  • T to A, chromosome 15 at 89,011,404 bp
  • C to A, chromosome 16 at 56,123,799 bp
  • A to C, chromosome 17 at 35,439,626 bp
  • T to C, chromosome 17 at 36,368,404 bp
  • A to G, chromosome 17 at 46,399,477 bp
  • G to A, chromosome 17 at 67,802,921 bp
  • A to C, chromosome 18 at 4,169,308 bp
  • C to A, chromosome 18 at 34,317,022 bp
  • A to G, chromosome 18 at 37,412,956 bp
  • A to T, chromosome 19 at 24,397,040 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1737 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039769-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.