Strain Name:
C57BL/6J-MtgxR1745Btlr/Mmmh
Stock Number:
039777-MU
Citation ID:
RRID:MMRRC_039777-MU
Other Names:
R1745 (G1), C57BL/6J-MtgxR1745Btlr
Major Collection:

Gene Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: D11Ertd530e, 2610028O16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52615
Homologene: 32256
Ip6k1
Name: inositol hexaphosphate kinase 1
Synonyms: InsP6k1, InsP6, Ihpk1, 1200016D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 27399
Homologene: 56602
Fryl
Name: FRY like transcription coactivator
Synonyms: 2510002A14Rik, 9030227G01Rik, 2310004H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: A330103N21Rik, hyft, line 186, CD221, IGF-1R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Nkx2-1
Name: NK2 homeobox 1
Synonyms: Ttf-1, Titf1, thyroid-specific enhancer-binding protein, tinman, T/EBP, thyroid transcription factor-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 21869
Homologene: 2488
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: Bchs, D5Ertd66e, Alfy, 2610509D04Rik, Ggtb3, Bwf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: A130069E23Rik, Gtar, 4933425K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 81702
Homologene: 82403
Diaph3
Name: diaphanous related formin 3
Synonyms: 4930417P13Rik, p134MDia2, Diap3, mDia2, Drf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56419
VEGA: 14
Homologene: 84829
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbb2ip, Erbin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 59079
Homologene: 41282
Zfhx3
Name: zinc finger homeobox 3
Synonyms: A230102L03Rik, Sci, Atbf1, WBP9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Med15
Name: mediator complex subunit 15
Synonyms: Pcqap, A230074L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 94112
VEGA: 16
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: BIG1, D130059B05Rik, D730028O18Rik, P200, ARFGEP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211673
Homologene: 4687
Myo9b
Name: myosin IXb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 2810429C13Rik, 1110031N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235559
Homologene: 38262
Dclk2
Name: doublecortin-like kinase 2
Synonyms: 6330415M09Rik, Dcamkl2, Click-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70762
Homologene: 69431
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
N4bp2
Name: NEDD4 binding protein 2
Synonyms: B3bp, LOC386488, LOC333789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 333789
Homologene: 32396
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: dgkd-2, DGKdelta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
Synonyms: VR-OAC, VRL-2, 0610033B08Rik, OTRPC4, VROAC, Trp12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 63873
Homologene: 11003
Ap2a1
Name: adaptor-related protein complex 2, alpha 1 subunit
Synonyms: Adtaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11771
HGNC: HGNC:561
Homologene: 68997
Hs1bp3
Name: HCLS1 binding protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 58240
VEGA: 12
Homologene: 10980
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71389
Homologene: 32772
Rnf44
Name: ring finger protein 44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105239
Homologene: 8934
Tor1aip1
Name: torsin A interacting protein 1
Synonyms: LAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208263
Homologene: 9208
Tsku
Name: tsukushi, small leucine rich proteoglycan
Synonyms: 9530051K01Rik, Lrrc54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244152
Homologene: 41045
Rapgef3
Name: Rap guanine nucleotide exchange factor (GEF) 3
Synonyms: 9330170P05Rik, Epac1, 2310016P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223864
Homologene: 21231
Anpep
Name: alanyl (membrane) aminopeptidase
Synonyms: Cd13, Apn, aminopeptidase N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Rundc3a
Name: RUN domain containing 3A
Synonyms: Rpip8, Rap2ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 51799
Homologene: 4871
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi, PTPROt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209590
Homologene: 16930
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69047
Homologene: 73463
Ttc38
Name: tetratricopeptide repeat domain 38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239570
Homologene: 41208
Capn3
Name: calpain 3
Synonyms: p94, Capa3, Lp82, Capa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12335
HGNC: HGNC:1480
Homologene: 52
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Mll2, Wbp7, 2610014H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75410
Homologene: 22838
Vmn1r170
Name: vomeronasal 1 receptor 170
Synonyms: Gm5999
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546944
Homologene: 128341
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: 2310067L16Rik, C80743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69700
Homologene: 43567
Prickle2
Name: prickle planar cell polarity protein 2
Synonyms: mpk2, 6720451F06Rik, 6230400G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243548
Homologene: 17889
Olfr638
Name: olfactory receptor 638
Synonyms: MOR5-1, GA_x6K02T2PBJ9-6737723-6738670
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259124
Homologene: 133592
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Bpifb6
Name: BPI fold containing family B, member 6
Synonyms: LOC228796, Bpil3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228796
Homologene: 18375
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: Dtgn1, MDC-L, C130072N01Rik, D430033C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Gad1-ps
Name: glutamate decarboxylase 1, pseudogene
Synonyms: Gad-1ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382407
VEGA: 10
Abcc10
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Synonyms: Mrp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Vmn1r71
Name: vomeronasal 1 receptor 71
Synonyms: V1re13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252910
Homologene: 74352
Fem1al
Name: fem-1 homolog A like
Synonyms: 4931440F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216622
Zswim9
Name: zinc finger SWIM-type containing 9
Synonyms: 6330408A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 321008
Homologene: 52386
Flot1
Name: flotillin 1
Synonyms: reggie-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14251
HGNC: HGNC:3757
Homologene: 31337
Ephb4
Name: Eph receptor B4
Synonyms: b2b2412Clo, Myk1, Htk, Tyro11, MDK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13846
HGNC: HGNC:3395
Homologene: 20939
N4bp2l2
Name: NEDD4 binding protein 2-like 2
Synonyms: 2700092H06Rik, zag1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381695
Homologene: 115380
Crnn
Name: cornulin
Synonyms: LOC381457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381457
HGNC: HGNC:1230
Homologene: 9416
Tnfsf13
Name: tumor necrosis factor (ligand) superfamily, member 13
Synonyms: 2310026N09Rik, TALL2, APRIL, TRDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69583
Homologene: 56971
AC159899.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Agrp
Name: agouti related neuropeptide
Synonyms: Agrt, agouti related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11604
HGNC: HGNC:330
Homologene: 7184
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 10,173,255 bp
  • A to G, chromosome 1 at 54,434,212 bp
  • T to C, chromosome 1 at 87,932,044 bp
  • G to T, chromosome 1 at 156,030,434 bp
  • G to A, chromosome 2 at 120,489,689 bp
  • A to G, chromosome 2 at 153,911,483 bp
  • A to T, chromosome 2 at 160,981,667 bp
  • C to T, chromosome 3 at 86,805,639 bp
  • T to C, chromosome 3 at 93,146,891 bp
  • A to G, chromosome 5 at 65,790,822 bp
  • G to A, chromosome 5 at 73,032,861 bp
  • A to T, chromosome 5 at 90,295,833 bp
  • A to T, chromosome 5 at 101,948,929 bp
  • A to T, chromosome 5 at 114,633,154 bp
  • A to T, chromosome 5 at 137,360,434 bp
  • A to T, chromosome 5 at 150,661,959 bp
  • G to A, chromosome 6 at 67,466,291 bp
  • A to T, chromosome 6 at 92,376,593 bp
  • A to G, chromosome 6 at 137,400,645 bp
  • T to C, chromosome 7 at 10,748,269 bp
  • A to G, chromosome 7 at 13,269,556 bp
  • A to G, chromosome 7 at 23,606,334 bp
  • A to T, chromosome 7 at 30,585,850 bp
  • T to C, chromosome 7 at 44,906,945 bp
  • T to C, chromosome 7 at 68,169,913 bp
  • C to T, chromosome 7 at 79,838,256 bp
  • A to T, chromosome 7 at 98,352,179 bp
  • A to G, chromosome 7 at 104,004,063 bp
  • A to G, chromosome 8 at 71,354,047 bp
  • T to A, chromosome 8 at 85,093,934 bp
  • G to T, chromosome 8 at 105,566,835 bp
  • T to A, chromosome 8 at 108,955,862 bp
  • G to A, chromosome 8 at 119,725,094 bp
  • T to C, chromosome 9 at 99,234,458 bp
  • G to A, chromosome 9 at 103,308,845 bp
  • G to A, chromosome 9 at 108,040,996 bp
  • A to T, chromosome 10 at 99,445,524 bp
  • A to G, chromosome 11 at 29,824,723 bp
  • G to A, chromosome 11 at 69,685,147 bp
  • T to C, chromosome 11 at 80,022,096 bp
  • GAGCC to GAGCCAGCC, chromosome 11 at 102,400,913 bp
  • C to T, chromosome 12 at 8,321,690 bp
  • A to G, chromosome 12 at 56,533,744 bp
  • A to G, chromosome 13 at 11,790,267 bp
  • G to A, chromosome 13 at 54,682,192 bp
  • G to T, chromosome 13 at 103,839,449 bp
  • A to G, chromosome 14 at 68,633,171 bp
  • A to G, chromosome 14 at 86,966,560 bp
  • C to T, chromosome 15 at 72,006,787 bp
  • T to C, chromosome 15 at 85,833,172 bp
  • T to C, chromosome 15 at 97,750,178 bp
  • G to A, chromosome 16 at 17,655,706 bp
  • A to G, chromosome 17 at 35,824,660 bp
  • A to T, chromosome 17 at 46,312,433 bp
  • A to T, chromosome 18 at 15,063,206 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1745 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039777-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.