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Strain Name:
C57BL/6J-MtgxR1791Btlr/Mmmh
Stock Number:
039821-MU
Citation ID:
RRID:MMRRC_039821-MU
Other Names:
R1791 (G1), C57BL/6J-MtgxR1791Btlr
Major Collection:

Strain Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, E030044M24Rik, NMHC II-A, Myhn-1, Myhn1, myosin IIA, Fltn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Glrb
Name: glycine receptor, beta subunit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14658
HGNC: HGNC:4329
Homologene: 20224
Cul4b
Name: cullin 4B
Synonyms: 2700050M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 72584
HGNC: HGNC:2555
Homologene: 2660
Prune1
Name: prune exopolyphosphatase
Synonyms: 9230112O05Rik, Prune-M1, Prune
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229589
Homologene: 41429
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: NBL2, 4.1G, D10Ertd398e, Epb4.1l2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Cdc42ep4
Name: CDC42 effector protein 4
Synonyms: CEP4, Borg4, 1500041M20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56699
Homologene: 8110
Hdac11
Name: histone deacetylase 11
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232232
Homologene: 11743
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 17,602,721 bp
  • A to G, chromosome 1 at 20,585,152 bp
  • A to T, chromosome 1 at 24,185,305 bp
  • C to T, chromosome 1 at 85,620,051 bp
  • G to T, chromosome 1 at 162,704,982 bp
  • T to C, chromosome 1 at 165,655,972 bp
  • G to A, chromosome 1 at 172,584,520 bp
  • T to C, chromosome 2 at 33,034,127 bp
  • T to C, chromosome 2 at 34,224,452 bp
  • T to C, chromosome 3 at 80,860,175 bp
  • T to A, chromosome 3 at 88,024,405 bp
  • T to A, chromosome 3 at 92,428,231 bp
  • A to G, chromosome 3 at 95,268,242 bp
  • A to T, chromosome 3 at 139,317,401 bp
  • C to A, chromosome 3 at 159,911,813 bp
  • G to A, chromosome 4 at 118,571,724 bp
  • G to T, chromosome 4 at 123,324,585 bp
  • A to G, chromosome 4 at 126,751,939 bp
  • G to A, chromosome 4 at 148,241,518 bp
  • A to G, chromosome 4 at 149,981,673 bp
  • G to A, chromosome 5 at 31,200,334 bp
  • A to T, chromosome 5 at 34,966,112 bp
  • A to G, chromosome 5 at 43,944,410 bp
  • A to G, chromosome 5 at 52,796,590 bp
  • A to G, chromosome 5 at 105,888,849 bp
  • G to A, chromosome 5 at 137,114,398 bp
  • A to G, chromosome 5 at 139,774,522 bp
  • A to G, chromosome 5 at 145,371,010 bp
  • A to G, chromosome 6 at 84,584,459 bp
  • G to T, chromosome 6 at 91,168,824 bp
  • C to A, chromosome 6 at 121,654,612 bp
  • T to G, chromosome 6 at 132,847,565 bp
  • A to C, chromosome 6 at 136,744,027 bp
  • A to C, chromosome 7 at 12,176,431 bp
  • G to A, chromosome 7 at 16,198,833 bp
  • A to G, chromosome 7 at 44,190,428 bp
  • C to T, chromosome 7 at 62,348,508 bp
  • T to G, chromosome 7 at 75,611,035 bp
  • A to G, chromosome 7 at 98,647,880 bp
  • G to A, chromosome 7 at 102,856,362 bp
  • T to C, chromosome 7 at 103,660,798 bp
  • T to A, chromosome 7 at 108,646,364 bp
  • A to G, chromosome 7 at 110,027,132 bp
  • T to C, chromosome 7 at 123,192,917 bp
  • T to C, chromosome 7 at 123,286,702 bp
  • A to G, chromosome 7 at 144,410,599 bp
  • A to T, chromosome 8 at 54,525,065 bp
  • G to T, chromosome 8 at 57,542,530 bp
  • A to T, chromosome 8 at 95,825,714 bp
  • T to A, chromosome 8 at 109,991,629 bp
  • T to A, chromosome 9 at 38,848,605 bp
  • A to T, chromosome 9 at 56,851,743 bp
  • T to C, chromosome 9 at 72,960,684 bp
  • A to G, chromosome 10 at 4,783,913 bp
  • T to A, chromosome 10 at 11,289,787 bp
  • T to C, chromosome 10 at 25,239,685 bp
  • A to T, chromosome 10 at 25,468,152 bp
  • T to A, chromosome 10 at 52,100,087 bp
  • A to G, chromosome 10 at 52,319,476 bp
  • A to G, chromosome 10 at 60,391,726 bp
  • C to A, chromosome 10 at 62,072,307 bp
  • C to T, chromosome 10 at 63,125,693 bp
  • T to A, chromosome 10 at 77,870,419 bp
  • T to C, chromosome 10 at 128,571,368 bp
  • A to G, chromosome 11 at 76,237,708 bp
  • A to G, chromosome 11 at 113,729,337 bp
  • G to A, chromosome 11 at 115,988,520 bp
  • G to A, chromosome 11 at 116,541,494 bp
  • T to A, chromosome 12 at 4,732,748 bp
  • T to C, chromosome 12 at 53,069,125 bp
  • T to C, chromosome 12 at 72,653,165 bp
  • C to A, chromosome 12 at 98,887,056 bp
  • A to G, chromosome 12 at 102,492,131 bp
  • T to C, chromosome 12 at 118,849,016 bp
  • C to A, chromosome 13 at 9,877,416 bp
  • A to G, chromosome 13 at 50,425,774 bp
  • A to G, chromosome 13 at 58,033,230 bp
  • T to C, chromosome 13 at 73,566,292 bp
  • A to G, chromosome 13 at 94,408,797 bp
  • T to C, chromosome 14 at 28,511,878 bp
  • A to G, chromosome 14 at 50,084,042 bp
  • AGGGATTGGG to AGGGATTGGGATTGGG, chromosome 14 at 50,736,687 bp
  • T to A, chromosome 14 at 56,504,007 bp
  • T to C, chromosome 14 at 60,709,459 bp
  • T to C, chromosome 14 at 75,047,549 bp
  • T to C, chromosome 14 at 121,256,745 bp
  • A to G, chromosome 15 at 27,841,756 bp
  • A to G, chromosome 15 at 77,773,264 bp
  • A to G, chromosome 15 at 85,020,614 bp
  • G to T, chromosome 16 at 4,552,069 bp
  • A to T, chromosome 16 at 46,117,999 bp
  • T to C, chromosome 17 at 7,931,467 bp
  • A to G, chromosome 17 at 7,933,545 bp
  • T to C, chromosome 17 at 14,685,813 bp
  • T to A, chromosome 17 at 27,894,746 bp
  • C to G, chromosome 17 at 28,286,374 bp
  • T to A, chromosome 17 at 57,190,867 bp
  • T to C, chromosome 17 at 71,801,942 bp
  • T to A, chromosome 18 at 60,300,517 bp
  • C to T, chromosome 18 at 77,185,735 bp
  • A to G, chromosome 18 at 82,554,349 bp
  • T to A, chromosome 19 at 5,695,572 bp
  • T to C, chromosome 19 at 36,609,416 bp
  • T to C, chromosome 19 at 41,928,085 bp
  • T to C, chromosome 19 at 59,032,200 bp
  • T to C, chromosome X at 7,620,439 bp
  • A to G, chromosome X at 37,669,195 bp
  • A to T, chromosome X at 38,547,851 bp
  • G to C, chromosome X at 101,258,463 bp
  • T to A, chromosome X at 151,864,753 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1791 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039821-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.