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Strain Name:
C57BL/6J-MtgxR1896Btlr/Mmmh
Stock Number:
039916-MU
Citation ID:
RRID:MMRRC_039916-MU
Other Names:
R1896 (G1), C57BL/6J-MtgxR1896Btlr
Major Collection:

Strain Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: transcytosis associated protein p115, TAP, Vdp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
Notch3
Name: notch 3
Synonyms: hpbk, N3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Acvr1c
Name: activin A receptor, type IC
Synonyms: ALK7, Alk-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269275
Homologene: 26724
Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: pCIP, TRAM-1, AIB1, RAC3, TRAM1, Src3, 2010305B15Rik, KAT13B, bHLHe42
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Rab5if
Name: RAB5 interacting factor
Synonyms: 1110008F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67388
Homologene: 10315
Adam23
Name: a disintegrin and metallopeptidase domain 23
Synonyms: MDC3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23792
HGNC: HGNC:202
Homologene: 2826
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 37,437,242 bp
  • G to A, chromosome 1 at 63,545,572 bp
  • T to C, chromosome 1 at 74,375,772 bp
  • C to T, chromosome 1 at 93,265,047 bp
  • T to C, chromosome 1 at 135,460,737 bp
  • C to A, chromosome 1 at 136,147,845 bp
  • T to C, chromosome 1 at 188,550,009 bp
  • A to G, chromosome 1 at 193,175,734 bp
  • A to G, chromosome 2 at 22,871,573 bp
  • C to A, chromosome 2 at 26,843,597 bp
  • A to G, chromosome 2 at 37,436,335 bp
  • A to C, chromosome 2 at 58,280,294 bp
  • A to G, chromosome 2 at 59,968,614 bp
  • C to T, chromosome 2 at 156,865,332 bp
  • C to T, chromosome 2 at 160,905,298 bp
  • T to A, chromosome 2 at 166,048,464 bp
  • T to A, chromosome 2 at 166,586,654 bp
  • T to C, chromosome 3 at 14,551,533 bp
  • T to C, chromosome 3 at 14,645,175 bp
  • C to T, chromosome 3 at 36,908,231 bp
  • A to G, chromosome 3 at 94,872,440 bp
  • T to C, chromosome 4 at 43,660,375 bp
  • C to G, chromosome 4 at 143,698,144 bp
  • A to G, chromosome 5 at 63,805,410 bp
  • A to G, chromosome 5 at 89,046,308 bp
  • A to T, chromosome 5 at 92,201,133 bp
  • C to A, chromosome 5 at 134,559,152 bp
  • A to T, chromosome 6 at 15,379,768 bp
  • T to C, chromosome 6 at 46,530,633 bp
  • T to A, chromosome 6 at 66,716,772 bp
  • T to C, chromosome 6 at 73,144,657 bp
  • T to A, chromosome 6 at 112,738,997 bp
  • A to G, chromosome 7 at 8,255,056 bp
  • A to T, chromosome 7 at 15,834,845 bp
  • A to G, chromosome 7 at 19,164,071 bp
  • A to G, chromosome 7 at 19,766,715 bp
  • C to T, chromosome 7 at 22,790,718 bp
  • T to C, chromosome 7 at 27,208,380 bp
  • A to T, chromosome 7 at 29,935,144 bp
  • A to G, chromosome 7 at 34,151,030 bp
  • A to G, chromosome 7 at 101,580,029 bp
  • C to A, chromosome 7 at 139,944,300 bp
  • C to A, chromosome 8 at 109,624,199 bp
  • C to A, chromosome 8 at 123,247,039 bp
  • A to G, chromosome 8 at 124,003,413 bp
  • T to C, chromosome 9 at 9,831,480 bp
  • A to G, chromosome 9 at 51,291,798 bp
  • A to T, chromosome 9 at 58,151,883 bp
  • T to A, chromosome 9 at 109,056,040 bp
  • C to T, chromosome 10 at 60,295,046 bp
  • T to C, chromosome 10 at 75,604,726 bp
  • T to A, chromosome 10 at 127,559,998 bp
  • A to G, chromosome 11 at 104,720,688 bp
  • A to G, chromosome 11 at 110,233,845 bp
  • G to T, chromosome 11 at 118,443,757 bp
  • A to G, chromosome 12 at 78,412,354 bp
  • A to C, chromosome 12 at 83,555,614 bp
  • A to T, chromosome 12 at 84,387,067 bp
  • T to C, chromosome 13 at 28,952,144 bp
  • T to C, chromosome 13 at 44,884,882 bp
  • T to C, chromosome 13 at 55,420,727 bp
  • A to G, chromosome 13 at 113,172,893 bp
  • T to A, chromosome 14 at 75,742,344 bp
  • T to C, chromosome 15 at 44,564,431 bp
  • A to G, chromosome 15 at 97,712,992 bp
  • T to C, chromosome 16 at 18,219,002 bp
  • A to G, chromosome 16 at 22,932,295 bp
  • T to C, chromosome 16 at 55,927,744 bp
  • T to C, chromosome 17 at 32,143,428 bp
  • G to A, chromosome 17 at 67,791,223 bp
  • A to G, chromosome 19 at 41,113,059 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1896 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039916-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.