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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR1909Btlr/Mmmh
Stock Number:
039928-MU
Citation ID:
RRID:MMRRC_039928-MU
Other Names:
R1909 (G1), C57BL/6J-MtgxR1909Btlr
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Sod2
Name: superoxide dismutase 2, mitochondrial
Synonyms: MnSOD, manganese SOD, manganese superoxide dismutase, Sod-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20656
VEGA: 17
Homologene: 530

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Gdf6
Name: growth differentiation factor 6
Synonyms: BMP13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242316
HGNC: HGNC:4221
Homologene: 40883

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Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351

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Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514

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Arid5b
Name: AT-rich interaction domain 5B
Synonyms: 5430435G07Rik, Desrt, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872

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Gene Ontology
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Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
Synonyms: Nur77, TIS1, TR3, N10, NP10, GFRP1, NGFI-B, Hbr-1, Gfrp, Hbr1, Hmr
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15370
VEGA: 15
HGNC: HGNC:7980
Homologene: 1612

Additional Resources
IMPC
Google
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Gene Ontology
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Dennd2b
Name: DENN domain containing 2B
Synonyms: 2610305K15Rik, 2010004M01Rik, St5, Denn2b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76954
Homologene: 3951

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 40,474,914 bp
  • C to T, chromosome 1 at 45,823,403 bp
  • G to T, chromosome 1 at 63,177,272 bp
  • A to G, chromosome 1 at 95,627,573 bp
  • T to C, chromosome 1 at 179,622,791 bp
  • T to A, chromosome 2 at 24,997,288 bp
  • T to C, chromosome 2 at 29,163,009 bp
  • C to G, chromosome 2 at 35,718,815 bp
  • G to C, chromosome 2 at 51,925,434 bp
  • T to C, chromosome 2 at 66,331,352 bp
  • T to A, chromosome 2 at 91,498,408 bp
  • T to A, chromosome 2 at 111,538,014 bp
  • T to A, chromosome 2 at 119,926,594 bp
  • C to T, chromosome 2 at 130,532,081 bp
  • G to T, chromosome 2 at 158,444,675 bp
  • T to C, chromosome 3 at 88,984,528 bp
  • C to A, chromosome 3 at 89,345,330 bp
  • T to C, chromosome 4 at 9,859,971 bp
  • T to A, chromosome 4 at 21,869,517 bp
  • CGGAGGAGGAGGAGGAG to CGGAGGAGGAGGAG, chromosome 4 at 32,760,839 bp
  • A to C, chromosome 4 at 34,722,714 bp
  • C to A, chromosome 4 at 126,312,133 bp
  • T to C, chromosome 4 at 126,346,737 bp
  • T to C, chromosome 4 at 133,693,761 bp
  • T to C, chromosome 4 at 154,152,782 bp
  • G to T, chromosome 5 at 4,757,481 bp
  • A to T, chromosome 5 at 36,614,058 bp
  • A to G, chromosome 5 at 109,363,987 bp
  • T to C, chromosome 5 at 111,284,054 bp
  • T to A, chromosome 5 at 131,111,838 bp
  • C to T, chromosome 5 at 135,152,991 bp
  • T to C, chromosome 5 at 139,546,630 bp
  • T to C, chromosome 5 at 140,432,937 bp
  • G to T, chromosome 5 at 140,752,461 bp
  • T to C, chromosome 5 at 143,985,491 bp
  • T to G, chromosome 6 at 65,703,313 bp
  • T to A, chromosome 6 at 71,239,579 bp
  • A to G, chromosome 6 at 92,793,474 bp
  • T to C, chromosome 6 at 141,250,239 bp
  • A to T, chromosome 6 at 146,810,810 bp
  • T to C, chromosome 6 at 148,444,048 bp
  • A to T, chromosome 7 at 3,714,588 bp
  • A to T, chromosome 7 at 3,822,919 bp
  • T to C, chromosome 7 at 24,862,306 bp
  • T to C, chromosome 7 at 28,144,348 bp
  • T to A, chromosome 7 at 34,258,036 bp
  • A to T, chromosome 7 at 42,819,928 bp
  • T to C, chromosome 7 at 46,020,134 bp
  • A to T, chromosome 7 at 58,828,712 bp
  • T to C, chromosome 7 at 80,386,861 bp
  • T to C, chromosome 7 at 80,743,828 bp
  • T to A, chromosome 7 at 81,142,035 bp
  • T to A, chromosome 7 at 85,234,052 bp
  • A to G, chromosome 7 at 103,597,343 bp
  • G to A, chromosome 7 at 103,979,790 bp
  • T to C, chromosome 7 at 106,752,995 bp
  • G to A, chromosome 7 at 109,525,326 bp
  • A to G, chromosome 7 at 118,154,199 bp
  • T to C, chromosome 7 at 140,345,465 bp
  • C to A, chromosome 7 at 142,968,163 bp
  • A to T, chromosome 8 at 15,906,116 bp
  • T to C, chromosome 8 at 46,209,400 bp
  • G to C, chromosome 8 at 83,316,369 bp
  • T to G, chromosome 8 at 110,587,772 bp
  • A to G, chromosome 8 at 123,080,741 bp
  • T to A, chromosome 8 at 125,939,954 bp
  • T to C, chromosome 9 at 15,998,115 bp
  • A to T, chromosome 9 at 80,113,774 bp
  • A to T, chromosome 9 at 121,982,191 bp
  • A to T, chromosome 10 at 30,689,800 bp
  • A to T, chromosome 10 at 68,101,885 bp
  • A to G, chromosome 10 at 76,563,917 bp
  • A to T, chromosome 10 at 89,640,905 bp
  • A to T, chromosome 10 at 122,452,208 bp
  • G to A, chromosome 11 at 6,274,694 bp
  • T to A, chromosome 11 at 40,708,098 bp
  • A to G, chromosome 11 at 70,989,107 bp
  • TC to T, chromosome 11 at 77,786,002 bp
  • A to T, chromosome 11 at 78,400,142 bp
  • A to C, chromosome 11 at 82,926,087 bp
  • G to A, chromosome 11 at 83,003,621 bp
  • G to T, chromosome 11 at 87,080,613 bp
  • G to T, chromosome 11 at 97,021,508 bp
  • A to C, chromosome 11 at 101,410,231 bp
  • G to A, chromosome 11 at 102,882,566 bp
  • A to T, chromosome 11 at 107,939,612 bp
  • A to T, chromosome 11 at 113,703,378 bp
  • A to G, chromosome 11 at 116,070,295 bp
  • A to G, chromosome 11 at 116,145,992 bp
  • A to C, chromosome 11 at 120,723,337 bp
  • G to T, chromosome 12 at 3,474,577 bp
  • C to T, chromosome 12 at 17,424,640 bp
  • C to G, chromosome 12 at 75,469,567 bp
  • T to C, chromosome 12 at 103,409,982 bp
  • G to A, chromosome 12 at 110,662,629 bp
  • A to T, chromosome 13 at 9,533,350 bp
  • A to T, chromosome 13 at 11,700,349 bp
  • A to T, chromosome 13 at 42,155,646 bp
  • T to A, chromosome 13 at 43,668,423 bp
  • A to T, chromosome 13 at 55,060,357 bp
  • A to T, chromosome 13 at 55,524,588 bp
  • A to C, chromosome 13 at 59,702,695 bp
  • T to C, chromosome 13 at 77,825,309 bp
  • A to T, chromosome 13 at 108,175,566 bp
  • T to A, chromosome 14 at 34,691,912 bp
  • A to T, chromosome 14 at 59,258,613 bp
  • A to T, chromosome 14 at 68,647,659 bp
  • C to T, chromosome 14 at 97,901,393 bp
  • T to A, chromosome 15 at 101,274,227 bp
  • A to G, chromosome 16 at 20,376,509 bp
  • T to C, chromosome 16 at 91,044,305 bp
  • T to C, chromosome 17 at 6,957,646 bp
  • T to C, chromosome 17 at 13,015,169 bp
  • C to T, chromosome 17 at 78,313,127 bp
  • A to T, chromosome 17 at 78,934,907 bp
  • T to C, chromosome 18 at 12,581,798 bp
  • T to A, chromosome 18 at 33,158,816 bp
  • A to G, chromosome 18 at 37,355,962 bp
  • T to A, chromosome 18 at 77,959,032 bp
  • A to G, chromosome 19 at 6,069,469 bp
  • A to T, chromosome 19 at 17,433,461 bp
  • C to A, chromosome 19 at 44,997,622 bp
  • A to T, chromosome 19 at 56,793,361 bp
  • A to G, chromosome X at 64,272,623 bp
  • T to C, chromosome X at 164,239,415 bp
Genotype Determination

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1909 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
039928-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.