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Strain Name:
C57BL/6J-MtgxR1918Btlr/Mmmh
Stock Number:
039936-MU
Citation ID:
RRID:MMRRC_039936-MU
Other Names:
R1918 (G1), C57BL/6J-MtgxR1918Btlr
Major Collection:

Strain Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, TonEBP, B130038B15Rik, OREBP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: PSGAP-s, PSGAP-m, A930033B01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Cd36
Name: CD36 molecule
Synonyms: FAT, fatty acid translocase, Scarb3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12491
HGNC: HGNC:1663
Homologene: 73871
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Mthfd1
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
Synonyms: Mthfd, DCS, E430024A07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108156
VEGA: 12
HGNC: HGNC:7432
Homologene: 55940
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 9,601,627 bp
  • C to T, chromosome 1 at 10,199,878 bp
  • A to C, chromosome 1 at 57,959,220 bp
  • G to A, chromosome 2 at 36,057,006 bp
  • T to G, chromosome 2 at 58,982,899 bp
  • A to G, chromosome 2 at 76,741,401 bp
  • G to T, chromosome 2 at 76,808,524 bp
  • C to T, chromosome 2 at 77,014,703 bp
  • C to T, chromosome 2 at 86,806,827 bp
  • T to C, chromosome 2 at 90,002,574 bp
  • G to A, chromosome 2 at 118,791,927 bp
  • A to T, chromosome 2 at 149,407,407 bp
  • T to C, chromosome 2 at 167,424,214 bp
  • A to G, chromosome 2 at 172,427,339 bp
  • T to G, chromosome 3 at 27,183,175 bp
  • T to A, chromosome 3 at 81,958,940 bp
  • A to T, chromosome 3 at 101,056,307 bp
  • C to T, chromosome 3 at 108,398,650 bp
  • A to C, chromosome 4 at 11,601,693 bp
  • T to C, chromosome 4 at 22,487,119 bp
  • T to C, chromosome 4 at 42,938,165 bp
  • A to G, chromosome 4 at 73,744,114 bp
  • A to G, chromosome 4 at 101,772,836 bp
  • T to C, chromosome 4 at 104,995,686 bp
  • C to T, chromosome 4 at 117,000,343 bp
  • A to T, chromosome 4 at 130,211,393 bp
  • T to C, chromosome 4 at 138,314,020 bp
  • T to C, chromosome 4 at 140,996,371 bp
  • A to T, chromosome 5 at 17,797,036 bp
  • T to A, chromosome 5 at 28,387,917 bp
  • C to T, chromosome 5 at 29,587,317 bp
  • G to T, chromosome 5 at 32,684,735 bp
  • C to A, chromosome 5 at 43,689,061 bp
  • T to C, chromosome 5 at 61,810,321 bp
  • G to A, chromosome 5 at 114,923,469 bp
  • T to C, chromosome 5 at 138,278,379 bp
  • T to C, chromosome 6 at 121,644,936 bp
  • T to A, chromosome 6 at 142,697,682 bp
  • A to T, chromosome 7 at 10,047,683 bp
  • T to A, chromosome 7 at 16,833,921 bp
  • C to T, chromosome 7 at 19,585,263 bp
  • G to A, chromosome 7 at 27,337,569 bp
  • T to G, chromosome 7 at 29,574,089 bp
  • T to C, chromosome 7 at 34,971,676 bp
  • T to C, chromosome 7 at 37,480,199 bp
  • A to G, chromosome 7 at 45,517,941 bp
  • T to C, chromosome 7 at 58,827,935 bp
  • C to T, chromosome 7 at 78,906,029 bp
  • C to T, chromosome 7 at 81,037,420 bp
  • C to T, chromosome 7 at 104,860,746 bp
  • G to T, chromosome 7 at 118,433,985 bp
  • C to A, chromosome 7 at 127,612,000 bp
  • T to C, chromosome 7 at 128,663,969 bp
  • T to C, chromosome 7 at 141,361,724 bp
  • C to A, chromosome 8 at 69,228,705 bp
  • T to A, chromosome 8 at 70,813,680 bp
  • C to A, chromosome 8 at 70,868,944 bp
  • T to C, chromosome 8 at 77,259,079 bp
  • A to G, chromosome 8 at 83,729,109 bp
  • T to C, chromosome 8 at 107,366,236 bp
  • T to A, chromosome 8 at 119,876,724 bp
  • T to A, chromosome 9 at 15,076,818 bp
  • T to C, chromosome 9 at 20,889,952 bp
  • C to T, chromosome 9 at 21,393,714 bp
  • C to A, chromosome 9 at 32,396,738 bp
  • C to G, chromosome 9 at 46,221,089 bp
  • A to G, chromosome 9 at 58,026,757 bp
  • T to C, chromosome 9 at 66,476,126 bp
  • T to A, chromosome 9 at 95,985,169 bp
  • C to T, chromosome 9 at 108,107,573 bp
  • T to A, chromosome 9 at 108,412,985 bp
  • C to T, chromosome 9 at 112,119,178 bp
  • C to T, chromosome 9 at 120,951,034 bp
  • C to A, chromosome 10 at 9,812,298 bp
  • T to A, chromosome 10 at 75,976,346 bp
  • G to A, chromosome 10 at 77,715,987 bp
  • A to T, chromosome 10 at 78,001,426 bp
  • C to T, chromosome 10 at 93,496,607 bp
  • T to A, chromosome 10 at 112,092,645 bp
  • T to A, chromosome 10 at 129,527,049 bp
  • A to G, chromosome 11 at 29,824,039 bp
  • A to T, chromosome 11 at 30,142,414 bp
  • A to G, chromosome 11 at 46,528,531 bp
  • C to T, chromosome 11 at 54,480,684 bp
  • A to G, chromosome 11 at 76,261,672 bp
  • A to G, chromosome 11 at 78,304,176 bp
  • A to G, chromosome 11 at 102,054,110 bp
  • A to T, chromosome 11 at 104,298,499 bp
  • G to T, chromosome 12 at 76,314,976 bp
  • A to T, chromosome 12 at 76,349,301 bp
  • G to T, chromosome 12 at 77,332,218 bp
  • A to T, chromosome 12 at 81,314,844 bp
  • A to G, chromosome 12 at 111,834,810 bp
  • A to C, chromosome 12 at 116,232,601 bp
  • T to A, chromosome 13 at 11,556,698 bp
  • G to A, chromosome 13 at 12,500,618 bp
  • A to T, chromosome 13 at 32,724,853 bp
  • A to G, chromosome 13 at 32,978,240 bp
  • T to C, chromosome 13 at 36,204,546 bp
  • T to C, chromosome 13 at 120,308,222 bp
  • T to C, chromosome 14 at 12,546,372 bp
  • G to T, chromosome 14 at 119,008,055 bp
  • G to A, chromosome 15 at 75,777,118 bp
  • T to C, chromosome 15 at 80,264,079 bp
  • C to T, chromosome 15 at 91,191,481 bp
  • A to T, chromosome 16 at 19,286,302 bp
  • A to G, chromosome 16 at 38,828,088 bp
  • G to A, chromosome 16 at 66,747,384 bp
  • T to C, chromosome 17 at 20,687,580 bp
  • T to A, chromosome 17 at 21,262,397 bp
  • A to G, chromosome 17 at 24,721,723 bp
  • T to C, chromosome 17 at 29,679,009 bp
  • G to A, chromosome 17 at 30,984,043 bp
  • G to A, chromosome 17 at 35,670,198 bp
  • A to G, chromosome 17 at 71,407,237 bp
  • T to C, chromosome 17 at 84,186,736 bp
  • T to C, chromosome 18 at 4,674,292 bp
  • T to A, chromosome 18 at 10,740,972 bp
  • T to C, chromosome 18 at 38,333,190 bp
  • T to C, chromosome 18 at 76,859,356 bp
  • C to T, chromosome 19 at 8,217,759 bp
  • A to G, chromosome 19 at 12,109,507 bp
  • A to G, chromosome 19 at 12,900,851 bp
  • A to T, chromosome 19 at 39,609,273 bp
  • A to G, chromosome 19 at 44,571,112 bp
  • C to T, chromosome 19 at 56,908,934 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1918 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039936-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.