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Strain Name:
C57BL/6J-MtgxR1926Btlr/Mmmh
Stock Number:
039944-MU
Citation ID:
RRID:MMRRC_039944-MU
Other Names:
R1926 (G1), C57BL/6J-MtgxR1926Btlr
Major Collection:

Strain Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Ly6k
Name: lymphocyte antigen 6 family member K
Synonyms: 3110035B01Rik, 2410015A16Rik, mLy-6K
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76486
Homologene: 130772
Lhx3
Name: LIM homeobox protein 3
Synonyms: P-LIM, mLim-3, Lim3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16871
HGNC: HGNC:6595
Homologene: 7814
Lefty1
Name: left right determination factor 1
Synonyms: lefty-1, Stra3, Lefty, Ebaf
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13590
HGNC: HGNC:6552
Homologene: 49231
Rarg
Name: retinoic acid receptor, gamma
Synonyms: RARgamma2, RAR gamma 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19411
HGNC: HGNC:9866
Homologene: 20263
Map1b
Name: microtubule-associated protein 1B
Synonyms: MAP5, Mtap-5, Mtap5, LC1, Mtap1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Zfp207
Name: zinc finger protein 207
Synonyms: Zep, 8430401D15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22680
Homologene: 134624
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 6,802,689 bp
  • A to G, chromosome 1 at 84,749,291 bp
  • A to G, chromosome 1 at 92,511,608 bp
  • A to T, chromosome 1 at 131,212,339 bp
  • A to T, chromosome 1 at 135,385,919 bp
  • A to T, chromosome 1 at 135,607,520 bp
  • G to A, chromosome 1 at 135,877,673 bp
  • T to C, chromosome 1 at 150,100,228 bp
  • A to G, chromosome 1 at 164,179,508 bp
  • A to T, chromosome 1 at 180,936,543 bp
  • G to A, chromosome 1 at 194,762,450 bp
  • A to G, chromosome 2 at 18,682,273 bp
  • A to T, chromosome 2 at 26,202,188 bp
  • T to C, chromosome 2 at 26,481,657 bp
  • T to A, chromosome 2 at 33,564,662 bp
  • A to T, chromosome 2 at 52,279,635 bp
  • T to C, chromosome 2 at 80,506,838 bp
  • A to G, chromosome 2 at 102,640,997 bp
  • T to A, chromosome 2 at 125,740,677 bp
  • G to A, chromosome 2 at 128,997,795 bp
  • T to C, chromosome 2 at 154,013,749 bp
  • A to T, chromosome 3 at 51,407,395 bp
  • G to A, chromosome 3 at 65,376,512 bp
  • T to C, chromosome 3 at 68,916,165 bp
  • A to G, chromosome 3 at 88,652,352 bp
  • G to A, chromosome 3 at 95,243,043 bp
  • A to G, chromosome 4 at 48,658,788 bp
  • A to T, chromosome 5 at 9,504,881 bp
  • T to A, chromosome 5 at 30,180,937 bp
  • A to G, chromosome 5 at 90,244,169 bp
  • A to G, chromosome 5 at 92,585,385 bp
  • A to G, chromosome 5 at 92,650,788 bp
  • T to C, chromosome 5 at 120,879,142 bp
  • T to C, chromosome 5 at 121,796,367 bp
  • A to T, chromosome 5 at 134,706,567 bp
  • G to T, chromosome 5 at 138,101,363 bp
  • T to C, chromosome 5 at 148,348,303 bp
  • T to G, chromosome 6 at 42,838,313 bp
  • T to C, chromosome 6 at 53,068,531 bp
  • C to T, chromosome 6 at 149,329,404 bp
  • T to A, chromosome 7 at 23,809,041 bp
  • G to A, chromosome 7 at 24,714,116 bp
  • T to C, chromosome 7 at 36,769,375 bp
  • T to C, chromosome 7 at 59,276,379 bp
  • C to T, chromosome 7 at 119,777,136 bp
  • T to A, chromosome 7 at 127,915,295 bp
  • A to G, chromosome 8 at 69,815,520 bp
  • A to G, chromosome 8 at 93,127,604 bp
  • T to C, chromosome 8 at 105,017,960 bp
  • C to T, chromosome 9 at 24,473,824 bp
  • T to C, chromosome 9 at 26,771,066 bp
  • A to T, chromosome 9 at 26,794,869 bp
  • C to A, chromosome 9 at 86,523,019 bp
  • C to T, chromosome 10 at 10,431,276 bp
  • T to C, chromosome 10 at 22,665,242 bp
  • T to C, chromosome 10 at 80,151,661 bp
  • T to C, chromosome 10 at 80,186,876 bp
  • C to T, chromosome 10 at 93,707,353 bp
  • T to A, chromosome 10 at 116,048,095 bp
  • T to A, chromosome 11 at 55,170,085 bp
  • T to C, chromosome 11 at 59,063,474 bp
  • A to T, chromosome 11 at 70,640,889 bp
  • T to A, chromosome 11 at 80,395,427 bp
  • C to A, chromosome 11 at 86,289,073 bp
  • G to C, chromosome 11 at 98,425,164 bp
  • A to G, chromosome 11 at 100,351,407 bp
  • A to T, chromosome 11 at 115,326,955 bp
  • T to C, chromosome 11 at 115,792,900 bp
  • T to C, chromosome 11 at 116,010,247 bp
  • A to T, chromosome 12 at 28,864,837 bp
  • G to T, chromosome 12 at 55,863,161 bp
  • A to T, chromosome 12 at 69,582,745 bp
  • A to T, chromosome 12 at 100,867,155 bp
  • G to A, chromosome 12 at 118,849,229 bp
  • A to G, chromosome 13 at 21,396,446 bp
  • T to C, chromosome 13 at 33,150,235 bp
  • A to G, chromosome 13 at 67,619,557 bp
  • A to T, chromosome 13 at 99,430,692 bp
  • A to G, chromosome 14 at 44,002,238 bp
  • A to G, chromosome 14 at 56,130,280 bp
  • T to C, chromosome 14 at 75,242,397 bp
  • T to A, chromosome 14 at 79,020,635 bp
  • G to T, chromosome 15 at 74,797,202 bp
  • G to T, chromosome 15 at 80,881,162 bp
  • A to G, chromosome 15 at 102,239,545 bp
  • G to T, chromosome 16 at 16,763,057 bp
  • A to T, chromosome 16 at 17,575,704 bp
  • A to G, chromosome 16 at 20,214,426 bp
  • A to G, chromosome 16 at 38,499,097 bp
  • C to T, chromosome 17 at 25,992,678 bp
  • A to G, chromosome 17 at 87,986,225 bp
  • A to G, chromosome 18 at 32,203,110 bp
  • G to A, chromosome 18 at 67,401,321 bp
  • C to T, chromosome 19 at 3,902,843 bp
  • T to C, chromosome 19 at 4,004,180 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1926 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039944-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.