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Strain Name:
C57BL/6J-MtgxR1959Btlr/Mmmh
Stock Number:
039973-MU
Citation ID:
RRID:MMRRC_039973-MU
Other Names:
R1959 (G1), C57BL/6J-MtgxR1959Btlr
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Btrc
Name: beta-transducin repeat containing protein
Synonyms: SCF b-TRCP, beta-TrCP, Slimb, Beta-Trcp1, Fbw1a
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12234
VEGA: 19
HGNC: HGNC:1144
Homologene: 39330
Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: PSGAP-s, PSGAP-m, A930033B01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Galnt10
Name: polypeptide N-acetylgalactosaminyltransferase 10
Synonyms: GalNAc-T10, Galnt9, C330012K04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171212
Homologene: 14924
Emx1
Name: empty spiracles homeobox 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13796
HGNC: HGNC:3340
Homologene: 55799
Dnajc24
Name: DnaJ heat shock protein family (Hsp40) member C24
Synonyms: MmDjC7, 2610027M02Rik, 1700030A21Rik, Zcsl3, Dph4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99349
Homologene: 41704
Ift70b
Name: intraflagellar transport 70B
Synonyms: 2510042P03Rik, Ttc30b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72421
Homologene: 71716
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 13,160,252 bp
  • A to G, chromosome 1 at 53,684,983 bp
  • A to T, chromosome 1 at 58,659,278 bp
  • C to A, chromosome 1 at 87,929,827 bp
  • T to C, chromosome 1 at 118,669,389 bp
  • A to G, chromosome 1 at 132,117,821 bp
  • T to C, chromosome 1 at 150,649,676 bp
  • A to G, chromosome 1 at 166,295,738 bp
  • A to T, chromosome 1 at 174,430,905 bp
  • G to A, chromosome 2 at 4,535,186 bp
  • A to T, chromosome 2 at 18,673,963 bp
  • A to G, chromosome 2 at 24,003,882 bp
  • C to A, chromosome 2 at 25,794,413 bp
  • T to A, chromosome 2 at 26,354,873 bp
  • A to T, chromosome 2 at 26,430,132 bp
  • C to T, chromosome 2 at 75,937,099 bp
  • T to C, chromosome 2 at 76,750,623 bp
  • A to G, chromosome 2 at 82,991,550 bp
  • T to C, chromosome 2 at 85,430,619 bp
  • T to C, chromosome 2 at 88,340,201 bp
  • T to G, chromosome 2 at 93,563,943 bp
  • T to C, chromosome 2 at 102,450,807 bp
  • A to G, chromosome 2 at 106,001,923 bp
  • T to C, chromosome 2 at 126,777,961 bp
  • C to A, chromosome 2 at 128,633,415 bp
  • T to A, chromosome 2 at 128,759,090 bp
  • C to A, chromosome 2 at 131,520,464 bp
  • C to T, chromosome 2 at 164,894,802 bp
  • A to T, chromosome 2 at 167,050,350 bp
  • A to T, chromosome 2 at 180,326,936 bp
  • T to A, chromosome 3 at 24,333,330 bp
  • T to C, chromosome 3 at 62,479,385 bp
  • T to C, chromosome 3 at 87,376,520 bp
  • A to G, chromosome 3 at 90,268,773 bp
  • A to G, chromosome 3 at 116,927,444 bp
  • C to T, chromosome 4 at 34,771,316 bp
  • T to C, chromosome 4 at 40,167,193 bp
  • T to G, chromosome 4 at 46,606,419 bp
  • T to A, chromosome 4 at 131,803,477 bp
  • C to T, chromosome 4 at 137,564,895 bp
  • A to T, chromosome 4 at 139,349,638 bp
  • T to G, chromosome 4 at 150,468,790 bp
  • A to G, chromosome 4 at 152,012,288 bp
  • A to G, chromosome 5 at 117,376,610 bp
  • A to T, chromosome 5 at 122,241,840 bp
  • A to T, chromosome 5 at 124,315,701 bp
  • A to G, chromosome 5 at 139,273,341 bp
  • T to A, chromosome 6 at 8,215,437 bp
  • C to A, chromosome 6 at 35,233,366 bp
  • T to C, chromosome 6 at 61,313,646 bp
  • G to A, chromosome 6 at 85,203,934 bp
  • T to C, chromosome 6 at 86,096,756 bp
  • A to G, chromosome 6 at 96,165,269 bp
  • A to G, chromosome 6 at 117,871,817 bp
  • T to C, chromosome 6 at 119,969,247 bp
  • T to G, chromosome 6 at 128,820,271 bp
  • A to C, chromosome 6 at 129,350,481 bp
  • A to G, chromosome 6 at 143,874,105 bp
  • A to G, chromosome 6 at 148,199,354 bp
  • T to C, chromosome 7 at 5,327,738 bp
  • G to A, chromosome 7 at 27,329,018 bp
  • G to A, chromosome 7 at 28,698,372 bp
  • A to T, chromosome 7 at 38,723,066 bp
  • A to T, chromosome 7 at 44,325,377 bp
  • T to A, chromosome 7 at 64,230,230 bp
  • A to G, chromosome 7 at 78,843,443 bp
  • A to T, chromosome 7 at 86,616,431 bp
  • C to A, chromosome 7 at 101,373,015 bp
  • T to C, chromosome 7 at 106,741,394 bp
  • A to T, chromosome 7 at 107,128,510 bp
  • A to G, chromosome 7 at 111,077,085 bp
  • GAGAAGAAGAAGAAGAAGAAGA to GAGAAGAAGAAGAAGAAGA, chromosome 7 at 140,924,113 bp
  • T to C, chromosome 7 at 141,862,637 bp
  • A to T, chromosome 8 at 23,182,936 bp
  • A to T, chromosome 8 at 40,914,965 bp
  • A to G, chromosome 8 at 77,409,626 bp
  • A to T, chromosome 8 at 117,043,231 bp
  • T to A, chromosome 9 at 48,319,726 bp
  • A to T, chromosome 9 at 56,206,789 bp
  • A to C, chromosome 9 at 65,484,492 bp
  • G to A, chromosome 9 at 87,055,849 bp
  • G to A, chromosome 9 at 110,251,026 bp
  • A to T, chromosome 10 at 10,395,249 bp
  • G to A, chromosome 10 at 12,698,155 bp
  • A to T, chromosome 10 at 14,132,709 bp
  • A to T, chromosome 10 at 24,677,905 bp
  • G to T, chromosome 10 at 27,422,618 bp
  • A to G, chromosome 10 at 34,160,206 bp
  • T to C, chromosome 10 at 42,956,021 bp
  • T to C, chromosome 10 at 61,175,844 bp
  • A to T, chromosome 10 at 75,735,090 bp
  • T to C, chromosome 10 at 79,626,791 bp
  • C to T, chromosome 10 at 82,225,631 bp
  • T to A, chromosome 10 at 115,423,253 bp
  • A to T, chromosome 10 at 120,201,861 bp
  • C to T, chromosome 11 at 3,490,983 bp
  • T to A, chromosome 11 at 6,346,638 bp
  • T to C, chromosome 11 at 57,765,617 bp
  • T to C, chromosome 11 at 67,283,574 bp
  • C to T, chromosome 11 at 68,994,284 bp
  • A to G, chromosome 11 at 86,298,979 bp
  • T to C, chromosome 11 at 98,995,977 bp
  • A to G, chromosome 11 at 99,851,547 bp
  • A to T, chromosome 11 at 101,431,496 bp
  • T to A, chromosome 11 at 105,910,295 bp
  • A to G, chromosome 11 at 120,448,136 bp
  • A to T, chromosome 12 at 40,710,798 bp
  • G to A, chromosome 12 at 95,780,300 bp
  • G to A, chromosome 12 at 103,853,800 bp
  • A to G, chromosome 13 at 20,794,394 bp
  • T to C, chromosome 13 at 23,136,513 bp
  • T to G, chromosome 13 at 58,293,123 bp
  • T to C, chromosome 13 at 78,189,816 bp
  • A to G, chromosome 13 at 93,720,559 bp
  • C to T, chromosome 13 at 95,976,645 bp
  • C to T, chromosome 14 at 7,884,735 bp
  • T to C, chromosome 14 at 20,692,120 bp
  • A to G, chromosome 14 at 47,416,386 bp
  • C to A, chromosome 14 at 51,457,440 bp
  • T to A, chromosome 14 at 55,607,717 bp
  • A to G, chromosome 14 at 78,982,360 bp
  • T to A, chromosome 14 at 122,126,164 bp
  • G to C, chromosome 15 at 68,146,543 bp
  • G to A, chromosome 15 at 76,297,464 bp
  • T to C, chromosome 15 at 76,911,114 bp
  • A to G, chromosome 15 at 85,511,044 bp
  • G to A, chromosome 15 at 90,970,848 bp
  • T to C, chromosome 15 at 98,456,753 bp
  • T to C, chromosome 16 at 14,396,393 bp
  • T to C, chromosome 16 at 20,602,191 bp
  • T to A, chromosome 16 at 58,718,007 bp
  • A to G, chromosome 17 at 24,295,257 bp
  • C to A, chromosome 17 at 24,513,281 bp
  • T to G, chromosome 17 at 55,897,404 bp
  • A to G, chromosome 17 at 66,130,728 bp
  • T to C, chromosome 18 at 34,812,395 bp
  • T to A, chromosome 18 at 37,403,316 bp
  • T to A, chromosome 18 at 46,894,717 bp
  • A to T, chromosome 18 at 65,624,492 bp
  • C to A, chromosome 19 at 8,169,193 bp
  • G to A, chromosome 19 at 12,462,911 bp
  • T to G, chromosome 19 at 16,677,938 bp
  • T to C, chromosome 19 at 17,433,418 bp
  • T to A, chromosome 19 at 37,687,377 bp
  • T to G, chromosome 19 at 45,527,343 bp
  • A to T, chromosome 19 at 46,004,335 bp
  • T to C, chromosome X at 42,827,201 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1959 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039973-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.