Strain Name:
C57BL/6J-MtgxR1976Btlr/Mmmh
Stock Number:
039989-MU
Citation ID:
RRID:MMRRC_039989-MU
Other Names:
R1976 (G1), C57BL/6J-MtgxR1976Btlr
Major Collection:

Strain Information

Trp53
Name: transformation related protein 53
Synonyms: p44, p53
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22059
Homologene: 460
Gsr
Name: glutathione reductase
Synonyms: D8Ertd238e, Gr-1, Gr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14782
HGNC: HGNC:4623
Homologene: 531
Lefty1
Name: left right determination factor 1
Synonyms: Stra3, Lefty, Ebaf, lefty-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13590
Homologene: 49231
Mta1
Name: metastasis associated 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 116870
HGNC: HGNC:7410
Homologene: 3442
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Ltbp4
Name: latent transforming growth factor beta binding protein 4
Synonyms: 2310046A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108075
HGNC: HGNC:6717
Homologene: 2645
Micu1
Name: mitochondrial calcium uptake 1
Synonyms: Cbara1, C730016L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216001
HGNC: HGNC:1530
Homologene: 4431
Stk4
Name: serine/threonine kinase 4
Synonyms: sterile 20-like kinase 1, Kas-2, Mst1, Ysk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58231
Homologene: 55965
Enox1
Name: ecto-NOX disulfide-thiol exchanger 1
Synonyms: D230005D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239188
VEGA: 14
Homologene: 56793
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, Helic1, B630009I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 117599
Homologene: 50463
Pan2
Name: PAN2 poly(A) specific ribonuclease subunit
Synonyms: Usp52, 1200014O24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103135
VEGA: 10
Homologene: 5918
Tut4
Name: terminal uridylyl transferase 4
Synonyms: 9230115F04Rik, Zcchc11, 6030404K05Rik, Tent3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230594
Homologene: 35279
Kank2
Name: KN motif and ankyrin repeat domains 2
Synonyms: Ankrd25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235041
VEGA: 9
Homologene: 9163
Prim1
Name: DNA primase, p49 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19075
HGNC: HGNC:9369
Homologene: 730
Rab23
Name: RAB23, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19335
Homologene: 7503
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: 4432416O06Rik, m407Asp, D330044F14Rik, Dnchc2, DHC1b, b2b414Clo, m152Asp, D030010H02Rik, DHC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Itsn2
Name: intersectin 2
Synonyms: Sh3d1B, Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3p18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Dazap1
Name: DAZ associated protein 1
Synonyms: mPrrp, 2410042M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70248
HGNC: HGNC:2683
Homologene: 134440
Dhtkd1
Name: dehydrogenase E1 and transketolase domain containing 1
Synonyms: C330018I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209692
Homologene: 10278
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237553
Homologene: 75007
Adgrd1
Name: adhesion G protein-coupled receptor D1
Synonyms: Gpr133, E230012M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243277
Homologene: 34616
Scn1a
Name: sodium channel, voltage-gated, type I, alpha
Synonyms: Nav1.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20265
Homologene: 21375
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
1700086L19Rik
Name: RIKEN cDNA 1700086L19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74284
Sall3
Name: spalt like transcription factor 3
Synonyms: B130022O04Rik, Msal, Salt, Spalt, Msal-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20689
VEGA: 18
Homologene: 18142
Garre1
Name: granule associated Rac and RHOG effector 1
Synonyms: 4931406P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233103
Homologene: 8795
Stab2
Name: stabilin 2
Synonyms: FEEL-2, STAB-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
Lonp1
Name: lon peptidase 1, mitochondrial
Synonyms: Prss15, LON, 1200017E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 74142
VEGA: 17
HGNC: HGNC:9479
Homologene: 3521
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227334
Homologene: 32400
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Hltf
Name: helicase-like transcription factor
Synonyms: P113, Snf2l3, Smarca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20585
Homologene: 30136
Tas2r123
Name: taste receptor, type 2, member 123
Synonyms: STC 9-2, mt2r55, T2R23, Tas2r23, mGR23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353167
Homologene: 45450
Cd101
Name: CD101 antigen
Synonyms: Igsf2, LOC381460
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 630146
HGNC: HGNC:5949
Homologene: 3142
Sprr3
Name: small proline-rich protein 3
Synonyms: SPR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20766
Homologene: 135951
Glis3
Name: GLIS family zinc finger 3
Synonyms: E330013K21Rik, 4833409N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226075
Homologene: 34989
Abcb5
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50720
Bcl9l
Name: B cell CLL/lymphoma 9-like
Synonyms: DLNB11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 80288
VEGA: 9
Homologene: 65615
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75729
Homologene: 123434
Dennd4b
Name: DENN domain containing 4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229541
Homologene: 28281
Naalad2
Name: N-acetylated alpha-linked acidic dipeptidase 2
Synonyms: GCPIII, NAADALASE2, D9Ertd285e, NAALADASE2, GCP3, Folh1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72560
Homologene: 3294
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330222
Homologene: 27395
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Alppl2
Name: alkaline phosphatase, placental-like 2
Synonyms: Akp5, D1Ertd816e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11650
Homologene: 129600
Foxn1
Name: forkhead box N1
Synonyms: Hfh11, whn, D11Bhm185e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15218
Homologene: 2664
Cdadc1
Name: cytidine and dCMP deaminase domain containing 1
Synonyms: NYD-SP15, 2310010M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71891
VEGA: 14
Homologene: 12794
Ccdc33
Name: coiled-coil domain containing 33
Synonyms: 4930535E21Rik, LOC382077
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382077
Homologene: 19641
Hdac7
Name: histone deacetylase 7
Synonyms: 5830434K02Rik, Hdac7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56233
Homologene: 9124
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, EG383258, Vmn2r119
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 383258
Homologene: 129687
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329679
Homologene: 46417
Slc36a4
Name: solute carrier family 36 (proton/amino acid symporter), member 4
Synonyms: 6330573I15Rik, PAT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234967
Homologene: 56300
Vmn1r4
Name: vomeronasal 1 receptor 4
Synonyms: V1rc21, C230065D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171194
Homologene: 131060
Hlx
Name: H2.0-like homeobox
Synonyms: Hlx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15284
HGNC: HGNC:4978
Homologene: 7363
Gm4953
Name: predicted pseudogene 4953
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240853
Gm20671
Name: predicted gene 20671
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Lpcat2b
Name: lysophosphatidylcholine acyltransferase 2B
Synonyms: Aytl1b, 4921521K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70902
Homologene: 86793
Zfp786
Name: zinc finger protein 786
Synonyms: A730012O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330301
Homologene: 51849
Lsamp
Name: limbic system-associated membrane protein
Synonyms: D930023J12Rik, B130007O04Rik, Lam, Lamp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268890
HGNC: HGNC:6705
Homologene: 20533
Slc22a17
Name: solute carrier family 22 (organic cation transporter), member 17
Synonyms: 1700094C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 59049
VEGA: 14
Homologene: 10684
Tspan8
Name: tetraspanin 8
Synonyms: E330007O21Rik, Tm4sf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216350
VEGA: 10
Homologene: 20968
Habp4
Name: hyaluronic acid binding protein 4
Synonyms: 4933428J01Rik, 4933413D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56541
VEGA: 13
Homologene: 8615
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 33,723,938 bp
  • T to A, chromosome 1 at 87,088,741 bp
  • T to G, chromosome 1 at 87,978,536 bp
  • T to A, chromosome 1 at 159,168,353 bp
  • T to C, chromosome 1 at 180,937,824 bp
  • G to T, chromosome 1 at 184,731,987 bp
  • T to C, chromosome 2 at 5,902,391 bp
  • T to C, chromosome 2 at 66,331,271 bp
  • C to T, chromosome 2 at 164,100,528 bp
  • A to G, chromosome 3 at 20,106,446 bp
  • A to T, chromosome 3 at 79,480,931 bp
  • A to T, chromosome 3 at 90,273,055 bp
  • T to A, chromosome 3 at 92,456,946 bp
  • C to T, chromosome 3 at 96,651,738 bp
  • A to G, chromosome 3 at 101,008,061 bp
  • T to C, chromosome 4 at 108,479,523 bp
  • A to G, chromosome 5 at 32,738,865 bp
  • A to T, chromosome 5 at 107,433,850 bp
  • A to T, chromosome 5 at 129,140,797 bp
  • T to A, chromosome 5 at 142,143,818 bp
  • T to A, chromosome 6 at 47,819,757 bp
  • T to C, chromosome 6 at 56,956,738 bp
  • T to A, chromosome 6 at 132,847,332 bp
  • A to T, chromosome 7 at 27,326,770 bp
  • A to C, chromosome 7 at 34,257,380 bp
  • A to G, chromosome 7 at 104,860,320 bp
  • C to T, chromosome 7 at 141,863,154 bp
  • T to G, chromosome 8 at 33,680,260 bp
  • A to T, chromosome 9 at 7,129,045 bp
  • T to A, chromosome 9 at 15,734,210 bp
  • T to C, chromosome 9 at 18,378,699 bp
  • A to T, chromosome 9 at 21,794,561 bp
  • T to A, chromosome 9 at 44,506,152 bp
  • A to T, chromosome 9 at 58,117,162 bp
  • T to A, chromosome 10 at 50,649,166 bp
  • T to C, chromosome 10 at 59,768,213 bp
  • T to A, chromosome 10 at 80,274,620 bp
  • A to C, chromosome 10 at 86,896,496 bp
  • T to G, chromosome 10 at 114,588,431 bp
  • A to G, chromosome 10 at 115,844,130 bp
  • T to C, chromosome 10 at 120,094,263 bp
  • T to A, chromosome 10 at 128,023,799 bp
  • T to C, chromosome 10 at 128,320,413 bp
  • T to C, chromosome 11 at 9,397,815 bp
  • C to T, chromosome 11 at 69,588,497 bp
  • T to C, chromosome 11 at 78,365,937 bp
  • A to G, chromosome 12 at 4,672,733 bp
  • T to A, chromosome 12 at 74,295,861 bp
  • A to G, chromosome 12 at 113,136,306 bp
  • T to C, chromosome 12 at 118,890,682 bp
  • G to T, chromosome 13 at 64,184,606 bp
  • A to T, chromosome 14 at 54,908,500 bp
  • A to T, chromosome 14 at 59,573,768 bp
  • A to G, chromosome 14 at 61,202,895 bp
  • T to A, chromosome 14 at 77,668,793 bp
  • T to A, chromosome 15 at 8,135,827 bp
  • T to C, chromosome 15 at 79,626,276 bp
  • G to A, chromosome 15 at 97,806,505 bp
  • T to C, chromosome 16 at 41,889,067 bp
  • C to T, chromosome 17 at 55,592,925 bp
  • T to C, chromosome 17 at 56,615,068 bp
  • T to C, chromosome 18 at 80,971,893 bp
  • T to C, chromosome 19 at 28,262,677 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1976 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039989-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.