Strain Name:
C57BL/6J-MtgxR2033Btlr/Mmmh
Stock Number:
040040-MU
Citation ID:
RRID:MMRRC_040040-MU
Other Names:
R2033 (G1), C57BL/6J-MtgxR2033Btlr
Major Collection:

Gene Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: Gsfsco5, Dominant white spotting, Tr-kit, belly-spot, Steel Factor Receptor, c-KIT, Gsfsow3, Gsfsco1, CD117, SOW3, SCO5, SCO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21366
Homologene: 2291
Gldc
Name: glycine decarboxylase
Synonyms: D030049L12Rik, b2b2679Clo, D19Wsu57e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104174
VEGA: 19
HGNC: HGNC:4313
Homologene: 141
Ppp1r14c
Name: protein phosphatase 1, regulatory inhibitor subunit 14C
Synonyms: 6330514J04Rik, KEPI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76142
VEGA: 10
Homologene: 12805
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269400
Homologene: 13168
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: XRCC7, DNA-PK, DOXNPH, slip, dxnph, DNAPDcs, DNA-PKcs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Rfesd
Name: Rieske (Fe-S) domain containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218341
VEGA: 13
Homologene: 18282
Stk17b
Name: serine/threonine kinase 17b (apoptosis-inducing)
Synonyms: Drak2, 3110009A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98267
Homologene: 31231
Gars
Name: glycyl-tRNA synthetase
Synonyms: Gena201, GENA202, Sgrp23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353172
HGNC: HGNC:4162
Homologene: 1547
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 360013
Homologene: 7977
Lonp2
Name: lon peptidase 2, peroxisomal
Synonyms: 1300002A08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66887
Homologene: 12050
Atp6v1c1
Name: ATPase, H+ transporting, lysosomal V1 subunit C1
Synonyms: 1700025B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66335
VEGA: 15
HGNC: HGNC:856
Homologene: 1281
Car12
Name: carbonic anhydrase 12
Synonyms: 2310047E01Rik, CA XII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76459
HGNC: HGNC:1371
Homologene: 20327
Nrros
Name: negative regulator of reactive oxygen species
Synonyms: E430025L02Rik, Lrrc33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224109
Homologene: 17134
Siah1a
Name: siah E3 ubiquitin protein ligase 1A
Synonyms: Sinh1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20437
Homologene: 20654
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Gpr155
Name: G protein-coupled receptor 155
Synonyms: PGR22, F730029F15Rik, 1110017O10Rik, DEPDC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68526
Homologene: 16584
Pde4b
Name: phosphodiesterase 4B, cAMP specific
Synonyms: dunce, Dpde4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18578
HGNC: HGNC:8781
Homologene: 1953
Nphs2
Name: nephrosis 2, podocin
Synonyms: podocin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 170484
Homologene: 22826
Trpc1
Name: transient receptor potential cation channel, subfamily C, member 1
Synonyms: Trp1, Trrp1, Mtrp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22063
Homologene: 2478
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: tumstatin, alpha3(IV)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alpha cardiac MHC, alphaMHC, alpha myosin, Myhca, cardiomyopathy, hypertrophic 1, Myhc-a, alpha-MHC, A830009F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Ptp4a3
Name: protein tyrosine phosphatase 4a3
Synonyms: Prl-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19245
VEGA: 15
HGNC: HGNC:9636
Homologene: 22500
Ttll7
Name: tubulin tyrosine ligase-like family, member 7
Synonyms: 1110049N09Rik, 4921517B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70892
Homologene: 41578
Mybpc3
Name: myosin binding protein C, cardiac
Synonyms: cardiac C-protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17868
HGNC: HGNC:7551
Homologene: 215
Galnt11
Name: polypeptide N-acetylgalactosaminyltransferase 11
Synonyms: A430075I06Rik, E430002F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231050
Homologene: 11126
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: MINK, Misshapen/NIKs-related kinase, Ysk2, Map4k6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 50932
Homologene: 56762
Eln
Name: elastin
Synonyms: E030024M20Rik, tropoelastin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13717
HGNC: HGNC:3327
Npsr1
Name: neuropeptide S receptor 1
Synonyms: VRR1, Gpr154, 9330128H10Rik, PGR14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319239
Homologene: 45515
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71947
Homologene: 8831
Elfn2
Name: leucine rich repeat and fibronectin type III, extracellular 2
Synonyms: Lrrc62
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207393
VEGA: 15
Homologene: 18835
Olfr1224-ps1
Name: olfactory receptor 1224, pseudogene 1
Synonyms: GA_x6K02T2Q125-50635980-50635046, MOR233-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258026
Pcnx
Name: pecanex homolog
Synonyms: 2900024E21Rik, 3526401J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Vmn2r83
Name: vomeronasal 2, receptor 83
Synonyms: EG625029
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625029
Homologene: 83669
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: 4732433M03Rik, CPSase I, CPS, D1Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Pdzrn3
Name: PDZ domain containing RING finger 3
Synonyms: LNX3, semaphorin cytoplasmic domain-associated protein 3A, 1110020C07Rik, Semcap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 55983
Homologene: 10328
Olfr390
Name: olfactory receptor 390
Synonyms: GA_x6K02T2P1NL-3938806-3939741, MOR135-26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258344
Homologene: 115483
Sun1
Name: Sad1 and UNC84 domain containing 1
Synonyms: 4632417G13Rik, 5730434D03Rik, Unc84a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 77053
Homologene: 11544
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: B430315C20Rik, Hisppd2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 327655
Homologene: 49395
Taar5
Name: trace amine-associated receptor 5
Synonyms: LOC215854
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215854
Homologene: 20850
Vmn1r60
Name: vomeronasal 1 receptor 60
Synonyms: Gm7184
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 636697
Homologene: 41799
Isg20
Name: interferon-stimulated protein
Synonyms: 2010107M23Rik, 20kDa, DnaQl, 1600023I01Rik, HEM45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57444
HGNC: HGNC:6130
Homologene: 31081
Tubb2a
Name: tubulin, beta 2A class IIA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 22151
VEGA: 13
Homologene: 134314
Slc5a5
Name: solute carrier family 5 (sodium iodide symporter), member 5
Synonyms: NIS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 114479
Homologene: 37311
Ttbk2
Name: tau tubulin kinase 2
Synonyms: 2610507N02Rik, B930008N24Rik, TTK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 140810
Homologene: 62795
Smtn
Name: smoothelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 29856
Homologene: 8482
Ccrl2
Name: chemokine (C-C motif) receptor-like 2
Synonyms: Cmkbr1l2, CCR11, Ackr5, 1810047I05Rik, L-CCR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54199
HGNC: HGNC:1612
Homologene: 2948
Inpp1
Name: inositol polyphosphate-1-phosphatase
Synonyms: 2300002C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16329
HGNC: HGNC:6071
Homologene: 1655
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Tmem132b
Name: transmembrane protein 132B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208151
Homologene: 28135
Aadacl3
Name: arylacetamide deacetylase like 3
Synonyms: LOC230883
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230883
Homologene: 28426
Olfr572
Name: olfactory receptor 572
Synonyms: GA_x6K02T2PBJ9-5638785-5639741, MOR10-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259093
Homologene: 131142
Cyb5r2
Name: cytochrome b5 reductase 2
Synonyms: D630003K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320635
Homologene: 6182
Bpifc
Name: BPI fold containing family C
Synonyms: Bpil2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 270757
Homologene: 18383
AC147806.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Olfr557
Name: olfactory receptor 557
Synonyms: MOR18-3, GA_x6K02T2PBJ9-5414934-5415902
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258358
Homologene: 123803
Olfr147
Name: olfactory receptor 147
Synonyms: MOR164-1, M3, GA_x6K02T2PVTD-32098059-32099003
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258869
VEGA: 9
Homologene: 128279
Nudt18
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 213484
VEGA: 14
Homologene: 32604
Nkain1
Name: Na+/K+ transporting ATPase interacting 1
Synonyms: 2610200G18Rik, 2810426C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67149
Homologene: 11566
Gm15645
Name: predicted gene 15645
Synonyms: EG626055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 626055
Odam
Name: odontogenic, ameloblast asssociated
Synonyms: 2310011G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69592
Homologene: 49511
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 52,790,173 bp
  • A to G, chromosome 1 at 53,761,076 bp
  • A to G, chromosome 1 at 67,160,972 bp
  • T to G, chromosome 1 at 82,718,011 bp
  • CACAGA to CA, chromosome 1 at 85,577,154 bp
  • T to C, chromosome 1 at 156,323,738 bp
  • T to A, chromosome 2 at 73,348,182 bp
  • A to G, chromosome 2 at 89,157,154 bp
  • A to T, chromosome 2 at 91,123,032 bp
  • T to C, chromosome 2 at 120,806,849 bp
  • C to T, chromosome 2 at 121,337,627 bp
  • G to A, chromosome 2 at 155,970,892 bp
  • A to T, chromosome 2 at 181,351,863 bp
  • T to C, chromosome 3 at 146,944,234 bp
  • G to T, chromosome 4 at 102,605,295 bp
  • A to G, chromosome 4 at 130,537,246 bp
  • T to C, chromosome 4 at 144,456,383 bp
  • C to T, chromosome 5 at 25,247,538 bp
  • G to C, chromosome 5 at 75,637,317 bp
  • A to G, chromosome 5 at 87,892,419 bp
  • G to T, chromosome 5 at 125,749,289 bp
  • C to T, chromosome 5 at 134,710,106 bp
  • C to T, chromosome 5 at 139,225,438 bp
  • C to T, chromosome 6 at 55,077,723 bp
  • A to T, chromosome 6 at 91,724,910 bp
  • T to C, chromosome 6 at 101,150,954 bp
  • T to A, chromosome 7 at 5,544,820 bp
  • A to C, chromosome 7 at 78,916,533 bp
  • A to G, chromosome 7 at 102,699,162 bp
  • T to C, chromosome 7 at 102,928,408 bp
  • T to C, chromosome 7 at 105,765,548 bp
  • T to C, chromosome 7 at 107,756,907 bp
  • G to T, chromosome 8 at 70,888,587 bp
  • A to G, chromosome 8 at 86,708,942 bp
  • T to A, chromosome 8 at 86,725,270 bp
  • A to G, chromosome 9 at 24,313,352 bp
  • G to T, chromosome 9 at 38,403,373 bp
  • A to G, chromosome 9 at 66,717,558 bp
  • T to C, chromosome 9 at 95,706,843 bp
  • A to G, chromosome 9 at 111,055,870 bp
  • C to T, chromosome 10 at 3,366,979 bp
  • T to C, chromosome 10 at 23,971,094 bp
  • C to A, chromosome 10 at 28,592,767 bp
  • A to G, chromosome 10 at 79,491,819 bp
  • G to A, chromosome 10 at 86,000,632 bp
  • T to C, chromosome 11 at 3,517,781 bp
  • T to C, chromosome 11 at 70,612,508 bp
  • T to C, chromosome 11 at 73,787,438 bp
  • T to A, chromosome 11 at 77,843,099 bp
  • C to A, chromosome 11 at 115,794,328 bp
  • T to C, chromosome 12 at 81,967,160 bp
  • T to C, chromosome 12 at 98,791,386 bp
  • A to T, chromosome 13 at 34,075,456 bp
  • C to A, chromosome 13 at 76,002,872 bp
  • A to C, chromosome 14 at 54,963,645 bp
  • G to T, chromosome 14 at 70,579,616 bp
  • T to C, chromosome 15 at 38,673,966 bp
  • A to G, chromosome 15 at 73,753,769 bp
  • A to G, chromosome 15 at 78,671,896 bp
  • T to A, chromosome 16 at 15,687,352 bp
  • C to T, chromosome 16 at 32,144,157 bp
  • A to G, chromosome 19 at 30,133,470 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2033 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040040-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.