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Strain Name:
C57BL/6J-MtgxR2037Btlr/Mmmh
Stock Number:
040044-MU
Citation ID:
RRID:MMRRC_040044-MU
Other Names:
R2037 (G1), C57BL/6J-MtgxR2037Btlr
Major Collection:

Strain Information

Tead3
Name: TEA domain family member 3
Synonyms: ETFR-1, TEAD-3, DTEF-1, Tcf13r2, TEF-5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21678
Homologene: 81821
Rnf111
Name: ring finger 111
Synonyms: Arkadia
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93836
VEGA: 9
Homologene: 9741
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224650
Homologene: 9068
Fam169a
Name: family with sequence similarity 169, member A
Synonyms: B230112C05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 320557
VEGA: 13
Homologene: 52656
Tmem104
Name: transmembrane protein 104
Synonyms: C630005D06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320534
Homologene: 9802
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 32,243,887 bp
  • A to T, chromosome 1 at 53,582,582 bp
  • C to A, chromosome 1 at 72,346,370 bp
  • A to G, chromosome 1 at 127,803,399 bp
  • A to G, chromosome 1 at 130,878,333 bp
  • T to A, chromosome 1 at 130,908,378 bp
  • A to T, chromosome 1 at 158,956,644 bp
  • G to A, chromosome 1 at 181,921,972 bp
  • T to C, chromosome 2 at 3,309,581 bp
  • A to G, chromosome 2 at 69,868,819 bp
  • A to G, chromosome 2 at 82,978,512 bp
  • T to C, chromosome 2 at 86,197,832 bp
  • T to C, chromosome 2 at 86,332,430 bp
  • C to T, chromosome 2 at 121,343,193 bp
  • T to C, chromosome 2 at 146,969,960 bp
  • A to T, chromosome 3 at 36,182,657 bp
  • A to G, chromosome 3 at 63,328,260 bp
  • GCC to GCCCCC, chromosome 4 at 53,563,243 bp
  • A to T, chromosome 4 at 117,904,661 bp
  • A to G, chromosome 4 at 124,798,299 bp
  • A to G, chromosome 4 at 141,046,942 bp
  • A to G, chromosome 4 at 152,028,170 bp
  • T to C, chromosome 5 at 66,261,086 bp
  • T to A, chromosome 5 at 76,976,491 bp
  • T to G, chromosome 5 at 88,772,717 bp
  • A to G, chromosome 5 at 106,880,287 bp
  • G to A, chromosome 5 at 108,338,652 bp
  • T to A, chromosome 5 at 116,467,828 bp
  • A to T, chromosome 5 at 124,746,704 bp
  • T to C, chromosome 5 at 134,229,552 bp
  • T to A, chromosome 5 at 135,854,377 bp
  • T to A, chromosome 5 at 150,540,669 bp
  • A to G, chromosome 6 at 28,443,590 bp
  • T to A, chromosome 6 at 51,471,813 bp
  • A to G, chromosome 6 at 55,897,875 bp
  • A to T, chromosome 6 at 57,003,124 bp
  • A to T, chromosome 6 at 88,617,797 bp
  • A to C, chromosome 6 at 119,722,255 bp
  • T to A, chromosome 7 at 14,254,709 bp
  • T to C, chromosome 7 at 41,374,391 bp
  • A to G, chromosome 7 at 43,352,616 bp
  • G to A, chromosome 7 at 56,205,961 bp
  • G to A, chromosome 7 at 111,046,807 bp
  • G to T, chromosome 8 at 71,290,866 bp
  • A to T, chromosome 8 at 123,917,419 bp
  • C to T, chromosome 9 at 57,096,825 bp
  • A to G, chromosome 9 at 70,443,396 bp
  • C to T, chromosome 9 at 105,650,335 bp
  • G to A, chromosome 10 at 37,141,121 bp
  • T to C, chromosome 10 at 129,966,140 bp
  • A to T, chromosome 11 at 75,185,853 bp
  • C to T, chromosome 11 at 80,140,230 bp
  • T to A, chromosome 11 at 83,944,606 bp
  • A to T, chromosome 11 at 89,456,120 bp
  • G to C, chromosome 11 at 104,186,481 bp
  • A to T, chromosome 11 at 110,089,984 bp
  • G to A, chromosome 11 at 115,201,395 bp
  • A to G, chromosome 12 at 8,007,488 bp
  • A to G, chromosome 12 at 17,361,151 bp
  • G to T, chromosome 12 at 54,929,646 bp
  • A to G, chromosome 12 at 76,025,569 bp
  • A to T, chromosome 12 at 101,507,962 bp
  • A to G, chromosome 12 at 112,768,558 bp
  • T to A, chromosome 13 at 22,851,964 bp
  • T to G, chromosome 13 at 55,167,889 bp
  • A to T, chromosome 13 at 91,902,629 bp
  • C to A, chromosome 13 at 97,107,092 bp
  • T to C, chromosome 13 at 100,230,799 bp
  • A to T, chromosome 14 at 120,749,885 bp
  • G to T, chromosome 15 at 5,034,238 bp
  • A to G, chromosome 15 at 34,433,117 bp
  • A to T, chromosome 15 at 38,493,644 bp
  • A to G, chromosome 15 at 44,568,221 bp
  • A to G, chromosome 15 at 74,609,761 bp
  • A to G, chromosome 15 at 80,560,349 bp
  • C to T, chromosome 15 at 100,353,586 bp
  • T to C, chromosome 16 at 48,874,252 bp
  • C to T, chromosome 17 at 27,996,067 bp
  • A to G, chromosome 17 at 28,336,570 bp
  • G to A, chromosome 17 at 34,699,205 bp
  • A to G, chromosome 17 at 57,075,498 bp
  • A to T, chromosome 17 at 78,829,505 bp
  • T to C, chromosome 18 at 31,212,648 bp
  • ATCTCTCTC to ATCTCTC, chromosome X at 75,322,998 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2037 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040044-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.