Strain Name:
C57BL/6J-MtgxR2043Btlr/Mmmh
Stock Number:
040050-MU
Citation ID:
RRID:MMRRC_040050-MU
Other Names:
R2043 (G1), C57BL/6J-MtgxR2043Btlr
Major Collection:

Strain Information

Aldh1l1
Name: aldehyde dehydrogenase 1 family, member L1
Synonyms: 1810048F20Rik, Fthfd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107747
HGNC: HGNC:3978
Homologene: 122031
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94187
Homologene: 9010
Zfp729a
Name: zinc finger protein 729a
Synonyms: A530054K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212281
Homologene: 133713
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Glcci1
Name: glucocorticoid induced transcript 1
Synonyms: GIG18, 2310047L21Rik, Tssn1, A130036A18Rik, Fam117c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170772
Homologene: 15773
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 360013
Homologene: 7977
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109135
Homologene: 10377
Bub1
Name: BUB1, mitotic checkpoint serine/threonine kinase
Synonyms: Bub1a, D2Xrf87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12235
HGNC: HGNC:1148
Homologene: 37910
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: Apaf1l, 6230400I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Tulip1, 2310003F20Rik, Garnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Zfp146
Name: zinc finger protein 146
Synonyms: OZF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26465
Homologene: 117615
Cftr
Name: cystic fibrosis transmembrane conductance regulator
Synonyms: Abcc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12638
HGNC: HGNC:1884
Homologene: 55465
Adnp2
Name: ADNP homeobox 2
Synonyms: Zfp508, 8430420L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240442
Homologene: 8945
Pcdh20
Name: protocadherin 20
Synonyms: PCDH13, C630015B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219257
Homologene: 11277
Il6st
Name: interleukin 6 signal transducer
Synonyms: gp130, CD130, D13Ertd699e, 5133400A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16195
HGNC: HGNC:6021
Homologene: 1645
Hspa13
Name: heat shock protein 70 family, member 13
Synonyms: 60kDa, B230217N24Rik, 1600002I10Rik, Stch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110920
Homologene: 5062
Zfp386
Name: zinc finger protein 386 (Kruppel-like)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56220
Homologene: 51668
Mis18bp1
Name: MIS18 binding protein 1
Synonyms: C79407
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217653
Homologene: 10147
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: IF2, A030003E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226982
Homologene: 134613
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: FIC1, Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Pdk4
Name: pyruvate dehydrogenase kinase, isoenzyme 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27273
HGNC: HGNC:8812
Homologene: 129720
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, Cchl1a1, Cav1.2, L-type Cav1.2, D930026N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Dhx57
Name: DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Nav1.2, A230052E19Rik, Scn2a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110876
Homologene: 75001
Slc24a2
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
Synonyms: 6330417K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76376
Homologene: 10669
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212392
Homologene: 17668
Capn3
Name: calpain 3
Synonyms: Capa-3, Capa3, Lp82, p94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12335
HGNC: HGNC:1480
Homologene: 52
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
Adam9
Name: a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Synonyms: MDC9, Mltng, MDC9, Mltng
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11502
HGNC: HGNC:216
Homologene: 20824
Gsdma
Name: gasdermin A
Synonyms: H312E, Gsdm, Gsdm1, Gsdma1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57911
Homologene: 10962
Spg20
Name: spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)
Synonyms: TAHCCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229285
Zfp955a
Name: zinc finger protein 955A
Synonyms: AI842447
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77652
VEGA: 17
Homologene: 104925
Fpr-rs4
Name: formyl peptide receptor, related sequence 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14291
Homologene: 130629
Piwil2
Name: piwi-like RNA-mediated gene silencing 2
Synonyms: Miwi like, mili
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57746
VEGA: 14
Homologene: 23071
Ankmy1
Name: ankyrin repeat and MYND domain containing 1
Synonyms: 4930483I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241158
Homologene: 9561
Smg9
Name: SMG9 nonsense mediated mRNA decay factor
Synonyms: N28092, 1500002O20Rik, smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71997
Homologene: 10426
Dsn1
Name: DSN1 homolog, MIS12 kinetochore complex component
Synonyms: 1700022L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66934
Homologene: 49806
P4ha2
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
Synonyms: P4hl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18452
HGNC: HGNC:8547
Homologene: 55806
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Gm5424
Name: predicted gene 5424
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432466
VEGA: 10
Entrep3
Name: endosomal transmembrane epsin interactor 3
Synonyms: 1110013L07Rik, Fam189b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68521
HGNC: HGNC:1233
Homologene: 4805
Cln5
Name: ceroid-lipofuscinosis, neuronal 5
Synonyms: A730075N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 211286
VEGA: 14
HGNC: HGNC:2076
Homologene: 4738
Mypop
Name: Myb-related transcription factor, partner of profilin
Synonyms: Myodysa, P42pop
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232934
Homologene: 17083
Fbxo25
Name: F-box protein 25
Synonyms: Fbx25, 9130015I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66822
Homologene: 41649
Or51ag1
Name: olfactory receptor family 51 subfamily AG member 1
Synonyms: GA_x6K02T2PBJ9-6221839-6220892, MOR9-2, Olfr610
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259085
Homologene: 17495
Heatr3
Name: HEAT repeat containing 3
Synonyms: C030036P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234549
Homologene: 45429
Ly6g6e
Name: lymphocyte antigen 6 complex, locus G6E
Synonyms: 2310011I02Rik, G6e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70274
Homologene: 41553
Dcaf5
Name: DDB1 and CUL4 associated factor 5
Synonyms: BCRP2, BCRG2, 9430020B07Rik, Wdr22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320808
VEGA: 12
Homologene: 18564
H3c3
Name: H3 clustered histone 3
Synonyms: H3-143, Hist1h3c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319148
Homologene: 134489
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 38,041,819 bp
  • T to C, chromosome 1 at 92,876,527 bp
  • T to A, chromosome 1 at 188,916,256 bp
  • A to T, chromosome 2 at 65,681,100 bp
  • A to G, chromosome 2 at 120,491,901 bp
  • A to T, chromosome 2 at 127,804,220 bp
  • G to A, chromosome 2 at 157,005,353 bp
  • G to A, chromosome 3 at 55,127,548 bp
  • A to G, chromosome 3 at 89,185,567 bp
  • A to T, chromosome 4 at 86,996,645 bp
  • A to T, chromosome 6 at 5,485,502 bp
  • T to A, chromosome 6 at 8,582,590 bp
  • T to C, chromosome 6 at 18,320,935 bp
  • T to A, chromosome 6 at 90,557,332 bp
  • C to T, chromosome 6 at 118,596,088 bp
  • T to C, chromosome 6 at 140,552,804 bp
  • T to C, chromosome 7 at 19,001,019 bp
  • T to A, chromosome 7 at 24,405,576 bp
  • C to T, chromosome 7 at 29,059,631 bp
  • T to C, chromosome 7 at 30,162,239 bp
  • A to G, chromosome 7 at 103,506,943 bp
  • A to G, chromosome 8 at 13,921,905 bp
  • A to G, chromosome 8 at 24,996,653 bp
  • T to C, chromosome 8 at 45,942,827 bp
  • T to C, chromosome 8 at 87,782,618 bp
  • T to A, chromosome 8 at 88,147,694 bp
  • C to T, chromosome 10 at 50,700,520 bp
  • A to T, chromosome 10 at 53,358,128 bp
  • A to G, chromosome 10 at 62,071,211 bp
  • T to C, chromosome 10 at 91,037,028 bp
  • T to C, chromosome 11 at 54,129,041 bp
  • T to C, chromosome 11 at 77,823,363 bp
  • G to A, chromosome 11 at 98,666,220 bp
  • T to A, chromosome 12 at 55,677,026 bp
  • A to T, chromosome 12 at 65,149,418 bp
  • A to T, chromosome 12 at 80,340,217 bp
  • T to A, chromosome 12 at 116,059,161 bp
  • A to G, chromosome 13 at 23,745,295 bp
  • T to C, chromosome 13 at 67,621,172 bp
  • T to A, chromosome 13 at 92,030,843 bp
  • A to C, chromosome 13 at 112,480,219 bp
  • A to G, chromosome 14 at 70,391,470 bp
  • G to A, chromosome 14 at 88,467,155 bp
  • T to C, chromosome 14 at 103,075,944 bp
  • A to G, chromosome 16 at 75,758,268 bp
  • CAGGAA to CA, chromosome 17 at 18,022,334 bp
  • G to A, chromosome 17 at 33,242,553 bp
  • G to A, chromosome 17 at 35,077,864 bp
  • A to G, chromosome 17 at 80,253,080 bp
  • T to C, chromosome 18 at 64,605,200 bp
  • A to C, chromosome 18 at 80,128,326 bp
  • A to G, chromosome 19 at 6,848,530 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2043 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040050-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.