Strain Name:
C57BL/6J-MtgxR2084Btlr/Mmmh
Stock Number:
040089-MU
Citation ID:
RRID:MMRRC_040089-MU
Other Names:
R2084 (G1), C57BL/6J-MtgxR2084Btlr
Major Collection:

Gene Information

Dnm2
Name: dynamin 2
Synonyms: Dyn2, b2b2159Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: PRCE, separase, SSE, ESP1, PRCE, Cerp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 104245
Homologene: 37901
Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: nNOS, bNOS, Nos-1, NO, 2310005C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Prkd3
Name: protein kinase D3
Synonyms: 4930557O20Rik, 5730497N19Rik, PKD3, Prkcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Efemp1
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216616
HGNC: HGNC:3218
Homologene: 3028
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108096
Homologene: 56603
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52850
Homologene: 64485
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 319765
Homologene: 4774
Rexo1
Name: REX1, RNA exonuclease 1
Synonyms: 1700021P10Rik, 2610511M11Rik, Tceb3bp1, Rex1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66932
Homologene: 41391
Sde2
Name: SDE2 telomere maintenance homolog (S. pombe)
Synonyms: BC031781
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208768
Homologene: 134327
Eed
Name: embryonic ectoderm development
Synonyms: l(7)5Rn, l7Rn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13626
HGNC: HGNC:3188
Homologene: 2814
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67724
Homologene: 41000
Ints8
Name: integrator complex subunit 8
Synonyms: D130008D20Rik, 2810013E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72656
Homologene: 9888
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214133
Homologene: 49498
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: mRPA1, RPA194, 194kDa, 3010014K16Rik, Rpo1-4, 2900087K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20019
Homologene: 7033
Prpf3
Name: pre-mRNA processing factor 3
Synonyms: 3632413F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70767
Homologene: 3447
Rffl
Name: ring finger and FYVE like domain containing protein
Synonyms: 4930516L10Rik, fring, rififylin, 1700051E09Rik, Carp-2, Carp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67338
Homologene: 12116
Arfgap3
Name: ADP-ribosylation factor GTPase activating protein 3
Synonyms: 1810004P07Rik, 1810035F16Rik, 0610009H19Rik, 9130416J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66251
VEGA: 15
HGNC: HGNC:661
Homologene: 134103
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 2810040A01Rik, 2810013C04Rik, 5630401D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Nup85
Name: nucleoporin 85
Synonyms: frount, Pcnt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 445007
HGNC: HGNC:8734
Homologene: 11755
Vps11
Name: VPS11, CORVET/HOPS core subunit
Synonyms: 1200011A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71732
VEGA: 9
Homologene: 6673
Aph1c
Name: aph1 homolog C, gamma secretase subunit
Synonyms: 0610008A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68318
Homologene: 134745
Fcrl5
Name: Fc receptor-like 5
Synonyms: BXMAS1-like protein 2, Fcrh3, mBXMH2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329693
Homologene: 137404
Ift81
Name: intraflagellar transport 81
Synonyms: CDV-1R, Cdv1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12589
Homologene: 7664
Krr1
Name: KRR1, small subunit (SSU) processome component, homolog (yeast)
Synonyms: 2610511F02Rik, D10Ertd773e, Hrb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52705
HGNC: HGNC:5176
Homologene: 5114
Cars
Name: cysteinyl-tRNA synthetase
Synonyms: CA3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27267
HGNC: HGNC:1493
Homologene: 1328
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Cpped1
Name: calcineurin-like phosphoesterase domain containing 1
Synonyms: C530044N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 223978
Homologene: 10142
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Zc3h12a
Name: zinc finger CCCH type containing 12A
Synonyms: Mcpip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230738
Homologene: 11824
Gh
Name: growth hormone
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14599
Homologene: 47932
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Sec24c
Name: Sec24 related gene family, member C (S. cerevisiae)
Synonyms: 2610204K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218811
VEGA: 14
Homologene: 3615
Ifit2
Name: interferon-induced protein with tetratricopeptide repeats 2
Synonyms: Ifi54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15958
HGNC: HGNC:5409
Homologene: 1187
Cyp2j11
Name: cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms: Cyp2j11-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100066
Homologene: 133819
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Astn1
Name: astrotactin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Taok2
Name: TAO kinase 2
Synonyms: MAP3K17, TAO2, TAO1, PSK1, 1110033K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381921
Homologene: 74531
Gm10267
Name: predicted gene 10267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100042855
Homologene: 104911
Spn
Name: sialophorin
Synonyms: leukosialin, 3E8 antigen, Cd43, Ly-48, A630014B01Rik, Ly48, Galgp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20737
Homologene: 36108
Ankrd36
Name: ankyrin repeat domain 36
Synonyms: 1700012M14Rik, GC3, 1700008J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76389
Homologene: 137366
Trmt1l
Name: tRNA methyltransferase 1 like
Synonyms: Trm1-like, 1190005F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98685
Homologene: 12801
Krba1
Name: KRAB-A domain containing 1
Synonyms: A930040G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 77827
Homologene: 15880
BC005537
Name: cDNA sequence BC005537
Synonyms: 8030460C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 79555
Homologene: 11551
Slco1c1
Name: solute carrier organic anion transporter family, member 1c1
Synonyms: OATP-F, Slc21a14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58807
Homologene: 23008
Ssc5d
Name: scavenger receptor cysteine rich family, 5 domains
Synonyms: s5d-srcrb, A430110N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269855
Homologene: 77555
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Pdzrn3
Name: PDZ domain containing RING finger 3
Synonyms: semaphorin cytoplasmic domain-associated protein 3A, 1110020C07Rik, LNX3, Semcap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 55983
Homologene: 10328
Pramel23
Name: PRAME like 23
Synonyms: Gm13089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277667
Cfap20dc
Name: CFAP20 domain containing
Synonyms: 4930452B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74430
Homologene: 18873
Hmgxb3
Name: HMG box domain containing 3
Synonyms: 2510002C16Rik, A630042L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 106894
VEGA: 18
Homologene: 44229
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 328505
Homologene: 106613
Tubal3
Name: tubulin, alpha-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238463
VEGA: 13
Homologene: 23488
Rps6ka4
Name: ribosomal protein S6 kinase, polypeptide 4
Synonyms: MSK2, 1110069D02Rik, 90kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56613
VEGA: 19
Homologene: 69288
Card10
Name: caspase recruitment domain family, member 10
Synonyms: CARMA3, Bimp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105844
Homologene: 8728
Vmn2r71
Name: vomeronasal 2, receptor 71
Synonyms: EG233445
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233445
Homologene: 115466
Olfr993
Name: olfactory receptor 993
Synonyms: GA_x6K02T2Q125-46891524-46890580, MOR203-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258427
Homologene: 79352
Ryk
Name: receptor-like tyrosine kinase
Synonyms: Vik, ERK-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20187
Homologene: 68287
Zfp2
Name: zinc finger protein 2
Synonyms: mkr-2, Zfp-2, Fnp-2, 9930007F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22678
Homologene: 121779
Psmg3
Name: proteasome (prosome, macropain) assembly chaperone 3
Synonyms: 4930403H09Rik, 1810042K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66506
Homologene: 11980
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 135,607,420 bp
  • A to G, chromosome 1 at 151,440,854 bp
  • T to C, chromosome 1 at 158,472,408 bp
  • A to G, chromosome 1 at 180,862,633 bp
  • T to C, chromosome 2 at 85,414,615 bp
  • T to C, chromosome 3 at 87,444,230 bp
  • C to T, chromosome 3 at 95,848,989 bp
  • C to T, chromosome 3 at 114,158,142 bp
  • T to C, chromosome 3 at 133,487,767 bp
  • A to G, chromosome 4 at 11,230,377 bp
  • T to A, chromosome 4 at 96,339,201 bp
  • T to A, chromosome 4 at 111,980,178 bp
  • C to T, chromosome 4 at 125,120,009 bp
  • T to A, chromosome 4 at 143,699,350 bp
  • T to G, chromosome 5 at 14,682,148 bp
  • G to A, chromosome 5 at 113,285,400 bp
  • C to A, chromosome 5 at 117,943,245 bp
  • T to G, chromosome 5 at 122,567,347 bp
  • C to T, chromosome 5 at 139,823,989 bp
  • T to A, chromosome 6 at 48,414,568 bp
  • A to G, chromosome 6 at 71,950,809 bp
  • T to C, chromosome 6 at 101,154,295 bp
  • T to A, chromosome 6 at 141,559,852 bp
  • T to C, chromosome 6 at 142,234,711 bp
  • A to G, chromosome 7 at 4,937,012 bp
  • G to A, chromosome 7 at 28,157,535 bp
  • T to A, chromosome 7 at 49,948,254 bp
  • A to G, chromosome 7 at 73,455,763 bp
  • A to T, chromosome 7 at 85,618,737 bp
  • A to G, chromosome 7 at 89,971,614 bp
  • G to A, chromosome 7 at 126,870,191 bp
  • T to C, chromosome 7 at 127,137,038 bp
  • T to C, chromosome 7 at 143,587,182 bp
  • T to C, chromosome 9 at 21,500,371 bp
  • G to T, chromosome 9 at 44,353,261 bp
  • T to G, chromosome 9 at 66,819,297 bp
  • C to T, chromosome 9 at 102,875,772 bp
  • T to G, chromosome 9 at 108,954,519 bp
  • G to A, chromosome 10 at 80,561,266 bp
  • T to C, chromosome 10 at 111,976,785 bp
  • C to T, chromosome 11 at 5,662,378 bp
  • A to G, chromosome 11 at 28,915,763 bp
  • A to G, chromosome 11 at 50,900,962 bp
  • G to A, chromosome 11 at 82,806,193 bp
  • G to A, chromosome 11 at 106,301,132 bp
  • A to T, chromosome 11 at 115,568,691 bp
  • T to C, chromosome 13 at 3,928,192 bp
  • G to T, chromosome 13 at 24,812,715 bp
  • T to C, chromosome 14 at 8,558,171 bp
  • A to G, chromosome 14 at 20,691,279 bp
  • T to C, chromosome 15 at 34,508,598 bp
  • G to A, chromosome 15 at 78,792,971 bp
  • T to A, chromosome 15 at 83,334,566 bp
  • T to C, chromosome 15 at 102,296,851 bp
  • T to C, chromosome 16 at 11,828,501 bp
  • C to T, chromosome 16 at 22,068,134 bp
  • A to G, chromosome 17 at 78,962,518 bp
  • T to C, chromosome 18 at 44,157,330 bp
  • C to T, chromosome 18 at 61,155,023 bp
  • T to C, chromosome 19 at 6,837,568 bp
  • T to C, chromosome 19 at 34,573,350 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2084 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040089-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.