Strain Name:
C57BL/6J-MtgxR2094Btlr/Mmmh
Stock Number:
040098-MU
Citation ID:
RRID:MMRRC_040098-MU
Other Names:
R2094 (G1), C57BL/6J-MtgxR2094Btlr
Major Collection:

Gene Information

Ifngr2
Name: interferon gamma receptor 2
Synonyms: Ifgt, Ifgr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15980
HGNC: HGNC:5440
Homologene: 4041
Etv1
Name: ets variant 1
Synonyms: ER81, Etsrp81
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20562
Homologene: 2302
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: Bat2l, 5830434P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227723
Homologene: 106649
Chst5
Name: carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
Synonyms: I-GlcNAc6ST, GST-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56773
Homologene: 56927
Oxsr1
Name: oxidative-stress responsive 1
Synonyms: 2210022N24Rik, 2810422B09Rik, Osr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108737
HGNC: HGNC:8508
Homologene: 31288
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: 1200014D22Rik, LIP1, LKB1IP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71728
Homologene: 12406
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: SDRP1, 8030445B08Rik, AIP5, Tiul1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 107568
Homologene: 21385
Dot1l
Name: DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Synonyms: KMT4, mDot1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 208266
Homologene: 32779
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Pde7a
Name: phosphodiesterase 7A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18583
HGNC: HGNC:8791
Homologene: 1956
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: SRm300, 5033413A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75956
Fndc3a
Name: fibronectin type III domain containing 3A
Synonyms: F730017H24Rik, Fndc3, 1700094E19Rik, sys, D14Ertd453e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 319448
Homologene: 8952
Ddb1
Name: damage specific DNA binding protein 1
Synonyms: damage-specific DNA-binding protein, DNA repair, p127-Ddb1, DNA repair protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13194
VEGA: 19
HGNC: HGNC:2717
Homologene: 1448
Cdx1
Name: caudal type homeobox 1
Synonyms: Cdx-1, Cdx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12590
HGNC: HGNC:1805
Homologene: 1366
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52357
Homologene: 32618
Iws1
Name: IWS1, SUPT6 interacting protein
Synonyms: 1700069O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 73473
Homologene: 134421
Gucy1a1
Name: guanylate cyclase 1, soluble, alpha 1
Synonyms: sGC-alpha1, Gucy1a3, 1200016O07Rik, alpha 1 sGC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 60596
HGNC: HGNC:4685
Homologene: 37360
Gpr4
Name: G protein-coupled receptor 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319197
HGNC: HGNC:4497
Homologene: 3867
Chrna2
Name: cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
Synonyms: Acra2, Acra-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110902
HGNC: HGNC:1956
Homologene: 20193
Crebbp
Name: CREB binding protein
Synonyms: CBP, KAT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Clhc1
Name: clathrin heavy chain linker domain containing 1
Synonyms: 1700034F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73324
Homologene: 17569
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, D030010H02Rik, b2b414Clo, D330044F14Rik, 4432416O06Rik, m152Asp, DHC1b, DHC2, m407Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Atg5
Name: autophagy related 5
Synonyms: Paddy, Apg5l, 2010107M05Rik, 3110067M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11793
VEGA: 10
HGNC: HGNC:589
Homologene: 3566
Tcerg1
Name: transcription elongation regulator 1 (CA150)
Synonyms: 2410022J09Rik, p144, 2900090C16Rik, Fbp28, ca150, Taf2s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 56070
Homologene: 4879
Cep170b
Name: centrosomal protein 170B
Synonyms: AW555464
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217882
VEGA: 12
Homologene: 46165
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Pkp2
Name: plakophilin 2
Synonyms: 1200008D14Rik, Pkp2l, 1200012P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 67451
HGNC: HGNC:9024
Homologene: 3364
Ttn
Name: titin
Synonyms: L56, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, shru, D830007G01Rik, mdm, D330041I19Rik, 2310057K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Rasgrp3
Name: RAS, guanyl releasing protein 3
Synonyms: LOC240168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240168
VEGA: 17
Homologene: 15019
Atmin
Name: ATM interactor
Synonyms: gpg6, Asciz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234776
Homologene: 35321
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Astn1
Name: astrotactin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11899
HGNC: HGNC:773
Homologene: 7233
Eno1b
Name: enolase 1B, retrotransposed
Synonyms: Gm5506
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 433182
VEGA: 18
HGNC: HGNC:3350
Homologene: 134343
Gm8251
Name: predicted gene 8251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: Rhoip3, RIP3, p116 Rho interacting protein, Gm34094, p116Rip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26936
Homologene: 9034
Ermp1
Name: endoplasmic reticulum metallopeptidase 1
Synonyms: b2b2633Clo, D19Wsu12e, D19Ertd410e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226090
Homologene: 121891
Rtl1
Name: retrotransposon Gaglike 1
Synonyms: Mor1, Mart1, Mar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 353326
VEGA: 12
Homologene: 120261
Trim42
Name: tripartite motif-containing 42
Synonyms: 4930486B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78911
Homologene: 12712
Slc25a29
Name: solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29
Synonyms: CACL, C030003J19Rik, mCACL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 214663
Homologene: 5385
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Cebpz
Name: CCAAT/enhancer binding protein zeta
Synonyms: Cebpa-rs1, Cbf, CBF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12607
VEGA: 17
Homologene: 4210
Serpina3m
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3M
Synonyms: Spi2-rs1, 3e46, Spi-2rs1, MMCM7, antitrypsin, Spi-2l, contrapsin-like, MMSPi2.4, Spi2.4, alpha-1 antiproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20717
HGNC: HGNC:16
Homologene: 111129
Slc10a1
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Synonyms: sodium bile acid cotransporting polypeptide, Ntcp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20493
VEGA: 12
Homologene: 31126
Arrdc5
Name: arrestin domain containing 5
Synonyms: 1700013E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76920
VEGA: 17
Homologene: 66277
Olfr725
Name: olfactory receptor 725
Synonyms: MOR246-3, MOR246-7_p, GA_x6K02T2PMLR-5725741-5724776
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258314
Homologene: 44957
Serpine2
Name: serine (or cysteine) peptidase inhibitor, clade E, member 2
Synonyms: PI7, B230326M24Rik, nexin, protease nexin 1, PN-1, Spi4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20720
HGNC: HGNC:8951
Homologene: 21247
Opcml
Name: opioid binding protein/cell adhesion molecule-like
Synonyms: 2900075O15Rik, B930023M13Rik, Obcam, LOC235104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330908
HGNC: HGNC:8143
Homologene: 55663
Tmprss11g
Name: transmembrane protease, serine 11g
Synonyms: Desc4, 9930032O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320454
Homologene: 82239
Tmem82
Name: transmembrane protein 82
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 213989
Homologene: 27088
Prl8a2
Name: prolactin family 8, subfamily a, member 2
Synonyms: DPRP, Dtprp, mdPRP, D/tPRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13529
Homologene: 49230
Casd1
Name: CAS1 domain containing 1
Synonyms: Cast1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213819
Homologene: 11287
Mrgprb8
Name: MAS-related GPR, member B8
Synonyms: MrgB8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404240
Homologene: 83620
Gm10699
Name: predicted gene 10699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Gimap8
Name: GTPase, IMAP family member 8
Synonyms: LOC243374, IAN9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243374
Homologene: 69703
Gm9947
Name: predicted gene 9947
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 105243866
A130010J15Rik
Name: RIKEN cDNA A130010J15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319266
Homologene: 17592
Gm12666
Name: predicted gene 12666
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68280
Bex6
Name: brain expressed family member 6
Synonyms: B020003O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 328660
Atp6v1g2
Name: ATPase, H+ transporting, lysosomal V1 subunit G2
Synonyms: Atp6g2, 1500002D01Rik, NG38, lysosomal 13kDa, VAG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66237
HGNC: HGNC:862
Homologene: 41518
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 14,755,684 bp
  • A to C, chromosome 1 at 44,059,730 bp
  • A to G, chromosome 1 at 75,525,521 bp
  • A to G, chromosome 1 at 79,810,694 bp
  • A to G, chromosome 1 at 158,667,609 bp
  • G to A, chromosome 1 at 172,287,433 bp
  • A to G, chromosome 1 at 193,174,846 bp
  • C to T, chromosome 2 at 32,182,570 bp
  • T to C, chromosome 2 at 76,830,088 bp
  • T to C, chromosome 3 at 19,227,636 bp
  • C to T, chromosome 3 at 82,113,332 bp
  • A to T, chromosome 3 at 87,803,181 bp
  • T to C, chromosome 4 at 19,650,390 bp
  • A to G, chromosome 4 at 92,191,656 bp
  • T to C, chromosome 4 at 141,616,287 bp
  • A to G, chromosome 5 at 86,499,556 bp
  • A to G, chromosome 6 at 4,608,705 bp
  • A to T, chromosome 6 at 48,650,568 bp
  • G to A, chromosome 7 at 19,222,578 bp
  • T to C, chromosome 7 at 48,389,205 bp
  • T to G, chromosome 8 at 14,090,527 bp
  • T to A, chromosome 8 at 16,079,978 bp
  • C to T, chromosome 8 at 47,852,035 bp
  • A to T, chromosome 8 at 111,890,544 bp
  • A to G, chromosome 8 at 116,957,538 bp
  • A to G, chromosome 9 at 7,148,735 bp
  • G to A, chromosome 9 at 28,901,590 bp
  • T to C, chromosome 9 at 97,366,097 bp
  • A to C, chromosome 9 at 119,294,494 bp
  • A to G, chromosome 10 at 44,319,548 bp
  • C to T, chromosome 10 at 80,785,878 bp
  • T to A, chromosome 11 at 29,557,771 bp
  • T to A, chromosome 11 at 59,749,508 bp
  • C to A, chromosome 12 at 38,835,116 bp
  • A to G, chromosome 12 at 80,956,048 bp
  • G to T, chromosome 12 at 104,389,270 bp
  • A to T, chromosome 12 at 108,827,432 bp
  • T to A, chromosome 12 at 109,591,397 bp
  • T to C, chromosome 12 at 112,735,730 bp
  • G to A, chromosome 13 at 27,353,866 bp
  • T to A, chromosome 14 at 7,873,504 bp
  • A to T, chromosome 14 at 50,034,714 bp
  • C to T, chromosome 14 at 66,149,463 bp
  • A to T, chromosome 14 at 72,573,276 bp
  • A to G, chromosome 16 at 4,092,369 bp
  • T to A, chromosome 16 at 16,246,967 bp
  • G to A, chromosome 16 at 32,186,460 bp
  • T to G, chromosome 16 at 91,561,779 bp
  • T to C, chromosome 17 at 23,812,429 bp
  • A to G, chromosome 17 at 35,236,809 bp
  • A to G, chromosome 17 at 56,297,856 bp
  • T to C, chromosome 17 at 75,503,141 bp
  • T to C, chromosome 17 at 78,935,554 bp
  • A to G, chromosome 18 at 32,084,666 bp
  • A to G, chromosome 18 at 42,564,145 bp
  • T to C, chromosome 18 at 48,047,475 bp
  • A to T, chromosome 18 at 57,281,713 bp
  • T to C, chromosome 18 at 61,035,912 bp
  • A to C, chromosome 19 at 10,612,936 bp
  • A to C, chromosome 19 at 29,639,928 bp
  • G to A, chromosome 19 at 41,606,380 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2094 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040098-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.