Strain Name:
C57BL/6J-MtgxR2096Btlr/Mmmh
Stock Number:
040100-MU
Citation ID:
RRID:MMRRC_040100-MU
Other Names:
R2096 (G1), C57BL/6J-MtgxR2096Btlr
Major Collection:

Strain Information

Ptch1
Name: patched 1
Synonyms: wig, Ptc, Ptc1, Patched 1, A230106A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Tmprss12
Name: transmembrane (C-terminal) protease, serine 12
Synonyms: 4930478A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75002
VEGA: 15
Homologene: 16598
Comp
Name: cartilage oligomeric matrix protein
Synonyms: thrombospondin-5, TSP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12845
HGNC: HGNC:2227
Homologene: 74
Ppa2
Name: pyrophosphatase (inorganic) 2
Synonyms: 1110013G13Rik, Sid6306
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74776
Homologene: 134244
Dhx38
Name: DEAH-box helicase 38
Synonyms: Prp16, 5730550P09Rik, Ddx38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 64340
Homologene: 8512
Psmd1
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Synonyms: P112, S1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70247
HGNC: HGNC:9554
Homologene: 2100
Kif15
Name: kinesin family member 15
Synonyms: HKLP2, Knsl7, 3930402I10Rik, N-10 kinesin, 3110023M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209737
VEGA: 9
Homologene: 23210
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Ndrp, 2810004D21Rik, Wdr11, 4632404O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83946
Homologene: 41209
Cenpf
Name: centromere protein F
Synonyms: 6530404A22Rik, Lek1, mitosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Tdrd3
Name: tudor domain containing 3
Synonyms: 4732418C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219249
Homologene: 12771
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: C130099L13Rik, 8430405D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195018
Homologene: 9027
Sema4d
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms: semaphorin H, coll-4, Semcl2, M-sema G, Semaj, Semacl2, CD100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20354
Homologene: 21282
Ctsl
Name: cathepsin L
Synonyms: 1190035F06Rik, Cat L, MEP, major excreted protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13039
VEGA: 13
Homologene: 76699
Dkk2
Name: dickkopf WNT signaling pathway inhibitor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56811
HGNC: HGNC:2892
Homologene: 8681
Ntng1
Name: netrin G1
Synonyms: A930010C08Rik, Lmnt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Btf3
Name: basic transcription factor 3
Synonyms: 1700054E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218490
HGNC: HGNC:1125
Homologene: 37453
Kel
Name: Kell blood group
Synonyms: CD238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 23925
HGNC: HGNC:6308
Homologene: 362
Zcchc7
Name: zinc finger, CCHC domain containing 7
Synonyms: 4930572I07Rik, D4Wsu132e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 319885
Homologene: 22217
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnahc2, D330014H01Rik, 2900022L05Rik, Dnhd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Spats2l
Name: spermatogenesis associated, serine-rich 2-like
Synonyms: 2810022L02Rik, A230104H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67198
Homologene: 56711
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Psdl, Efa6a, 1110007H17Rik, Efa6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Slc45a1
Name: solute carrier family 45, member 1
Synonyms: Dnb5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242773
Homologene: 44908
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Camk2d
Name: calcium/calmodulin-dependent protein kinase II, delta
Synonyms: 2810011D23Rik, CaMK II, 8030469K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 108058
HGNC: HGNC:1462
Homologene: 55561
Nlrp12
Name: NLR family, pyrin domain containing 12
Synonyms: Nalp12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 378425
Homologene: 16972
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Accs
Name: 1-aminocyclopropane-1-carboxylate synthase (inactive)
Synonyms: 2610203E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329470
Homologene: 75335
Pik3r6
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p87PIKAP, p84 Pikap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104709
Homologene: 46215
Serpinb1a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1a
Synonyms: M/NEI, ELANH2, LEI, MNEI, ovalbumin, EIA, 1190005M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66222
HGNC: HGNC:3311
Homologene: 133768
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217718
Homologene: 13222
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
P2ry14
Name: purinergic receptor P2Y, G-protein coupled, 14
Synonyms: A330108O13Rik, P2Y14, Gpr105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 140795
Homologene: 15769
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Psg23
Name: pregnancy-specific beta-1-glycoprotein 23
Synonyms: 1620401C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56868
Homologene: 110989
Rfc3
Name: replication factor C (activator 1) 3
Synonyms: 38kDa, 2810416I22Rik, Recc3, 38kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69263
HGNC: HGNC:9971
Homologene: 2188
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Dpy19l3
Name: dpy-19 like C-mannosyltransferase 3
Synonyms: 9330164H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233115
Homologene: 18692
Ankfn1
Name: ankyrin-repeat and fibronectin type III domain containing 1
Synonyms: nmf9, LOC382543, mWAKE, 4932411E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 382543
Homologene: 34996
Mael
Name: maelstrom spermatogenic transposon silencer
Synonyms: 4933405K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98558
Homologene: 13143
Cnga1
Name: cyclic nucleotide gated channel alpha 1
Synonyms: Cncg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12788
HGNC: HGNC:2148
Homologene: 55432
Tas2r118
Name: taste receptor, type 2, member 118
Synonyms: Tas2r18, mGR18, mt2r40, T2R18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387347
Homologene: 9660
Phf2
Name: PHD finger protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18676
VEGA: 13
HGNC: HGNC:8920
Homologene: 3934
Insyn2b
Name: inhibitory synaptic factor family member 2B
Synonyms: Gm6041, Fam196b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 574403
VEGA: 11
Homologene: 107175
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100042165
Abcb10
Name: ATP-binding cassette, sub-family B member 10
Synonyms: ABC-me
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
Vmn1r35
Name: vomeronasal 1 receptor 35
Synonyms: V1rc12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171185
Homologene: 110800
Cyp3a44
Name: cytochrome P450, family 3, subfamily a, polypeptide 44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 337924
Homologene: 133568
Actr3b
Name: ARP3 actin-related protein 3B
Synonyms: Arp3b, ARP11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242894
Homologene: 4180
Cd209f
Name: CD209f antigen
Synonyms: 1810029C22Rik, SIGNR8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69142
Homologene: 114519
Tmem214
Name: transmembrane protein 214
Synonyms: 1110039B18Rik, 4921530J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68796
Homologene: 9801
Dcpp1
Name: demilune cell and parotid protein 1
Synonyms: p20, Dcpp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13184
VEGA: 17
Homologene: 103921
Snai2
Name: snail family zinc finger 2
Synonyms: Slug, Slugh, Snail2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 20583
VEGA: 16
Homologene: 31127
Slc38a8
Name: solute carrier family 38, member 8
Synonyms: LOC234788
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234788
Homologene: 19028
Or5g25
Name: olfactory receptor family 5 subfamily G member 25
Synonyms: GA_x6K02T2Q125-47127746-47126790, Olfr1002, MOR175-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258566
Homologene: 104131
Rab11b
Name: RAB11B, member RAS oncogene family
Synonyms: A730055L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 19326
HGNC: HGNC:9761
Homologene: 68691
Gm12888
Name: predicted gene 12888
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 545677
Homologene: 111034
Sprr2j-ps
Name: small proline-rich protein 2J, pseudogene
Synonyms: Sprr2j
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20764
Dpf1
Name: double PHD fingers 1
Synonyms: neuro-d4, Neud4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29861
Homologene: 3415
Tlnrd1
Name: talin rod domain containing 1
Synonyms: Mesdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80889
Homologene: 11209
Atg101
Name: autophagy related 101
Synonyms: 9430023L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68118
VEGA: 15
Homologene: 11072
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 57,946,299 bp
  • T to A, chromosome 1 at 86,133,624 bp
  • G to T, chromosome 1 at 166,225,675 bp
  • A to G, chromosome 1 at 189,653,459 bp
  • A to G, chromosome 2 at 85,648,090 bp
  • C to T, chromosome 2 at 93,842,619 bp
  • C to T, chromosome 3 at 59,115,317 bp
  • T to C, chromosome 3 at 92,419,105 bp
  • T to A, chromosome 3 at 109,832,555 bp
  • G to A, chromosome 3 at 126,780,442 bp
  • T to C, chromosome 3 at 132,086,097 bp
  • A to G, chromosome 3 at 133,326,684 bp
  • C to A, chromosome 4 at 44,931,059 bp
  • T to G, chromosome 4 at 121,319,458 bp
  • G to A, chromosome 4 at 150,631,134 bp
  • T to A, chromosome 5 at 25,831,745 bp
  • T to A, chromosome 5 at 30,876,370 bp
  • C to T, chromosome 5 at 72,619,061 bp
  • T to C, chromosome 5 at 104,519,969 bp
  • G to T, chromosome 5 at 145,788,405 bp
  • A to T, chromosome 5 at 151,644,918 bp
  • T to G, chromosome 6 at 23,969,913 bp
  • A to T, chromosome 6 at 41,688,777 bp
  • G to T, chromosome 6 at 48,461,674 bp
  • A to G, chromosome 6 at 66,678,945 bp
  • T to C, chromosome 7 at 3,233,195 bp
  • T to A, chromosome 7 at 18,614,743 bp
  • T to C, chromosome 7 at 29,316,205 bp
  • A to G, chromosome 7 at 35,727,288 bp
  • G to A, chromosome 7 at 83,882,854 bp
  • A to G, chromosome 8 at 4,105,537 bp
  • T to C, chromosome 8 at 70,376,063 bp
  • A to G, chromosome 8 at 109,554,259 bp
  • A to G, chromosome 8 at 119,480,857 bp
  • A to G, chromosome 8 at 123,982,456 bp
  • A to T, chromosome 8 at 125,759,248 bp
  • T to C, chromosome 9 at 82,915,339 bp
  • T to A, chromosome 9 at 122,986,187 bp
  • G to A, chromosome 10 at 80,889,434 bp
  • C to A, chromosome 11 at 34,402,936 bp
  • T to A, chromosome 11 at 68,525,585 bp
  • C to T, chromosome 11 at 69,455,916 bp
  • T to C, chromosome 11 at 72,872,639 bp
  • A to T, chromosome 11 at 89,456,035 bp
  • T to C, chromosome 12 at 85,314,548 bp
  • A to T, chromosome 13 at 32,847,454 bp
  • T to A, chromosome 13 at 48,832,113 bp
  • A to T, chromosome 13 at 51,710,001 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • A to G, chromosome 13 at 64,369,026 bp
  • T to A, chromosome 13 at 98,313,151 bp
  • T to G, chromosome 14 at 31,349,887 bp
  • C to T, chromosome 14 at 87,506,352 bp
  • A to T, chromosome 15 at 47,657,684 bp
  • T to A, chromosome 15 at 100,285,236 bp
  • T to A, chromosome 15 at 101,290,501 bp
  • T to A, chromosome 16 at 14,706,997 bp
  • A to T, chromosome 17 at 23,880,997 bp
  • A to G, chromosome 17 at 33,749,002 bp
  • T to A, chromosome 19 at 18,825,752 bp
  • G to A, chromosome 19 at 46,324,649 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2096 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040100-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.