Strain Name:
C57BL/6J-MtgxR2178Btlr/Mmmh
Stock Number:
040180-MU
Citation ID:
RRID:MMRRC_040180-MU
Other Names:
R2178 (G1), C57BL/6J-MtgxR2178Btlr
Major Collection:

Strain Information

Prkar2a
Name: protein kinase, cAMP dependent regulatory, type II alpha
Synonyms: 1110061A24Rik, RII(alpha)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19087
HGNC: HGNC:9391
Homologene: 3064
Tgfb1
Name: transforming growth factor, beta 1
Synonyms: TGF-beta1, TGF-beta 1, TGFbeta1, Tgfb, Tgfb-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21803
Homologene: 540
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, Tkrb, C030027L06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Vps39
Name: VPS39 HOPS complex subunit
Synonyms: A230065P22Rik, Vam6P, Vam6, mVam6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269338
Homologene: 41025
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Fntb
Name: farnesyltransferase, CAAX box, beta
Synonyms: 2010013E13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110606
Homologene: 1535
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381644
Homologene: 45709
Cspp1
Name: centrosome and spindle pole associated protein 1
Synonyms: 4930413O22Rik, 2310020J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211660
Homologene: 23487
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328110
Homologene: 32377
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
Ddx3y
Name: DEAD box helicase 3, Y-linked
Synonyms: D1Pas1-rs1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked, Dby, 8030469F12Rik
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 26900
HGNC: HGNC:2699
Homologene: 55839
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104401
Homologene: 17000
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99100
Homologene: 37159
Mcoln1
Name: mucolipin 1
Synonyms: TRPML1, 2210015I05Rik, mucolipidin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94178
Homologene: 10744
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola2, Cola-2, Col1a-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Kmt5b
Name: lysine methyltransferase 5B
Synonyms: C630029K18Rik, Suv4-20h1, Suv420h1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225888
Homologene: 32351
Hmgb4
Name: high-mobility group box 4
Synonyms: 1700001F22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69317
Homologene: 83321
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Gvin3
Name: GTPase, very large interferon inducible, family member 3
Synonyms: Gm1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70737
Homologene: 41394
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAPP-A, IGFBP-4ase, 8430414N03Rik, PAG1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268527
Homologene: 8780
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: Scnn1, mENaC, ENaC alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20276
Homologene: 811
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Eyk, nmf12, Nyk, Tyro 12, Mer
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Pramel23
Name: PRAME like 23
Synonyms: Gm13089
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277667
Qrich2
Name: glutamine rich 2
Synonyms: LOC217341
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217341
Homologene: 12951
Chil3
Name: chitinase-like 3
Synonyms: Chi3l3, Ym1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12655
Homologene: 74931
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Cpt1b
Name: carnitine palmitoyltransferase 1b, muscle
Synonyms: M-CPTI, Cpt1, M-CPT I
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12895
HGNC: HGNC:2329
Homologene: 22548
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620697
Homologene: 115466
Cdh15
Name: cadherin 15
Synonyms: M cadherin, Mcad, Cdh14
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Dzip1
Name: DAZ interacting protein 1
Synonyms: 2810422M04Rik, 2510025K24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66573
VEGA: 14
Homologene: 45708
Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: RANKL, OPGL, ODF, Ly109l, OPGL, Trance, osteoclast differentiation factor
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21943
VEGA: 14
Homologene: 2744
S1pr5
Name: sphingosine-1-phosphate receptor 5
Synonyms: lpB4, S1P5, Edg8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 94226
Homologene: 11031
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16552
Homologene: 7796
Ganc
Name: glucosidase, alpha; neutral C
Synonyms: 5830445O15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76051
HGNC: HGNC:4139
Homologene: 25627
Clca1
Name: chloride channel accessory 1
Synonyms: gob5, gob-5, Clca3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Tjp3
Name: tight junction protein 3
Synonyms: ZO-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27375
VEGA: 10
Homologene: 8458
Or2a5
Name: olfactory receptor family 2 subfamily A member 5
Synonyms: GA_x6K02T2P3E9-4663051-4662119, Olfr448, MOR261-13
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258270
HGNC: HGNC:8232
Homologene: 64846
Rnf183
Name: ring finger protein 183
Synonyms: 5830442J12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76072
Homologene: 44917
Leprot
Name: leptin receptor overlapping transcript
Synonyms: OB-RGRP, Obrgrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230514
Homologene: 10582
Or7c70
Name: olfactory receptor family 7 subfamily C member 70
Synonyms: MOR142-2_p, GA_x6K02T2QGN0-2962025-2962987, Olfr1356, MOR142-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258305
Homologene: 71958
Slc25a2
Name: solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2
Synonyms: Ornt2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83885
Homologene: 129775
Tdrkh
Name: tudor and KH domain containing protein
Synonyms: 2700091C21Rik, Tdrd2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72634
Homologene: 4999
Apon
Name: apolipoprotein N
Synonyms: D10Ucla2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28194
VEGA: 10
Homologene: 51183
Or6z1
Name: olfactory receptor family 6 subfamily Z member 1
Synonyms: MOR103-9, Olfr1348, GA_x6K02T2QGBW-3232059-3231121
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258915
Homologene: 17435
Or1e31
Name: olfactory receptor family 1 subfamily E member 31
Synonyms: MOR135-24, Olfr391, Olfr391-ps, MOR135-30_i, Olfr391-ps1, GA_x6K02T2P1NL-3951666-3950698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258236
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 10,104,246 bp
  • C to T, chromosome 1 at 169,994,682 bp
  • C to A, chromosome 2 at 120,323,679 bp
  • G to A, chromosome 2 at 120,428,912 bp
  • A to T, chromosome 2 at 125,580,034 bp
  • G to A, chromosome 2 at 128,793,064 bp
  • T to G, chromosome 3 at 94,425,714 bp
  • A to T, chromosome 3 at 94,779,144 bp
  • A to T, chromosome 3 at 106,167,484 bp
  • T to C, chromosome 3 at 145,006,102 bp
  • T to C, chromosome 4 at 62,428,096 bp
  • G to A, chromosome 4 at 63,166,959 bp
  • C to A, chromosome 4 at 65,351,687 bp
  • T to C, chromosome 4 at 101,656,111 bp
  • A to G, chromosome 4 at 128,260,482 bp
  • A to T, chromosome 4 at 143,698,042 bp
  • T to C, chromosome 5 at 76,631,450 bp
  • T to C, chromosome 6 at 4,531,143 bp
  • A to G, chromosome 6 at 42,896,798 bp
  • G to T, chromosome 6 at 91,269,957 bp
  • C to T, chromosome 6 at 125,331,002 bp
  • T to A, chromosome 6 at 125,642,132 bp
  • G to T, chromosome 7 at 6,501,488 bp
  • A to G, chromosome 7 at 25,704,809 bp
  • T to C, chromosome 7 at 28,093,987 bp
  • T to C, chromosome 7 at 79,665,685 bp
  • TCC to TC, chromosome 7 at 85,221,550 bp
  • T to C, chromosome 7 at 106,603,678 bp
  • C to A, chromosome 7 at 116,348,111 bp
  • A to G, chromosome 7 at 141,864,116 bp
  • A to G, chromosome 8 at 3,508,766 bp
  • T to A, chromosome 8 at 122,864,976 bp
  • T to C, chromosome 9 at 21,244,464 bp
  • A to T, chromosome 9 at 27,088,549 bp
  • T to C, chromosome 9 at 108,740,538 bp
  • T to A, chromosome 10 at 78,847,778 bp
  • T to C, chromosome 10 at 81,280,107 bp
  • C to A, chromosome 10 at 128,254,765 bp
  • A to T, chromosome 11 at 73,799,785 bp
  • T to C, chromosome 11 at 116,443,777 bp
  • A to G, chromosome 12 at 16,696,387 bp
  • T to G, chromosome 12 at 65,057,725 bp
  • C to A, chromosome 12 at 76,887,888 bp
  • T to C, chromosome 13 at 58,808,802 bp
  • A to G, chromosome 14 at 78,284,242 bp
  • T to C, chromosome 14 at 118,889,404 bp
  • T to C, chromosome 15 at 89,419,043 bp
  • A to T, chromosome 15 at 98,594,355 bp
  • T to C, chromosome 16 at 37,062,829 bp
  • G to T, chromosome 17 at 67,769,515 bp
  • T to C, chromosome 18 at 37,638,258 bp
  • A to C, chromosome 19 at 3,815,372 bp
  • A to T, chromosome 19 at 5,680,399 bp
  • A to G, chromosome 19 at 9,872,887 bp
  • A to G, chromosome Y at 1,263,964 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2178 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040180-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.