Strain Name:
C57BL/6J-MtgxR2178Btlr/Mmmh
Stock Number:
040180-MU
Citation ID:
RRID:MMRRC_040180-MU
Other Names:
R2178 (G1), C57BL/6J-MtgxR2178Btlr
Major Collection:

Gene Information

Prkar2a
Name: protein kinase, cAMP dependent regulatory, type II alpha
Synonyms: RII(alpha), 1110061A24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19087
HGNC: HGNC:9391
Homologene: 3064
Tgfb1
Name: transforming growth factor, beta 1
Synonyms: TGF-beta 1, Tgfb-1, Tgfb, TGFbeta1, TGF-beta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21803
Homologene: 540
Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, C030027L06Rik, Tkrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 77011
Homologene: 67120
Vps39
Name: VPS39 HOPS complex subunit
Synonyms: A230065P22Rik, Vam6P, Vam6, mVam6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269338
Homologene: 41025
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 4632407J06Rik, 2810487N22Rik, B130055D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Fntb
Name: farnesyltransferase, CAAX box, beta
Synonyms: 2010013E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 110606
HGNC: HGNC:3785
Homologene: 1535
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381644
Homologene: 45709
Cspp1
Name: centrosome and spindle pole associated protein 1
Synonyms: 4930413O22Rik, 2310020J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211660
Homologene: 23487
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 328110
Homologene: 32377
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
Ddx3y
Name: DEAD box helicase 3, Y-linked
Synonyms: Dby, 8030469F12Rik, D1Pas1-rs1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 26900
HGNC: HGNC:2699
Homologene: 55839
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104401
Homologene: 17000
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99100
Homologene: 37159
Mcoln1
Name: mucolipin 1
Synonyms: 2210015I05Rik, mucolipidin, TRPML1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94178
Homologene: 10744
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Kmt5b
Name: lysine methyltransferase 5B
Synonyms: Suv4-20h1, C630029K18Rik, Suv420h1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225888
Homologene: 32351
Hmgb4
Name: high-mobility group box 4
Synonyms: 1700001F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69317
Homologene: 83321
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Gvin3
Name: GTPase, very large interferon inducible, family member 3
Synonyms: Gm1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22371
Homologene: 466
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Cgn
Name: cingulin
Synonyms: 6330408J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70737
Homologene: 41394
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAG1, IGFBP-4ase, PAPP-A, 8430414N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268527
Homologene: 8780
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: mENaC, ENaC alpha, Scnn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20276
Homologene: 811
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Tyro 12, Nyk, Eyk, Mer, nmf12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Pramel23
Name: PRAME like 23
Synonyms: Gm13089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277667
Qrich2
Name: glutamine rich 2
Synonyms: LOC217341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217341
Homologene: 12951
Chil3
Name: chitinase-like 3
Synonyms: Ym1, Chi3l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12655
Homologene: 74931
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Cpt1b
Name: carnitine palmitoyltransferase 1b, muscle
Synonyms: M-CPTI, M-CPT I, Cpt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12895
HGNC: HGNC:2329
Homologene: 22548
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 215384
Homologene: 68369
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620697
Homologene: 115466
Cdh15
Name: cadherin 15
Synonyms: Cdh14, Mcad, M cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Dzip1
Name: DAZ interacting protein 1
Synonyms: 2510025K24Rik, 2810422M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66573
VEGA: 14
Homologene: 45708
Tnfsf11
Name: tumor necrosis factor (ligand) superfamily, member 11
Synonyms: RANKL, OPGL, ODF, Ly109l, Trance, osteoclast differentiation factor, OPGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21943
VEGA: 14
Homologene: 2744
S1pr5
Name: sphingosine-1-phosphate receptor 5
Synonyms: lpB4, S1P5, Edg8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 94226
Homologene: 11031
Kif12
Name: kinesin family member 12
Synonyms: N-9 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 16552
Homologene: 7796
Ganc
Name: glucosidase, alpha; neutral C
Synonyms: 5830445O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76051
HGNC: HGNC:4139
Homologene: 25627
Clca1
Name: chloride channel accessory 1
Synonyms: gob-5, gob5, Clca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Tjp3
Name: tight junction protein 3
Synonyms: ZO-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27375
VEGA: 10
Homologene: 8458
Olfr448
Name: olfactory receptor 448
Synonyms: GA_x6K02T2P3E9-4663051-4662119, MOR261-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258270
HGNC: HGNC:8232
Homologene: 64846
Rnf183
Name: ring finger protein 183
Synonyms: 5830442J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76072
Homologene: 44917
Leprot
Name: leptin receptor overlapping transcript
Synonyms: OB-RGRP, Obrgrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230514
Homologene: 10582
Olfr1356
Name: olfactory receptor 1356
Synonyms: GA_x6K02T2QGN0-2962025-2962987, MOR142-2_p, MOR142-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258305
HGNC: HGNC:8374
Homologene: 71958
Slc25a2
Name: solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2
Synonyms: Ornt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 83885
Homologene: 129775
Tdrkh
Name: tudor and KH domain containing protein
Synonyms: Tdrd2, 2700091C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72634
Homologene: 4999
Apon
Name: apolipoprotein N
Synonyms: D10Ucla2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 28194
VEGA: 10
Homologene: 51183
Olfr1348
Name: olfactory receptor 1348
Synonyms: GA_x6K02T2QGBW-3232059-3231121, MOR103-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258915
Homologene: 17435
Olfr391
Name: olfactory receptor 391
Synonyms: GA_x6K02T2P1NL-3951666-3950698, MOR135-30_i, MOR135-24, Olfr391-ps1, Olfr391-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258236
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 10,104,246 bp
  • C to T, chromosome 1 at 169,994,682 bp
  • C to A, chromosome 2 at 120,323,679 bp
  • G to A, chromosome 2 at 120,428,912 bp
  • A to T, chromosome 2 at 125,580,034 bp
  • G to A, chromosome 2 at 128,793,064 bp
  • T to G, chromosome 3 at 94,425,714 bp
  • A to T, chromosome 3 at 94,779,144 bp
  • A to T, chromosome 3 at 106,167,484 bp
  • T to C, chromosome 3 at 145,006,102 bp
  • T to C, chromosome 4 at 62,428,096 bp
  • G to A, chromosome 4 at 63,166,959 bp
  • C to A, chromosome 4 at 65,351,687 bp
  • T to C, chromosome 4 at 101,656,111 bp
  • A to G, chromosome 4 at 128,260,482 bp
  • A to T, chromosome 4 at 143,698,042 bp
  • T to C, chromosome 5 at 76,631,450 bp
  • T to C, chromosome 6 at 4,531,143 bp
  • A to G, chromosome 6 at 42,896,798 bp
  • G to T, chromosome 6 at 91,269,957 bp
  • C to T, chromosome 6 at 125,331,002 bp
  • T to A, chromosome 6 at 125,642,132 bp
  • G to T, chromosome 7 at 6,501,488 bp
  • A to G, chromosome 7 at 25,704,809 bp
  • T to C, chromosome 7 at 28,093,987 bp
  • T to C, chromosome 7 at 79,665,685 bp
  • TCC to TC, chromosome 7 at 85,221,550 bp
  • T to C, chromosome 7 at 106,603,678 bp
  • C to A, chromosome 7 at 116,348,111 bp
  • A to G, chromosome 7 at 141,864,116 bp
  • A to G, chromosome 8 at 3,508,766 bp
  • T to A, chromosome 8 at 122,864,976 bp
  • T to C, chromosome 9 at 21,244,464 bp
  • A to T, chromosome 9 at 27,088,549 bp
  • T to C, chromosome 9 at 108,740,538 bp
  • T to A, chromosome 10 at 78,847,778 bp
  • T to C, chromosome 10 at 81,280,107 bp
  • C to A, chromosome 10 at 128,254,765 bp
  • A to T, chromosome 11 at 73,799,785 bp
  • T to C, chromosome 11 at 116,443,777 bp
  • A to G, chromosome 12 at 16,696,387 bp
  • T to G, chromosome 12 at 65,057,725 bp
  • C to A, chromosome 12 at 76,887,888 bp
  • T to C, chromosome 13 at 58,808,802 bp
  • A to G, chromosome 14 at 78,284,242 bp
  • T to C, chromosome 14 at 118,889,404 bp
  • T to C, chromosome 15 at 89,419,043 bp
  • A to T, chromosome 15 at 98,594,355 bp
  • T to C, chromosome 16 at 37,062,829 bp
  • G to T, chromosome 17 at 67,769,515 bp
  • T to C, chromosome 18 at 37,638,258 bp
  • A to C, chromosome 19 at 3,815,372 bp
  • A to T, chromosome 19 at 5,680,399 bp
  • A to G, chromosome 19 at 9,872,887 bp
  • A to G, chromosome Y at 1,263,964 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2178 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040180-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.