Strain Name:
C57BL/6J-MtgxR2188Btlr/Mmmh
Stock Number:
040190-MU
Citation ID:
RRID:MMRRC_040190-MU
Other Names:
R2188 (G1), C57BL/6J-MtgxR2188Btlr
Major Collection:

Gene Information

Ccdc12
Name: coiled-coil domain containing 12
Synonyms: 2700094L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72654
Homologene: 41751
Srpk1
Name: serine/arginine-rich protein specific kinase 1
Synonyms: SR protein-specific kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20815
Homologene: 110962
Fam91a1
Name: family with sequence similarity 91, member A1
Synonyms: D15Ertd621e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 210998
VEGA: 15
Homologene: 13388
Kdm5a
Name: lysine (K)-specific demethylase 5A
Synonyms: RBP2, Jarid1a, Rbbp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Sec24a
Name: Sec24 related gene family, member A (S. cerevisiae)
Synonyms: 9430090N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77371
Homologene: 70131
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, KRAP, CS1, CS-1, SPAG13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70599
Homologene: 4912
Trim27
Name: tripartite motif-containing 27
Synonyms: Rfp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19720
HGNC: HGNC:9975
Homologene: 111010
Snapc1
Name: small nuclear RNA activating complex, polypeptide 1
Synonyms: 9630050P21Rik, 2700033G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75627
VEGA: 12
Homologene: 2317
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TAF3B1, B130055N23Rik, Tfnr, TFIIIB90, TFIIIB150, G630013P12Rik, TFC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544971
Homologene: 34582
Atad3a
Name: ATPase family, AAA domain containing 3A
Synonyms: Tob3, 2400004H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 108888
Homologene: 10059
Steap2
Name: six transmembrane epithelial antigen of prostate 2
Synonyms: 4921538B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74051
Homologene: 17682
Myl6
Name: myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
Synonyms: Myln, MLC3nm, MLC3NM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17904
VEGA: 10
HGNC: HGNC:7587
Homologene: 69080
Hmg20a
Name: high mobility group 20A
Synonyms: Hmgxb1, 1200004E06Rik, 5730490E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66867
VEGA: 9
HGNC: HGNC:5001
Homologene: 32399
Tbk1
Name: TANK-binding kinase 1
Synonyms: 1200008B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56480
VEGA: 10
Homologene: 22742
Qrfprl
Name: pyroglutamylated RFamide peptide receptor like
Synonyms: C130060K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243407
Homologene: 135976
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: Dnahc1, E030034C22Rik, B230373P09Rik, MDHC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Slc7a8
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Synonyms: LAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50934
VEGA: 14
Homologene: 8166
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Nlrp9a
Name: NLR family, pyrin domain containing 9A
Synonyms: Nalp9a, D7Ertd565e, Nalp-theta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233001
Homologene: 116072
Gm5134
Name: predicted gene 5134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 333669
Homologene: 129891
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: B130017I01Rik, Parg1, C76601, 6720461J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214137
Homologene: 3539
Parp3
Name: poly (ADP-ribose) polymerase family, member 3
Synonyms: Adprt3, Adprtl3, A930002C11Rik, PARP-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235587
HGNC: HGNC:273
Homologene: 4005
4932441B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74424
Homologene: 11713
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll2, Mll4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Vil1
Name: villin 1
Synonyms: Villin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22349
Homologene: 5169
Gmpr
Name: guanosine monophosphate reductase
Synonyms: 2310004P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66355
HGNC: HGNC:4376
Homologene: 5009
Olfr652
Name: olfactory receptor 652
Synonyms: MOR31-8, GA_x6K02T2PBJ9-7191524-7192471
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259050
Homologene: 17477
Ndor1
Name: NADPH dependent diflavin oxidoreductase 1
Synonyms: NR1, 4930447P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78797
Homologene: 7144
Mucl2
Name: mucin-like 2
Synonyms: Spt1, Spt-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20770
Homologene: 137219
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: Vmn2r68-ps, EG620697
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620697
Homologene: 115466
Klk14
Name: kallikrein related-peptidase 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 317653
HGNC: HGNC:6362
Homologene: 69348
Gbp2b
Name: guanylate binding protein 2b
Synonyms: Gbp1, Gbp-1, Mag-1, Mpa-1, Mpa1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14468
HGNC: HGNC:4184
Homologene: 137233
Olfr52
Name: olfactory receptor 52
Synonyms: IE6, GA_x6K02T2Q125-47650922-47649963, MOR185-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18352
Homologene: 105200
Sdsl
Name: serine dehydratase-like
Synonyms: SDS-RS1, 4432411H13Rik, SDH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 257635
Homologene: 44224
Abca7
Name: ATP-binding cassette, sub-family A (ABC1), member 7
Synonyms: Abc51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: Glut12, GLUT-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 353169
Homologene: 59263
Ccpg1
Name: cell cycle progression 1
Synonyms: 1810073J13Rik, 9430028F23Rik, D9Ertd392e, 1700030B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72278
Homologene: 3487
Tekt5
Name: tektin 5
Synonyms: 3300001K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 70426
Homologene: 71928
Zfp583
Name: zinc finger protein 583
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 213011
Homologene: 65048
Cdc34b
Name: cell division cycle 34B
Synonyms: Cdc34-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 111266
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 74,427,565 bp
  • A to T, chromosome 2 at 25,251,753 bp
  • G to A, chromosome 2 at 31,419,935 bp
  • T to C, chromosome 2 at 41,408,959 bp
  • T to C, chromosome 2 at 79,644,923 bp
  • A to T, chromosome 2 at 86,181,436 bp
  • A to C, chromosome 3 at 121,991,009 bp
  • A to T, chromosome 3 at 142,608,279 bp
  • A to T, chromosome 4 at 155,751,519 bp
  • G to T, chromosome 5 at 5,673,643 bp
  • C to T, chromosome 5 at 120,458,420 bp
  • C to A, chromosome 6 at 65,441,276 bp
  • T to A, chromosome 6 at 120,406,640 bp
  • A to G, chromosome 6 at 139,852,874 bp
  • C to T, chromosome 7 at 6,317,611 bp
  • A to G, chromosome 7 at 26,564,929 bp
  • G to A, chromosome 7 at 43,692,077 bp
  • TCC to TC, chromosome 7 at 85,221,550 bp
  • G to A, chromosome 7 at 104,564,676 bp
  • G to T, chromosome 7 at 118,654,955 bp
  • A to G, chromosome 9 at 56,477,300 bp
  • A to G, chromosome 9 at 73,013,106 bp
  • G to A, chromosome 9 at 106,475,852 bp
  • G to T, chromosome 9 at 110,656,631 bp
  • C to T, chromosome 10 at 22,664,837 bp
  • T to C, chromosome 10 at 75,995,836 bp
  • T to C, chromosome 10 at 80,002,533 bp
  • A to C, chromosome 10 at 121,563,931 bp
  • A to G, chromosome 10 at 128,492,697 bp
  • A to G, chromosome 11 at 51,723,584 bp
  • T to C, chromosome 11 at 94,742,172 bp
  • T to A, chromosome 12 at 73,970,227 bp
  • T to C, chromosome 13 at 21,183,817 bp
  • T to C, chromosome 13 at 45,532,414 bp
  • T to A, chromosome 13 at 65,034,917 bp
  • A to T, chromosome 13 at 100,059,477 bp
  • A to G, chromosome 14 at 31,279,164 bp
  • A to G, chromosome 14 at 54,737,669 bp
  • A to C, chromosome 15 at 58,430,663 bp
  • A to G, chromosome 15 at 98,839,300 bp
  • T to A, chromosome 15 at 103,897,574 bp
  • T to C, chromosome 16 at 10,358,325 bp
  • A to T, chromosome 17 at 28,594,189 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2188 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040190-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.