Strain Name:
C57BL/6J-MtgxR2200Btlr/Mmmh
Stock Number:
040202-MU
Citation ID:
RRID:MMRRC_040202-MU
Other Names:
R2200 (G1), C57BL/6J-MtgxR2200Btlr
Major Collection:

Gene Information

Npr1
Name: natriuretic peptide receptor 1
Synonyms: NPR-A, GC-A, NPRA, guanylyl cyclase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18160
HGNC: HGNC:7943
Homologene: 37367
Rgs9
Name: regulator of G-protein signaling 9
Synonyms: RGS9-1, Rgs9-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 19739
Homologene: 2845
Rgs10
Name: regulator of G-protein signalling 10
Synonyms: 2310010N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67865
HGNC: HGNC:9992
Homologene: 37710
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9430095K15Rik, 9030421L11Rik, 9130004I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 320398
VEGA: 10
Homologene: 62452
Mrpl35
Name: mitochondrial ribosomal protein L35
Synonyms: 1110066C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 66223
Homologene: 9598
Fus
Name: fused in sarcoma
Synonyms: D930039C12Rik, pigpen, Tls, translocated in liposarcoma, D430004D17Rik, hnRNP P2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233908
HGNC: HGNC:4010
Homologene: 134091
Ergic1
Name: endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
Synonyms: 1200007D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 67458
Homologene: 41667
Ipo13
Name: importin 13
Synonyms: Imp13, Kap13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230673
Homologene: 40968
Pyroxd1
Name: pyridine nucleotide-disulphide oxidoreductase domain 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232491
Homologene: 11758
Itgb3
Name: integrin beta 3
Synonyms: platelet glycoprotein IIIa (GP3A), CD61
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16416
HGNC: HGNC:6156
Homologene: 55444
Taf1c
Name: TATA-box binding protein associated factor, RNA polymerase I, C
Synonyms: mTAFI95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 21341
Homologene: 21163
Mme
Name: membrane metallo endopeptidase
Synonyms: neprilysin, NEP, neutral endopeptidase, CD10, 6030454K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Samd8
Name: sterile alpha motif domain containing 8
Synonyms: Smsr, 1700010P07Rik, 1110053F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67630
Homologene: 41670
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71389
Homologene: 32772
Morc2a
Name: microrchidia 2A
Synonyms: Zcwcc1, 8430403M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74522
Homologene: 8966
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99003
Homologene: 11710
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319670
VEGA: 12
Homologene: 26807
Sec22a
Name: SEC22 homolog A, vesicle trafficking protein
Synonyms: Sec22l2, 1810005C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 317717
Homologene: 8246
Podn
Name: podocan
Synonyms: SLRR5A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242608
Homologene: 17803
B3gat2
Name: beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
Synonyms: GlcAT-S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 280645
HGNC: HGNC:922
Homologene: 50574
Rec8
Name: REC8 meiotic recombination protein
Synonyms: mrec, Rec8L1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56739
Homologene: 3768
Fam160a1
Name: family with sequence similarity 160, member A1
Synonyms: 9930021J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229488
Homologene: 85149
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 142682
Homologene: 9037
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80797
Homologene: 77224
Acer1
Name: alkaline ceramidase 1
Synonyms: Cer1, 2310024P18Rik, Asah3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 171168
VEGA: 17
Homologene: 15853
Rbm46
Name: RNA binding motif protein 46
Synonyms: LOC329687, ENSMUSG00000033882
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 633285
Homologene: 17016
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: 5730414M22Rik, BKCa, Slo, BK channel alpha subunit, MaxiK, Slo1, mSlo1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Mxr2, Abcp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 27405
Homologene: 86845
Sun1
Name: Sad1 and UNC84 domain containing 1
Synonyms: 4632417G13Rik, Unc84a, 5730434D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 77053
Homologene: 11544
Scaf11
Name: SR-related CTD-associated factor 11
Synonyms: SRRP129, 2610510E10Rik, SIP1, 1110061H03Rik, CASP11, Sfrs2ip, Srsf2ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 72193
VEGA: 15
Homologene: 37957
Bpifb9b
Name: BPI fold containing family B, member 9B
Synonyms: OTTMUSG00000015915, 5430413K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 433492
Homologene: 128535
Ptpru
Name: protein tyrosine phosphatase, receptor type, U
Synonyms: Ptprl, RPTPlambda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19273
HGNC: HGNC:9683
Homologene: 4168
Cpxm1
Name: carboxypeptidase X 1 (M14 family)
Synonyms: Cpx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56264
Homologene: 10485
Bmp8b
Name: bone morphogenetic protein 8b
Synonyms: Op3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12164
HGNC: HGNC:1075
Homologene: 130625
Cbs
Name: cystathionine beta-synthase
Synonyms: HIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12411
Homologene: 37258
Ano7
Name: anoctamin 7
Synonyms: NGEP, Tmem16g, Pcanap5, NGEP-L, IPCA-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 404545
Homologene: 45787
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 80721
Homologene: 23530
Cyp4f16
Name: cytochrome P450, family 4, subfamily f, polypeptide 16
Synonyms: 2310021J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 70101
Homologene: 135840
Lrif1
Name: ligand dependent nuclear receptor interacting factor 1
Synonyms: 2010012G17Rik, 4933421E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 321000
Homologene: 10160
Sccpdh
Name: saccharopine dehydrogenase (putative)
Synonyms: C330023F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109232
Homologene: 9334
Asah1
Name: N-acylsphingosine amidohydrolase 1
Synonyms: 2310081N20Rik, acid ceramidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11886
HGNC: HGNC:735
Homologene: 10504
Clec2d
Name: C-type lectin domain family 2, member d
Synonyms: Ocil, Clr-b, Clrb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 93694
Homologene: 136309
Eva1a
Name: eva-1 homolog A (C. elegans)
Synonyms: Tmem166, Fam176a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232146
Homologene: 12969
Rnaseh2b
Name: ribonuclease H2, subunit B
Synonyms: 2610207P08Rik, 1110019N06Rik, Dleu8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67153
Homologene: 41572
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 23,762,792 bp
  • A to G, chromosome 1 at 83,022,943 bp
  • A to G, chromosome 1 at 93,380,436 bp
  • G to T, chromosome 1 at 179,670,606 bp
  • A to T, chromosome 2 at 41,284,165 bp
  • A to G, chromosome 2 at 104,789,013 bp
  • G to T, chromosome 2 at 130,393,197 bp
  • C to A, chromosome 2 at 154,313,654 bp
  • A to G, chromosome 2 at 160,983,753 bp
  • A to T, chromosome 3 at 63,380,292 bp
  • A to T, chromosome 3 at 82,864,044 bp
  • A to G, chromosome 3 at 85,730,321 bp
  • A to T, chromosome 3 at 90,463,802 bp
  • T to A, chromosome 3 at 106,734,558 bp
  • T to A, chromosome 3 at 144,813,924 bp
  • T to C, chromosome 4 at 108,022,590 bp
  • A to C, chromosome 4 at 117,904,903 bp
  • A to T, chromosome 4 at 123,123,022 bp
  • A to T, chromosome 4 at 131,820,813 bp
  • T to G, chromosome 5 at 104,961,263 bp
  • C to A, chromosome 5 at 139,231,219 bp
  • A to C, chromosome 6 at 71,817,739 bp
  • A to G, chromosome 6 at 82,091,913 bp
  • A to T, chromosome 6 at 129,184,868 bp
  • G to T, chromosome 6 at 142,359,082 bp
  • T to A, chromosome 7 at 127,977,228 bp
  • T to C, chromosome 7 at 128,389,037 bp
  • A to G, chromosome 8 at 41,343,728 bp
  • A to G, chromosome 8 at 119,598,678 bp
  • A to T, chromosome 8 at 121,605,428 bp
  • A to T, chromosome 10 at 88,555,695 bp
  • A to G, chromosome 10 at 125,996,609 bp
  • A to G, chromosome 11 at 3,683,919 bp
  • T to A, chromosome 11 at 104,640,986 bp
  • T to C, chromosome 11 at 109,259,912 bp
  • T to C, chromosome 11 at 118,102,409 bp
  • T to C, chromosome 12 at 98,825,417 bp
  • C to T, chromosome 14 at 21,775,320 bp
  • C to T, chromosome 14 at 23,336,135 bp
  • A to G, chromosome 14 at 55,622,730 bp
  • G to A, chromosome 14 at 62,370,561 bp
  • T to C, chromosome 15 at 96,420,523 bp
  • A to T, chromosome 16 at 35,314,157 bp
  • C to A, chromosome 17 at 26,641,592 bp
  • T to C, chromosome 17 at 31,624,264 bp
  • G to T, chromosome 17 at 32,537,104 bp
  • T to C, chromosome 17 at 56,958,423 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2200 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040202-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.