Strain Name:
C57BL/6J-MtgxR2243Btlr/Mmmh
Stock Number:
040243-MU
Citation ID:
RRID:MMRRC_040243-MU
Other Names:
R2243 (G1), C57BL/6J-MtgxR2243Btlr
Major Collection:

Gene Information

Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: Dicer1, 1110006F08Rik, D12Ertd7e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Akap10
Name: A kinase (PRKA) anchor protein 10
Synonyms: B130049N18Rik, D-AKAP2, 1500031L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56697
HGNC: HGNC:368
Homologene: 32452
Golga4
Name: golgi autoantigen, golgin subfamily a, 4
Synonyms: Olp-1, golgin-245
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Fxr2
Name: fragile X mental retardation, autosomal homolog 2
Synonyms: Fxr2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23879
HGNC: HGNC:4024
Homologene: 21014
Kif18a
Name: kinesin family member 18A
Synonyms: N-8 kinesin, gcd2, B130001M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228421
Homologene: 41820
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: hensin, CRP-[b], CRP-[a], vomeroglandin, MUCLIN, ebnerin, gp300, Crpd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Lig4
Name: ligase IV, DNA, ATP-dependent
Synonyms: 5830471N16Rik, tiny, DNA ligase IV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319583
HGNC: HGNC:6601
Homologene: 1736
Uimc1
Name: ubiquitin interaction motif containing 1
Synonyms: Rxrip110, 9430016E08Rik, D630032M02Rik, D330018D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20184
Homologene: 9455
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: Hnrpul2, 1110031M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Fchsd2
Name: FCH and double SH3 domains 2
Synonyms: Sh3md3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207278
Homologene: 8887
Tatdn3
Name: TatD DNase domain containing 3
Synonyms: 1500010M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68972
Homologene: 45949
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328783
VEGA: 17
Homologene: 18633
Myof
Name: myoferlin
Synonyms: E030042N20Rik, 2310051D19Rik, Fer1l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Agbl1
Name: ATP/GTP binding protein-like 1
Synonyms: EG244071, Nna1-l1, Ccp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244071
Homologene: 17552
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Shn-2, Gm20114, MIBP1, Schnurri-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, fibrocystin L, PKHDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: Nalp2, Nbs1, PYPAF2, Pan1, E330007A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232827
Homologene: 56789
Fam160b2
Name: family with sequence similarity 160, member B2
Synonyms: Rai16, G430067P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239170
VEGA: 14
Homologene: 23379
Pcnx
Name: pecanex homolog
Synonyms: 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Bnc1
Name: basonuclin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12173
HGNC: HGNC:1081
Homologene: 31048
Vmn1r68
Name: vomeronasal 1 receptor 68
Synonyms: Gm6898
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628580
Homologene: 120153
Lilr4b
Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4B
Synonyms: gp49, Gp49a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14727
HGNC: HGNC:6608
Homologene: 86756
Serpina6
Name: serine (or cysteine) peptidase inhibitor, clade A, member 6
Synonyms: Cbg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12401
HGNC: HGNC:1540
Homologene: 20417
Hbb-b1
Name: hemoglobin, beta adult major chain
Synonyms: beta maj, MommeD7, beta1, beta major globin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Slc43a3
Name: solute carrier family 43, member 3
Synonyms: SEEEG-1, Eeg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58207
Homologene: 40925
Lrrc31
Name: leucine rich repeat containing 31
Synonyms: E230002P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320352
Dnaaf2
Name: dynein, axonemal assembly factor 2
Synonyms: Ktu, 1110034A24Rik, 2810020C19Rik, kintoun
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 109065
Homologene: 10026
Klhdc10
Name: kelch domain containing 10
Synonyms: 2410127E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76788
Homologene: 15267
Zer1
Name: zyg-11 related, cell cycle regulator
Synonyms: C230075L19Rik, Zyg11bl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227693
Homologene: 4621
Timm44
Name: translocase of inner mitochondrial membrane 44
Synonyms: Mimt44, D8Ertd118e, Tim44, 0710005E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21856
Homologene: 4631
Aadacl4fm5
Name: AADACL4 family member 5
Synonyms: LOC329993, Gm438
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329993
Homologene: 135765
Olfr317
Name: olfactory receptor 317
Synonyms: GA_x6K02T2NKPP-680866-681849, MOR256-47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 257931
Homologene: 128382
Foxb1
Name: forkhead box B1
Synonyms: Mf3, Fkh5, Foxb1b, Foxb1a, TWH, C43, Hfh-e5.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64290
VEGA: 9
HGNC: HGNC:3799
Homologene: 8138
S100a14
Name: S100 calcium binding protein A14
Synonyms: S100a15, 1110013O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66166
Homologene: 10781
Taldo1
Name: transaldolase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21351
Homologene: 4916
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 191,052,900 bp
  • A to T, chromosome 2 at 30,101,127 bp
  • T to C, chromosome 2 at 84,948,438 bp
  • C to A, chromosome 2 at 109,298,107 bp
  • T to A, chromosome 3 at 30,685,030 bp
  • A to G, chromosome 3 at 90,527,807 bp
  • G to A, chromosome 4 at 144,777,421 bp
  • T to A, chromosome 5 at 41,821,545 bp
  • A to G, chromosome 6 at 30,449,559 bp
  • G to A, chromosome 6 at 84,186,509 bp
  • C to T, chromosome 7 at 5,335,598 bp
  • A to T, chromosome 7 at 10,528,162 bp
  • A to T, chromosome 7 at 76,418,722 bp
  • T to C, chromosome 7 at 81,974,073 bp
  • A to G, chromosome 7 at 101,233,885 bp
  • T to C, chromosome 7 at 103,827,811 bp
  • T to C, chromosome 7 at 131,046,562 bp
  • C to A, chromosome 7 at 141,392,304 bp
  • A to T, chromosome 8 at 4,267,871 bp
  • A to G, chromosome 8 at 9,972,161 bp
  • T to C, chromosome 9 at 69,759,864 bp
  • C to A, chromosome 9 at 118,556,904 bp
  • C to A, chromosome 10 at 14,128,969 bp
  • A to T, chromosome 10 at 51,481,608 bp
  • G to A, chromosome 11 at 58,732,445 bp
  • C to A, chromosome 11 at 61,915,501 bp
  • A to T, chromosome 11 at 69,642,070 bp
  • T to G, chromosome 12 at 69,196,644 bp
  • T to C, chromosome 12 at 81,918,705 bp
  • T to A, chromosome 12 at 103,646,928 bp
  • T to A, chromosome 12 at 104,730,188 bp
  • A to T, chromosome 13 at 55,050,739 bp
  • G to C, chromosome 14 at 50,854,210 bp
  • A to G, chromosome 14 at 70,587,950 bp
  • T to C, chromosome 15 at 44,546,927 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • T to A, chromosome 19 at 8,820,637 bp
  • C to T, chromosome 19 at 37,901,319 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2243 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040243-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.