Strain Name:
C57BL/6J-MtgxR2246Btlr/Mmmh
Stock Number:
040246-MU
Citation ID:
RRID:MMRRC_040246-MU
Other Names:
R2246 (G1), C57BL/6J-MtgxR2246Btlr
Major Collection:

Strain Information

Pank3
Name: pantothenate kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 211347
Homologene: 56999
Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Cwf19l2
Name: CWF19-like 2, cell cycle control (S. pombe)
Synonyms: 3230401L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244672
Homologene: 12366
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: GALT, alpha Gal, Gal, glycoprotein alpha galactosyl transferase 1, alpha3GalT, Ggta-1, Ggta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: B930007L02Rik, Vprbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 321006
Homologene: 8805
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: 9630039I18Rik, 1810043M20Rik, Bat2d, Bat2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226562
Homologene: 41015
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76464
Homologene: 44890
Hip1
Name: huntingtin interacting protein 1
Synonyms: 2610109B09Rik, A930014B11Rik, E130315I21Rik, HIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21819
Homologene: 2430
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Shisal1
Name: shisa like 1
Synonyms: 1810041L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72301
Homologene: 28255
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233410
Homologene: 8759
Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms: MTP2, PSF2, Ham2, Ham-2, Tap-2, HAM2, Abcb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21355
HGNC: HGNC:44
Homologene: 37323
Clec7a
Name: C-type lectin domain family 7, member a
Synonyms: dectin-1, BGR, beta-GR, beta-glucan receptor, Clecsf12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56644
Homologene: 49606
Igsf9
Name: immunoglobulin superfamily, member 9
Synonyms: NRT1, Dasm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 93842
Homologene: 10815
Anapc16
Name: anaphase promoting complex subunit 16
Synonyms: 2310005G07Rik, D10Ertd641e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 52717
Homologene: 11957
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72333
Homologene: 75052
Phaf1
Name: phagosome assembly factor 1
Synonyms: Lin10, D230025D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234678
Homologene: 11864
Ldb3
Name: LIM domain binding 3
Synonyms: ZASP, cypher
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 24131
VEGA: 14
Homologene: 134626
Zbed5
Name: zinc finger BED-type containing 5
Synonyms: 2410018M08Rik, Zbed5, Chchd2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71970
Homologene: 84838
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104271
Homologene: 12837
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: MIBP1, Schnurri-2, Shn-2, Gm20114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Zfyve9
Name: zinc finger, FYVE domain containing 9
Synonyms: Madhip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230597
HGNC: HGNC:6775
Homologene: 3527
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: Pept2, 8430408C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57738
Homologene: 56912
Ror2
Name: receptor tyrosine kinase-like orphan receptor 2
Synonyms: Ntrkr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 26564
Homologene: 55831
Slc38a7
Name: solute carrier family 38, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234595
Homologene: 41237
Hcls1
Name: hematopoietic cell specific Lyn substrate 1
Synonyms: HS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15163
HGNC: HGNC:4844
Homologene: 38034
Wipf3
Name: WAS/WASL interacting protein family, member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330319
Homologene: 113391
Srrd
Name: SRR1 domain containing
Synonyms: Srr1, 2810002G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70118
Homologene: 33447
Zkscan16
Name: zinc finger with KRAB and SCAN domains 16
Synonyms: Zfp483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041581
Homologene: 26419
Tmem67
Name: transmembrane protein 67
Synonyms: 5330408M12Rik, b2b1291.1Clo, b2b1163.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329795
Homologene: 71886
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: Glur-6, Glur6, Glurbeta2, C130030K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Or10ab4
Name: olfactory receptor family 10 subfamily AB member 4
Synonyms: GA_x6K02T2PBJ9-10384085-10385068, MOR267-15, Olfr479
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257891
Homologene: 79346
Vmn2r67
Name: vomeronasal 2, receptor 67
Synonyms: EG620672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620672
Homologene: 115466
Try4
Name: trypsin 4
Synonyms: Td, 0910001B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22074
Homologene: 106639
Or10ag57
Name: olfactory receptor family 10 subfamily AG member 57
Synonyms: GA_x6K02T2Q125-48880078-48881058, MOR264-1, Olfr1122
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259033
Homologene: 73977
Traf5
Name: TNF receptor-associated factor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22033
Homologene: 27079
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244178
Homologene: 9700
4921522P10Rik
Name: RIKEN cDNA 4921522P10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66719
Or6c3b
Name: olfactory receptor family 6 subfamily C member 3B
Synonyms: GA_x6K02T2PULF-11370664-11369738, MOR111-3, Olfr803
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258547
Homologene: 105153
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 71,628,535 bp
  • A to G, chromosome 1 at 162,707,791 bp
  • T to A, chromosome 1 at 172,491,649 bp
  • T to C, chromosome 1 at 192,066,890 bp
  • T to C, chromosome 2 at 35,402,109 bp
  • T to A, chromosome 2 at 87,387,851 bp
  • C to T, chromosome 2 at 119,072,227 bp
  • G to A, chromosome 4 at 12,040,651 bp
  • A to G, chromosome 4 at 58,957,329 bp
  • A to T, chromosome 4 at 108,689,264 bp
  • A to G, chromosome 4 at 143,897,220 bp
  • A to T, chromosome 5 at 112,339,756 bp
  • A to T, chromosome 5 at 129,902,751 bp
  • A to C, chromosome 5 at 135,452,844 bp
  • C to T, chromosome 6 at 41,305,472 bp
  • C to T, chromosome 6 at 54,489,073 bp
  • G to A, chromosome 6 at 84,186,509 bp
  • T to G, chromosome 6 at 85,622,967 bp
  • T to A, chromosome 6 at 129,467,569 bp
  • A to G, chromosome 7 at 81,041,613 bp
  • T to C, chromosome 7 at 85,136,556 bp
  • C to T, chromosome 7 at 104,142,311 bp
  • C to T, chromosome 7 at 108,055,782 bp
  • T to A, chromosome 8 at 8,663,474 bp
  • G to A, chromosome 8 at 33,582,512 bp
  • T to C, chromosome 8 at 61,877,135 bp
  • A to T, chromosome 8 at 95,843,840 bp
  • T to A, chromosome 8 at 105,246,500 bp
  • A to G, chromosome 9 at 3,430,661 bp
  • A to G, chromosome 9 at 106,854,177 bp
  • C to A, chromosome 10 at 14,128,969 bp
  • C to T, chromosome 10 at 49,535,436 bp
  • G to T, chromosome 10 at 59,996,476 bp
  • A to G, chromosome 10 at 129,691,943 bp
  • A to G, chromosome 11 at 35,783,506 bp
  • C to T, chromosome 13 at 53,111,602 bp
  • A to T, chromosome 14 at 34,529,475 bp
  • T to C, chromosome 15 at 66,729,689 bp
  • T to A, chromosome 15 at 84,417,199 bp
  • A to T, chromosome 16 at 36,762,361 bp
  • G to T, chromosome 16 at 36,962,622 bp
  • C to A, chromosome 17 at 34,208,801 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2246 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040246-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.