Strain Name:
C57BL/6J-MtgxR2698Btlr/Mmmh
Stock Number:
040436-MU
Citation ID:
RRID:MMRRC_040436-MU
Other Names:
R2698 (G1), C57BL/6J-MtgxR2698Btlr
Major Collection:

Strain Information

Lamb1
Name: laminin B1
Synonyms: Lamb-1, C81607, C80098, D130003D08Rik, Lamb1-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Mbd4
Name: methyl-CpG binding domain protein 4
Synonyms: Med1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17193
HGNC: HGNC:6919
Homologene: 2916
Cwc27
Name: CWC27 spliceosome-associated protein
Synonyms: NY-CO-10, 3110009E13Rik, Sdccag10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67285
Homologene: 21192
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75786
Homologene: 8844
Ctage5
Name: CTAGE family, member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Fbxo28
Name: F-box protein 28
Synonyms: 5730505P19Rik, 4833428J17Rik, Fbx28, D1Ertd578e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67948
Homologene: 9050
Wapl
Name: WAPL cohesin release factor
Synonyms: A530089A20Rik, Wapal
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218914
Homologene: 41002
Plcg1
Name: phospholipase C, gamma 1
Synonyms: Plc-1, Plcg-1, Plc-gamma1, Cded
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18803
HGNC: HGNC:9065
Homologene: 1997
Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
Synonyms: 4930431E10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75788
Homologene: 10712
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 84585
Homologene: 11112
Osbpl11
Name: oxysterol binding protein-like 11
Synonyms: ORP-11
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106326
Homologene: 23385
Lin54
Name: lin-54 DREAM MuvB core complex component
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231506
Homologene: 18212
Pdcd6ip
Name: programmed cell death 6 interacting protein
Synonyms: Alix, AIP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18571
HGNC: HGNC:8766
Homologene: 22614
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: BRAG3, synarfGEF
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sra4, Sfrs15, Srsf15
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Ypel3
Name: yippee like 3
Synonyms: 1190001G19Rik, Suap, 0610043B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66090
Homologene: 116010
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: D14Ertd171e, ELKS2alpha, CAST
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 238988
Homologene: 69188
Morc2a
Name: microrchidia 2A
Synonyms: 8430403M08Rik, Zcwcc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74522
Homologene: 8966
Nptx1
Name: neuronal pentraxin 1
Synonyms: Np1, D11Bwg1004e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18164
HGNC: HGNC:7952
Homologene: 1891
Trpa1
Name: transient receptor potential cation channel, subfamily A, member 1
Synonyms: ANKTM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 277328
HGNC: HGNC:497
Homologene: 7189
Zfp998
Name: zinc finger protein 998
Synonyms: Gt(Ayu21)35Imeg, Gt(pU21)35Imeg, 2410141K09Rik, Snerv1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76803
Homologene: 136362
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Irbp, Rbp-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Txnip
Name: thioredoxin interacting protein
Synonyms: THIF, VDUP1, mVDUP1, Hyplip1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56338
Homologene: 38186
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Dusp8
Name: dual specificity phosphatase 8
Synonyms: Nttp1, 5530400B01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18218
HGNC: HGNC:3074
Homologene: 31239
Dpysl4
Name: dihydropyrimidinase-like 4
Synonyms: unc-33-like phosphoprotein 4, Ulip4, CRMP-3, Drp-4, DPY4, Crmp3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26757
HGNC: HGNC:3016
Homologene: 4691
Or1j20
Name: olfactory receptor family 1 subfamily J member 20
Synonyms: GA_x6K02T2NLDC-33564136-33565083, MOR136-10, Olfr352
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258942
Homologene: 121523
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Tnfaip8l2
Name: tumor necrosis factor, alpha-induced protein 8-like 2
Synonyms: 1810019A08Rik, Tipe2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69769
Homologene: 56998
Usp50
Name: ubiquitin specific peptidase 50
Synonyms: 1700086G18Rik, 4930511O11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75083
Homologene: 75281
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Ttc22
Name: tetratricopeptide repeat domain 22
Synonyms: 4732467L16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230576
Homologene: 89253
Abcc9
Name: ATP-binding cassette, sub-family C member 9
Synonyms: SUR2B, SUR2A, Sur2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Dcaf11
Name: DDB1 and CUL4 associated factor 11
Synonyms: 0710008A13Rik, GLO14, D14Ucla1, Wdr23
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 28199
Homologene: 11886
Abhd18
Name: abhydrolase domain containing 18
Synonyms: 3110057O12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269423
Homologene: 105457
Plcxd1
Name: phosphatidylinositol-specific phospholipase C, X domain containing 1
Synonyms: LOC231597, A330045H12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 403178
Homologene: 138628
Gpr87
Name: G protein-coupled receptor 87
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84111
HGNC: HGNC:4538
Homologene: 13021
Vmn2r66
Name: vomeronasal 2, receptor 66
Synonyms: F830104D24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233437
Homologene: 115466
Taar4
Name: trace amine-associated receptor 4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209513
Homologene: 45509
Hid1
Name: HID1 domain containing
Synonyms: C630004H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217310
Homologene: 12737
Zfp175
Name: zinc finger protein 175
Synonyms: Zfp658
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210104
Homologene: 134007
Fsd2
Name: fibronectin type III and SPRY domain containing 2
Synonyms: Spryd1, 9830160G03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244091
Homologene: 18252
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Tmprss11c
Name: transmembrane protease, serine 11c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 435845
Homologene: 78847
Lnpk
Name: lunapark, ER junction formation factor
Synonyms: 2310011O18Rik, 4921514L11Rik, 9530051D01Rik, lunapark, Lnpk1, Lnp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69605
Homologene: 12319
Mrps23
Name: mitochondrial ribosomal protein S23
Synonyms: 2310047I09Rik, Rpms23, D11Bwg1153e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 64656
Homologene: 41101
Sema5a
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Synonyms: M-Sema D, semF, Semaf, 9130201M22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20356
VEGA: 15
Homologene: 2949
Slc24a3
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms: NCKX3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94249
Homologene: 41390
Muc17
Name: mucin 17, cell surface associated
Synonyms: Muc3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666339
Homologene: 141159
Ano2
Name: anoctamin 2
Synonyms: Tmem16b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243634
HGNC: HGNC:1183
Homologene: 23221
Vmn2r117
Name: vomeronasal 2, receptor 117
Synonyms: EG619788, V2Rp6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619788
Homologene: 86604
Pabpc1l
Name: poly(A) binding protein, cytoplasmic 1-like
Synonyms: ePAB, 1810053B01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381404
Homologene: 77989
Rhag
Name: Rhesus blood group-associated A glycoprotein
Synonyms: Rh50A, Rh50, CD241
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19743
Homologene: 68045
Zfp760
Name: zinc finger protein 760
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240034
VEGA: 17
Rps6ka4
Name: ribosomal protein S6 kinase, polypeptide 4
Synonyms: MSK2, 1110069D02Rik, 90kDa
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56613
VEGA: 19
Homologene: 69288
Scrn2
Name: secernin 2
Synonyms: SES2, D11Moh48
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217140
Homologene: 26698
Qars1
Name: glutaminyl-tRNA synthetase 1
Synonyms: 1110018N24Rik, 1200016L19Rik, Qars
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 97541
HGNC: HGNC:9751
Homologene: 133975
Scx
Name: scleraxis scleraxis bHLH transcription factor
Synonyms: Scl, bHLHa41
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20289
VEGA: 15
Homologene: 85195
Nlrp4g
Name: NLR family, pyrin domain containing 4G
Synonyms: nalp4g, Gm47182, Gm47180
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235779
VEGA: 9
Kbtbd8
Name: kelch repeat and BTB (POZ) domain containing 8
Synonyms: Takrp, SSEC-51, SSEC 51, SSEC51
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243574
Homologene: 13043
Gabra4
Name: gamma-aminobutyric acid type A receptor subunit alpha 4
Synonyms: Gabra-4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14397
HGNC: HGNC:4078
Homologene: 631
Vta1
Name: vesicle (multivesicular body) trafficking 1
Synonyms: 1110001D18Rik, 1110059P08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66201
Homologene: 6473
Gm5113
Name: predicted gene 5113
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330503
Gm11541
Name: predicted gene 11541
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 432589
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 14,905,998 bp
  • T to A, chromosome 1 at 182,317,154 bp
  • T to A, chromosome 2 at 36,870,196 bp
  • T to C, chromosome 2 at 74,537,501 bp
  • C to T, chromosome 2 at 91,475,212 bp
  • T to C, chromosome 2 at 91,578,081 bp
  • A to G, chromosome 2 at 126,778,029 bp
  • A to G, chromosome 2 at 145,613,567 bp
  • A to G, chromosome 2 at 160,761,463 bp
  • T to G, chromosome 2 at 164,044,382 bp
  • T to A, chromosome 3 at 40,930,966 bp
  • T to A, chromosome 3 at 59,179,166 bp
  • T to A, chromosome 3 at 95,140,361 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • T to A, chromosome 3 at 158,135,391 bp
  • A to G, chromosome 4 at 106,639,238 bp
  • T to C, chromosome 5 at 71,572,078 bp
  • A to G, chromosome 5 at 86,271,463 bp
  • A to T, chromosome 5 at 100,480,250 bp
  • A to G, chromosome 5 at 110,102,483 bp
  • A to T, chromosome 5 at 137,146,636 bp
  • G to T, chromosome 5 at 142,212,050 bp
  • A to G, chromosome 5 at 144,883,562 bp
  • C to A, chromosome 6 at 95,126,589 bp
  • T to C, chromosome 6 at 115,844,730 bp
  • C to T, chromosome 6 at 121,413,471 bp
  • C to A, chromosome 6 at 125,712,346 bp
  • T to C, chromosome 6 at 142,633,136 bp
  • T to A, chromosome 7 at 30,178,725 bp
  • A to G, chromosome 7 at 43,573,545 bp
  • T to C, chromosome 7 at 81,545,860 bp
  • A to T, chromosome 7 at 84,995,399 bp
  • T to A, chromosome 7 at 126,780,016 bp
  • A to G, chromosome 7 at 139,096,765 bp
  • A to G, chromosome 7 at 142,081,964 bp
  • T to A, chromosome 8 at 110,609,929 bp
  • A to T, chromosome 9 at 108,067,207 bp
  • G to A, chromosome 9 at 108,508,443 bp
  • A to T, chromosome 9 at 113,674,507 bp
  • T to A, chromosome 9 at 124,349,630 bp
  • G to T, chromosome 10 at 14,667,922 bp
  • T to C, chromosome 10 at 23,961,430 bp
  • T to C, chromosome 11 at 3,685,400 bp
  • T to A, chromosome 11 at 30,874,282 bp
  • T to C, chromosome 11 at 88,205,367 bp
  • A to T, chromosome 11 at 94,695,615 bp
  • T to C, chromosome 11 at 97,032,296 bp
  • A to T, chromosome 11 at 115,355,129 bp
  • A to G, chromosome 11 at 119,410,144 bp
  • A to T, chromosome 11 at 119,544,843 bp
  • G to T, chromosome 12 at 31,298,883 bp
  • T to C, chromosome 12 at 59,170,994 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • T to A, chromosome 13 at 63,542,224 bp
  • A to G, chromosome 13 at 66,433,434 bp
  • A to T, chromosome 13 at 104,806,751 bp
  • G to A, chromosome 14 at 28,271,705 bp
  • C to T, chromosome 14 at 33,956,018 bp
  • G to A, chromosome 14 at 34,691,777 bp
  • T to C, chromosome 14 at 55,566,885 bp
  • C to A, chromosome 15 at 32,673,400 bp
  • T to A, chromosome 15 at 76,458,163 bp
  • T to C, chromosome 16 at 33,196,155 bp
  • T to A, chromosome 16 at 90,244,356 bp
  • C to T, chromosome 17 at 21,720,954 bp
  • A to G, chromosome 17 at 23,459,911 bp
  • T to C, chromosome 17 at 40,836,476 bp
  • T to C, chromosome 19 at 6,837,352 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2698 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040436-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.