Strain Name:
C57BL/6J-MtgxR2909Btlr/Mmmh
Stock Number:
040496-MU
Citation ID:
RRID:MMRRC_040496-MU
Other Names:
R2909 (G1), C57BL/6J-MtgxR2909Btlr
Major Collection:

Gene Information

Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Pml
Name: promyelocytic leukemia
Synonyms: Trim19, 1200009E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18854
HGNC: HGNC:9113
Homologene: 13245
Glcci1
Name: glucocorticoid induced transcript 1
Synonyms: 2310047L21Rik, GIG18, Tssn1, A130036A18Rik, Fam117c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170772
Homologene: 15773
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Commd9
Name: COMM domain containing 9
Synonyms: 1810029F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76501
Homologene: 8584
Ap4m1
Name: adaptor-related protein complex AP-4, mu 1
Synonyms: 4930443L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11781
HGNC: HGNC:574
Homologene: 3467
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: DD1, AF529169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209743
Homologene: 17782
Epg5
Name: ectopic P-granules autophagy protein 5 homolog (C. elegans)
Synonyms: 5430411K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Ncam1
Name: neural cell adhesion molecule 1
Synonyms: CD56, NCAM-1, NCAM-120, NCAM-140, NCAM-180, E-NCAM, NCAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17967
HGNC: HGNC:7656
Homologene: 40754
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, D330044F14Rik, D030010H02Rik, 4432416O06Rik, Dnchc2, b2b414Clo, m407Asp, m152Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Dapk1
Name: death associated protein kinase 1
Synonyms: 2310039H24Rik, D13Ucla1, 2810425C21Rik, DAP-Kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Slc12a9
Name: solute carrier family 12 (potassium/chloride transporters), member 9
Synonyms: CIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83704
Homologene: 5429
Ice1
Name: interactor of little elongation complex ELL subunit 1
Synonyms: BC018507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218333
VEGA: 13
Homologene: 18902
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Rsl24d1
Name: ribosomal L24 domain containing 1
Synonyms: 2410159K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 225215
Homologene: 9462
Pax7
Name: paired box 7
Synonyms: Pax-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18509
HGNC: HGNC:8621
Homologene: 55665
Clic5
Name: chloride intracellular channel 5
Synonyms: 5730531E12Rik, nmf318
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224796
VEGA: 17
Homologene: 987
Sharpin
Name: SHANK-associated RH domain interacting protein
Synonyms: SIPL1, 0610041B22Rik, cpdm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 106025
Homologene: 11918
Gramd4
Name: GRAM domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223752
Homologene: 18199
Stxbp5l
Name: syntaxin binding protein 5-like
Synonyms: t2md1, LLGL4, A830015P08Rik, insulin level locus 1, tomosyn-2, T2dm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207227
Homologene: 18173
Trp63
Name: transformation related protein 63
Synonyms: KET protein, p63, p73L, Trp53rp1, TAp63, p51/p63, deltaNp63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 22061
Homologene: 31189
Tnfrsf18
Name: tumor necrosis factor receptor superfamily, member 18
Synonyms: Gitr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21936
Homologene: 48270
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224552
Homologene: 115024
Vmn2r92
Name: vomeronasal 2, receptor 92
Synonyms: EG627111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627111
Homologene: 115024
Chrm3
Name: cholinergic receptor, muscarinic 3, cardiac
Synonyms: M3R, Chrm-3, muscarinic acetylcholine receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12671
HGNC: HGNC:1952
Homologene: 20191
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665210
Homologene: 115024
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 29816
Homologene: 78348
B3glct
Name: beta-3-glucosyltransferase
Synonyms: LOC381694, B3galtl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381694
Homologene: 14978
Vmn2r87
Name: vomeronasal 2, receptor 87
Synonyms: EG625131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625131
Homologene: 129606
Kcnq3
Name: potassium voltage-gated channel, subfamily Q, member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110862
HGNC: HGNC:6297
Homologene: 20949
Plbd1
Name: phospholipase B domain containing 1
Synonyms: 1100001H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66857
Homologene: 11745
Il12a
Name: interleukin 12a
Synonyms: IL-12p35, p35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16159
HGNC: HGNC:5969
Homologene: 681
Tmem40
Name: transmembrane protein 40
Synonyms: 9030407H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 94346
Homologene: 10124
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, potassium channel Kv4.3L, Kv4.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Or1af1
Name: olfactory receptor family 1 subfamily AF member 1
Synonyms: GA_x6K02T2NLDC-33902472-33903401, MOR138-5P, MOR138-6, Olfr366
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 236509
Homologene: 114744
Actr5
Name: ARP5 actin-related protein 5
Synonyms: B430109J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109275
Homologene: 6818
Mrps11
Name: mitochondrial ribosomal protein S11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67994
Homologene: 32554
Ppp1r42
Name: protein phosphatase 1, regulatory subunit 42
Synonyms: 1700011J18Rik, 4930418G15Rik, Lrrc67
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69312
Homologene: 27077
Kbtbd7
Name: kelch repeat and BTB (POZ) domain containing 7
Synonyms: LOC211255, 1110008P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 211255
VEGA: 14
Homologene: 41849
Mboat2
Name: membrane bound O-acyltransferase domain containing 2
Synonyms: 2810049G06Rik, Oact2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67216
VEGA: 12
Homologene: 6971
Cers4
Name: ceramide synthase 4
Synonyms: 2900019C14Rik, Trh1, CerS4, Lass4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67260
Homologene: 11582
Rtp2
Name: receptor transporter protein 2
Synonyms: LOC224055
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224055
VEGA: 16
Homologene: 19503
CT573034.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Pea15a
Name: proliferation and apoptosis adaptor protein 15A
Synonyms: Pkcs15, Mat1, PEA-15, Pea15, phosphoprotein enriched in astrocytes 15A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18611
HGNC: HGNC:8822
Homologene: 7884
Ly6l
Name: lymphocyte antigen 6 complex, locus L
Synonyms: Gm20654
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 102637705
Homologene: 140539
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 10,003,412 bp
  • T to C, chromosome 1 at 172,200,400 bp
  • C to T, chromosome 2 at 37,220,176 bp
  • G to A, chromosome 2 at 101,886,331 bp
  • G to A, chromosome 2 at 158,625,220 bp
  • A to G, chromosome 3 at 36,947,953 bp
  • TCAC to TC, chromosome 3 at 68,697,987 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • T to C, chromosome 4 at 139,828,696 bp
  • A to T, chromosome 4 at 156,028,270 bp
  • T to A, chromosome 5 at 124,000,593 bp
  • T to C, chromosome 5 at 137,332,201 bp
  • G to T, chromosome 5 at 138,172,957 bp
  • T to C, chromosome 5 at 149,746,616 bp
  • C to T, chromosome 6 at 8,579,749 bp
  • A to G, chromosome 6 at 115,736,381 bp
  • A to T, chromosome 6 at 136,634,574 bp
  • C to A, chromosome 7 at 78,788,749 bp
  • A to G, chromosome 8 at 4,519,517 bp
  • A to T, chromosome 9 at 7,049,114 bp
  • A to G, chromosome 9 at 49,566,822 bp
  • T to C, chromosome 9 at 58,247,243 bp
  • T to C, chromosome 9 at 73,122,303 bp
  • T to C, chromosome 9 at 89,591,278 bp
  • A to T, chromosome 10 at 130,478,996 bp
  • T to C, chromosome 12 at 24,878,179 bp
  • T to C, chromosome 12 at 65,124,856 bp
  • T to A, chromosome 12 at 82,357,331 bp
  • G to T, chromosome 13 at 9,877,997 bp
  • G to A, chromosome 13 at 60,716,817 bp
  • G to C, chromosome 13 at 62,369,018 bp
  • G to T, chromosome 13 at 70,596,173 bp
  • A to G, chromosome 14 at 79,428,482 bp
  • T to C, chromosome 15 at 66,025,236 bp
  • T to G, chromosome 15 at 75,449,632 bp
  • A to G, chromosome 15 at 76,350,611 bp
  • G to T, chromosome 15 at 86,122,183 bp
  • T to C, chromosome 16 at 23,927,485 bp
  • C to T, chromosome 16 at 25,884,970 bp
  • G to A, chromosome 16 at 37,208,186 bp
  • A to G, chromosome 17 at 18,136,399 bp
  • T to A, chromosome 17 at 18,185,115 bp
  • T to C, chromosome 17 at 19,067,402 bp
  • A to C, chromosome 17 at 44,275,259 bp
  • G to C, chromosome 18 at 77,983,476 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2909 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040496-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.