Strain Name:
C57BL/6J-MtgxR3434Btlr/Mmmh
Stock Number:
040652-MU
Citation ID:
RRID:MMRRC_040652-MU
Other Names:
R3434 (G1), C57BL/6J-MtgxR3434Btlr
Major Collection:

Gene Information

Notch3
Name: notch 3
Synonyms: N3, hpbk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
Synonyms: Acra3, Acra-3, A730007P14Rik, neuronal nicotinic acetylcholine receptor, alpha 3 subunit, alpha 3, (a)3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110834
VEGA: 9
HGNC: HGNC:1957
Homologene: 591
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Ppat
Name: phosphoribosyl pyrophosphate amidotransferase
Synonyms: 5730454C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231327
HGNC: HGNC:9238
Homologene: 68272
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: Mtssk, MAST205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17776
Homologene: 7428
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 328329
Homologene: 42094
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 70797
Homologene: 19076
Sf3a3
Name: splicing factor 3a, subunit 3
Synonyms: 4930512K19Rik, 60kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75062
Homologene: 4949
Fasn
Name: fatty acid synthase
Synonyms: A630082H08Rik, FAS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, D4Abb1e, 4833432B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100019
Homologene: 39689
Azin1
Name: antizyme inhibitor 1
Synonyms: ODC antizyme inhibitor, 1700085L02Rik, Oazin, Oazi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 54375
Homologene: 22933
Ift74
Name: intraflagellar transport 74
Synonyms: 1700029H06Rik, Cmg1, b2b796Clo, Ccdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67694
Homologene: 11831
Drg2
Name: developmentally regulated GTP binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 13495
HGNC: HGNC:3030
Homologene: 1061
Lhx4
Name: LIM homeobox protein 4
Synonyms: Gsh4, A330062J17Rik, Gsh-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16872
Homologene: 56497
Rsbn1l
Name: round spermatid basic protein 1-like
Synonyms: C330002G24Rik, 8430412F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242860
Homologene: 19435
Spag5
Name: sperm associated antigen 5
Synonyms: D11Bhm180e, s17, Deepest, Mastrin, S17, Astrin, MAP126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 54141
Homologene: 4718
Fnbp1l
Name: formin binding protein 1-like
Synonyms: 2610318I01Rik, TOCA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 214459
Homologene: 134636
Abca17
Name: ATP-binding cassette, sub-family A (ABC1), member 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 381072
Homologene: 86807
Tle3
Name: transducin-like enhancer of split 3
Synonyms: Grg3a, 2610103N05Rik, Grg3b, ESG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 21887
Homologene: 21059
Atp7a
Name: ATPase, Cu++ transporting, alpha polypeptide
Synonyms: br, MNK, Menkes protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 11977
HGNC: HGNC:869
Homologene: 35
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: 4432416O06Rik, DHC2, b2b414Clo, Dnchc2, m407Asp, m152Asp, D030010H02Rik, D330044F14Rik, DHC1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Carm1
Name: coactivator-associated arginine methyltransferase 1
Synonyms: Prmt4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 59035
Homologene: 10990
Tubgcp3
Name: tubulin, gamma complex associated protein 3
Synonyms: Spc98p, GCP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 259279
Homologene: 4609
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, Ryr, calcium release channel isoform 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20190
Homologene: 68069
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: RdgB, DRES9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
P2rx4
Name: purinergic receptor P2X, ligand-gated ion channel 4
Synonyms: D5Ertd444e, P2X4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18438
HGNC: HGNC:8535
Homologene: 1923
Epb41l4b
Name: erythrocyte membrane protein band 4.1 like 4b
Synonyms: Lulu2, 6430543G08Rik, Epb4.1l4b, Ehm2, D4Ertd346e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 54357
Homologene: 69270
Mslnl
Name: mesothelin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 328783
VEGA: 17
Homologene: 18633
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Psdl, 1110007H17Rik, Efa6, Efa6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Dpysl3
Name: dihydropyrimidinase-like 3
Synonyms: Ulip1, TUC4, CRMP-4, Ulip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 22240
HGNC: HGNC:3015
Homologene: 20361
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, A930037M10Rik, A930011D15Rik, LOC269160, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, 1110034K09Rik, Nax, Scn6a, Nav2, NaG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20272
Homologene: 55706
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80797
Homologene: 77224
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231238
Homologene: 9054
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50720
Phykpl
Name: 5-phosphohydroxy-L-lysine phospholyase
Synonyms: Agxt2l2, 2900006B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72947
Homologene: 75268
Mup6
Name: major urinary protein 6
Synonyms: Gm12544
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 620807
Homologene: 74304
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 665210
Homologene: 115024
Mrps23
Name: mitochondrial ribosomal protein S23
Synonyms: Rpms23, D11Bwg1153e, 2310047I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 64656
Homologene: 41101
Slc39a10
Name: solute carrier family 39 (zinc transporter), member 10
Synonyms: 2900042E17Rik, Zip10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227059
Homologene: 34076
Adora3
Name: adenosine A3 receptor
Synonyms: A3AR, Gpcr 2, 4930578J19Rik, 1700001D09Rik, ARA3, A3R, AA3R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11542
HGNC: HGNC:268
Homologene: 550
Olfr1131
Name: olfactory receptor 1131
Synonyms: MOR177-4, GA_x6K02T2Q125-49133664-49134593
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258652
Homologene: 133019
Olfr1200
Name: olfactory receptor 1200
Synonyms: GA_x6K02T2Q125-50243231-50242221, MOR225-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 257887
Homologene: 123770
Fhl4
Name: four and a half LIM domains 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14202
VEGA: 10
Vmn1r209
Name: vomeronasal 1 receptor 209
Synonyms: Gm11315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 432736
Homologene: 110880
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 320709
VEGA: 15
Homologene: 12992
Olfr705
Name: olfactory receptor 705
Synonyms: MOR283-2, GA_x6K02T2PBJ9-9256348-9255398
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259034
Homologene: 128075
Fam47e
Name: family with sequence similarity 47, member E
Synonyms: LOC384198, Gm1381
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 384198
Homologene: 129958
Clstn2
Name: calsyntenin 2
Synonyms: CS2, Cst-2, 2900042C18Rik, CSTN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 64085
Homologene: 49698
Slc35a5
Name: solute carrier family 35, member A5
Synonyms: D16Ertd450e, D730043G07Rik, 1010001J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74102
Homologene: 9930
Ccnjl
Name: cyclin J-like
Synonyms: LOC380694
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380694
Homologene: 11588
Rpgr
Name: retinitis pigmentosa GTPase regulator
Synonyms: Rp3h, Rd9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 19893
Homologene: 55455
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 46,835,717 bp
  • A to T, chromosome 1 at 93,428,161 bp
  • A to G, chromosome 1 at 155,702,401 bp
  • C to T, chromosome 1 at 188,733,758 bp
  • T to C, chromosome 2 at 66,675,503 bp
  • T to C, chromosome 2 at 76,868,377 bp
  • T to C, chromosome 2 at 87,629,074 bp
  • T to C, chromosome 2 at 88,768,069 bp
  • A to G, chromosome 3 at 105,904,915 bp
  • C to T, chromosome 3 at 122,546,306 bp
  • G to A, chromosome 3 at 144,808,761 bp
  • T to C, chromosome 4 at 32,733,726 bp
  • T to C, chromosome 4 at 57,040,865 bp
  • G to T, chromosome 4 at 60,004,116 bp
  • A to G, chromosome 4 at 94,621,852 bp
  • A to T, chromosome 4 at 116,308,095 bp
  • C to A, chromosome 4 at 124,725,077 bp
  • A to G, chromosome 5 at 3,692,760 bp
  • T to C, chromosome 5 at 20,905,930 bp
  • T to C, chromosome 5 at 53,117,090 bp
  • A to G, chromosome 5 at 76,918,065 bp
  • T to A, chromosome 5 at 92,585,362 bp
  • T to A, chromosome 5 at 122,725,070 bp
  • A to T, chromosome 6 at 84,070,888 bp
  • C to A, chromosome 7 at 29,115,545 bp
  • A to T, chromosome 7 at 106,873,769 bp
  • T to C, chromosome 8 at 12,658,381 bp
  • A to C, chromosome 9 at 7,011,236 bp
  • T to C, chromosome 9 at 21,569,473 bp
  • T to A, chromosome 9 at 55,024,326 bp
  • T to A, chromosome 9 at 61,414,094 bp
  • T to A, chromosome 9 at 97,454,715 bp
  • T to C, chromosome 10 at 85,098,444 bp
  • A to G, chromosome 11 at 43,579,861 bp
  • A to G, chromosome 11 at 51,598,655 bp
  • A to T, chromosome 11 at 60,461,392 bp
  • T to C, chromosome 11 at 78,313,949 bp
  • A to G, chromosome 11 at 88,210,114 bp
  • G to A, chromosome 11 at 120,822,773 bp
  • A to T, chromosome 13 at 22,806,097 bp
  • A to G, chromosome 13 at 102,787,379 bp
  • A to G, chromosome 14 at 61,212,303 bp
  • T to C, chromosome 15 at 38,493,576 bp
  • T to C, chromosome 15 at 95,094,692 bp
  • A to G, chromosome 16 at 45,144,033 bp
  • A to T, chromosome 17 at 18,110,108 bp
  • G to A, chromosome 17 at 24,289,537 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • A to T, chromosome 17 at 32,158,618 bp
  • C to T, chromosome 18 at 43,361,061 bp
  • G to A, chromosome 19 at 4,112,234 bp
  • A to G, chromosome 19 at 46,312,939 bp
  • A to G, chromosome X at 10,176,602 bp
  • G to A, chromosome X at 106,094,857 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3434 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040652-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.