Strain Name:
C57BL/6J-MtgxR3624Btlr/Mmmh
Stock Number:
040678-MU
Citation ID:
RRID:MMRRC_040678-MU
Other Names:
R3624 (G1), C57BL/6J-MtgxR3624Btlr
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: 9930031C03Rik, brain spectrin, elf1, spectrin G, beta fodrin, Spnb2, non-erythrocytic, Spnb-2, elf3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Met
Name: met proto-oncogene
Synonyms: HGF receptor, Par4, c-Met
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Cdkn2a
Name: cyclin dependent kinase inhibitor 2A
Synonyms: p16, p19ARF, p16INK4a, MTS1, Arf, Ink4a/Arf, INK4a-ARF, Pctr1, ARF-INK4a, p19ARF
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12578
HGNC: HGNC:1787
Homologene: 55430
Htr1d
Name: 5-hydroxytryptamine (serotonin) receptor 1D
Synonyms: Htr1db, Gpcr14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15552
HGNC: HGNC:5289
Homologene: 20240
Mga
Name: MAX gene associated
Synonyms: Mga, D030062C11Rik, C130042M01Rik, Mad5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224650
Homologene: 9068
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107182
Homologene: 31978
Smad1
Name: SMAD family member 1
Synonyms: Smad 1, Madr1, Madh1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17125
HGNC: HGNC:6767
Homologene: 21196
Racgap1
Name: Rac GTPase-activating protein 1
Synonyms: Band25, gtl11, GTPase, MgcRacGAP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26934
HGNC: HGNC:9804
Homologene: 8077
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: Hpve6a, A130086L21Rik, 5830462N02Rik, E6-AP ubiquitin protein ligase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Akap9
Name: A kinase anchor protein 9
Synonyms: G1-448-15, repro12, AKAP450, mei2-5, 5730481H23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Elp1
Name: elongator complex protein 1
Synonyms: C78473, Ikbkap, IKAP, 3110040G09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Snrpb
Name: small nuclear ribonucleoprotein B
Synonyms: SM11, SMB, SNRNP-B, SM-B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20638
Homologene: 134543
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Rspry1
Name: ring finger and SPRY domain containing 1
Synonyms: 4930470D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67610
Homologene: 12164
Strn3
Name: striatin, calmodulin binding protein 3
Synonyms: SG2NA
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 94186
VEGA: 12
Homologene: 82078
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: Fam208b, BC016423
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Mgat4a
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms: GnT-IVa, 9530018I07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269181
HGNC: HGNC:7047
Homologene: 8153
Uhrf1
Name: ubiquitin-like, containing PHD and RING finger domains, 1
Synonyms: ICBP90, Np95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18140
Homologene: 7866
Coch
Name: cochlin
Synonyms: D12H14S564E, Coch-5B2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Adcy1
Name: adenylate cyclase 1
Synonyms: I-AC, D11Bwg1392e, AC1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432530
HGNC: HGNC:232
Homologene: 41419
Colec11
Name: collectin sub-family member 11
Synonyms: 1010001H16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71693
VEGA: 12
Homologene: 11423
Zfp60
Name: zinc finger protein 60
Synonyms: 6330516O17Rik, Mfg-3, Mfg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22718
Homologene: 137228
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Ese2, Sh3d1B, Eh domain, SH3 domain regulator of endocytosis 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Midn
Name: midnolin
Synonyms: 3000003C15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59090
Homologene: 32510
Zkscan8
Name: zinc finger with KRAB and SCAN domains 8
Synonyms: Zfp192, LD5-1, D430019P06Rik, 2510038J07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 93681
Homologene: 21268
Dock8
Name: dedicator of cytokinesis 8
Synonyms: 1200017A24Rik, 5830472H07Rik, A130095G14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76088
VEGA: 19
Homologene: 52414
Hyal4
Name: hyaluronoglucosaminidase 4
Synonyms: 4632428M18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 77042
HGNC: HGNC:5323
Homologene: 69117
Klhl14
Name: kelch-like 14
Synonyms: 6330403N15Rik, printor
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225266
Homologene: 28121
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: 4732499L03Rik, Mlsn1, melastatin, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: 2610103N14Rik, PRO0813, TAT1, Mct10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72472
VEGA: 10
Homologene: 75089
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Irs2
Name: insulin receptor substrate 2
Synonyms: Irs-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384783
HGNC: HGNC:6126
Homologene: 2778
Sgcz
Name: sarcoglycan zeta
Synonyms: C230085N17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244431
Homologene: 26726
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll4, C430014K11Rik, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Cyp2c54
Name: cytochrome P450, family 2, subfamily c, polypeptide 54
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 404195
VEGA: 19
Homologene: 137231
Scml4
Name: Scm polycomb group protein like 4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268297
Homologene: 18262
Pbld1
Name: phenazine biosynthesis-like protein domain containing 1
Synonyms: 0610038K03Rik, Pbld
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68371
VEGA: 10
Homologene: 41470
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234135
Homologene: 56960
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Fpr-rs4
Name: formyl peptide receptor, related sequence 4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14291
HGNC: HGNC:3827
Homologene: 130629
Tgm6
Name: transglutaminase 6
Synonyms: TGM3L
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241636
Homologene: 27970
Mog
Name: myelin oligodendrocyte glycoprotein
Synonyms: B230317G11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17441
HGNC: HGNC:7197
Homologene: 111009
Trim54
Name: tripartite motif-containing 54
Synonyms: Rnf30, 4930486E09Rik, 4930566I02Rik, MuRF3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58522
Homologene: 10983
Dffb
Name: DNA fragmentation factor, beta subunit
Synonyms: DFF40, CPAN, CAD, caspase-activated DNase, 40kDa, 5730477D02Rik, Didff
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13368
HGNC: HGNC:2773
Homologene: 3241
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: 2810471M23Rik, Veph
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72789
Homologene: 11624
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Itih-3, Intin3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
1110020G09Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243628
Homologene: 135915
Vmn1r30
Name: vomeronasal 1 receptor 30
Synonyms: V1rc9, V1rc22
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171195
Homologene: 137652
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Emilin3
Name: elastin microfibril interfacer 3
Synonyms: EMILIN-T, 1110013O17Rik, Emilin5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 280635
Homologene: 18817
Ankrd53
Name: ankyrin repeat domain 53
Synonyms: 4930564N15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75305
Homologene: 49810
Fam186b
Name: family with sequence similarity 186, member B
Synonyms: EG545136
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545136
VEGA: 15
Homologene: 69502
Gm2128
Name: predicted gene 2128
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100039269
Homologene: 45597
D17H6S53E
Name: DNA segment, Chr 17, human D6S53E
Synonyms: NG34
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 114585
Homologene: 75155
Loxl4
Name: lysyl oxidase-like 4
Synonyms: 4833426I20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67573
Homologene: 12977
Esp4
Name: exocrine gland secreted peptide 4
Synonyms: Gm20580
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126777
VEGA: 17
Homologene: 136356
Vmn1r88
Name: vomeronasal 1 receptor, 88
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100312474
Homologene: 74345
H2-T3
Name: histocompatibility 2, T region locus 3
Synonyms: H2-Tw3, H-2T3, TL
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15043
Homologene: 74884
Smad9
Name: SMAD family member 9
Synonyms: SMAD8B, MADH6, SMAD8A, Madh9
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55994
HGNC: HGNC:6774
Homologene: 21198
Spag11a
Name: sperm associated antigen 11A
Synonyms: Spag11, Bin1b, 9230111C08Rik, Ep2e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78128
Homologene: 14385
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,444,696 bp
  • A to G, chromosome 2 at 119,941,764 bp
  • T to A, chromosome 2 at 130,151,761 bp
  • C to A, chromosome 2 at 130,175,379 bp
  • T to C, chromosome 2 at 160,908,257 bp
  • C to T, chromosome 3 at 54,789,284 bp
  • C to T, chromosome 3 at 66,215,437 bp
  • C to T, chromosome 3 at 96,651,738 bp
  • C to T, chromosome 4 at 56,798,708 bp
  • A to G, chromosome 4 at 89,276,630 bp
  • T to C, chromosome 4 at 136,443,504 bp
  • T to C, chromosome 4 at 153,965,519 bp
  • C to A, chromosome 5 at 3,976,235 bp
  • G to A, chromosome 5 at 31,136,976 bp
  • A to T, chromosome 6 at 17,549,086 bp
  • A to T, chromosome 6 at 24,765,738 bp
  • A to T, chromosome 6 at 58,435,452 bp
  • A to G, chromosome 6 at 83,763,262 bp
  • A to G, chromosome 6 at 123,816,038 bp
  • A to C, chromosome 7 at 13,177,863 bp
  • T to A, chromosome 7 at 27,749,328 bp
  • T to C, chromosome 7 at 41,157,628 bp
  • T to A, chromosome 7 at 59,272,112 bp
  • A to G, chromosome 7 at 64,244,853 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • C to T, chromosome 8 at 11,007,643 bp
  • A to G, chromosome 8 at 19,159,401 bp
  • A to G, chromosome 8 at 25,662,819 bp
  • T to C, chromosome 8 at 37,953,047 bp
  • A to G, chromosome 8 at 79,339,698 bp
  • A to G, chromosome 8 at 94,649,777 bp
  • A to G, chromosome 10 at 40,141,894 bp
  • T to C, chromosome 10 at 42,930,611 bp
  • T to C, chromosome 10 at 63,061,691 bp
  • A to G, chromosome 10 at 80,150,310 bp
  • A to G, chromosome 10 at 88,757,993 bp
  • A to G, chromosome 11 at 7,130,348 bp
  • T to C, chromosome 11 at 30,140,593 bp
  • T to A, chromosome 12 at 4,671,395 bp
  • T to C, chromosome 12 at 28,594,908 bp
  • A to G, chromosome 12 at 51,602,826 bp
  • T to C, chromosome 12 at 51,661,216 bp
  • C to T, chromosome 12 at 85,268,395 bp
  • T to C, chromosome 13 at 3,595,556 bp
  • C to T, chromosome 13 at 21,520,776 bp
  • T to C, chromosome 13 at 68,642,531 bp
  • A to G, chromosome 14 at 30,914,743 bp
  • T to A, chromosome 15 at 9,084,223 bp
  • A to G, chromosome 15 at 90,965,595 bp
  • T to C, chromosome 15 at 98,842,902 bp
  • A to G, chromosome 15 at 99,280,515 bp
  • T to A, chromosome 15 at 99,642,891 bp
  • CAGGAA to CA, chromosome 17 at 18,022,334 bp
  • T to C, chromosome 17 at 27,986,288 bp
  • A to G, chromosome 17 at 35,127,536 bp
  • T to C, chromosome 17 at 36,190,065 bp
  • T to C, chromosome 17 at 37,012,446 bp
  • A to G, chromosome 17 at 40,602,593 bp
  • C to T, chromosome 17 at 56,317,023 bp
  • A to T, chromosome 18 at 21,557,896 bp
  • A to G, chromosome 19 at 25,079,877 bp
  • A to G, chromosome 19 at 36,981,086 bp
  • A to G, chromosome 19 at 40,070,244 bp
  • A to G, chromosome 19 at 42,607,576 bp
  • A to T, chromosome 19 at 48,535,618 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3624 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040678-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.